LOCUS       NM_001005522            2422 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily T member 8
            (OR2T8), mRNA.
ACCESSION   NM_001005522 XM_011544178 XM_291439
VERSION     NM_001005522.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099571.3.
            
            On or before Aug 5, 2020 this sequence version replaced
            XM_011544178.2, NM_001005522.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF849296.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641945.2/ ENSP00000493286.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AC099571.3         136361-136627
            268-2422            AC099571.3         137107-139261
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..2422
                     /gene="OR2T8"
                     /gene_synonym="OR2T8P"
                     /note="olfactory receptor family 2 subfamily T member 8"
                     /db_xref="GeneID:343172"
                     /db_xref="HGNC:HGNC:15020"
     exon            1..267
                     /gene="OR2T8"
                     /gene_synonym="OR2T8P"
                     /inference="alignment:Splign:2.1.0"
     exon            268..2422
                     /gene="OR2T8"
                     /gene_synonym="OR2T8P"
                     /inference="alignment:Splign:2.1.0"
     CDS             288..1226
                     /gene="OR2T8"
                     /gene_synonym="OR2T8P"
                     /note="olfactory receptor, family 2, subfamily T, member 8
                     pseudogene"
                     /codon_start=1
                     /product="olfactory receptor 2T8"
                     /protein_id="NP_001005522.1"
                     /db_xref="CCDS:CCDS31100.1"
                     /db_xref="GeneID:343172"
                     /db_xref="HGNC:HGNC:15020"
                     /translation="MENGSYTSYFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMI
                     LLIHWDHRLHTPMYFLLSQLSLMDVMLVSTTVPKMAADYLTGSKAISRAGCGAQIFFL
                     PTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMNLSCWLLGAADGLLQAVA
                     TLSFPYCGAHEIDHFFCETPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGL
                     ILAAVLHMRSTEARKKAFATCSSHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFY
                     TMFTPLLNPLIYSVKNSEVKGALTRCMGRCVALSRE"
     regulatory      2389..2394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2T8"
                     /gene_synonym="OR2T8P"
                     /note="hexamer: AATAAA"
     polyA_site      2422
                     /gene="OR2T8"
                     /gene_synonym="OR2T8P"
                     /note="major polyA site"
ORIGIN      
        1 cattgcaaca aagtaccttg tacagttaat gaaaatgtgt gtttaccatt atactcttac
       61 actgcaaaga aataaaaaat atccaagaag gtcagtactg ttttcagtct atcacctata
      121 aaggaggact aaatgtgttc acaactccaa attaactatg ttttcatctg cagactcagc
      181 ctttccagac ctgagaatat aagtcaccct ctttagaaag gaaaaaaagt cttcttggat
      241 taagtcaggg aaaactgcct gattttgtgt cactcttatt tgaaatcatg gaaaatggga
      301 gctatacctc ttatttcatt ctcctaggac tctttaacca caccagagcc caccaagtcc
      361 tcttcatgat ggttctgagt atcgttttga cctccctgtt tggcaattcc ctcatgattc
      421 tcctgattca ctgggaccac cggctccaca cgcccatgta cttcctcctg agccaacttt
      481 ccctcatgga cgtgatgctg gtttccacca ctgtgcccaa aatggcggct gactacttga
      541 ccggaagtaa ggccatctcc cgcgctggct gtggtgcgca gatcttcttc ctccccacac
      601 tgggtggtgg agagtgcttc ctcttagcag ccatggccta tgaccgctat gcggctgtct
      661 gccacccact ccgatatccc actctcatga gctggcagct gtgcctgagg atgaacctgt
      721 cgtgttggct cctgggtgca gctgacgggc tcctgcaggc tgttgctacc ctgagcttcc
      781 catattgcgg tgcacacgag atcgatcact tcttctgcga gacccccgtg ctggtgcgtt
      841 tggcttgtgc tgacacttca gtcttcgaaa acgccatgta catctgctgt gtgttaatgc
      901 tcctggtccc cttttccctc atcctgtcct cctatggtct catcctcgct gctgttctgc
      961 acatgcgctc tacagaagcc cgcaagaagg cctttgccac ctgctcttca catgtggctg
     1021 tggtgggact cttttatgga gctgccattt ttacctatat gagacccaaa tcccacaggt
     1081 ccactaacca cgacaaggtt gtgtcagcct tctatactat gttcacccct ttactaaacc
     1141 ccctcatcta cagtgtgaag aacagtgagg tgaagggagc cctgacaagg tgtatgggtc
     1201 ggtgtgtggc cttaagtcgt gaataagact atatatttgc cccaacattc aaaactgtgc
     1261 aaagtgtttg tgtggaattt cctagaaata aggaatatac acttttattt ctacatctgt
     1321 tgtctctgtg tgtgtgtgtg tttgtgtgtt gctttgaatt gcagatgaat cttcattcct
     1381 cgggttcatt tactcagcta tcattaccca atcaaatcat ggattgttaa aaatcggtga
     1441 actcactaat ccttagtaag atggttttac atcatacctc acaataattt tttgttcaaa
     1501 gaatgaatta accattcaag cagttttgaa agttgttgcc atttgtttca aattgaggtg
     1561 tagcttacac acagtagaat gctcgcattt aagatgttcc ttttcaacta atttccacaa
     1621 atatctaccc tggtaattca cccattagga agagacacca ttttcaccac ctcagaaagg
     1681 tcctgcaggc ccttttccag tgatacccca ggcctaagat acatccactg ctctaatttt
     1741 tatctctgtt cgttagtttg ggctattcta aaatttcaca tcaaaggaaa caaatagtat
     1801 ggtcttgaat cttgtttcct tctttcagct taatgtattt ctaaaatccc tccacatttt
     1861 tacctcattg ttacattgct tttttttact gctaagtagt attttgtttt ctgaaaattt
     1921 catcatttgt ttatccatta ttttgctgat ggacatctgg gctattttca gtttgaagtt
     1981 ctggtgactg aaatgtatgt taatctccta tttgtaatca tatgttttta tttttcttgg
     2041 taggtgtctg gtgaactctt cagtaaactg ttttcaaagt ggttgtttac tcttatactg
     2101 ccgctgacaa tgcacacaag ttcctgttgc tccaaatgtc gatgttttct tcattttagc
     2161 aattcttctg agtgtagtag gaactcagtt tgcttttaat ttgcattttc ctgatgacta
     2221 ataatgttga ggcctcttgc gttagcttat tatctattgc ctattgatgt aaactgtcta
     2281 cttcagtttt tggaaaaaaa aatctgtata tgcttccaaa gcgaaaacaa cttggtcatt
     2341 aactaatagg caatctatgg cattcatagg gctacttgga attttggaaa taaaatcata
     2401 tattgggtta ttttttatta ta
//
