LOCUS       NM_001001963             939 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily L member 8
            (OR2L8), mRNA.
ACCESSION   NM_001001963
VERSION     NM_001001963.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK004459.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be non-functional as an olfactory receptor
            according to the Classifier for Olfactory Receptor Pseudogenes.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000623922.1/ ENSP00000485287.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..939
                     /gene="OR2L8"
                     /note="olfactory receptor family 2 subfamily L member 8"
                     /db_xref="GeneID:391190"
                     /db_xref="HGNC:HGNC:15014"
     CDS             1..939
                     /gene="OR2L8"
                     /note="olfactory receptor OR1-46"
                     /codon_start=1
                     /product="olfactory receptor 2L8"
                     /protein_id="NP_001001963.1"
                     /db_xref="GeneID:391190"
                     /db_xref="HGNC:HGNC:15014"
                     /translation="MENYNQTSTDFILLGLFPPSRIDLFFFILIVFIFLMALIGNLSM
                     ILLIFLDTHLHTPMYFLLSQLSLIDLNYISTIVPKMASDFLHGNKSISFTGCGIQSFF
                     FLALGGAEALLLASMAYDRYIAICFPLHYLIRMSKRVCVLMITGSWIIGSINACAHTV
                     YVLHIPYCRSRAINHFFCDVPAMVTLACMDTWVYEGTVFLSATIFLVFPFIGISCSYG
                     QVLFAVYHMKSAEGRKKAYLTCSTHLTVVTFYYAPFVYTYLRPRSLRSPTEDKVLAVF
                     YTILTPMLNPIIYSLRNKEVMGALTRVSQRICSVKM"
     exon            1..939
                     /gene="OR2L8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaaaatt acaatcaaac atcaactgat ttcatcttat tggggctgtt tccaccatca
       61 agaattgacc ttttcttctt cattctcatt gttttcattt tcctgatggc tctaattgga
      121 aacctgtcca tgattcttct catcttcttg gacacccatc tccacacacc catgtatttc
      181 ctactgagtc agctctccct cattgaccta aattacatct ccaccattgt tcctaagatg
      241 gcatctgatt ttctgcatgg aaacaagtct atctccttca ctgggtgtgg gattcagagt
      301 ttcttcttct tggcattagg aggtgcagaa gcactacttt tggcatctat ggcctatgat
      361 cgttacattg ctatttgctt tcctctccac tatctcatcc gcatgagcaa aagagtgtgt
      421 gtgctgatga taacagggtc ttggatcata ggctcgatca atgcttgtgc tcacactgta
      481 tatgtactcc atattcctta ttgccgatcc agggccatca atcatttctt ctgtgatgtc
      541 ccagcaatgg tgactctggc ctgcatggac acctgggtct atgagggcac agtgtttttg
      601 agtgccacca tctttctcgt gtttcccttc attggtattt catgttccta tggccaggtt
      661 ctctttgctg tctaccacat gaaatctgca gaagggagga agaaagccta tttgacctgc
      721 agcacccacc tcactgtagt aactttctac tatgcacctt ttgtctacac ttatctacgt
      781 ccaagatccc tgcgatctcc aacagaggac aaggttctgg ctgtcttcta caccatcctc
      841 accccaatgc tcaaccccat catctatagc ctgaggaaca aggaggtgat gggggccctg
      901 acacgagtga gtcagagaat ctgctctgtg aaaatgtag
//
