LOCUS       NM_001396058            5000 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily I member 1
            (gene/pseudogene) (OR2I1), mRNA.
ACCESSION   NM_001396058
VERSION     NM_001396058.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5000)
  AUTHORS   Hao,Y., Liu,X., Lu,X., Yang,X., Wang,L., Chen,S., Li,H., Li,J.,
            Cao,J., Chen,J., Li,Y., Zhao,L., Shi,Y., Shen,C., Yan,W., He,J.,
            Huang,J. and Gu,D.
  TITLE     Genome-wide association study in Han Chinese identifies three novel
            loci for human height
  JOURNAL   Hum Genet 132 (6), 681-689 (2013)
   PUBMED   23456168
REFERENCE   2  (bases 1 to 5000)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662860.3 and AL645936.5.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000641137.2/ ENSP00000493715.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               AL662860.3         49084-49534
            452-5000            AL645936.5         4211-8759
FEATURES             Location/Qualifiers
     source          1..5000
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..5000
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
                     /note="olfactory receptor family 2 subfamily I member 1
                     (gene/pseudogene)"
                     /db_xref="GeneID:442197"
                     /db_xref="HGNC:HGNC:8258"
     exon            1..451
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..1393
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
                     /note="olfactory receptor, family 2, subfamily I, member 3
                     pseudogene; olfactory receptor, family 2, subfamily I,
                     member 4 pseudogene; olfactory receptor, family 2,
                     subfamily I, member 2; olfactory receptor, family 2,
                     subfamily I, member 5 pseudogene; putative olfactory
                     receptor 2I2; olfactory receptor, family 2, subfamily I,
                     member 6; olfactory receptor, family 2, subfamily I,
                     member 7 pseudogene; olfactory receptor, family 2,
                     subfamily I, member 8 pseudogene; olfactory receptor,
                     family 2, subfamily I, member 9 pseudogene; olfactory
                     receptor OR6-1 pseudogene; olfactory receptor OR6-34
                     pseudogene; seven transmembrane helix receptor; putative
                     olfactory receptor 2I3; putative olfactory receptor 2I4;
                     olfactory receptor family 2 subfamily I member 1
                     pseudogene"
                     /codon_start=1
                     /product="putative olfactory receptor 2I1"
                     /protein_id="NP_001382987.1"
                     /db_xref="CCDS:CCDS93877.1"
                     /db_xref="GeneID:442197"
                     /db_xref="HGNC:HGNC:8258"
                     /translation="MKANYSAEERFLLLGFSDWPSLQPVLFALVLLCYLLTLTGNSAL
                     VLLAVRDPRLHTPMYYFLCHLALVDAGFTTSVVPPLLANLRGPALWLPRSHCTAQLCA
                     SLALGSAECVLLAVMALDRAAAVCRPLRYAGLVSPRLCRTLASASWLSGLTNSVAQTA
                     LLAERPLCAPRLLDHFICELPALLKLACGGDGDTTENQMFAARVVILLLPFAVILASY
                     GAVARAVCCMRFSGGRRRAVGTCGSHLTAVCLFYGSAIYTYLQPAQRYNQARGKFVSL
                     FYTVVTPALNPLIYTLRNKKVKGAARRLLRSLGRGQAGQ"
     exon            452..5000
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3817..3822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
                     /note="hexamer: AATAAA"
     polyA_site      3841
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
     regulatory      4978..4983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
                     /note="hexamer: AATAAA"
     polyA_site      5000
                     /gene="OR2I1"
                     /gene_synonym="HS6M1-14; OR2I1P; OR2I2; OR2I3P; OR2I4P;
                     OR2I5P; OR2I6; OR2I7P; OR2I8P; OR2I9P; OR6-1; OR6-34"
                     /note="major polyA site"
ORIGIN      
        1 agagcactca tcagcatgct tcctcctctc taactgtgtc ctttagatcc aggagggata
       61 tttgctacca ccaccagcta atgctgattt gctaccagca caaggcccag gtccttgtct
      121 ggtctgtacc ccattacaag gttctccagg aacagacatc accacctctg cctagatcct
      181 gaaatttcac aaatgtaggt tctttcttac ccgttctttt tattcctcta tttacaagca
      241 caatgacacc cacccctcgt cttcttcctg aaatacctgg ctctgatccc aggcatccat
      301 tccagaaatc aacacagcta tgcaattgca tcttttatta aatactccca actccatttc
      361 aaatccagag aatccagagc aggagcaaga gaccaaccta tcatctggaa actcaaggtg
      421 taaacattag tgccaaagat tagtcatgaa ggccaactac agcgcagagg agcgctttct
      481 cctgctgggt ttctccgact ggccttccct gcagccggtc ctcttcgccc ttgtcctcct
      541 gtgctacctc ctgaccttga cgggcaactc ggcgctggtg ctgctggcgg tgcgcgaccc
      601 gcgcctgcac acgcccatgt actacttcct ctgccacctg gccttggtag acgcgggctt
      661 cactactagc gtggtgccgc cgctgctggc caacctgcgc ggaccagcgc tctggctgcc
      721 gcgcagccac tgcacggccc agctgtgcgc atcgctggct ctgggttccg ccgaatgcgt
      781 cctcctggcg gtgatggctc tggaccgcgc ggccgcagtg tgccgcccgc tgcgctatgc
      841 ggggctcgtc tccccgcgcc tatgtcgcac gctggccagc gcctcctggc taagcggcct
      901 caccaactcg gttgcgcaaa ccgcgctcct ggctgagcgg ccgctgtgcg cgccccgcct
      961 gctggaccac ttcatctgtg agctgccggc gttgctcaag ctggcctgcg gaggcgacgg
     1021 agacactacc gagaaccaga tgttcgccgc ccgcgtggtc atcctgctgc tgccgtttgc
     1081 cgtcatcctg gcctcctacg gtgccgtggc ccgagctgtc tgttgcatgc ggttcagcgg
     1141 aggccggagg agggcggtgg gcacgtgtgg gtcccacctg acagccgtct gcctgttcta
     1201 cggctcggcc atctacacct acctgcagcc cgcgcagcgc tacaaccagg cacggggcaa
     1261 gttcgtatcg ctcttctaca ccgtggtcac acctgctctc aacccgctca tctacaccct
     1321 caggaataag aaagtgaagg gggcagcgag gaggctgctg cggagtctgg ggagaggcca
     1381 ggctgggcag tgagtagttg gggaggggag aaagtattaa gccagaaccc aaggatggaa
     1441 atacccctta gtgagtcagt ttagacttca ggctgttcat ttttgtatga taatctgcaa
     1501 gatttgtcct aaggagtcca atgggggata tgttttcctc ccgtgaggaa atgtttagtt
     1561 cttgagggaa aatccctaaa tcctctatat actcaggttt agggaaggaa aacctacccc
     1621 tcacaactcc acgcgcaggg aaaatgatgg acgtgatgct cgcctttagc ttcctcccta
     1681 tctgatggaa gaccatggaa gacctcttgg tctctgcaat cagaagtctc aagttgacaa
     1741 gaaaatcata gtccctaccc tgcaggagag ggtacatcca gaaaaagcga ccatggactc
     1801 tattctcaga aatcagtcca acttagtgca gacctggcca gatgaccagt gccctccccg
     1861 gggcatttca cccataaatg tgatgaggaa agcccataaa tggtggtgaa ttttgctgag
     1921 tggggttaag actggaaacc cccctgcagg agttggttct tgagcaagtt ttaaagaaac
     1981 aaggaactag gatgagtgtg gaagaaggcg ggcacgtctc agcccgtgaa aaaaactcac
     2041 aggtgatcag tagtgagtca tgagagagag agcaagagag agagtcagag agaggagtaa
     2101 atggagggag gaagatggag gaagggactc aagttctcaa gacaggaaca gggatctcct
     2161 catgaaaaaa agaagagagg aaaatgctca atcagcagaa cctgagcaga atattgaggt
     2221 caacccagaa gccagctcct cacccaccct cacccagact ggcgccctca tcctggagaa
     2281 gacctgctag accctaaggc aggtaggaga gagggtggtc cacagtcccc cagctttaga
     2341 aagtttgttc gctcccaatg tccatctacc cctaggaatc cccactagtt aaacagaatt
     2401 gctagatccc tgtggaaaat acctttcctt gcccaccatc atccccagaa ataataacta
     2461 ttttagttgg gtgtgagaca tagagaataa aagggggcat ggtgccagac ttcatttcat
     2521 acaaatagct ttaaaggaga agagggggga aggagtttaa tttagtttct aaaatgttta
     2581 gtaatttgat tgtgatcatg tcagagcaac taattcattt tataaaatat catttcacta
     2641 tgctctataa gtagaaattc aatttggttc aaccattatt gagtgatata aataaagcac
     2701 tggacttaac aaagacagaa atacagaaat cagtagaaca tggatcccaa cctaaaactt
     2761 actctcttgt cataaaggaa aggagatagg agtttttgca taaataacaa ggtatcaaga
     2821 cagaattaaa ttccaagctg gctttgaatg ctctattttg ccttaaaaat ttatttacta
     2881 gtctcagtaa tacattagta aaaatcatgt cacttaatta attgtgttag aatcaaagaa
     2941 acatagagtt gggcaatata cttcatccta cccatcccac ccaaatctta ctctactcat
     3001 ctcattctca ttaattttgg gaaatcatca gaagatgtgt tcgttgagta agagattaaa
     3061 agaaataagc tttttgaccc ctgccaacac cccatgccca gggtggtcac cctccaatac
     3121 aataacatgc caggaagagt aagttgccct ttctgatgcc gtaatctgcc atcatcttcc
     3181 catcttccag tctctttcca ttgcaagtca caatctgggt ctcagggatt atacccgtct
     3241 tagtctcgat cattgctttc acttgtgcca ctgagctgga ccttcgcacc tggaggaggt
     3301 gcctctttgc ctcatcacct gactccacaa gaaacaaggg cagctcctca tcactgggct
     3361 tcaccacttt cagggtaagg tggatggtct tctctttgtc aatgccataa gatgagaggc
     3421 ttctccgtgg ctttaagatc ttggagccca gcaaaagaac ctggtcctgc acaggaacct
     3481 tggtcttaga ccggacatgt tctttgattt ttttcacgct gtcatatggg ttggcatcaa
     3541 aggtcattaa atcccattcc tcggaacgga catgcacctg ggaagtgaaa gccacaagac
     3601 agttacctag gatgcctgcc tcctttacac ttctactccc caccacaatg gctccccctc
     3661 ttccactatc tatctggtcc tctagctcct attcagtagc cagtgtccct ctctttcttg
     3721 gaacttcttt tttggaatta ccaagttaca acacaaataa gataatttgt cccattcctt
     3781 tataatcaca cctttttttc gatcttgaga atggaaaata aaatcctgag cccccaacca
     3841 actgaacgga cgctcttttg ctcaggggga ccctagagaa actttaaaaa cttagtcatt
     3901 gggccaaggg tggtggctta cacctgtaat cccagaactt tgggaagctg aggcaggctg
     3961 atcaattgat gctgggagtt cgagaccagc ctggtgaact tggtgaaact ctgtctctac
     4021 taaaaataca aaaattagcc agtagtggtg gcaagtccct gtaatcccag ctactcagga
     4081 ggctgaggca ggagaatcat ttgaatccag gaggcagagg ttgcagtgag tggagatggc
     4141 actactgcac tccagccagg gcaacagagt gagactctgt ctcaaaaata taaataaata
     4201 aaacattcag tcatgatgga acaggaggtt ggatatgcct cattgtatct tctccctttt
     4261 gcagtttaga cacaactgac cagcaaagtt agagattata agactgagag aatggattct
     4321 ttgtggcaat aagatagcaa attataaaca agaccgaggg ctataacagg caaaagttaa
     4381 gtcatgcatc ccttacactt aaagaataaa ctatgttctg ccacaaagtt ttttcttttt
     4441 tctctagcag ctaaacaagc actggccttg acaggaacaa tattaaaaca attacagctc
     4501 accctgtgtt ggggaacaca ggctaactga ccccgtgttc cacaagccat aactacagtt
     4561 ttaattggac aaaagactga tttcagtaat tttctcctga taagagacca ctgaccatgg
     4621 actggttctg gctagtttac agaagctgtg catttgaatg cctttgtgtc cctgcttcac
     4681 cttttcatgt ataaggccta actgtaatgc aattaaatgt taagtctcca cttcagagtg
     4741 accatgggtg gtatgtaaca tgcaagctta ttcaatatgc atgcattagg accccctcca
     4801 tgaatattca ttgcctctgc tataacctat tggatatgta tacttagcaa accccttcag
     4861 cataaattcc tgtgtcacct ttcctcctgc aaagtgcttg cttttggttt tcaatcagaa
     4921 gcaaaacttc ccagcctgtc agaatggcta ccttgcagac tataaccttt cataagaaat
     4981 aaactcccct tctaaattta
//
