LOCUS       NM_205859               1373 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily K member 2
            (OR2K2), mRNA.
ACCESSION   NM_205859 XM_011518520 XM_095961
VERSION     NM_205859.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Alves,V.C., Figueiro-Silva,J., Trullas,R., Ferrer,I. and Carro,E.
  TITLE     Olfactory Receptor OR2K2 Expression in Human Choroid Plexus as a
            Potential Marker in Early Sporadic Alzheimer's Disease
  JOURNAL   Genes (Basel) 15 (3), 385 (2024)
   PUBMED   38540444
  REMARK    GeneRIF: Olfactory Receptor OR2K2 Expression in Human Choroid
            Plexus as a Potential Marker in Early Sporadic Alzheimer's Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Nalls,M.A., Couper,D.J., Tanaka,T., van Rooij,F.J., Chen,M.H.,
            Smith,A.V., Toniolo,D., Zakai,N.A., Yang,Q., Greinacher,A.,
            Wood,A.R., Garcia,M., Gasparini,P., Liu,Y., Lumley,T., Folsom,A.R.,
            Reiner,A.P., Gieger,C., Lagou,V., Felix,J.F., Volzke,H.,
            Gouskova,N.A., Biffi,A., Doring,A., Volker,U., Chong,S.,
            Wiggins,K.L., Rendon,A., Dehghan,A., Moore,M., Taylor,K.,
            Wilson,J.G., Lettre,G., Hofman,A., Bis,J.C., Pirastu,N., Fox,C.S.,
            Meisinger,C., Sambrook,J., Arepalli,S., Nauck,M., Prokisch,H.,
            Stephens,J., Glazer,N.L., Cupples,L.A., Okada,Y., Takahashi,A.,
            Kamatani,Y., Matsuda,K., Tsunoda,T., Tanaka,T., Kubo,M.,
            Nakamura,Y., Yamamoto,K., Kamatani,N., Stumvoll,M., Tonjes,A.,
            Prokopenko,I., Illig,T., Patel,K.V., Garner,S.F., Kuhnel,B.,
            Mangino,M., Oostra,B.A., Thein,S.L., Coresh,J., Wichmann,H.E.,
            Menzel,S., Lin,J., Pistis,G., Uitterlinden,A.G., Spector,T.D.,
            Teumer,A., Eiriksdottir,G., Gudnason,V., Bandinelli,S.,
            Frayling,T.M., Chakravarti,A., van Duijn,C.M., Melzer,D.,
            Ouwehand,W.H., Levy,D., Boerwinkle,E., Singleton,A.B.,
            Hernandez,D.G., Longo,D.L., Soranzo,N., Witteman,J.C., Psaty,B.M.,
            Ferrucci,L., Harris,T.B., O'Donnell,C.J. and Ganesh,S.K.
  TITLE     Multiple loci are associated with white blood cell phenotypes
  JOURNAL   PLoS Genet 7 (6), e1002113 (2011)
   PUBMED   21738480
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Aloni,R., Olender,T. and Lancet,D.
  TITLE     Ancient genomic architecture for mammalian olfactory receptor
            clusters
  JOURNAL   Genome Biol 7 (10), R88 (2006)
   PUBMED   17010214
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   6  (bases 1 to 1373)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   7  (bases 1 to 1373)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354661.14.
            
            On or before Dec 4, 2018 this sequence version replaced
            XM_011518520.2, NM_205859.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660807.160432.1, BC111086.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2158188, SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302681.3/ ENSP00000305055.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL354661.14        39849-39967         c
            120-1373            AL354661.14        36972-38225         c
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..1373
                     /gene="OR2K2"
                     /gene_synonym="HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P"
                     /note="olfactory receptor family 2 subfamily K member 2"
                     /db_xref="GeneID:26248"
                     /db_xref="HGNC:HGNC:8264"
     exon            1..119
                     /gene="OR2K2"
                     /gene_synonym="HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P"
                     /inference="alignment:Splign:2.1.0"
     exon            120..1373
                     /gene="OR2K2"
                     /gene_synonym="HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1119
                     /gene="OR2K2"
                     /gene_synonym="HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P"
                     /note="olfactory receptor, family 2, subfamily AR, member
                     1 pseudogene; olfactory receptor, family 2, subfamily AN,
                     member 1 pseudogene; olfactory receptor OR9-17"
                     /codon_start=1
                     /product="olfactory receptor 2K2"
                     /protein_id="NP_995581.1"
                     /db_xref="CCDS:CCDS6778.1"
                     /db_xref="GeneID:26248"
                     /db_xref="HGNC:HGNC:8264"
                     /translation="MQGENFTIWSIFFLEGFSQYPGLEVVLFVFSLVMYLTTLLGNST
                     LILITILDSRLKTPMYLFLGNLSFMDICYTSASVPTLLVNLLSSQKTIIFSGCAVQMY
                     LSLAMGSTECVLLAVMAYDRYVAICNPLRYSIIMNRCVCARMATVSWVTGCLTALLET
                     SFALQIPLCGNLIDHFTCEILAVLKLACTSSLLMNTIMLVVSILLLPIPMLLVCISYI
                     FILSTILRITSAEGRNKAFSTCGAHLTVVILYYGAALSMYLKPSSSNAQKIDKIISLL
                     YGVLTPMLNPIIYSLRNKEVKDAMKKLLGKITLHQTHEHL"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2K2"
                     /gene_synonym="HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P"
                     /note="hexamer: ATTAAA"
     polyA_site      1373
                     /gene="OR2K2"
                     /gene_synonym="HSHTPCRH06; HTPCRH06; OR2AN1P; OR2AR1P"
                     /note="major polyA site"
ORIGIN      
        1 ttaactttat gaagtgcatc ataaaacaac gttttatttg aagttgctga tacggaattc
       61 agatgggagg accaattctt cttggctact attaaatact tttgaatatc aaatctcaga
      121 ttaaatgaag ggaatagtac tggaagaaat atagatgaaa gaaagaaaat gcaaggagaa
      181 aacttcacca tttggagcat ttttttcttg gagggatttt cccagtaccc agggttagaa
      241 gtggttctct tcgtcttcag ccttgtaatg tatctgacaa cgctcttggg caacagcact
      301 cttattttga tcactatcct agattcacgc cttaaaaccc ccatgtactt attccttgga
      361 aatctctctt tcatggatat ttgttacaca tctgcctctg ttcctacttt gctggtgaac
      421 ttgctgtcat cccagaaaac cattatcttt tctgggtgtg ctgtacagat gtatctgtcc
      481 cttgccatgg gctccacaga gtgtgtgctc ctggccgtga tggcatatga ccgttatgtg
      541 gccatttgta acccgctgag atactccatc atcatgaaca ggtgcgtctg tgcacggatg
      601 gctacggtct cctgggtgac gggttgcctg accgctctgc tggaaaccag ttttgccctg
      661 cagatacccc tctgtgggaa tctcatcgat cacttcacgt gtgaaattct ggcggtgcta
      721 aagttagctt gcacaagttc actgctcatg aacaccatca tgctggtggt cagcattctc
      781 ctcttgccaa ttccaatgct cttagtttgc atctcttaca tcttcatcct ttccactatt
      841 ctgagaatca cctcagcaga gggaagaaac aaggcttttt ctacctgtgg tgcccatttg
      901 actgtggtga ttttgtatta tggggctgcc ctctctatgt acctaaagcc ttcttcatca
      961 aatgcacaaa aaatagacaa aatcatctcg ttgctttacg gagtgcttac ccctatgttg
     1021 aaccccataa tttacagttt aagaaacaag gaagtcaaag atgctatgaa gaaattgctg
     1081 ggcaaaataa cattgcatca aacacacgaa catctctgat tgggtcccta tggttttacc
     1141 agagatgtgc ccctggcaga gctcatcaga gaaattcgag acaacataca acctcttaga
     1201 actctgatcg gatcttatct ctatataatt tcacagttat gagctgcata cacagagtga
     1261 ttgcctatta ataatagtag gtttcaattt gcatttgtta atatttcctt tttgtgtttt
     1321 gtggttgtga ggttttgagt tatagagtca ttaaatgttt gctacagaag aaa
//
