LOCUS       NM_001004692            5708 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily T member 12
            (OR2T12), transcript variant 1, mRNA.
ACCESSION   NM_001004692 XM_060305
VERSION     NM_001004692.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5708)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5708)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450303.10.
            
            On Aug 5, 2020 this sequence version replaced NM_001004692.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the allele encoded
            by the GRCh38 reference genome and encodes the longer isoform (1).
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641276.1/ ENSP00000493000.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AL450303.10        111187-111265       c
            80-260              AL450303.10        109214-109394       c
            261-5708            AL450303.10        97980-103427        c
FEATURES             Location/Qualifiers
     source          1..5708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..5708
                     /gene="OR2T12"
                     /gene_synonym="OR1-57"
                     /note="olfactory receptor family 2 subfamily T member 12"
                     /db_xref="GeneID:127064"
                     /db_xref="HGNC:HGNC:19592"
     exon            1..79
                     /gene="OR2T12"
                     /gene_synonym="OR1-57"
                     /inference="alignment:Splign:2.1.0"
     exon            80..260
                     /gene="OR2T12"
                     /gene_synonym="OR1-57"
                     /inference="alignment:Splign:2.1.0"
     exon            261..5708
                     /gene="OR2T12"
                     /gene_synonym="OR1-57"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1231
                     /gene="OR2T12"
                     /gene_synonym="OR1-57"
                     /note="isoform 1 is encoded by transcript variant 1;
                     olfactory receptor 2T12; olfactory receptor OR1-57; novel
                     7 transmembrane receptor (rhodopsin family) protein"
                     /codon_start=1
                     /product="olfactory receptor 2T12 isoform 1"
                     /protein_id="NP_001004692.1"
                     /db_xref="CCDS:CCDS31110.1"
                     /db_xref="GeneID:127064"
                     /db_xref="HGNC:HGNC:19592"
                     /translation="MEMRNTTPDFILLGLFNHTRAHQVLFMMLLATVLTSLFSNALMI
                     LLIHWDHRLHRPMYFLLSQLSLMDMMLVSTTVPKMAADYLTGNKAISRAGCGVQIFFL
                     PTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMTMSSWLLGAADGLLQAVA
                     TLSFPYCGAHEIDHFFCEAPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGL
                     ILAAVLLMRSTEARKKAFATCSSHVAVVGLFYGAGIFTYMRPKSHRSTNHDKVVSAFY
                     TMFTPLLNPLIYSVRNSEVKEALKRWLGTCVNLKHQQNEAHRSR"
ORIGIN      
        1 aagatattta tatgtttttg cctttttagg aaactacaat ctcattgaaa atatacacta
       61 ttcagatcag tactaagagt gaagagtcct ggataacttg gagttgcaat gatatttcac
      121 cacagatcca tttttatagg aatatataca aatacctctt ggaatcccaa tgttatcttc
      181 actgcatttt cagattgttt atatcctgga taacttacac tgagcttcag gattgggtct
      241 catattcctg gtgcctaaag gggaaattat ggagatgaga aatactaccc cagattttat
      301 tctcctagga ctctttaacc acaccagagc ccaccaagtc ctcttcatga tgcttctggc
      361 caccgttttg acctccctgt ttagcaatgc cctcatgatt ctcctgattc actgggacca
      421 ccggctccac aggcccatgt acttcctcct gagccaactt tccctcatgg acatgatgct
      481 ggtttccacc actgtgccca aaatggcggc tgactacttg accggaaata aggccatctc
      541 ccgcgctggc tgtggtgtgc agatcttctt cctccccaca ctgggtggtg gagagtgctt
      601 cctcttagca gccatggcct atgaccgcta tgcggctgtc tgccacccac tccgatatcc
      661 cactctcatg agctggcagc tgtgcctgag gatgaccatg tcgtcctggc tcctgggtgc
      721 agctgacggc ctcctgcagg ctgttgctac cctgagcttc ccatattgcg gtgcacacga
      781 gatcgatcac ttcttctgcg aggcccccgt gttggtgcgt ttggcttgtg ctgacacttc
      841 agtcttcgaa aacgccatgt acatctgctg tgtgttaatg ctcctggtcc ccttttccct
      901 catcctgtcc tcctatggtc tcatcctcgc tgctgttctg ctcatgcgct ctacagaagc
      961 ccgcaagaag gcctttgcca cctgctcttc acatgtggct gtggtgggac tcttttatgg
     1021 agctggcatt tttacctata tgagacccaa atcccacagg tccactaacc acgataaggt
     1081 tgtgtcagcc ttctatacta tgttcacccc tttactaaat cccctcatct acagtgtgag
     1141 gaacagtgag gtcaaggaag ccctgaaacg gtggctgggg acgtgtgtaa acctaaaaca
     1201 ccagcaaaat gaggcccaca ggtcaagatg atctagtgtc agatgagtct aagttcctga
     1261 atttattaac attttaacac tatgtaattc tctcccttta gtaattcatg aagagaaaat
     1321 taagtttgtg tattgatata ataagatatt tttaagaatg aagtgagcca attgtattga
     1381 cagataccat ttttgagcat ttatgtactt ttcttcaagt gaagtaatac ctatagatta
     1441 ctttgtatcc tacaacaacc ccatgatata agttttcttt ttttcttttg caaactccaa
     1501 atctttaaaa ggtgtcccaa atttttcatc aaaaatatct ctacttacct atgccttggg
     1561 agaagtaagg taacccaata atgtataagg ttgttgagtg ttactcaatt tcctactatc
     1621 tgaaaaaaga aattaacaca tggaaagtta aatatggttc ctaatttcac atagaacaga
     1681 aatattaaaa agtgactcca aagcttgtac cctaacctgg aagagtttat ttctgttcaa
     1741 taatgtattt tgagtgttat ttcccatgtg tatgctctac aattaaaaac taaatatgag
     1801 gactccacca aagacaaata acattatttt taagttatat tttaaaatat agatgcatga
     1861 caaaagggga agtacacaac tcaaatgtaa ctgctatatt gtcacaatct ttttttattt
     1921 tttccagtct ctttttattt ggtgttttaa ggcaaacttt tttaaattca tgtaattttt
     1981 tatataagta atatttatct tttccaagag cgtcattgta attgcattgg aaaattgttt
     2041 taaactacaa ataagttctc ttttctacac gtgctttaag gttaccttga cttattgaca
     2101 tacctccatc gatatgaact ctgaattgca tgatcatgct gaatcttgac agttactaac
     2161 aatgagttat caaagctgag taagactcaa caaccttata cattattggg ttaccttact
     2221 tctcccaagg cataggtaag tagagatatt tctgatgaaa aatttgggac acattttaaa
     2281 gatttggagt ttgcagaaga ataaaagaag actatactat tattaaagac acaagataga
     2341 tagtgatgga ggaaagcagt ggttatcaaa gccaaattgt aatcagagac tggatatcaa
     2401 attgtcttag agagttttat gataaaggct atatttccca tatgtaaaac acacttaaga
     2461 aataatataa gtttttaaca cgaaggagga aataactaag agcttccagg gacaatgtat
     2521 cttcaatata agtgtctgaa agttaacccg ccatttcaga ccaacctgaa tttcaaaagg
     2581 taactgttct agaacaagtg aaaggagttt cctgcttcat ctagatcttc aggttccaaa
     2641 gcagtaatat agttaagata gtaccttaac cactgcatgc agatcctgag cccatgtctt
     2701 aagagaaggc tattcagtaa actcttgtct ccttggaaga cttgaggatg acaggagaga
     2761 gtgtcatctg tttaagacta agagtttcct actcttgtta attaatctcc ttacccagtg
     2821 ttagagtgag aaaggaacag aactgcacaa attctgtcat tataccatct aaaaaatctt
     2881 ctcttagaat gggtgaaaat tacacaagta catgtagtcg tggaaatttc attactcata
     2941 ccaggttcat gcaccatcag agaaattatt ttagaacacg ttgagttaca aatggtaaac
     3001 taagccttta aaattttgta aggataaaat attctaacca gaaaattaag cctaatgttc
     3061 aggagaaaac taaaacaaca acaacaacaa aaccacggaa tgaacattat ctccaagcaa
     3121 acgtaagaca ttaataaaaa cacaaaatat gtataaaaat agacatgttt caaagaagtg
     3181 gtatttcaga ctagttatct gatcacaatg aaaataaata tgaaataaaa attttaaata
     3241 cttttagaaa ttatatgttc atttcttatt gcttttgtaa cttgcagatg tttctactct
     3301 tattttctta ataaaggttt gcatagaaaa tcttcaaaat cttcaaaatg acaggttaac
     3361 tttcagacac ttatattgaa gatacattgt ctctggaagc ttttagttat ttcccattgt
     3421 gtgtttgaaa atgagaagat atggttctta tgaatctcta aagttaaaga aggagtacct
     3481 gatagagaca gagtatacaa gagcatgaat ggtagaaaca aaattttgaa tgaggagtta
     3541 cttcgaacat atgaagctct agcacccagt aacacagaat caagatgagg ctttgaacta
     3601 atcttggata ttacctgcta tcttcaatca ttctggctct ttcctttaca ctgcctatat
     3661 attctcttta atgtgtaatt tttaagtcat taagaaacat aatgttgtgg ctccgactag
     3721 aatttattca tcttctgctg tgcagaagct atttagttta attatatccc atttgtcaat
     3781 tttggctttt gttgccattg ctttggtgtt ttagtcatga agtctttgcc catgcctatg
     3841 tcctgaatgg tactgcctag gttttcttct agggttttta tggttttatg ttttatgttt
     3901 aagtcttcat cttgagtgat tttttgtata aagttgaagg aaggggtcca gtttcagttt
     3961 tctccatatg gctagccagt tttcccaaca tcatttatta aatagggaat cctttcccca
     4021 ttgcttgttt ttgtcaggtt tgtcaaagaa gagatggttg tatggcatga attctgaggc
     4081 ctctgttctg tttattggtc tatatatctg ttttggtacc agtaccatgc tgttttggtt
     4141 actgtagcct tgtagtaaag tttgaagtaa ggtagcatga tgccaccagc tttgttcttt
     4201 ttgcttagga ttgtcttggc taaatgggct ctttattgat tccatatgaa atttaaagta
     4261 tttttttcta attctgtgaa gaaagtctat ggtagcttga tggggatagc actgaatgta
     4321 ttaattactt tgggcactat ggtttttttc atggtattga ttcttcctat ccatgagcat
     4381 ggaatatttt ttcatttgtt tgtgtcctct cttatttcct tgagcagtgg tttgtagttc
     4441 tccttgaaga ggtccttcat atcctttata agttgtattc ctaggtgttt tattcccttt
     4501 gtagcaattc tgaatgggaa ttcactcatg atttggctct ctgtctatta ttggtgtatg
     4561 ggaaagcttg tgatttttac acattgatat tgtatcctga gactttgctg aagttgctta
     4621 tcagcttaag gagattttga gctgagatga tggggtgttc taaatatgca atcatgtaat
     4681 ctgcaaacag aggcagtttg acttcctctc ttcctttgga ttcatcagag taaacaggca
     4741 acttagagaa tgggagaaaa tttttgcaat ctatccatct gacaaatggc taatatcaag
     4801 aatctacaag gaacttaaac atatttataa gaaaaaaaaa acaaccccat caaaaagtgg
     4861 gcaaagtata tgaacagaca tttctcaaac gaagacattt atgtggccaa gaaatatatg
     4921 aaaaaaagct catcatcact ggtccttata gaaatgcaaa tcgaaaccac agtgagatac
     4981 catgtcacat cagttagaat ggcaattatt aaaaagtcac caacatggca catgtataca
     5041 tatgtaacaa acctgcacat tgtgcacatg taccctaaaa cttaaagtat aataaaataa
     5101 agtaaaaaaa gtcaggaaac aacagacgct ggcacgtatg cggagaaata gcaacgcttt
     5161 taccatgttg ttttgggagt gtaaattagt tcaaccattg tggaagacag tgtggtgatt
     5221 cctcaaggat ctagaactag aaatgccatt tgacccagaa atcccatttc tgggtatata
     5281 cccaaaggat tttaaatcat tccactaaaa agacacatgc acacatatgt ttattgcagt
     5341 tattcccaat agtaaatatg tgaatccaac ccaaaagccc atcaatgata gactggctaa
     5401 agtagctgtg gcacatatac accacaaata ctatacagcc attggaaagg atgagtttat
     5461 gtcctttgca gggacatgga tgaaactgga gaccatcatt cccaggaaac taacacagga
     5521 acagaaaacc aaacaccgca tgttctcatt cataagtgga attaaatagg gaatcctttc
     5581 cccattgctt gtttttgtca gggttgtcaa agaacagatg gttgtatggc attaattctg
     5641 aggcctcttt tctgtttatg aggcctctgt tcatgaacaa tgagaataca tggacacagg
     5701 gagggaaa
//
