LOCUS       NM_001001964            3770 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily T member 11
            (OR2T11), mRNA.
ACCESSION   NM_001001964
VERSION     NM_001001964.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098483.2.
            
            On Aug 5, 2020 this sequence version replaced NM_001001964.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be non-functional as an olfactory receptor
            according to the Classifier for Olfactory Receptor Pseudogenes.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641193.1/ ENSP00000492951.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC098483.2         110830-110883       c
            55-3770             AC098483.2         99349-103064        c
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..3770
                     /gene="OR2T11"
                     /gene_synonym="OR2T11Q"
                     /note="olfactory receptor family 2 subfamily T member 11"
                     /db_xref="GeneID:127077"
                     /db_xref="HGNC:HGNC:19574"
     exon            1..54
                     /gene="OR2T11"
                     /gene_synonym="OR2T11Q"
                     /inference="alignment:Splign:2.1.0"
     exon            55..3770
                     /gene="OR2T11"
                     /gene_synonym="OR2T11Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1149
                     /gene="OR2T11"
                     /gene_synonym="OR2T11Q"
                     /note="olfactory receptor OR1-65"
                     /codon_start=1
                     /product="olfactory receptor 2T11"
                     /protein_id="NP_001001964.1"
                     /db_xref="GeneID:127077"
                     /db_xref="HGNC:HGNC:19574"
                     /translation="MTNTSSSDFTLLGLLVNSEAAGIVFTVILAVFLGAVTANLVMIF
                     LIQVDSRLHTPMYFLLSQLSIMDTLFICTTVPKLLADMVSKEKIISFVACGIQIFLYL
                     TMIGSEFFLLGLMAYDCYVAVCNPLRYPVLMNRKKCLLLAAGAWFGGSLDGFLLTPIT
                     MNVPYCGSRSINHFFCEIPAVLKLACADTSLYETLMYICCVLMLLIPISIISTSYSLI
                     LLTIHRMPSAEGRKKAFTTCSSHLTVVSIFYGAAFYTYVLPQSFHTPEQDKVVSAFYT
                     IVTPMLNPLIYSLRNKDVIGAFKKVFACCSSAQKVATSDA"
ORIGIN      
        1 acctgatgac ccacattgag gggtaatcag attccctgtg gggtctttct gcagcctcta
       61 gcctggaagc ttcatcctga cggtaccctc agaagtgtca cctctactgc agacctttcc
      121 catcttgacc gtgttctctt gcctccttcc tggtccttgt gtcttcccgt tgccctggga
      181 cgctcgtggg ccatatcaat gacgaacaca tcatcctctg acttcaccct cctggggctt
      241 ctggtgaaca gtgaggctgc cgggattgta tttacagtga tccttgctgt tttcttgggg
      301 gccgtgactg caaatttggt catgatattc ttgattcagg tggactctcg cctccacacc
      361 cccatgtact ttctgctcag tcagctgtcc atcatggaca cccttttcat ctgtaccact
      421 gtcccaaaac tcctggcaga catggtttct aaagagaaga tcatttcctt tgtggcctgt
      481 ggcatccaga tcttcctcta cctgaccatg attggttctg agttcttcct cctgggcctc
      541 atggcctatg actgctacgt ggctgtctgt aaccctctga gatacccagt cctgatgaac
      601 cgcaagaagt gtcttttgct ggctgctggt gcctggtttg ggggctccct cgatggcttt
      661 ctgctcactc ccatcaccat gaatgtccct tactgtggct cccgaagtat caaccatttt
      721 ttctgtgaga tcccagcagt tctgaaactg gcctgtgcag acacgtcctt gtatgaaact
      781 ctgatgtaca tctgctgtgt cctcatgttg ctcatcccca tctctatcat ctccacttcc
      841 tactccctca tcttgttaac catccaccgc atgccctctg ctgaaggtcg caaaaaggcc
      901 ttcaccactt gttcctccca cttgactgta gttagcatct tctatggggc tgccttctac
      961 acatacgtgc tgccccagtc cttccacacc cccgagcagg acaaagtagt gtcagccttc
     1021 tataccattg tcacgcccat gcttaatcct ctcatctaca gcctcagaaa caaggacgtc
     1081 ataggggcat ttaaaaaggt atttgcatgt tgctcatctg ctcagaaagt agcaacaagt
     1141 gatgcttaga gagtcactgc ccagaggata aggcttccta aggacttcct ccatttgccc
     1201 tgtttccctg gagatgatct gctcagctat caacctacac ttactactgg cagttaagat
     1261 gattcaccct gtctggattc ttgctcctcg ggagcaaggg aaagatgttt tactgttatg
     1321 cagagatctt tcagtgaagt atcaaaaatg gtttattatg aagttaaata atttatctag
     1381 tctttttatt tagggaagaa aaaccccaaa tattagagtt cacagcaacc tttcactctg
     1441 aactagatct ccttcacaac atttgttcat gtttaaacaa cacaatgaaa gaaacctgca
     1501 aaagctatca aatgtttaca gtcaaattct gtgattagca gcaatagagt aaaagaatgc
     1561 caatacacaa gtggcaaaga agataaaagc acacacttta gtcgtgtttt ttattttagt
     1621 attaacccca agtaactata agctctaata ttatcgttga atctctgacc ctcttgagta
     1681 cagacagcag ctatcaaata ctaggccaca ataaatggtg gtgaattgaa cagaactgag
     1741 tatgaatggg tggaggttca gcatgacaca gctactcaca gggaatagac tctaacactt
     1801 agcatcaaag aacatgactg ccactttcct tgaggatgta ttaacaggat accaggttcg
     1861 ttaacatcca tggccagaaa cttccctttt ccaagttctg tgattcaaca gcaacactta
     1921 aggcactttg agactgactg agtggggtgg gaagtccctg gagttttcca tgcgggtgtt
     1981 acatgataac agacacgttt ttaaagcatc actatgccta cagtgtagga aaatagaaca
     2041 aagggcaaac atggatacag gaagacaatt gaggtttcag agatgagaaa caaggatggc
     2101 ttgtgtaggg tgtggacaca aaggatttgg ctcatggatt tggcgtgtgt tagcaacagg
     2161 tgtagagtga aggataactt attggtttgg gcccaagtga ataaaaaaat ggaatattga
     2221 tatttggaaa acttgtcggt agcagaagtc aagaattcac ttaagataat ttggaaatat
     2281 ctattaggta tttaagctag gccgggtgca gtagctcata cctgtactcc cagcacttta
     2341 gtggagacca aggagggtgg attgcttgag ctcaggagtt tgagaccagc ctgccaacat
     2401 agcaaaaccc catctaccaa aaacacaaat atcagttgga tgtggtggca catgcctgta
     2461 gtcccagcta cttgggaggc tgaggtggga ggatcacggg aggctgagaa gttgaggctg
     2521 cagtgagccg tgatggcacc actgtgctcc agcctgactg gcagagaggc cttgtctcaa
     2581 gataaataca taaatacaga aagatattga agctatatgt aaagtcaatt gtacttcaga
     2641 ttagagttct gaacataaag catacattta ataatcagag tacgaagagc atttaaaaac
     2701 aggttttttg agagttttct taagagaaag cttgagactg agatctgagg cagctggcgt
     2761 cacatgaaaa attagaaaga tagggtttta tgaggttaga agaaatctaa gacaaagtgt
     2821 ttaaagaaag taaaagcaac tgcaacaagt gcagtctatg gttgaaataa gtgagatttg
     2881 gttactgtat ttagcaacat gaaaggttac ttgtaacctt agtgaccatt tttaatggag
     2941 atatgcttag agatgattca gggtaaaatc aagggggagg aagtggataa ggtaagttga
     3001 gtatgaattt ttagattttt ttgtaaagga aatggagtat aactagaaaa acgtgatacc
     3061 aatgtgtttg atgttaatgg tgctgtcatg tgatattgag tatgaagttc aaaggaataa
     3121 ttcagtacaa aaagaaaatc gatatatgag aaatggagga aagtttcaga aagatggcct
     3181 ttgagagtgg ccgaaagcac agaaaccagt ttagaagtgg agagtttgaa cttttgtaag
     3241 agcatggcca actcagtgac aatagcagga ggtcaggcag agcgtgtgtt ataactaaga
     3301 tcccttccga tggtttgtat cttctcggtg cagttagaat caatgagagc gtctatgagt
     3361 aaagatcagg gtggtcccgt caaaagtttg agaggagaag agaatcatct tggagaagag
     3421 gtaagttaat aagctagtag agacatctgg gttgtaggac aaccttcgga ctccccctcc
     3481 tttgcattga atttatgaat ttagcacagc acatttgtca gacgattcat gatgtgtgtt
     3541 cgggatggtg gccagaaaat agtaggcact caatatgtta actagaatta tgttaaaaac
     3601 aaggacaaaa taacagcagc aactgctgtt actactacaa acttattcct ttgtgaataa
     3661 agtgtgtcat atttatgctt ttccaaggca tataatttgc agtatgtaat agatgttcag
     3721 tagctgttta tttcaataaa tttgtctctt tgggcaatta aaagttgtat
//
