LOCUS       NM_001001824            1136 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily T member 27
            (OR2T27), transcript variant 2, mRNA.
ACCESSION   NM_001001824 XM_377659
VERSION     NM_001001824.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1136)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1136)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098483.2.
            
            On Aug 5, 2020 this sequence version replaced NM_001001824.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000460972.4/
                                                ENSP00000493412.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC098483.2         131236-131320       c
            86-1136             AC098483.2         125630-126680       c
FEATURES             Location/Qualifiers
     source          1..1136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1136
                     /gene="OR2T27"
                     /note="olfactory receptor family 2 subfamily T member 27"
                     /db_xref="GeneID:403239"
                     /db_xref="HGNC:HGNC:31252"
     exon            1..85
                     /gene="OR2T27"
                     /inference="alignment:Splign:2.1.0"
     exon            86..1136
                     /gene="OR2T27"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1043
                     /gene="OR2T27"
                     /note="olfactory receptor OR1-67"
                     /codon_start=1
                     /product="olfactory receptor 2T27"
                     /protein_id="NP_001001824.1"
                     /db_xref="CCDS:CCDS31124.1"
                     /db_xref="GeneID:403239"
                     /db_xref="HGNC:HGNC:31252"
                     /translation="MEQSNYSVYADFILLGLFSNARFPWLLFALILLVFLTSIASNVV
                     KIILIHIDSRLHTPMYFLLSQLSLRDILYISTIVPKMLVDQVMSQRAISFAGCTAQHF
                     LYLTLAGAEFFLLGLMSYDRYVAICNPLHYPVLMSRKICWLIVAAAWLGGSIDGFLLT
                     PVTMQFPFCASREINHFFCEVPALLKLSCTDTSAYETAMYVCCIMMLLIPFSVISGSY
                     TRILITVYRMSEAEGRGKAVATCSSHMVVVSLFYGAAMYTYVLPHSYHTPEQDKAVSA
                     FYTILTPMLNPLIYSLRNKDVTGALQKVVGRCVSSGKVTTF"
ORIGIN      
        1 tgaacaattg catgtactac cttagttctg taaggtttct ctctaaatat tcagatcatc
       61 gtgtttgggg aagatactgt gtaagagcta tggagcagag caattattcc gtgtatgccg
      121 actttatcct tctgggtttg ttcagcaacg cccgtttccc ctggcttctc tttgccctca
      181 ttctcctggt ctttttgacc tccatagcca gcaacgtggt caagatcatt ctcatccaca
      241 tagactcccg cctccacacc cccatgtact tcctgctcag ccagctctcc ctcagggaca
      301 tcctgtatat ttccaccatt gtgcccaaaa tgctggtcga ccaggtgatg agccagagag
      361 ccatttcctt tgctggatgc actgcccaac acttcctcta cttgacctta gcaggggctg
      421 agttcttcct cctaggactc atgtcctatg atcgctacgt agccatctgc aaccctctgc
      481 actatcctgt cctcatgagc cgcaagatct gctggttgat tgtggcggca gcctggctgg
      541 gagggtctat cgatggtttc ttgctcaccc ccgtcaccat gcagttcccc ttctgtgcct
      601 ctcgggagat caaccacttc ttctgcgagg tgcctgccct tctgaagctc tcctgcacgg
      661 acacatcagc ctacgagaca gccatgtatg tctgctgtat tatgatgctc ctcatccctt
      721 tctctgtcat ctcgggctct tacacaagaa ttctcattac tgtttatagg atgagcgagg
      781 cagaggggag gggaaaggct gtggccacct gctcctcaca catggtggtt gtcagcctct
      841 tctatggggc tgccatgtac acatacgtgc tgcctcattc ttaccacacc cctgagcagg
      901 acaaagctgt atctgccttc tacaccatcc ttactcccat gctcaatcca ctcatttaca
      961 gccttaggaa caaggatgtc acaggggccc tacagaaggt tgtggggagg tgtgtgtcct
     1021 caggaaaggt aaccactttc taaagaaatt tcatatgctg ctagagactt gaaatgaagg
     1081 atacaagact ttatcattgc ccttgaattt aaatattctc tgcctggaaa caagtg
//
