LOCUS       NM_001395936            2002 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily L member 13
            (OR2L13), transcript variant 3, mRNA.
ACCESSION   NM_001395936
VERSION     NM_001395936.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2002)
  AUTHORS   Morrell,C.N., Mix,D., Aggarwal,A., Bhandari,R., Godwin,M., Owens,P.
            3rd, Lyden,S.P., Doyle,A., Krauel,K., Rondina,M.T., Mohan,A.,
            Lowenstein,C.J., Shim,S., Stauffer,S., Josyula,V.P., Ture,S.K.,
            Yule,D.I., Wagner,L.E. 3rd, Ashton,J.M., Elbadawi,A. and
            Cameron,S.J.
  TITLE     Platelet olfactory receptor activation limits platelet reactivity
            and growth of aortic aneurysms
  JOURNAL   J Clin Invest 132 (9) (2022)
   PUBMED   35324479
  REMARK    GeneRIF: Platelet olfactory receptor activation limits platelet
            reactivity and growth of aortic aneurysms.
REFERENCE   2  (bases 1 to 2002)
  AUTHORS   de Sa Machado Araujo,G., da Silva Francisco Junior,R., Dos Santos
            Ferreira,C., Mozer Rodrigues,P.T., Terra Machado,D., Louvain de
            Souza,T., Teixeira de Souza,J., Figueiredo Osorio da Silva,C.,
            Alves da Silva,A.F., Andrade,C.C.F., da Silva,A.T., Ramos,V.,
            Garcia,A.B., Machado,F.B. and Medina-Acosta,E.
  TITLE     Maternal 5mCpG Imprints at the PARD6G-AS1 and GCSAML Differentially
            Methylated Regions Are Decoupled From Parent-of-Origin Expression
            Effects in Multiple Human Tissues
  JOURNAL   Front Genet 9, 36 (2018)
   PUBMED   29545821
  REMARK    GeneRIF: RNA-Seq evidence of testis-specific monoallelic expression
            of OR2L13, located 419 kb downstream of the GCSAML somatic
            (secondary), imprinted differentially methylated region (iDMR).
            OR2L13 has a predicted CGI-bearing allelically methylated region
            overlapping the promoter region in blood, spleen, lung, liver,
            esophagus, and brain, but hypomethylated in gamete, blastocyst,
            placenta, thymus, and spinal cord methylomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2002)
  AUTHORS   Naz,R.K. and Dhandapani,L.
  TITLE     Identification of human sperm proteins that interact with human
            zona pellucida3 (ZP3) using yeast two-hybrid system
  JOURNAL   J Reprod Immunol 84 (1), 24-31 (2010)
   PUBMED   19945174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513488.11.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660803.32748.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358120.4/ ENSP00000350836.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL513488.11        32054-32124
            72-196              AL513488.11        35521-35645
            197-2002            AL513488.11        36228-38033
FEATURES             Location/Qualifiers
     source          1..2002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..2002
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /note="olfactory receptor family 2 subfamily L member 13"
                     /db_xref="GeneID:284521"
                     /db_xref="HGNC:HGNC:19578"
     exon            1..71
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /inference="alignment:Splign:2.1.0"
     exon            72..196
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /inference="alignment:Splign:2.1.0"
     exon            197..2002
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1153
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /note="olfactory receptor, family 2, subfamily L, member
                     14; olfactory receptor 2L14"
                     /codon_start=1
                     /product="olfactory receptor 2L13"
                     /protein_id="NP_001382865.1"
                     /db_xref="CCDS:CCDS1637.1"
                     /db_xref="GeneID:284521"
                     /db_xref="HGNC:HGNC:19578"
                     /translation="MEKWNHTSNDFILLGLLPPNQTGIFLLCLIILIFFLASVGNSAM
                     IHLIHVDPRLHTPMYFLLSQLSLMDLMYISTTVPKMAYNFLSGQKGISFLGCGVQSFF
                     FLTMACSEGLLLTSMAYDRYLAICHSLYYPIRMSKMMCVKMIGGSWTLGSINSLAHTV
                     FALHIPYCRSRAIDHFFCDVPAMLLLACTDTWVYEYMVFVSTSLFLLFPFIGITSSCG
                     RVLFAVYHMHSKEGRKKAFTTISTHLTVVIFYYAPFVYTYLRPRNLRSPAEDKILAVF
                     YTILTPMLNPIIYSLRNKEVLGAMRRVFGIFSFLKE"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /note="hexamer: AGTAAA"
     polyA_site      1761
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /note="major polyA site"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /note="hexamer: AATAAA"
     polyA_site      1879
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
     regulatory      1976..1981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /note="hexamer: AATAAA"
     polyA_site      2002
                     /gene="OR2L13"
                     /gene_synonym="OR2L14"
                     /note="major polyA site"
ORIGIN      
        1 ttctgtcttc caatggtgga acctgagaga cttcagtgta aaatgcctta ttctgttctc
       61 actgaaacaa gcaaaagttg aaaaatcagt aacccaagat gactaaccaa atcaatatgc
      121 tgggcaggat gagacatcag tgtctgcctc agacagaaga gcacacacaa aacatgacct
      181 ctcactccaa gcccagttac agcagaaagt tttcatggag aaatggaatc acacttcaaa
      241 tgatttcatt ttgttgggtc tgcttccccc aaatcaaact ggaatatttc tcttgtgcct
      301 tatcatcctc atattctttc tggcctcggt gggtaactcg gccatgattc acctcatcca
      361 cgtggatcct cgtctccaca caccgatgta ctttcttctc agccagctct cccttatgga
      421 cctgatgtac atctccacca ccgtccccaa gatggcgtac aacttcctgt ccggccagaa
      481 aggcatctcc ttcctgggat gtggtgtgca aagcttcttc ttcctgacca tggcgtgttc
      541 tgaaggctta ctcctgacct ccatggccta cgaccgttat ttggccatct gccactctct
      601 ctattatcct atccgcatga gtaaaatgat gtgtgtgaag atgattggag gctcttggac
      661 actggggtcc atcaactcct tggcacacac agtctttgcc cttcatattc cctactgcag
      721 gtctagggct attgaccatt tcttctgcga tgtcccagcc atgttgcttc ttgcctgtac
      781 agatacttgg gtctatgaat atatggtttt tgtaagtaca agcctctttc tccttttccc
      841 tttcattggc atcacttctt cctgtggccg agtcctattt gctgtctatc atatgcactc
      901 aaaggagggg agaaaaaagg ccttcaccac catttcaaca catttaactg tagtgatctt
      961 ttactatgca ccttttgtct acacctatct tcggcccagg aatctccgct caccagctga
     1021 agacaagatc ctggcagtct tctacaccat ccttaccccc atgctcaatc ccattatcta
     1081 cagcctgagg aataaggaag tcctgggggc tatgaggaga gtgtttggga tattctcttt
     1141 cctgaaagaa taatcatggc catccccact ccctttgtat ttcctctttc caagttgatt
     1201 ccaacacgct agagcagggt tgtccaatag aaatacaaca taatttaaaa ttttctaata
     1261 ggtacattta agcagtcaaa taaatttaaa taatatattt aattcaaaac aatgttataa
     1321 ttaatattaa tattaacaat attgatgtta attacatagc atactatttc aataaattat
     1381 atgcaatata ttatagtaca tgtttgtaca tatattacta ttaacgtgat aatgtttatt
     1441 cttgtatatt gacatagaat ttcttcatgt aataacacaa atttgttaat gttgcctttt
     1501 actctgtttg cattctaagt cttcaaagtc ttgtgtttgt tttatagagt gcagcgcagc
     1561 ttggacaaaa cacatttcaa gtgcccagta gtcagtgtct atagtgttgg acagcacatt
     1621 cttagagcat ccccaatcaa tagtttcaga agttatatat gcatgtgtat gtgcatgtat
     1681 ggtgtataca aacatatttt tgttatatac aatattgctg atgaactgaa aattaacaag
     1741 taaaatgcac atgctaaggt agtgtttatg tgtttcttta tctgttggct catttttagc
     1801 atatgcacat ttattgtaat taacatttga agtccagttt atcctaactc ctttaataaa
     1861 actattcagg gagagcttat ctgacttatg attttgctga tttcataaag atactgagat
     1921 aaaataactt gaatatgaat ataaaagaac ccacatttat gtatacataa aaattaataa
     1981 aatctttata taaataactt ta
//
