LOCUS       NM_019897               1047 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily S member 2
            (OR2S2), mRNA.
ACCESSION   NM_019897
VERSION     NM_019897.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 1047)
  AUTHORS   Hoppe,R., Breer,H. and Strotmann,J.
  TITLE     Organization and evolutionary relatedness of OR37 olfactory
            receptor genes in mouse and human
  JOURNAL   Genomics 82 (3), 355-364 (2003)
   PUBMED   12906860
REFERENCE   6  (bases 1 to 1047)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   7  (bases 1 to 1047)
  AUTHORS   Strotmann,J., Hoppe,R., Conzelmann,S., Feinstein,P., Mombaerts,P.
            and Breer,H.
  TITLE     Small subfamily of olfactory receptor genes: structural features,
            expression pattern and genomic organization
  JOURNAL   Gene 236 (2), 281-291 (1999)
   PUBMED   10452948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC104869.1.
            
            On Feb 14, 2008 this sequence version replaced NM_019897.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jul 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be functional according to the Classifier for
            Olfactory Receptor Pseudogenes.
            
            CCDS Note: This olfactory receptor gene is a segregating pseudogene
            (PMID:22908908), where some individuals have an allele that encodes
            a functional olfactory receptor, while other individuals have an
            allele that is predicted to be non-functional. This CCDS is being
            retained because the Classifier for Olfactory Receptor Pseudogenes
            (CORP) predicts the reference genome allele to be functional.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC104869.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341959.2/ ENSP00000344040.2
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1047
                     /gene="OR2S2"
                     /gene_synonym="OR37A; OST715"
                     /note="olfactory receptor family 2 subfamily S member 2"
                     /db_xref="GeneID:56656"
                     /db_xref="HGNC:HGNC:8276"
     exon            1..1047
                     /gene="OR2S2"
                     /gene_synonym="OR37A; OST715"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1016
                     /gene="OR2S2"
                     /gene_synonym="OR37A; OST715"
                     /note="olfactory receptor OR9-3"
                     /codon_start=1
                     /product="olfactory receptor 2S2"
                     /protein_id="NP_063950.2"
                     /db_xref="CCDS:CCDS6596.2"
                     /db_xref="GeneID:56656"
                     /db_xref="HGNC:HGNC:8276"
                     /translation="MEKANETSPVMGFVLLRLSAHPELEKTFFVLILLMYLVILLGNG
                     VLILVTILDSRLHTPMYFFLGNLSFLDICFTTSSVPLVLDSFLTPQETISFSACAVQM
                     ALSFAMAGTECLLLSMMAFDRYVAICNPLRYSVIMSKAAYMPMAASSWAIGGAASVVH
                     TSLAIQLPFCGDNVINHFTCEILAVLKLACADISINVISMEVTNVIFLGVPVLFISFS
                     YVFIITTILRIPSAEGRKKVFSTCSAHLTVVIVFYGTLFFMYGKPKSKDSMGADKEDL
                     SDKLIPLFYGVVTPMLNPIIYSLRNKDVKAAVRRLLRPKGFTQ"
ORIGIN      
        1 tcccaaaaag cctgatgcgc tgctcagtac tttgctgatg gcagagggga tatcacatgg
       61 aaaaagccaa tgagacctcc cctgtgatgg ggttcgttct cctgaggctc tctgcccacc
      121 cagagctgga aaagacattc ttcgtgctca tcctgctgat gtacctcgtg atcctgctgg
      181 gcaatggggt cctcatcctg gtgaccatcc ttgactcccg cctgcacacg cccatgtact
      241 tcttcctagg gaacctctcc ttcctggaca tctgcttcac tacctcctca gtcccactgg
      301 tcctggacag ctttttgact ccccaggaaa ccatctcctt ctcagcctgt gctgtgcaga
      361 tggcactctc ctttgccatg gcaggaacag agtgcttgct cctgagcatg atggcatttg
      421 atcgctatgt ggccatctgc aaccccctta ggtactccgt gatcatgagc aaggctgcct
      481 acatgcccat ggctgccagc tcctgggcta ttggtggtgc tgcttccgtg gtacacacat
      541 ccttggcaat tcagctgccc ttctgtggag acaatgtcat caaccacttc acctgtgaga
      601 ttctggctgt tctaaagttg gcctgtgctg acatttccat caatgtgatc agcatggagg
      661 tgacgaatgt gatcttccta ggagtcccgg ttctgttcat ctctttctcc tatgtcttca
      721 tcatcaccac catcctgagg atcccctcag ctgaggggag gaaaaaggtc ttctccacct
      781 gctctgccca cctcaccgtg gtgatcgtct tctacgggac cttattcttc atgtatggga
      841 agcctaagtc taaggactcc atgggagcag acaaagagga tctttcagac aaactcatcc
      901 cccttttcta tggggtggtg accccgatgc tcaaccccat catctatagc ctgaggaaca
      961 aggatgtgaa ggctgctgtg aggagactgc tgagaccaaa aggcttcact cagtgatggt
     1021 ggaagggtcc tctgtgattg tcaccca
//
