LOCUS       NM_030883               3054 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily H member 1
            (OR2H1), transcript variant 2, mRNA.
ACCESSION   NM_030883 XM_011514480 XM_011546294 XM_011547215 XM_011547626
            XM_011547859 XM_011548033 XM_011548212 XM_011548404
VERSION     NM_030883.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3054)
  AUTHORS   Kennedy,R.B., Ovsyannikova,I.G., Pankratz,V.S., Haralambieva,I.H.,
            Vierkant,R.A. and Poland,G.A.
  TITLE     Genome-wide analysis of polymorphisms associated with cytokine
            responses in smallpox vaccine recipients
  JOURNAL   Hum Genet 131 (9), 1403-1421 (2012)
   PUBMED   22610502
REFERENCE   2  (bases 1 to 3054)
  AUTHORS   McElroy,J.P., Cree,B.A., Caillier,S.J., Gregersen,P.K., Herbert,J.,
            Khan,O.A., Freudenberg,J., Lee,A., Bridges,S.L. Jr., Hauser,S.L.,
            Oksenberg,J.R. and Gourraud,P.A.
  TITLE     Refining the association of MHC with multiple sclerosis in African
            Americans
  JOURNAL   Hum Mol Genet 19 (15), 3080-3088 (2010)
   PUBMED   20466734
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3054)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3054)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 3054)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   6  (bases 1 to 3054)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB457588.1, DB053988.1, BC048991.2, BC036097.2 and AL645927.3.
            
            On Aug 13, 2020 this sequence version replaced NM_030883.4.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate exon in the
            5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB053988.1, DB091702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377133.6/ ENSP00000366337.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DB457588.1         1-23
            24-588              DB053988.1         9-573
            589-1949            BC048991.2         537-1897
            1950-1950           BC036097.2         1893-1893
            1951-3048           BC048991.2         1899-2996
            3049-3054           AL645927.3         73578-73583
FEATURES             Location/Qualifiers
     source          1..3054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..3054
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /note="olfactory receptor family 2 subfamily H member 1"
                     /db_xref="GeneID:26716"
                     /db_xref="HGNC:HGNC:8252"
     exon            1..53
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            54..169
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            170..220
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /inference="alignment:Splign:2.1.0"
     exon            221..3054
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..1446
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /note="olfactory receptor, family 2, subfamily H, member
                     6; olfactory receptor, family 2, subfamily H, member 8;
                     olfactory receptor 6-2; olfactory receptor OR6-32;
                     olfactory receptor 2H6; olfactory receptor 2H8"
                     /codon_start=1
                     /product="olfactory receptor 2H1"
                     /protein_id="NP_112145.1"
                     /db_xref="CCDS:CCDS4660.1"
                     /db_xref="GeneID:26716"
                     /db_xref="HGNC:HGNC:8252"
                     /translation="MVNQSSPMGFLLLGFSEHPALERTLFVVVFTSYLLTLVGNTLII
                     LLSVLYPRLHSPMYFFLSDLSFLDLCFTTSCVPQMLVNLWGPKKTISFLGCSVQLFIF
                     LSLGTTECILLTVMAFDRYVAVCQPLHYATIIHPRLCWQLASVAWVMSLVQSIVQTPS
                     TLHLPFCPHQQIDDFLCEVPSLIRLSCGDTSYNEIQLAVSSVIFVVVPLSLILASYGA
                     TAQAVLRINSATAWRKAFGTCSSHLTVVTLFYSSVIAVYLQPKNPYAQGRGKFFGLFY
                     AVGTPSLNPLVYTLRNKEIKRALRRLLGKERDSRESWRAA"
     regulatory      3028..3033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /note="hexamer: AATAAA"
     polyA_site      3054
                     /gene="OR2H1"
                     /gene_synonym="6M1-16; dJ994E9.4; HS6M1-16;
                     OLFR42A-9004-14; OLFR42A-9004.14/9026.2; OR2H6; OR2H8;
                     OR6-2"
                     /note="major polyA site"
ORIGIN      
        1 taccagattc tatttgttaa aactgagtca ctcagtacag ctcccatgca aagtttgctt
       61 ttagttctca ttgtgagatc acaagtggag gctccaacca gtccagaagt tcctttctat
      121 ggggaagctg tggcagcaag gccgtgaaga gagtctgact taattgcaaa gacgaggttt
      181 caccatgttg accaggctga tctcaaacat ctgacctcag gaagtcagag gcaccaatgt
      241 gaggttccac ctgctttcca gcacattctt ggtttcctca cttctgctag acaacgtttg
      301 atcagaagga acagggaacg agaaggagct gctggatgac gataagcctg ggaaagggag
      361 gctgggtgag cagagacaga aaagaaacac ctacctgctg tgacctcaca aacacccagg
      421 ctgagttttg ataagacagg ttgaatcaca ctggggtgac agcctcatcc ctccaggtac
      481 aaacaagaac aggccatggt taaccaaagc tcccccatgg gcttcctcct tctgggcttc
      541 tctgaacacc cagcactgga aaggactctc tttgtggttg tcttcacttc ctacctcttg
      601 accctggtgg gcaacacact catcatcctg ctgtctgtac tgtaccccag gctccactct
      661 ccaatgtact ttttcctctc tgacctctcc ttcttggacc tctgctttac cacaagttgt
      721 gtcccccaga tgctggtcaa cctctggggc ccaaagaaga ccatcagctt cctgggatgc
      781 tctgtccagc tcttcatctt cctgtccctg gggaccactg agtgcatcct cctgacagtg
      841 atggcctttg accgatacgt ggctgtctgc cagcccctcc actatgccac catcatccac
      901 ccccgcctgt gctggcagct ggcatctgtg gcctgggtta tgagtctggt tcaatcgata
      961 gtccagacac catccaccct ccacttgccc ttctgtcccc accagcagat agatgacttt
     1021 ttatgtgagg tcccatctct gattcgactc tcctgtggag atacctccta caatgaaatc
     1081 cagttggctg tgtccagtgt catcttcgtg gttgtgcctc tcagcctcat ccttgcctct
     1141 tatggagcca ctgcccaggc agtgctgagg attaactctg ccacagcatg gagaaaggcc
     1201 tttgggacct gctcctccca tctcactgtg gtcaccctct tctacagctc agtcattgct
     1261 gtctacctcc agcccaaaaa tccgtatgcc caagggaggg gcaagttctt tggtctcttc
     1321 tatgcagtgg gcactccttc acttaaccct ctcgtataca ccctgaggaa caaggagata
     1381 aagcgagcac tcaggaggtt actagggaag gaaagagact ccagggaaag ctggagagct
     1441 gcttaatata ctttcgaaag taagaagagt ttcttcaaga tttatgaaca tgttaagttt
     1501 tccagactac tacccttccc acatacacct gagccactgt ggtgggtcac agtgtggcta
     1561 tgttatctat gagagggaga atgagaaaga gagggacaga gagataaaag aaattgggtg
     1621 agaggagata ggtagctcca taaggcacac aaattcaaat attatcattc ctatcactgt
     1681 ccattcttaa tatttctatc ctccattctg ttctttttac tgtcatcact tctatagatt
     1741 tcctaactcc accatgccta tttctggtta tataattgct ctccaattgt catgtcagtg
     1801 taggggaact actccatcat agcattctgg acaccttgca tgtatctacg taggtcatgt
     1861 aagcaaaggc ttgaagaaca gctaatctga gatttagaag aatgcttttt gatcctcctg
     1921 gaatatgaga ggatgggagg ccctttagaa cctgcctcaa tgccatctct cactctcctt
     1981 cttatatccc tgggagtatg tcatgtgaca agtctttact gtctcccagg ttttggatgg
     2041 agcatggggt tttctgcccc acacccttta ggatatagct gaagaatata atgaggaata
     2101 gctggattct agaactgact cctcaccagt ggtatattcc acaacagtgt cacagtcgtc
     2161 tggccccttt ggtttccgtg tcatcctttt tggtgtgtag gacaaggagc cagggaattg
     2221 gcacgtttgg cttttacttc ttttttatat gtaaataata agccatctaa gtgtaaaagt
     2281 ggctcatatc ttctccagcc aaatcagcta ggccatggcc ttgccttgct tctcatgagt
     2341 gtgcttgaca gtcatcaccg tcactctatc ttcatttctg gttcttaccg tgttagctta
     2401 gttcattcaa gctactatca caagctacac ataaattggg tggtttataa ataacaaaca
     2461 tttctttctt acagttctgg aggctggaaa ctccaagatt aaggcagatt tcatgcctat
     2521 tgagggcctg ctttctgatt atagaaggtg acttcttgct gtgcccacac atggtgaaag
     2581 ggactaccaa ctctctggag tctcttttat gagggcacta attccaatta tgaagcctct
     2641 tccctcatga cctaatcact gcccaaaggc cccatgttct aatgccatca tcttggtggt
     2701 ttaggatttc aacatatgaa ttttggaagg acataagcat tcaaccccct gcacatgtct
     2761 tctttcctac ttcctcaagg ttctttctgt ccagttgctc cttcttctat tgaccctttt
     2821 ttgccttctc tttctccttc actgcctcaa gttacagcca gaggaaagga ggaactaaaa
     2881 cttagcaaat ctataatcac atgcaaatac acagaatgga ttgttacaac caaaatgcag
     2941 gctctattgt tttcaattta gcagcctttc aaatgtatat ggttctggcc acattaaagt
     3001 tgcaaataac actttttttg agactgaaat aaaggtgaaa tattggaagg aaaa
//
