LOCUS       NM_007160               3061 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily H member 2
            (OR2H2), mRNA.
ACCESSION   NM_007160
VERSION     NM_007160.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3061)
  AUTHORS   Thompson,E.E., Haller,G., Pinto,J.M., Sun,Y., Zelano,B., Jacob,S.,
            McClintock,M.K., Nicolae,D.L. and Ober,C.
  TITLE     Sequence variations at the human leukocyte antigen-linked olfactory
            receptor cluster do not influence female preferences for male odors
  JOURNAL   Hum Immunol 71 (1), 100-103 (2010)
   PUBMED   19833159
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 3061)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3061)
  AUTHORS   Burfoot,R.K., Jensen,C.J., Field,J., Stankovich,J., Varney,M.D.,
            Johnson,L.J., Butzkueven,H., Booth,D., Bahlo,M., Tait,B.D.,
            Taylor,B.V., Speed,T.P., Heard,R., Stewart,G.J., Foote,S.J.,
            Kilpatrick,T.J. and Rubio,J.P.
  TITLE     SNP mapping and candidate gene sequencing in the class I region of
            the HLA complex: searching for multiple sclerosis susceptibility
            genes in Tasmanians
  JOURNAL   Tissue Antigens 71 (1), 42-50 (2008)
   PUBMED   17971048
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3061)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 3061)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
REFERENCE   6  (bases 1 to 3061)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   7  (bases 1 to 3061)
  AUTHORS   Younger,R.M., Amadou,C., Bethel,G., Ehlers,A., Lindahl,K.F.,
            Forbes,S., Horton,R., Milne,S., Mungall,A.J., Trowsdale,J.,
            Volz,A., Ziegler,A. and Beck,S.
  TITLE     Characterization of clustered MHC-linked olfactory receptor genes
            in human and mouse
  JOURNAL   Genome Res 11 (4), 519-530 (2001)
   PUBMED   11282967
REFERENCE   8  (bases 1 to 3061)
  AUTHORS   Eklund,A.C., Belchak,M.M., Lapidos,K., Raha-Chowdhury,R. and
            Ober,C.
  TITLE     Polymorphisms in the HLA-linked olfactory receptor genes in the
            Hutterites
  JOURNAL   Hum Immunol 61 (7), 711-717 (2000)
   PUBMED   10880742
REFERENCE   9  (bases 1 to 3061)
  AUTHORS   Fan,W., Cai,W., Parimoo,S., Schwarz,D.C., Lennon,G.G. and
            Weissman,S.M.
  TITLE     Identification of seven new human MHC class I region genes around
            the HLA-F locus
  JOURNAL   Immunogenetics 44 (2), 97-103 (1996)
   PUBMED   8662070
  REMARK    Erratum:[Immunogenetics 1997;46(2):169]
REFERENCE   10 (bases 1 to 3061)
  AUTHORS   Fan,W., Liu,Y.C., Parimoo,S. and Weissman,S.M.
  TITLE     Olfactory receptor-like genes are located in the human major
            histocompatibility complex
  JOURNAL   Genomics 27 (1), 119-123 (1995)
   PUBMED   7665158
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645936.5.
            
            On Aug 6, 2020 this sequence version replaced NM_007160.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641840.1/ ENSP00000492959.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AL645936.5         36107-36336
            231-3061            AL645936.5         38656-41486
FEATURES             Location/Qualifiers
     source          1..3061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3061
                     /gene="OR2H2"
                     /gene_synonym="dJ271M21.2; FAT11; hs6M1-12; OLFR2;
                     OLFR42B; OR2H3"
                     /note="olfactory receptor family 2 subfamily H member 2"
                     /db_xref="GeneID:7932"
                     /db_xref="HGNC:HGNC:8253"
                     /db_xref="MIM:600578"
     exon            1..230
                     /gene="OR2H2"
                     /gene_synonym="dJ271M21.2; FAT11; hs6M1-12; OLFR2;
                     OLFR42B; OR2H3"
                     /inference="alignment:Splign:2.1.0"
     exon            231..3061
                     /gene="OR2H2"
                     /gene_synonym="dJ271M21.2; FAT11; hs6M1-12; OLFR2;
                     OLFR42B; OR2H3"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..1444
                     /gene="OR2H2"
                     /gene_synonym="dJ271M21.2; FAT11; hs6M1-12; OLFR2;
                     OLFR42B; OR2H3"
                     /note="Olfactory receptor 2; olfactory receptor, family 2,
                     subfamily H, member 3; olfactory receptor OR6-36;
                     olfactory receptor 2H3; olfactory receptor-like protein
                     FAT11"
                     /codon_start=1
                     /product="olfactory receptor 2H2"
                     /protein_id="NP_009091.3"
                     /db_xref="CCDS:CCDS34365.1"
                     /db_xref="GeneID:7932"
                     /db_xref="HGNC:HGNC:8253"
                     /db_xref="MIM:600578"
                     /translation="MVNQSSTPGFLLLGFSEHPGLERTLFVVVLTSYLLTLVGNTLII
                     LLSALDPKLHSPMYFFLSNLSFLDLCFTTSCVPQMLVNLWGPKKTISFLDCSVQIFIF
                     LSLGTTECILLTVMAFDRYVAVCQPLHYATIIHPRLCWQLASVAWVIGLVESVVQTPS
                     TLHLPFCPDRQVDDFVCEVPALIRLSCEDTSYNEIQVAVASVFILVVPLSLILVSYGA
                     ITWAVLRINSAKGRRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPYAQERGKFFGLFY
                     AVGTPSLNPLIYTLRNKEVTRAFRRLLGKEMGLTQS"
ORIGIN      
        1 gataatctga gccagctcca gctcatcaca cacatgtgtg cttagaaaag tgccagatgg
       61 tcagcattag caatccctat tgtgaccaga gatgcagttg cccattcaag gatgcccatt
      121 cctttttatt tttttgtttc ttcctgatgt acaagtggag gctgggcacc agttaagagc
      181 tctgtcatgg ggaattgctg gtaccagaag agatttttat ttgattgaag gaagtcagag
      241 gcaccagtgt gagtatccat ctgctgtcca gtacattcat ggattcctca ctctcactag
      301 acaatgtttg accaggaaga acagggaatg agaaggagct gctggatggt gatgagcctt
      361 ggaaagggag gctgggcgag cagagacaga agagaaacac ctacctgctg tgacctcaca
      421 aacacccagg ctgagttttg ataagacagg ttgaatcaca ctggagtgac agcctcatcc
      481 ctccaggtac aaacaagaac aggccatggt taaccaaagc tccacaccgg gcttcctcct
      541 tctgggcttc tctgaacacc cagggctgga aaggactctc ttcgtggttg tcctcacttc
      601 ctacctccta accctagtgg gcaacacact catcatcctg ctgtctgcgc tggaccccaa
      661 gctccactct ccaatgtact ttttcctctc caacctctcc ttcttggacc tctgtttcac
      721 cacgagttgt gttccccaaa tgctggtcaa cctctggggc ccaaagaaga ccatcagctt
      781 cctggactgc tctgtccaga tcttcatctt cctgtccctg gggacaactg agtgcatcct
      841 cttgacagtg atggcttttg atcgctacgt ggctgtctgc cagcccctcc actatgccac
      901 catcatccac ccccgcctgt gctggcagct ggcatctgtg gcctgggtca ttgggctagt
      961 ggagtcagtg gtccagacac catccaccct gcacctgccc ttctgccccg atcggcaggt
     1021 ggatgatttt gtctgtgagg tcccagctct aattcgactc tcctgtgaag acacctccta
     1081 caatgagatc caggtggctg ttgccagtgt cttcatcttg gttgtgcctc tcagcctcat
     1141 ccttgtctct tacggagcca ttacctgggc agtgctgagg attaactctg caaaagggcg
     1201 gaggaaagct tttgggacct gctcctccca tctcactgtg gtcaccctct tctacagctc
     1261 agtcattgct gtctacctcc agcccaaaaa tccctatgcc caagagaggg gcaagttctt
     1321 tggtctcttc tatgcagtgg gcactccttc acttaaccct ctcatataca ccctgaggaa
     1381 caaggaggta accagggcat tcaggagatt gctggggaag gaaatggggc tcacacaaag
     1441 ctgagggaga gctgcttaat gtgctttaaa agagaggaga ttctatgtgc ttttatcaga
     1501 aagtttgagt tccctgcccc tctgccttct tcacacccat tacattgtgg gaatggatga
     1561 aagccacatg tctgtgtgtg tgcatgtatg tgtgcaagag acagcgactg aaatgtagta
     1621 aagggaggta tctttatgcg aaaaattata ggcatcaagt atattttata tttttttcta
     1681 ctttaagtct tcgcctccat agtcatgttc ctacctttat cacttccatt tttaattccc
     1741 ctcccttgcc atatccccac tattccttca cctccaattc taattcctac catatcttct
     1801 ttgcttctcc ctcatgtttt tcccacttca ctatatgtct gttttgtatt ctcattctat
     1861 tttattcctc aaataacagc aaaagagaag gggaagctga agcccagcta agttcggaaa
     1921 ctcacccaag aacacacagt gtccacagca tcagaactaa aatccaggcc ccataatttt
     1981 cagtcaggca actctcaaat acacactgtt gctttcacac cataatcaaa tatcccagta
     2041 tttcaggctt gagccttaca aaggaaactt agcttcttca gtcctatttc ttctcttaca
     2101 atgcccacaa atcgcaggta aaggagcagc caaaaagaca caaaaatatc ttcatgttta
     2161 ggctggcaca ttgtggacct tggtgtcatc taccggccaa atatggtatt gcatgtgaca
     2221 tcccagactt ctgctccagg gtcatccgaa ctgtactttg ctcaaagaca tagatatggt
     2281 tatgatacta taagcattta tgtaattgtt atgttaaccc aagtaacact taaagtacag
     2341 atgctccttg acttataatg atgttacctc ccaaaaaacc tatcatatac tgaaaatatt
     2401 gtaagttgaa tatgcatttc atacacctaa cctaccaaac atcatagctt agcctagcct
     2461 accttaaaca tactcagaac acttacatta gcctacagtt cagcaaaatc ctcaatacaa
     2521 agtctatttt ataataaagt tttgaatatc tcatgtaatt tactgaatac tgtactaaaa
     2581 gtgaaaaaac agaatggtta tattggtact caaagtacgg tttctactga atgtatctct
     2641 tttgcattat tataaagtca aaaaatggtc aaagtcagga accccctgca atttacacat
     2701 attgacttat ttaaccctta taacaacact atgaagcaga taatattatt atcctttttc
     2761 agaggtaaaa actaaaacac agaatttatg ttaccacttg caaatgtgca agacaggatt
     2821 tgaacccagg aaaactggct ccagactcct tgctcttaac cttgcctttt ggtaaaaata
     2881 atgcctccca ggcccaggtg aaaagcttca acttctcaac aagctttgag gaaatcattt
     2941 caatctaaaa ctatatctaa atgatccccc agccgaaggg gtttcacttc cttaaaataa
     3001 gagtttttca aatacttcaa agcataagaa acaacagaac aataaaactt ttggaaaaag
     3061 t
//
