LOCUS       NM_001005216            3298 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily J member 3
            (OR2J3), mRNA.
ACCESSION   NM_001005216 XM_498070
VERSION     NM_001005216.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3298)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3298)
  AUTHORS   Kalbe,B., Schulz,V.M., Schlimm,M., Philippou,S., Jovancevic,N.,
            Jansen,F., Scholz,P., Lubbert,H., Jarocki,M., Faissner,A.,
            Hecker,E., Veitinger,S., Tsai,T., Osterloh,S. and Hatt,H.
  TITLE     Helional-induced activation of human olfactory receptor 2J3
            promotes apoptosis and inhibits proliferation in a non-small-cell
            lung cancer cell line
  JOURNAL   Eur J Cell Biol 96 (1), 34-46 (2017)
   PUBMED   27939274
  REMARK    GeneRIF: OR2J3 activation induces apoptosis and inhibits cell
            proliferation and migration in long-term stimulus experiments with
            helional.
REFERENCE   3  (bases 1 to 3298)
  AUTHORS   St Pourcain,B., Whitehouse,A.J., Ang,W.Q., Warrington,N.M.,
            Glessner,J.T., Wang,K., Timpson,N.J., Evans,D.M., Kemp,J.P.,
            Ring,S.M., McArdle,W.L., Golding,J., Hakonarson,H., Pennell,C.E.
            and Smith,G.D.
  TITLE     Common variation contributes to the genetic architecture of social
            communication traits
  JOURNAL   Mol Autism 4 (1), 34 (2013)
   PUBMED   24047820
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3298)
  AUTHORS   Garcia-Esparcia,P., Schluter,A., Carmona,M., Moreno,J.,
            Ansoleaga,B., Torrejon-Escribano,B., Gustincich,S., Pujol,A. and
            Ferrer,I.
  TITLE     Functional genomics reveals dysregulation of cortical olfactory
            receptors in Parkinson disease: novel putative chemoreceptors in
            the human brain
  JOURNAL   J Neuropathol Exp Neurol 72 (6), 524-539 (2013)
   PUBMED   23656994
REFERENCE   5  (bases 1 to 3298)
  AUTHORS   McRae,J.F., Mainland,J.D., Jaeger,S.R., Adipietro,K.A.,
            Matsunami,H. and Newcomb,R.D.
  TITLE     Genetic variation in the odorant receptor OR2J3 is associated with
            the ability to detect the 'grassy' smelling odor, cis-3-hexen-1-ol
  JOURNAL   Chem Senses 37 (7), 585-593 (2012)
   PUBMED   22714804
  REMARK    GeneRIF: Two amino acid substitutions, T113A and R226Q, impaired
            the ability of OR2J3 to respond to cis-3-hexen-1-ol, and together
            these two substitutions effectively abolished the response to the
            compound.
REFERENCE   6  (bases 1 to 3298)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3298)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   8  (bases 1 to 3298)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
REFERENCE   9  (bases 1 to 3298)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   10 (bases 1 to 3298)
  AUTHORS   Glusman,G., Yanai,I., Rubin,I. and Lancet,D.
  TITLE     The complete human olfactory subgenome
  JOURNAL   Genome Res 11 (5), 685-702 (2001)
   PUBMED   11337468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645937.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 6, 2020 this sequence version replaced NM_001005216.3.
            
            Summary: This gene encodes a G-protein-coupled receptor (GPCR) that
            functions as an olfactory receptor. Olfactory receptors interact
            with odorant molecules in the nose to initiate a neuronal response
            that triggers the perception of a smell. The protein encoded by
            this gene responds to cis-3-hexen-1-ol, which is released by
            wounded plants, including cut grass. This gene is situated in a
            cluster of similar olfactory-receptor coding genes on chromosome 6.
            [provided by RefSeq, May 2013].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641151.2/ ENSP00000492961.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AL645937.6         10326-10563
            239-356             AL645937.6         10805-10922
            357-408             AL645937.6         11092-11143
            409-3298            AL645937.6         14149-17038
FEATURES             Location/Qualifiers
     source          1..3298
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3298
                     /gene="OR2J3"
                     /gene_synonym="6M1-3; C3HEXS; HS6M1-3; OR6-16; OR6-6;
                     OR6.3.6; ORL671"
                     /note="olfactory receptor family 2 subfamily J member 3"
                     /db_xref="GeneID:442186"
                     /db_xref="HGNC:HGNC:8261"
                     /db_xref="MIM:615016"
     exon            1..238
                     /gene="OR2J3"
                     /gene_synonym="6M1-3; C3HEXS; HS6M1-3; OR6-16; OR6-6;
                     OR6.3.6; ORL671"
                     /inference="alignment:Splign:2.1.0"
     exon            239..356
                     /gene="OR2J3"
                     /gene_synonym="6M1-3; C3HEXS; HS6M1-3; OR6-16; OR6-6;
                     OR6.3.6; ORL671"
                     /inference="alignment:Splign:2.1.0"
     exon            357..408
                     /gene="OR2J3"
                     /gene_synonym="6M1-3; C3HEXS; HS6M1-3; OR6-16; OR6-6;
                     OR6.3.6; ORL671"
                     /inference="alignment:Splign:2.1.0"
     exon            409..3298
                     /gene="OR2J3"
                     /gene_synonym="6M1-3; C3HEXS; HS6M1-3; OR6-16; OR6-6;
                     OR6.3.6; ORL671"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1354
                     /gene="OR2J3"
                     /gene_synonym="6M1-3; C3HEXS; HS6M1-3; OR6-16; OR6-6;
                     OR6.3.6; ORL671"
                     /note="olfactory receptor OR6-16; olfactory receptor 6-6"
                     /codon_start=1
                     /product="olfactory receptor 2J3"
                     /protein_id="NP_001005216.2"
                     /db_xref="CCDS:CCDS43433.1"
                     /db_xref="GeneID:442186"
                     /db_xref="HGNC:HGNC:8261"
                     /db_xref="MIM:615016"
                     /translation="MNDDGKVNASSEGYFILVGFSNWPHLEVVIFVVVLIFYLMTLIG
                     NLFIIILSYLDSHLHTPMYFFLSNLSFLDLCYTTSSIPQLLVNLWGPEKTISYAGCMI
                     QLYFVLALGTTECVLLVVMSYDRYAAVCRPLHYTVLMHPRFCHLLAVASWVSGFTNSA
                     LHSSFTFWVPLCGHRQVDHFFCEVPALLRLSCVDTHVNELTLMITSSIFVLIPLILIL
                     TSYGAIVRAILRMQSTTGLQKVFGTCGAHLMAVSLFFIPAMCMYLQPPSGNSQDQGKF
                     IALFYTVVTPSLNPLIYTLRNKVVRGAVKRLMGWE"
ORIGIN      
        1 agctttctct tctgtagcaa tgatagtcat agctacattc agactgtttt cctaattgat
       61 gtagtagatg agggaagtgt aggcatttat gttggtgatt tcaaggtgat caaaatcaga
      121 gatcagatca gtctgtgcat gatgagggca tcagctagga agacaatata cagggaatgt
      181 ggacagatac aggaaggaca gagtgaaagg cattgtttga gtactgctta agtactagag
      241 acatggtctc acttcattgc ccaggctagt ctcgaacttc tgggctccag agatccaccc
      301 accttggcct cccaaagtgt caggattaca ggtgtgagcc acggcacccg acccaggaag
      361 aagaaaatta acccagaaaa attcctacct tttccttgct tgcatctggt aataggaaat
      421 gaatgatgat ggaaaagtca atgctagctc tgaggggtac tttattttag ttggattttc
      481 taattggcct catctggaag tagttatctt tgtggttgtc ttgatcttct acttgatgac
      541 actgatagga aacctgttca tcatcatcct gtcatacctg gactcccatc tgcacacacc
      601 aatgtacttc ttcctttcaa acctctcatt tctggatctc tgctacacca ccagctctat
      661 ccctcagttg ctggtcaatc tctggggccc ggaaaagacc atctcttatg ctggttgcat
      721 gattcaactt tactttgttc tcgcactggg aaccacagag tgtgtcctac tggtggtgat
      781 gtcctatgac cgttatgcag ctgtgtgtag acctttgcat tacactgtcc tcatgcaccc
      841 tcgtttctgc cacctgctgg ctgtggcttc ttgggtaagt ggttttacca actcagcact
      901 tcattcctcc ttcaccttct gggtacctct gtgtggacac cgccaagtag atcacttttt
      961 ctgtgaagtt ccagcacttc tgcgattatc gtgtgttgat acccatgtca atgagctgac
     1021 cctcatgatc acaagctcca tatttgttct catacctctc atcctcattc tcacttctta
     1081 tggtgccatc gtccgagcta tactgaggat gcagtcaacc actgggcttc agaaagtgtt
     1141 tggaacatgt ggagctcatc ttatggctgt atctctcttt ttcattccgg ccatgtgcat
     1201 gtatctccag ccaccatcag gaaattctca agatcaaggc aagttcattg ccctctttta
     1261 tactgttgtc acacctagtc ttaaccctct aatctacacc ctcagaaaca aagttgtaag
     1321 aggggcagtg aagagactaa tggggtggga atgagcctgt gtatgtgtca tattaacaat
     1381 ataacagagt ctcccctcac aatgattcat ccttctattt atttatcaac cattctttta
     1441 ttcactcact ctgttagcac ttgctgagca tgtactctaa caaggtcgtg gagttcctgg
     1501 taacaggtag gaataaaaca cagtcagcct aaataccatt cacttgtgga gaaaacagct
     1561 atgtaaaatc aagataaaac atctatagtg atgtttttcc atggtacaaa cctaatgtat
     1621 ccaagacaga catttctcga ttgaaaataa ggcatgaaat ttgttgtaaa tcttgataaa
     1681 agcgaagctg taaatcctat gaaaagatga tactctcaat ttaaaaatct ctacaatatg
     1741 tcttttaatt tcttgctttt tgggcagaat acttttgtct tctatcttta gtttagttaa
     1801 atacacagca aaatacttca aatccttttc tccaacaatg cttattcttt gtcggatagt
     1861 aaattttgag aggaattttg gtccatattc tttcatatcc agtatcaata gtagaacaat
     1921 aagttttatg aattgtagta agagaggctt tgaaacagta tagcagaagt cagcatctga
     1981 gatccctctt ttttgcaagg cagtgagaaa tatataggaa gtaaaaggag ctggtaaagc
     2041 tgagctatgg agcttataaa caaatggtca tcataggcta ggtatactta ggtgaggtaa
     2101 gtgcttggag caactgcatt acctaaggaa ctaaggaaaa catttgaggc aaatagagag
     2161 gctctgaaaa tgacttgaag ccaatgggtg tatgaaagaa ttatgtgaaa atatattgga
     2221 aaaattttat gatagaaact gtcatatgga aaatgatagc ttatttttat tttaaagctt
     2281 gatctaattt gagtatttat ggttaataag tatattatgt atgtcaatat atgtgtttca
     2341 aataaagaaa tctattttat agaagtaatc attttgtttt atatattatt gtcaaccatc
     2401 ttcgtttgaa ataattgcgc tatacctaga gcaatttaaa ctgacagtca tagtcaaatg
     2461 aagcggaaaa atggctaaag gagaattcag tataaagtaa cgtacttgca atgcctgagt
     2521 tttctctata actcaaatgt cagctgtagc ttttgaggcc tgtgagattt agatatgatt
     2581 gattcacaca ctatttccta aattattata aaaataaaaa cgcatctcag aacttccctc
     2641 caatttctag tgtgacttgc aattgcattg attctgctga ctttatcttc cttctgcatc
     2701 tctgactctt cctttatttc taactaggca tgaaaaatat gaggcatgtg cccttgtcct
     2761 taaccttacc caagaagtga agaaccaaga ataatgtatg taaaatgact tttagcaaga
     2821 attgggacca catacggtaa aacatcacat aaaaacacat ttttaaaaac ttaaagaaca
     2881 taacttcgcc ctttgaactg ttttctacta tggaaatctt acgatttgga gcacttacgg
     2941 tagcatcctg gtttctcacc tactcaaata tcccccccct ccccatcttt attaaggata
     3001 agtgaaaaaa atgtatttat ttataatata cagcataatg ttttgacata tgcataatta
     3061 tgcaattatt actcaagcta attaacagat cattaactca catacttacc tgttttgtgg
     3121 tgagaacatt taggatctat tatcttagca gttttcaact atgcagtaca gtattattag
     3181 ctatagtcac cataccgtag aatagatctc ttgaatttgt tccttccatc tgaaactttg
     3241 taccctttga ccaatatctc cccattttcc ctatttctct ccactgctaa cccctgac
//
