LOCUS       NM_001385855            4300 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily L member 2
            (OR2L2), transcript variant 2, mRNA.
ACCESSION   NM_001385855
VERSION     NM_001385855.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4300)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   2  (bases 1 to 4300)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099570.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641771.1/ ENSP00000493410.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC099570.2         164765-164930
            167-241             AC099570.2         170245-170319
            242-4300            AC099570.2         172942-177000
FEATURES             Location/Qualifiers
     source          1..4300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..4300
                     /gene="OR2L2"
                     /gene_synonym="HSHTPCRH07; HTPCRH07; OR1-48; OR2L12;
                     OR2L4P"
                     /note="olfactory receptor family 2 subfamily L member 2"
                     /db_xref="GeneID:26246"
                     /db_xref="HGNC:HGNC:8266"
     exon            1..166
                     /gene="OR2L2"
                     /gene_synonym="HSHTPCRH07; HTPCRH07; OR1-48; OR2L12;
                     OR2L4P"
                     /inference="alignment:Splign:2.1.0"
     exon            167..241
                     /gene="OR2L2"
                     /gene_synonym="HSHTPCRH07; HTPCRH07; OR1-48; OR2L12;
                     OR2L4P"
                     /inference="alignment:Splign:2.1.0"
     exon            242..4300
                     /gene="OR2L2"
                     /gene_synonym="HSHTPCRH07; HTPCRH07; OR1-48; OR2L12;
                     OR2L4P"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1201
                     /gene="OR2L2"
                     /gene_synonym="HSHTPCRH07; HTPCRH07; OR1-48; OR2L12;
                     OR2L4P"
                     /note="isoform 1 is encoded by transcript variant 2;
                     olfactory receptor, family 2, subfamily L, member 12;
                     olfactory receptor, family 2, subfamily L, member 4
                     pseudogene; olfactory receptor 2L2; olfactory receptor
                     OR1-48 pseudogene; olfactory receptor 2L4; olfactory
                     receptor 2L12"
                     /codon_start=1
                     /product="olfactory receptor 2L2 isoform 1"
                     /protein_id="NP_001372784.1"
                     /db_xref="CCDS:CCDS31103.1"
                     /db_xref="GeneID:26246"
                     /db_xref="HGNC:HGNC:8266"
                     /translation="MENYNQTSTDFILLGLFPQSRIGLFVFTLIFLIFLMALIGNLSM
                     ILLIFLDIHLHTPMYFLLSQLSLIDLNYISTIVPKMVYDFLYGNKSISFTGCGIQSFF
                     FLTLAVAEGLLLTSMAYDRYVAICFPLHYPIRISKRVCVMMITGSWMISSINSCAHTV
                     YALCIPYCKSRAINHFFCDVPAMLTLACTDTWVYESTVFLSSTIFLVLPFTGIACSYG
                     RVLLAVYRMHSAEGRKKAYSTCSTHLTVVSFYYAPFAYTYVRPRSLRSPTEDKILAVF
                     YTILTPMLNPIIYSLRNKEVMGALTQVIQKIFSVKM"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2L2"
                     /gene_synonym="HSHTPCRH07; HTPCRH07; OR1-48; OR2L12;
                     OR2L4P"
                     /note="hexamer: AATACA"
     polyA_site      1383
                     /gene="OR2L2"
                     /gene_synonym="HSHTPCRH07; HTPCRH07; OR1-48; OR2L12;
                     OR2L4P"
                     /note="major polyA site"
ORIGIN      
        1 aggtctctga aatctcgtgt gtagggaaga aaaatgaata tatgcatttc tttaagcaat
       61 attcttaatg cttactcaga aaaatgaatt tgttcctatg atgactgtag gactgccgtc
      121 agctaagcaa aggcactgag tgtttggaaa tgaggaaata ataaagtaat gcgtagacat
      181 ggtgacaaca gtccacaggc taaaatattg gacccataac agacccttcc tgaacccaaa
      241 ggatggattg taggaattcc ccatggaaaa ttacaatcaa acatcaactg atttcatctt
      301 attggggctg ttcccacaat caagaattgg ccttttcgta ttcaccctca tttttctcat
      361 tttcctaatg gctctaattg gaaatctatc catgattctt ctcatctttt tggacatcca
      421 tctccacaca cctatgtatt tcctacttag tcagctctcc ctcattgacc taaattacat
      481 ctccaccatt gttccaaaga tggtttatga ttttctgtat ggaaacaagt ctatctcctt
      541 cactggatgt gggattcaga gtttcttctt cttgacttta gcagttgcag aagggctgct
      601 cctgacatca atggcctatg atcgttatgt ggccatttgc tttcctctcc actatcccat
      661 ccgtataagc aaaagagtgt gtgtgatgat gataacagga tcttggatga taagctctat
      721 caactcttgt gctcacacag tatatgcact ctgtatccca tattgcaagt ccagagccat
      781 caatcatttt ttctgtgatg ttccagctat gttgacgcta gcctgcacag acacttgggt
      841 ctatgagagc acagtgtttt tgagcagcac catctttctt gtgcttcctt tcactggtat
      901 tgcatgttcc tatggccggg ttctccttgc tgtctaccgc atgcactctg cagaagggag
      961 gaagaaggcc tattcaacct gtagcaccca cctcactgta gtgtccttct actatgcacc
     1021 ctttgcttat acctatgtac gtccaagatc cctgcgatct ccaacagagg acaagattct
     1081 ggctgttttc tacaccatcc tcaccccaat gctcaacccc atcatctaca gcctgagaaa
     1141 caaggaggtg atgggggccc tgacacaagt gattcagaaa atcttctcag tgaaaatgta
     1201 gacatacgtt ctgtgttaga gtcaaagcgc taggttcata tcaacttagt agtgtacagc
     1261 agtgaagaaa aacattatta catgcccagt gtgtcaaaca gaagttaatc tagaagaaat
     1321 ttgtctttta atttagtctt gacaatatta taatacatat taatacatat tctaagacat
     1381 ctattttgat tttgtttgtg tgtggttttt gtttgtttgt ttgtttgtct ttttaatgga
     1441 ttttggctct tgttgcccag gctctaatgc aatggcgcaa tctcagctcc ccataacctc
     1501 tgcctcctgg gttcaagcga ttctcctgcc tagcctccta agttagctgc gattacaggt
     1561 gtgagccacc atgccctgcc tgtttttttt ttaatcaaat ataggtcata tattttctac
     1621 taaattgtgg gcaacagggt ttcattaaca tgtagaaatc aaaacaataa aggtccaaac
     1681 taatcatatc attcagcata ataattacat aatagttgtt tatctcccat tattataaaa
     1741 ataagacaaa aataacaaat tagttaaaat tactgaatct aattgaatat taaatagttt
     1801 ttatttactc tcaactggta tgtatgtctt cttctttttc ttaaagtaat gttttactaa
     1861 taagtttacc tgaggataaa taattatgtt tgtggagcag ccaatttggc tttagaaaaa
     1921 caagagtttc tgtataagaa gttctataga agttacagtc tatagaccct cttagactat
     1981 agttgactta gtggagtgtg gagtaggtta tttgaatcat ttcccagtca cgtcacaaca
     2041 cactcaagat ttgcctcctc agttgccacg ggtattttca tgcaagacat tctcttctgc
     2101 acaattttat ttccacttac tcttctcata aatcaatagg actattcagc ttggattggg
     2161 atcagctcct ctgctccact atttttatac ctgcttaggc atgtgcttaa aaggatcaac
     2221 attatttcat aaaggttatc tgcttaggtc cattctctga gtgaaaggcc attgctctcc
     2281 agaagagccc attcctgaga gactctttta tctctgagga gagaaggcaa gaaggaaggt
     2341 agaatgagca agtaagaaga gcctcatatt atccaagtga cagcagtggt gaatgactga
     2401 atggtccttg agcaacacag atttgaactg tgcaggtcca catatatgtg gattttgttc
     2461 tgcctccacc actcctgaga caacaagtac aacctctcct cctcttcctc cgcctcagcc
     2521 cactcaacgt gaagacaaca atgatgaaga actttatgac aaacctctat ccctaaataa
     2581 atagtaaaca tattttctct ttctgatgat tttctcaata agatattctt ttttagctca
     2641 ctttactgta agagtagagt atataagaca tataagatac aaagttgtgt taattgaatg
     2701 cttatgttat ttgtaaggct tgctgtcaat agtaggatat cagtagttag gttttgggga
     2761 gttcaaagtt aaatgcatat tctactgctt ggcggtcagt gaccctaatt tccgcgttgt
     2821 cctagagtca tctgtactac aattggaata atcattttca aacaagaaca ttaacatttg
     2881 aataggagat acaaatatgg atctggatat actcatttca attaagcatt tagagtttac
     2941 tagagtactg aataatttaa attttgactt atagaatggc aaatgtttat gactttcttc
     3001 tcctctaatt taaattaagt agaattttct catcattagg actgtatgag aatgtcataa
     3061 taatatgaga aaaggtagta gttgcctgat gttgaaagat ttacctaatc tcacataaat
     3121 aaccaaaaca gcatggtact ggtaccaaaa cagaaatata gatcaatgca acagaacaga
     3181 gccctcagaa ataacgccgc atatctacaa ctatctgatc tttgacaaac ctgagaaaaa
     3241 caagcaatgg ggaaaggatt ccctatttaa taaatggtgc tgggaaaact ggctagccat
     3301 atgtaaaaag ctgaaactgg atcccttcct tacaccttat acaaaaatca attcaagatg
     3361 gattaaagac ttaaacgtta gacctaaaac cataaaaacc ctagaagaaa acctaggctt
     3421 taccattcag gacataggca tgggcaagga cttcatgtct aaaataccaa aagcaatggc
     3481 aacaaaagcc aaaattgaca attgagatct aattaaacta aagagcttct gcacagcaaa
     3541 agaaactacc atcagagtga acaggcaacc tacagaatgg gagaaaattt ttgcaaccta
     3601 ctcatctgac aaagggctaa tatccagaat ctacaatgaa ctcaaacaaa cttacaagaa
     3661 aaaaacaaac aaccccatca aaaagtgggt gaaggacatg aacagacact tctcaaaaga
     3721 agacatttat gcagccaaaa aacacatgaa aaaatgctca ccgttactgg ccgtcagaga
     3781 aatgcaaatc aaaaccacaa tgagatacca tctcacacca gttagaatgg caatcattaa
     3841 aacgtcagga aacaacaggt gctggagagg atgtggagaa aacactttta cactgttgtt
     3901 gggactgtaa actagttcaa ccattgtgga agtcagtgtg gcgattcctc agggatctag
     3961 aactagaaat accatttgac ccaaccatcc cattactggg tatataacca aaggactata
     4021 aatcatgctg ctataaagac acatgcacac ctatgtttat tgcggcacta ttcacaatag
     4081 caaagacttg gaaccaaccc aaatgtccaa cgatgataga ctggattaag aaaatgtggc
     4141 acatatacac catggaatac tatgcagcca taaaagatga tgagttcatg tcctttgtag
     4201 ggacatggat gaaattggaa atcatcattc tcactaaact atcacaagaa caaaaaacca
     4261 aacaccgcat attctcactc ataggtggga attgaacaat
//
