LOCUS       NM_017504               5934 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily M member 4
            (OR2M4), mRNA.
ACCESSION   NM_017504 XM_371358
VERSION     NM_017504.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5934)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5934)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 5934)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   4  (bases 1 to 5934)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Specific repertoire of olfactory receptor genes in the male germ
            cells of several mammalian species
  JOURNAL   Genomics 39 (3), 239-246 (1997)
   PUBMED   9119360
REFERENCE   5  (bases 1 to 5934)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450303.10.
            
            On Aug 3, 2020 this sequence version replaced NM_017504.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641868.1/ ENSP00000492992.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AL450303.10        39258-39421
            165-5934            AL450303.10        46751-52520
FEATURES             Location/Qualifiers
     source          1..5934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..5934
                     /gene="OR2M4"
                     /gene_synonym="HSHTPCRX18; HTPCRX18; OR1-55; OST710;
                     TPCR100"
                     /note="olfactory receptor family 2 subfamily M member 4"
                     /db_xref="GeneID:26245"
                     /db_xref="HGNC:HGNC:8270"
     exon            1..164
                     /gene="OR2M4"
                     /gene_synonym="HSHTPCRX18; HTPCRX18; OR1-55; OST710;
                     TPCR100"
                     /inference="alignment:Splign:2.1.0"
     exon            165..5934
                     /gene="OR2M4"
                     /gene_synonym="HSHTPCRX18; HTPCRX18; OR1-55; OST710;
                     TPCR100"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1119
                     /gene="OR2M4"
                     /gene_synonym="HSHTPCRX18; HTPCRX18; OR1-55; OST710;
                     TPCR100"
                     /note="olfactory receptor OR1-55; novel 7 transmembrane
                     receptor (rhodopsin family) protein; olfactory receptor
                     TPCR100"
                     /codon_start=1
                     /product="olfactory receptor 2M4"
                     /protein_id="NP_059974.1"
                     /db_xref="CCDS:CCDS31108.1"
                     /db_xref="GeneID:26245"
                     /db_xref="HGNC:HGNC:8270"
                     /translation="MVWENQTFNSIFILLGIFNHSPTHTFLFSLVLGIFSLALMENIS
                     MVLLIYIEKQLHTPMYFLLSQLSLMDLMLICTTLPKMIFSYLSGKKSISLAGCGTQIF
                     FYVSLLGAECFLLAVMAYDRYVAICHPLQYTILMNPKLCVFMTVASWTLGSLDGIIVL
                     AAVLSFSYCSSLEIHHFFCDVAALLPLSCTETSAFERLLVICCVVMLIFPVSVIILSY
                     SHVLRAVIHMGSGESRRKAFTTCSSHLSVVGLYYGAAMFMYMRPASKHTPDQDKMVSA
                     FYTILTPMLNPLIYSLRNKEVFRALQKVLKKRKLI"
ORIGIN      
        1 cttcggacaa gtgggtcatt tggactactg gagttgctgc ttttgaatct tttctagaag
       61 agaaagaaga aaaggttgta atacagctca ggcagtgatt attatattcc agagtataaa
      121 gaacccagaa ctgatttggc gaattttccc cttgatcacc acctataagg caaattatcc
      181 aggatggtgt gggaaaacca gaccttcaac tccatcttca tcctgctggg aatcttcaat
      241 cacagtccca cccacacctt ccttttttct ctggtcctgg gcatcttctc actggcattg
      301 atggaaaata tttccatggt tctcctcatc tacatagaga aacagctcca cacccccatg
      361 tacttcctcc tcagtcaact gtcccttatg gacctcatgc tcatctgcac cactctaccc
      421 aagatgatct tcagctactt gtctgggaag aaatctatct ctctggcagg ttgtggaact
      481 cagatattct tctatgtgtc cctgcttgga gctgaatgtt tcttgttggc tgtcatggct
      541 tatgaccgct atgtggctat atgtcaccct cttcagtaca ccatcctcat gaatccgaaa
      601 ctctgtgtct tcatgactgt tgcttcctgg accttggggt ctcttgatgg gatcatagtg
      661 cttgcagctg tcctgtcatt ttcttactgc agctctctgg aaattcatca ctttttctgt
      721 gatgttgctg cccttttacc tctatcctgc acagaaacat ctgcatttga aagactactt
      781 gtcatttgtt gtgtggtaat gctaatcttt ccagtttcag ttatcatact ttcctattcc
      841 catgtccttc gagccgtcat ccacatgggc tctggggaaa gtcgtcgcaa ggccttcact
      901 acctgctcct cccacctgtc tgtggtcgga ctctactacg gtgctgctat gttcatgtac
      961 atgagaccag cttctaaaca tacgccagac caggacaaga tggtgtcggc cttctacact
     1021 attctcaccc ctatgctgaa ccctctcatt tatagcctcc gcaacaaaga agtgttcagg
     1081 gcactacaga aggtactgaa gaaaagaaag ttaatatgac cttatcaaaa tctttttgag
     1141 tgcctactgt ggtcaacact cattcaaaaa aactggaatc tcttaaatta ttctatttct
     1201 atttctggta atttgtatta atattttcca cttcttttca aaattatcta ttcagtatat
     1261 tattacatat acatcgtttg tatactaagc tagatttgga tgttagtata agtggtttaa
     1321 tccctgtgaa tgacaattat attattaggt gtcacacatg ggtggtactt gattttagga
     1381 tgcttacttt tgaagccagg tataagtccg aagggtctta gctgtatcaa aaagcaaagg
     1441 ttggagttga tcctctgttt ttggagagat gcttctttgt tcacaaatta cttacctatt
     1501 agtacttgtt tttaatttgc ccatcctcaa acccaagaat gactatttta atactgattc
     1561 ttctttactt gactcccaag tatttaaaag tgcggagtta gtatcaacac tttcttcaat
     1621 caagttttat gtctgcataa aatatttcct agaaactcgt ataaacatac acacacttaa
     1681 gtatatatgt gtgtgatctt tatgctaata aaattaaata ttttaaggag tccacataaa
     1741 atatctattt gggctgcaca gtcaacatct gtatcatgtc tgcttttatt ccttataatc
     1801 cttatattaa ccatcagaat ctgaaggcag agcaagatga tggaatagaa ggctccactg
     1861 atcgttcaca tgcaaggaca gcaatttaac aataatccat acacgaacaa cacattcatg
     1921 agagccaaaa atcaggtgag ccttcgtagt acctggtttt aactttatat cactgaagag
     1981 gcagtgaaga ggtagaaaaa acaacttgaa cagacaatgc cacccctctc tcaccactga
     2041 cagaaggaac agtgtgctaa gagtgtctct gggctctggt gagaaagaac acagcaattg
     2101 tgaggctttg agctcagtgc tgtcctgtaa gagcagaaag gaaaaccaga taaaattcag
     2161 ctgatgcctg gccacagaca gagcatttaa accagccctt gtcagagggg aattactgat
     2221 cccagtggtc aaaacttgtg ttcccacaaa ccttgacact gagggctaaa atgcgctgag
     2281 gctctaagta aacttaaaag gcggtctatg ccataagtac tgcaactctt aggtgagtcc
     2341 tagtgctgaa ttgggccccg agatagtgga ctgtgcggcg ggcacgtgaa ctacagagac
     2401 agcagctggg gcaactgagg ttgtgctggc atcacccttg cctaacctca ggctgcacag
     2461 ctcatggctc caaaagagtt cttccacttg aggagaagaa agagtggaga ggactttgtc
     2521 tcacatcttg gataccagtt tagccacagc aagaaaatgc actcgtcaaa gctgtgaggc
     2581 ccttattcca ggacctccat cccagatgac atttctatat acaccctggg caagaaggga
     2641 ctaacactgt tgcttaatat tttgcttcgt aagcaccaat ggattgattc aactgaaatt
     2701 tttgtactca ccacagtaat attcataatt attatttaga ttgacatgct tatttttaag
     2761 tatagtataa tcaaatgttt tctaatttaa aaatgtgcta gcaaatttta aaaattaaaa
     2821 caaaggctaa ttttatcctt aaaaaaaata atttctgggc cggatgcagt ggctcgctca
     2881 tgcctgtaat cccagcactt tgggaggccg aggcgggcag attatctgag gttgggagtt
     2941 caaggccagc ctgaccaaca tggagaaatt tcatctcgac taaaaaaata caaaatcagc
     3001 cgggcgtggt ggcccatgcc tgtaatccca gctactcgtg gggctgaggc aggagaatcg
     3061 cttgaacttg ggaagtggag gttgctgtga gccgagatca tgccattgca ctccagcctg
     3121 ggcaacaaaa gcaaaactcc atctcagtaa ataaataaat aaataatttc tgttaaatat
     3181 aaaaagtagt ttttatcata gcaaatgtcg ccctagctat gtcaagtcaa aaatttagat
     3241 ttattgggat tttaaaagaa gataatacta tgtccctatg tgtttcattc cactttatga
     3301 tacacactgg aaatgtttat gctcagtttt tggaagcaga atatatgtgt cgtgggtaca
     3361 gttgctcaat ttattcaatt tatacttgta tatgctgatt cttcaccaat gaattcaatt
     3421 ttattaattc aattaattaa attttataat acaaaacagt gaatttaatg acatatcttt
     3481 gccagtcagt gttcactggt tgagccagaa agagttttac aaagtttttt tttgagacgg
     3541 agtcttgctc tgtcaccagg ctggagtgca atggtgggat cttggctcac tgcagcctcc
     3601 acctcctggg tccaagtgat tctcctgcct cagcctcccg agtagccagg actacaggcg
     3661 catgctacca caactggcta atttttgtat ttttagtaga gacgggattt caccatgttg
     3721 gccaggatgg tctcaatctc ttgacctcgt gatccgcccg ccttggcctc ccaaagtgcc
     3781 tggattacat gcgtcagcca cagcacccag ccccgagttt tacaaagatt tactgtactt
     3841 tcactcccac tccggatctt ctttaatcaa aatatatagc aagcatttca atagtcatga
     3901 taacaaatag aagtgtgatt tacattttgt cagcaacatc acaccttatg tgaaacaggt
     3961 aaatttagaa caaccagaaa agaaagactt atctgtgatc tactaagaga agtatgaaaa
     4021 ttgagcttga aatggaaaca ttttatgata tgaatcgata atgattttgt acatttgatt
     4081 ttacacataa tatgcagaaa aaagtaattt taatatgcaa ttatgtaaac tgcaaaatct
     4141 acaagaaaca tttgaaaaca attttgatat tgatgaattt aaagttactt tttaatttat
     4201 atgttaaatt tttgaatttg atgttaataa taccgacttg aaagaagtta tattgcttac
     4261 tcaatttagt gatgaaaaat gttttgagta tgtttgggac attgcgtata tgtgaatcta
     4321 atttttcaac tgtaaatttt attaaattta aatgcagacc aagtattttt gaaaaaaaat
     4381 tagtgtctga attatgagct gaaaatgtaa aataaacgct tgattttaaa aagtttatac
     4441 ataaaatgta aaatatatcg ttattaattt ttaaggttgc ttgcctgttg aaacaatatt
     4501 ttggacgtat tagttttaac ttaatttttg gtgttgaagt ttgggctgta atccagtaga
     4561 tggcgcctaa gagtaatgcc cgtagagagg ctcttgatcg gccacttggc tctttcgtgt
     4621 ttcctggcat tcgcaggcac gctgtccggt gggggttgag agagatgcct ccttaccagg
     4681 acgactcctg agccttggag gaggcccctc caattactag cacttcgcct gcatttcttt
     4741 tattagatgt ttcgggctac agccctccct caggcagagg ccacagcaga gagagctacc
     4801 tttcagcatg tacagaaatt aactcgagat ggattaaaga cttaaacgta agaaaatcct
     4861 agaagaaaac ttaggaaatg ccgttcttga taccaggctt ggcaaataat ttttggctaa
     4921 tttcccaaaa acatttgcaa caaaaattga caagctagac ctaattaaag agcttcttca
     4981 cagcaacaga aattatcagc agagtaaaca gacaatctac agaatgggag aagatattag
     5041 caaaatgtgc atccaacaaa ggtctaacat ccagattcta tacggaactt aagtcaacaa
     5101 gcaaaacccc attaaataat cccattaaaa agtgggcaaa gcacatgacc atgcatttct
     5161 caaaagaagg catatgagca gccaacaaac atgaaaaaat ggtcatcata gttagttatg
     5221 agagaaatgc aaatcaaaac ctaaatgaga gaccatctca caccagtccc gtcaaaatga
     5281 ccattaataa agtcaaataa taacaaatac tagtgaagct gtggagaaaa ggaacacata
     5341 tacactgttg gtgggaatgt aaattatagt tgagccactg tggaaagcag tttggagatt
     5401 tctcgaagaa cttaaaacag ggctgctact tgacccagga atgctattac tggggataca
     5461 tccaaaagaa aataaattgt tctaccccaa agacaaatta ttcattcatt gcagtgttat
     5521 tcccaatagc aaggaatcaa cctacatgcc catcaatggt ggattggata aagaaaatgt
     5581 agcacataaa caccacagag tgctacatag ccataaaaaa gaacaaaatc atgtcctttg
     5641 tagcaacatg gatgcaactg gaggccatta tcctaagtga attaatgcag taacaaaaaa
     5701 ccaaatactg catgttctca cttatacata ggagctaaac tttgggtact caaggatgta
     5761 aagatggaaa caatagacac tgtggactac caaatgggga aggaagggag gggagtgtgg
     5821 gttgcaaaac tacctatggg atactatgct cacaacctgg gtgatgggat ctatacccta
     5881 aacctcagcg tgatgaaata tacacatgta acaaacacgc acatgtaccc actg
//
