LOCUS       NM_012369               4829 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily F member 1
            (OR2F1), mRNA.
ACCESSION   NM_012369
VERSION     NM_012369.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4829)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4829)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4829)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   4  (bases 1 to 4829)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
REFERENCE   5  (bases 1 to 4829)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   6  (bases 1 to 4829)
  AUTHORS   Rouquier,S., Taviaux,S., Trask,B.J., Brand-Arpon,V., van den
            Engh,G., Demaille,J. and Giorgi,D.
  TITLE     Distribution of olfactory receptor genes in the human genome
  JOURNAL   Nat Genet 18 (3), 243-250 (1998)
   PUBMED   9500546
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   7  (bases 1 to 4829)
  AUTHORS   Issel-Tarver,L. and Rine,J.
  TITLE     The evolution of mammalian olfactory receptor genes
  JOURNAL   Genetics 145 (1), 185-195 (1997)
   PUBMED   9017400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004853.1.
            
            On Aug 11, 2020 this sequence version replaced NM_012369.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be non-functional as an olfactory receptor
            according to the Classifier for Olfactory Receptor Pseudogenes.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2142853 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641412.1/ ENSP00000493004.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC004853.1         36773-37032
            261-416             AC004853.1         40882-41037
            417-4829            AC004853.1         41877-46289
FEATURES             Location/Qualifiers
     source          1..4829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..4829
                     /gene="OR2F1"
                     /gene_synonym="7M1-2; OLF3; OR14-60; OR2F3; OR2F3P; OR2F4;
                     OR2F5; OR7-139; OR7-140"
                     /note="olfactory receptor family 2 subfamily F member 1"
                     /db_xref="GeneID:26211"
                     /db_xref="HGNC:HGNC:8246"
                     /db_xref="MIM:608497"
     exon            1..260
                     /gene="OR2F1"
                     /gene_synonym="7M1-2; OLF3; OR14-60; OR2F3; OR2F3P; OR2F4;
                     OR2F5; OR7-139; OR7-140"
                     /inference="alignment:Splign:2.1.0"
     exon            261..416
                     /gene="OR2F1"
                     /gene_synonym="7M1-2; OLF3; OR14-60; OR2F3; OR2F3P; OR2F4;
                     OR2F5; OR7-139; OR7-140"
                     /inference="alignment:Splign:2.1.0"
     exon            417..4829
                     /gene="OR2F1"
                     /gene_synonym="7M1-2; OLF3; OR14-60; OR2F3; OR2F3P; OR2F4;
                     OR2F5; OR7-139; OR7-140"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..1393
                     /gene="OR2F1"
                     /gene_synonym="7M1-2; OLF3; OR14-60; OR2F3; OR2F3P; OR2F4;
                     OR2F5; OR7-139; OR7-140"
                     /note="olfactory receptor, family 2, subfamily F, member
                     5; olfactory receptor, family 2, subfamily F, member 4;
                     olfactory receptor, family 2, subfamily F, member 3;
                     olfactory receptor OR7-7; olfactory receptor 2F3;
                     olfactory receptor 2F4; olfactory receptor 2F5; olfactory
                     receptor-like protein OLF3"
                     /codon_start=1
                     /product="olfactory receptor 2F1"
                     /protein_id="NP_036501.2"
                     /db_xref="GeneID:26211"
                     /db_xref="HGNC:HGNC:8246"
                     /db_xref="MIM:608497"
                     /translation="MGTDNQTWVSEFILLGLSSDWDTRVSLFVLFLVMYVVTVLGNCL
                     IVLLIRLDSRLHTPMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLF
                     FSLALGGIEFVLLAVMAYDRYVAVCDALRYSAIMHGGLCARLAITSWVSGFISSPVQT
                     AITFQLPMCRNKFIDHISCELLAVVRLACVDTSSNEVTIMVSSIVLLMTPFCLVLLSY
                     IQIISTILKIQSREGRKKAFHTCASHLTVVALCYGVAIFTYIQPHSSPSVLQEKLFSV
                     FYAILTPMLNPMIYSLRNKEVKGAWQKLLWKFSGLTSKLAT"
ORIGIN      
        1 aataaagaaa atagattcca tggaatcaat gaattgattt gctttactaa agagagatct
       61 tgactgattg aaatttaact gttaaattag agtttttttg ttatgtaaaa tgaactgtgt
      121 gaggaatcta aacacttatt tttttgttct ttctttgtcg ttgatagaag aatatttcag
      181 tcctgatatt tgctgtaact aataattact ggataaacag agaagacaca tggaggatat
      241 tttacctggg tccaacaaaa ccatagcaac agcagcaagt tgaaaagagc aaaaaaaaaa
      301 aaaagagaga gaccgaagta caattacaat cccatcccac aaaaaggtca agggctacct
      361 gaaagaccgg tggccccagg atcctcaaag catccaaacc atccctatac tctcagatta
      421 ataatccttg aatattttaa tgggaacaga taaccagact tgggtgagtg aatttattct
      481 cctcggcctg tccagtgact gggacactcg ggtctccctg tttgtcctgt tcttggtcat
      541 gtatgtggtg accgtgctgg ggaactgtct cattgtcctt ctgatcagac tggacagccg
      601 actccacact cccatgtatt tctttctcac caacctctcc cttgtcgatg tctcctatgc
      661 cacaagtgta gtccctcagc tgctggcaca ttttcttgca gaacataaag ccatcccatt
      721 ccagagctgt gcagcccagt tatttttctc cctggccttg ggtgggattg agtttgttct
      781 cctggcggtg atggcctatg accgctatgt ggctgtgtgt gatgccctgc gatactcggc
      841 catcatgcat ggagggctgt gtgctaggtt ggccatcaca tcctgggtca gtggcttcat
      901 cagctctcct gtgcagactg ctatcacctt tcagctgccc atgtgcagaa acaagtttat
      961 tgatcacata tcctgtgaac tcctagctgt ggtcaggctg gcttgtgtgg acacctcctc
     1021 caatgaggtc accatcatgg tgtctagcat tgttcttctg atgacaccct tctgcctggt
     1081 tcttttgtcc tacatccaga tcatctccac catcctaaag atccagtcca gagaaggaag
     1141 aaagaaagct ttccacacgt gtgcctctca cctcacagtg gttgccctgt gctatggtgt
     1201 ggccattttc acttacatcc agccccactc cagtccctct gtccttcagg agaagttgtt
     1261 ctctgtcttt tatgccattt taacaccaat gctgaacccc atgatttaca gcctaaggaa
     1321 taaagaggtg aagggggcct ggcagaaact attatggaaa ttctctgggt taacatcaaa
     1381 gctggcaact tgactcatga gtatgactta gagaaaacag ctttgcctca gtgttctcca
     1441 cccagctgag atctgacagg tgtaaactac attgccctgg caaccaggaa ggagatgacg
     1501 tagcatgtac tgtggatgtt atggaggagg gggagtggtt caattggatg gggtgtggga
     1561 cgtggggtta tatttatgaa cagtggagtt agatactgct gttataaaac ctcccacact
     1621 tcttccacct ccactcttac agcctgacaa tcgttgaaaa aaaattacta cttactgttt
     1681 tgatttgtca tatcgtttgt aatgatagac ctactcatgg atcttacctt ggaccactgg
     1741 tacttacaca tccacatttt ataaaaggtt atggggcttc cattgaaaac aaaatgcatt
     1801 tttacatttg aagactcact ttaaataatt tgtagtgtat gtcatcacat gcagtaattg
     1861 tgtgagtcaa cattctgaga aaagtgttat tgtcaaggct gactaaaatg tttttgtgca
     1921 ggacctacaa aaggtgaaca taatgtcttc tcctgagtgc tggagctaat tcagtgaaaa
     1981 aatatcaact caaggtcttg tttcacctcg atagggtgac agtcaatggt tgtttgtact
     2041 gaagacaatt attgaccaag aaaagttaag cttcaggtgc ttcttgacag tattcaaaca
     2101 gtttgagaag gattttactg catatatagg tatatcgttg aaaatattaa aaatgatcaa
     2161 tctctgaaaa atctgtaagc tctttctcag aatcttcaga aacacacaaa aaagcacaca
     2221 aattatgaga tactgtgaaa aatgtcaaag acatagttaa tttaaggaaa aactcttcag
     2281 ccaaagtcaa tgaagggtaa gataatttaa tatgaagttt ggaacgtcaa ggaaggtcag
     2341 tcaactatgc aaatgttacc ctcaagtctt cacattgaga acttctcttg ccacctccgt
     2401 cttcgtcacc ttcacacaca caacagagcc ataggtgaat ttttgtaaat cttgtaacct
     2461 gggcttgtct gagaatggac ttccctttga aaaggagcat aactgatgta aaaggagaag
     2521 acataattga aaaagtggaa agaaaagaaa gaatatgatc atagctgctc ttcctactcc
     2581 cttgaaggag tcagtctttt cttccttttg tgtcttcttt aagtcagttg atttgcagtt
     2641 cttacatttg tcaacacatc atcatagaat ctaagagttt ttacagtgtt gaaggcatat
     2701 aactcaaagc ccatttgaca tctgaatttt atattaatag taatgcaatc ttaaattttg
     2761 caagataggc aggcatccta aaagatgaca atgctggcaa attaaatttt tattttaagt
     2821 attatcagtg gagtatctat tctgtgtcag tgtcaataaa tggttgttgc acacaatagt
     2881 caatatgata ccatcataac aaggataatc tcacatagta gggaggacag atgatgaaac
     2941 aatgataatg cattgtggta agtgttacag tgaaggggag cccactggaa atgattgcag
     3001 aaggcttcct ataaaaggac ccttggattg agaccagaaa tgtaagaaca agttatccag
     3061 aagacaagaa acccaaaaaa gaaacaacct gtacaaagtt gtagagatgt gagcaagcat
     3121 gaaagtccaa aaaatgttgg aagttcaatt tcagggcaga gaagagtgag agagtagtga
     3181 ggacgaagca gacgggttag acacggtcag atcctggaag gcgtcgaatg tctaagtatc
     3241 ttttaacttt attctaatag aaaacaatag tccgtcaaaa atttttagaa ggagtataga
     3301 ttgaaaacaa ttacatttta aaagtatcac tctggcaaat gagatagtgg aagaaaagat
     3361 tagaggcaag atgaccagcc tgtctgctgg gtctgcttca gtaatactct tgagacattc
     3421 gagacatctg aattaagtta gatgcaattg gaaggagaca agtaaagtgg tgtcatttaa
     3481 aagtgatgtc agctaaaaca cttcatctcc cagattggaa atgccatctg aatatcattc
     3541 ctcttctaaa atgtgaggat gctgtctgaa cattctgtaa attgtgtagt aaactggaaa
     3601 attcaccatc gtgaacatgc tctatatgaa atggtatggg aaagagataa gaagaaagta
     3661 atcaaaaata caaacataca cataatacat caaggaggaa aatacgtgaa gatgctatat
     3721 cttcatttct gccagcggtc gtgtggtcac ggtgttcgtg acatttctcc atcaaccatc
     3781 acacaatcct ttgccttcaa acaactccta agcatgttgg ggttcttcct ggaagggtta
     3841 tccaagtctt gatatctcag gaagcagaaa tgctgagagt gggcattagg tatgtagaaa
     3901 tagactacta tagtctcata ttctgtatta gtcaggtttc tttagagaga caagactaat
     3961 aggatagatg aatatatgaa aaggagttta ttaaggagta ttgactcaca cgatcaaaag
     4021 gtaaagtacc acaataggcc ttctgtaagc tgaggagcac agaagccagt tggagttcca
     4081 aaacctcaaa agtagggaag ccaacagtgc agccctcagt ctgtggccaa aggcccgaga
     4141 gcccctggtc aaccactggt gtaggtccaa gagtccgaaa gctgaagaaa ttggagtgga
     4201 gtctgatgtt taaggtcagg aagcatccag cacaggagaa agatagaggc cagaagactc
     4261 aggcaatcta gtccttccat gttcctctgc ctgcttttat cctagccatg ctggcagctg
     4321 attagatggt gcctacccag attgaggatg ggcctgcctc tcctagtcca ctgactcaga
     4381 tgttaatctc ctttggcatc acctccatag acacacccag gaacaatact ttgtaacctt
     4441 caatccaatc aagttgatgg tcaatattaa ccatcatata ttccatctat taaatttcaa
     4501 tttttatctt ttttatttga tagagttttt aatttcaagg ctgcactttc tcggtaactt
     4561 taatcttcat aaattaaatt agttggatca ccttaagact acacacactt ctaattcata
     4621 gctgcttgtg aaggacattc ccaatagaag gcatgaacat tgtcttgata caggaataca
     4681 aaataagatg ctattctaaa ctttattgtt tatttagcca ttaaatagaa aaaatttaaa
     4741 aagacactga aaagtatttg aaaataaaat atttttcatt agttaataac cataaaaaca
     4801 ccactgaagg ttttccttaa aaatctaat
//
