LOCUS       NM_001001957             945 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily W member 3
            (OR2W3), mRNA.
ACCESSION   NM_001001957 XM_291438
VERSION     NM_001001957.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Huang,J., Lam,H., Koziol-White,C., Limjunyawong,N., Kim,D., Kim,N.,
            Karmacharya,N., Rajkumar,P., Firer,D., Dalesio,N.M., Jude,J.,
            Kurten,R.C., Pluznick,J.L., Deshpande,D.A., Penn,R.B.,
            Liggett,S.B., Panettieri,R.A. Jr., Dong,X. and An,S.S.
  TITLE     The odorant receptor OR2W3 on airway smooth muscle evokes
            bronchodilation via a cooperative chemosensory tradeoff between
            TMEM16A and CFTR
  JOURNAL   Proc Natl Acad Sci U S A 117 (45), 28485-28495 (2020)
   PUBMED   33097666
  REMARK    GeneRIF: The odorant receptor OR2W3 on airway smooth muscle evokes
            bronchodilation via a cooperative chemosensory tradeoff between
            TMEM16A and CFTR.
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Melroy-Greif,W.E., Wilhelmsen,K.C., Yehuda,R. and Ehlers,C.L.
  TITLE     Genome-Wide Association Study of Post-Traumatic Stress Disorder in
            Two High-Risk Populations
  JOURNAL   Twin Res Hum Genet 20 (3), 197-207 (2017)
   PUBMED   28262088
  REMARK    GeneRIF: A signal in a nearby olfactory receptor on chromosome 1,
            olfactory receptor family 2 subfamily L member 13 (OR2L13), tagged
            by rs151319968, was nominally associated with PTSD in the AI
            sample. Although no variants were significantly associated after
            correction for multiple testing in a meta-analysis of the two
            cohorts, pathway analysis of the top hits showed an enrichment
            cluster of terms related to sensory transduction.
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Noe,F., Polster,J., Geithe,C., Kotthoff,M., Schieberle,P. and
            Krautwurst,D.
  TITLE     OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor
            for the Sensitive Detection of Onion Key Food Odorant
            3-Mercapto-2-methylpentan-1-ol
  JOURNAL   Chem Senses 42 (3), 195-210 (2017)
   PUBMED   27916748
  REMARK    GeneRIF: This outstanding specificity of extremely narrowly tuned
            human OR2M3 can explain both odor qualities and odor threshold
            trend within a homologous series of 3-mercapto-2-methylalkan-1-ols
            and suggests a modern human-specific, food-related function of
            OR2M3 in detecting a single onion key food odorant.
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Sharon,D., Kimchi,A. and Rivolta,C.
  TITLE     OR2W3 sequence variants are unlikely to cause inherited retinal
            diseases
  JOURNAL   Ophthalmic Genet 37 (4), 366-368 (2016)
   PUBMED   26891008
  REMARK    GeneRIF: We therefore conclude that this sequence variant, and
            hence the OR2W3 gene, do not cause RP. Prompted by these findings
            and based on simple principles of population genetics, we suggest
            that WES studies should consider DNA variants as the possible cause
            of dominant RP only if they are present in less than 1:100,000
            individuals from the general population.
            Review article
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Chihara,M., Yoshihara,K., Ishiguro,T., Yokota,Y., Adachi,S.,
            Okada,H., Kashima,K., Sato,T., Tanaka,A., Tanaka,K. and Enomoto,T.
  TITLE     Susceptibility to male infertility: replication study in Japanese
            men looking for an association with four GWAS-derived loci
            identified in European men
  JOURNAL   J Assist Reprod Genet 32 (6), 903-908 (2015)
   PUBMED   25847845
  REMARK    GeneRIF: OR2W3 is associated with genetic susceptibility to
            Japanese male infertility.
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Ma,X., Guan,L., Wu,W., Zhang,Y., Zheng,W., Gao,Y.T., Long,J.,
            Wu,N., Wu,L., Xiang,Y., Xu,B., Shen,M., Chen,Y., Wang,Y., Yin,Y.,
            Li,Y., Xu,H., Xu,X. and Li,Y.
  TITLE     Whole-exome sequencing identifies OR2W3 mutation as a cause of
            autosomal dominant retinitis pigmentosa
  JOURNAL   Sci Rep 5, 9236 (2015)
   PUBMED   25783483
  REMARK    GeneRIF: A novel missense mutation, c. 424 C > T transition
            (p.R142W) in OR2W3 gene, was identified as a potentially causative
            mutation for autosomal dominant Retinitis pigmentosa.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 945)
  AUTHORS   Zhang,Y., He,X.J., Song,B., Ye,L., Xie,X.S., Ruan,J., Zhou,F.S.,
            Zuo,X.B., Cao,Y.X. and Du,W.D.
  TITLE     Association of single nucleotide polymorphisms in the USF1, GTF2A1L
            and OR2W3 genes with non-obstructive azoospermia in the Chinese
            population
  JOURNAL   J Assist Reprod Genet 32 (1), 95-101 (2015)
   PUBMED   25374392
  REMARK    GeneRIF: Our results provided a new insight into susceptibility of
            USF1 variant with male infertility. rs11204546 of OR2W3 and
            rs11677854 of GTF2A1L might be additional valuable molecular
            predictive markers
REFERENCE   8  (bases 1 to 945)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   9  (bases 1 to 945)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099571.3.
            
            On Jul 2, 2005 this sequence version replaced NM_001001957.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC146848.1, SRR1803615.412140.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360358.3/ ENSP00000353516.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-945               AC099571.3         111696-112640
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..945
                     /gene="OR2W3"
                     /gene_synonym="OR2W3P; OR2W8P; OST718"
                     /note="olfactory receptor family 2 subfamily W member 3"
                     /db_xref="GeneID:343171"
                     /db_xref="HGNC:HGNC:15021"
                     /db_xref="MIM:616729"
     CDS             1..945
                     /gene="OR2W3"
                     /gene_synonym="OR2W3P; OR2W8P; OST718"
                     /note="olfactory receptor, family 2, subfamily W, member 8
                     pseudogene; olfactory receptor, family 2, subfamily W,
                     member 3 pseudogene; olfactory receptor OR1-49; olfactory
                     receptor 2W8"
                     /codon_start=1
                     /product="olfactory receptor 2W3"
                     /protein_id="NP_001001957.2"
                     /db_xref="CCDS:CCDS31099.1"
                     /db_xref="GeneID:343171"
                     /db_xref="HGNC:HGNC:15021"
                     /db_xref="MIM:616729"
                     /translation="MDGTNGSTQTHFILLGFSDRPHLERILFVVILIAYLLTLVGNTT
                     IILVSRLDPHLHTPMYFFLAHLSFLDLSFTTSSIPQLLYNLNGCDKTISYMGCAIQLF
                     LFLGLGGVECLLLAVMAYDRCVAICKPLHYMVIMNPRLCRGLVSVTWGCGVANSLAMS
                     PVTLRLPRCGHHEVDHFLREMPALIRMACVSTVAIEGTVFVLAVGVVLSPLVFILLSY
                     SYIVRAVLQIRSASGRQKAFGTCGSHLTVVSLFYGNIIYMYMQPGASSSQDQGMFLML
                     FYNIVTPLLNPLIYTLRNREVKGALGRLLLGKRELGKE"
     exon            1..945
                     /gene="OR2W3"
                     /gene_synonym="OR2W3P; OR2W8P; OST718"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggatggaa ccaatggcag cacccaaacc catttcatcc tactgggatt ctctgaccga
       61 ccccatctgg agaggatcct ctttgtggtc atcctgatcg cgtacctcct gaccctcgta
      121 ggcaacacca ccatcatcct ggtgtcccgg ctggaccccc acctccacac ccccatgtac
      181 ttcttcctcg cccacctttc cttcctggac ctcagtttca ccaccagctc catcccccag
      241 ctgctctaca accttaatgg atgtgacaag accatcagct acatgggctg tgccatccag
      301 ctcttcctgt tcctgggtct gggtggtgtg gagtgcctgc ttctggctgt catggcctat
      361 gaccggtgtg tggctatctg caagcccctg cactacatgg tgatcatgaa ccccaggctc
      421 tgccggggct tggtgtcagt gacctggggc tgtggggtgg ccaactcctt ggccatgtct
      481 cctgtgaccc tgcgcttacc ccgctgtggg caccacgagg tggaccactt cctgcgtgag
      541 atgcccgccc tgatccggat ggcctgcgtc agcactgtgg ccatcgaagg caccgtcttt
      601 gtcctggcgg tgggtgttgt gctgtccccc ttggtgttta tcctgctctc ttacagctac
      661 attgtgaggg ctgtgttaca aattcggtca gcatcaggaa ggcagaaggc cttcggcacc
      721 tgcggctccc atctcactgt ggtctccctt ttctatggaa acatcatcta catgtacatg
      781 cagccaggag ccagttcttc ccaggaccag ggcatgttcc tcatgctctt ctacaacatt
      841 gtcacccccc tcctcaatcc tctcatctac accctcagaa acagagaggt gaagggggca
      901 ctgggaaggt tgcttctggg gaagagagag ctaggaaagg agtaa
//
