LOCUS       NM_198074               8509 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily C member 3
            (OR2C3), mRNA.
ACCESSION   NM_198074 XM_060575
VERSION     NM_198074.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8509)
  AUTHORS   Trevino,L.R., Yang,W., French,D., Hunger,S.P., Carroll,W.L.,
            Devidas,M., Willman,C., Neale,G., Downing,J., Raimondi,S.C.,
            Pui,C.H., Evans,W.E. and Relling,M.V.
  TITLE     Germline genomic variants associated with childhood acute
            lymphoblastic leukemia
  JOURNAL   Nat Genet 41 (9), 1001-1005 (2009)
   PUBMED   19684603
REFERENCE   2  (bases 1 to 8509)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 8509)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606804.11.
            
            On Dec 15, 2020 this sequence version replaced NM_198074.5.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038195.1753770.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641802.1/ ENSP00000493385.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AL606804.11        94108-94380         c
            274-645             AL606804.11        91447-91818         c
            646-8509            AL606804.11        82617-90480         c
FEATURES             Location/Qualifiers
     source          1..8509
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..8509
                     /gene="OR2C3"
                     /gene_synonym="OR2C4; OR2C5P; OST742"
                     /note="olfactory receptor family 2 subfamily C member 3"
                     /db_xref="GeneID:81472"
                     /db_xref="HGNC:HGNC:15005"
     exon            1..273
                     /gene="OR2C3"
                     /gene_synonym="OR2C4; OR2C5P; OST742"
                     /inference="alignment:Splign:2.1.0"
     exon            274..645
                     /gene="OR2C3"
                     /gene_synonym="OR2C4; OR2C5P; OST742"
                     /inference="alignment:Splign:2.1.0"
     exon            646..8509
                     /gene="OR2C3"
                     /gene_synonym="OR2C4; OR2C5P; OST742"
                     /inference="alignment:Splign:2.1.0"
     CDS             675..1637
                     /gene="OR2C3"
                     /gene_synonym="OR2C4; OR2C5P; OST742"
                     /note="olfactory receptor, family 2, subfamily C, member 5
                     pseudogene; olfactory receptor, family 2, subfamily C,
                     member 4; olfactory receptor OR1-30; olfactory receptor
                     2C4; olfactory receptor 2C5"
                     /codon_start=1
                     /product="olfactory receptor 2C3"
                     /protein_id="NP_932340.4"
                     /db_xref="CCDS:CCDS1634.2"
                     /db_xref="GeneID:81472"
                     /db_xref="HGNC:HGNC:15005"
                     /translation="MMEIANVSSPEVFVLLGFSTRPSLETVLFIVVLSFYMVSILGNG
                     IIILVSHTDVHLHTPMYFFLANLPFLDMSFTTSIVPQLLANLWGPQKTISYGGCVVQF
                     YISHWLGATECVLLATMSYDRYAAICRPLHYTVIMHPQLCLGLALASWLGGLTTSMVG
                     STLTMLLPLCGNNCIDHFFCEMPLIMQLACVDTSLNEMEMYLASFVFVVLPLGLILVS
                     YGHIARAVLKIRSAEGRRKAFNTCSSHVAVVSLFYGSIIFMYLQPAKSTSHEQGKFIA
                     LFYTVVTPALNPLIYTLRNTEVKSALRHMVLENCCGSAGKLAQI"
     regulatory      8484..8489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2C3"
                     /gene_synonym="OR2C4; OR2C5P; OST742"
                     /note="hexamer: AATAAA"
     polyA_site      8507
                     /gene="OR2C3"
                     /gene_synonym="OR2C4; OR2C5P; OST742"
                     /note="major polyA site"
ORIGIN      
        1 agtgctttct gctagttcaa tcccattgtg atttaaatac ttaataatgt gtcctttaga
       61 catgaatttg aacagaatct aacacgtctg ctaccaccga cttagagatt tccactattt
      121 gcagggcttt aaaatcccct ggctaaactc ctattttttt aatgccacac gcattgaatt
      181 catgaatgtt atcagtcttt ttaataaaat attgcccatt ttacaacatt tccaccctgc
      241 ataaatagag atgatgctgc tagctcacca ttagagtgag ggaaaatttc acctttgtcc
      301 tctgaaattt cacagaaatc aactgacaaa tggcagattc ataggagaaa agacatacac
      361 atttatttga tcatagtttt acataacaga ggagccttca gatgagaatc caaagataca
      421 agagaaactt cccattttta tgcttaggtt caaagccata tggacagcca tgtagaaata
      481 tgattgaaca tgaagggcat gatctaatac tgatggactg agtgaagaag cccagcaaga
      541 cccatcgtga gattcttttt ggcctctctg agcagtgttc cttttttctt ggtatgcaat
      601 aagacctctc tggaatggag gtcttatgat ctacaatcca gtaaggtggc cttttgcccc
      661 acccccagca tacaatgatg gaaatagcca atgtgagttc tccagaagtc tttgtcctcc
      721 tgggcttctc cacacgaccc tcactagaaa ctgtcctctt catagttgtc ttgagttttt
      781 acatggtatc gatcttgggc aatggcatca tcattctggt ctcccataca gatgtgcacc
      841 tccacacacc tatgtacttc tttcttgcca acctcccctt cctggacatg agcttcacca
      901 cgagcattgt cccacagctc ctggctaacc tctggggacc acagaaaacc ataagctatg
      961 gagggtgtgt ggtccagttc tatatctccc attggctggg ggcaaccgag tgtgtcctgc
     1021 tggccaccat gtcctatgac cgctacgctg ccatctgcag gccactccat tacactgtca
     1081 ttatgcatcc acagctttgc cttgggctag ctttggcctc ctggctgggg ggtctgacca
     1141 ccagcatggt gggctccacg ctcaccatgc tcctaccgct gtgtgggaac aattgcatcg
     1201 accacttctt ttgcgagatg cccctcatta tgcaactggc ttgtgtggat accagcctca
     1261 atgagatgga gatgtacctg gccagctttg tctttgttgt cctgcctctg gggctcatcc
     1321 tggtctctta cggccacatt gcccgggccg tgttgaagat caggtcagca gaagggcgga
     1381 gaaaggcatt caacacctgt tcttcccacg tggctgtggt gtctctgttt tacgggagca
     1441 tcatcttcat gtatctccag ccagccaaga gcacctccca tgagcagggc aagttcatag
     1501 ctctgttcta caccgtagtc actcctgcgc tgaacccact tatttacacc ctgaggaaca
     1561 cggaggtgaa gagcgccctc cggcacatgg tattagagaa ctgctgtggc tctgcaggca
     1621 agctggcgca aatttagaga ctccagtgcc ttctgagaag gaagatcaag tttacatcga
     1681 gcaaagtgac cttggaagac agggcacttg ggatgtcgtt tttcttctaa tattgtttga
     1741 gctcaaggta gatggaaatc tgaaaggagt gtgctcatgc catttccaga ccaagaaaat
     1801 acatttatta tttgctaatt atcatagttt tgttcaattg cgttgttggt ttttgctata
     1861 tatacacatg ttgactgtca tcttgttttg taaactcctt gcgttgttgt tcagctgttc
     1921 ctcagtatcc gaagcgggtg gattccagga cgctccgtgg ataataaact ttgacgacgc
     1981 tgagagcgcg cggggagacc ggagccggcc tgttccccag agcccccgga gccctcccag
     2041 ccctcaggcc tgcgcctggg gtgagctgag cccgggactc cgccttgcag gctccggaac
     2101 cctcgctgtg gctcccccgc tcggcccagg ccttgaagcc gcggcgaacc tcttcctacc
     2161 ctacctcggg gacctggtgg cagcggcggc ctcccccagc ctggaccccg ccggccgcgg
     2221 gtctcccggc ccaaccccac cgacccagac caagaccgcg ccgagccgcc gggactcagc
     2281 gccttcgggt ggcggcggta agcggggagg aaacatggcg ccgcccaaat gcgcccggag
     2341 gccgttaggc tgtggagggc gaggaaggcg gtccagaggc ggccggcagg tccacgtcct
     2401 gggcgaccgc tctgtcgcag ttgggcgaga cctacctagt cctgacgggt cgtatttcca
     2461 agacattttc atattctatc cattgttttg tgtgcatttt attacttctg tatatagagg
     2521 taacaacgct aagctttttt gagatgtctg tttcttctag atgttctgaa gtacctgata
     2581 catgttaaaa ttagaggtag taaaatgaca cattttgtaa ataacttttt gttaaaattc
     2641 ataggaaatg ttattttgtg ggggggggat ggcatggtgt ttgtggactg gttcagggaa
     2701 ggaggggaaa agggaggtgc agagagctct aagccagtgt gcttacagtg aggcgagatt
     2761 caccattgtt tcttatgatt gtgcattttg ttttacttat ctatgtatac agtgtatcta
     2821 aaggacaaac gagtcctaat ttacaacagc tagtctttcc agatgttaaa gaacttctat
     2881 caatagagta acctatcact agagttcacc tctatcaata gagtaacctc attctctgcc
     2941 tgatgattca aaggcatggg aagaccaaaa ccatgtggca gttcctgttt ttgattttat
     3001 tatatatatg tatataatat gaaagtagtc attaaagtag tctttccttt cgtactagga
     3061 tcttccaatt cactgtatta gtcagggttc tccagagaaa cagaaccaaa aatatgtgta
     3121 aaagagaata cacacacaca cacacaccct gagggggaga gagagaaaaa agagtgagag
     3181 agattgagag ttaagaaata ggctcacaca atttagggaa ctggcaagtc tgaaatttgc
     3241 agggcaagcc agcaggctgt aaattttgac agaggttgat gttgcagctt gagttcaaag
     3301 tctggaggca aaattccctc tttttggaag caggtcagtc ttttctctta aggctttcaa
     3361 ctgatgggat gagacccact cacattataa agggtaatct gctttactaa aagtctactg
     3421 atttaaatgt taatcgcatc aaaaaaaaaa aaaaaaaaaa aaaaaaacac cttcacagta
     3481 acaccgaggc ttgtgtttga acaaaaactg ggcaccatag tccaaccaag ttgatatgta
     3541 aaatgaacca tcacaccaaa cccaaacttt cagtgaagtg aagcaacatt cttcaactgg
     3601 attattatgc atcatgtacg agacactctc atgtcttgtt ggtttctgga ctcatgtatc
     3661 aggttacggt gactgcaggt ttagggcata cactgcagcc tgcaggaaag cagtgcttat
     3721 ttacacagta ttgtttctca gcttcaataa ctaaaccttc agcaggccat tccatcattc
     3781 aataaagccc attccatcat tcagtcaagc ccactgcttc tgaatattga ggtatgaagt
     3841 atgaatcatg aattccaagg gcaattctat tgccacaccc cttttgctgt gaaatatgtt
     3901 tcctggttac aggtgatatt gcaggggatg ccatggtgat gattaaggct ttgttcacta
     3961 tgtaaatggt tcgggcatgg aagacaaaac tgtccccaca atattattct gtccctataa
     4021 agactaacat tgcttactct atgctcaaag gagtccagag taatcactat gctactagtc
     4081 cagccagacg cctggaaata gtgccaaatc acatgctaac cttggtgaga gaaatgtcat
     4141 aatgctgagc ccattcatag tttccatccc tgcttccatg ttaaatttct cataggctca
     4201 atgagcaagc ctgctggcaa aagagattga ctgattacct actagatgag tcatcttatc
     4261 taccatacca ccaagatcca tctctgcagt ggatgccctc tcatgggcat ttatgtcaga
     4321 cagatatctt catgatctgt gcacttttca ggaaattctt caatgtcctc ttctccagat
     4381 ttgcctgcca ttaattttcc agccttattc ttcacaaatc tctcagcaaa ataataactt
     4441 gttatccaat gctcctaaat cagtgcatat ccaaacttct gtgcctgtct ccttctataa
     4501 aaaattaaca accagctaaa ctgcctgtag tttgaccact gggaagtttc ccttcctcac
     4561 catctttcag caacacctgg aggggtactg tggtttaatg ccatttgctt ctttctgttg
     4621 ctggtgtata atgcagattc atttgtaaac tggcccatgc tttttccttc tttaacagtt
     4681 ggctaaacat gaaatatggg tgagatcatg caggatttgt ccctttgtgt ttggcttatt
     4741 tcacttaaca caatgtcttc taggttcatg catgttgtga agacaggatt ttgaacgctc
     4801 tcaccacaaa gaaatgacaa gtgtttgagg taatggatat gttaattacc ttgatttgat
     4861 cattacacaa gtatacatgt atcaaaacat catactgcac cccataagtg tgtacaattg
     4921 ttatttgtga attaaaaaca aactaaaatg aaatttaaaa aataattata caattttggg
     4981 ggcttggggg tgggggaagg ggaagtaaaa aagcagacag caggtactct aggagtcaga
     5041 gacacatgat aacattatta tgagtcagga aggtaggaaa tcaagttact gacatttttt
     5101 actcagttta gaacccaaag accgaagaaa cagaaacaaa tgggggaaat cataactttt
     5161 aaagtattag ataaaatttt tgagaaagtt aaatactgca tgttctcatt catctgtgaa
     5221 agctaaaaaa gggttgatct catagaaata agtagaacag aggatacttg aggctgggaa
     5281 tggatagcag gggtggggga atgagaagag atttgttaaa ggatacaaaa ttacagctcc
     5341 attggaggag taagttctag tgttctatac cactgcggga tgaccataac aataatatat
     5401 tctgtatttt caaacagcta gaaggaggat attgaatgtt cccagcacga agaaacgata
     5461 aatgtttgag atgatggata ttctaatcac acttatctga tcactataca ttatgtgctt
     5521 ccaaacatca ctgtttaccc cagaaatatg ttcaattatt atatgtccac taaaagctaa
     5581 aataaaaaaa ttttcaaaca ttcaagatct gaagaaaaac ttcaatctga atactaaaaa
     5641 ctttccctaa cctcttgaaa agactaatta aaaatctctg gagtttggat gcactgtaat
     5701 tttcatctgc cagttcatgg ctttgtttaa gctcagtagt caagttggta gaacctccag
     5761 agaaagcaat gaggaagtgg cagtaggacc ctctgggacc cgttacccca aatatctgtc
     5821 atcttcttga cctcaaggct gggtgtcaac tcaggacagg agtgcaggtc ctcatcagtt
     5881 tatgtgggga tagcagacaa cgcagaccct cccagaacca tgaggacagc actgtgcttt
     5941 gccctgacca tccatcagcc cctgtttggc acagaggaga atgatgacca taactcacac
     6001 tctcctccaa ctgccttaaa tgctcaggct gattggtcat gtgctcaccc aactgctccc
     6061 taaatgctta acagaaaatg aagacatcct ctccagaacc caaggaaata cacttgaaat
     6121 gtgatttgta cctcagattg gcatccaaga actgaaagaa acaccaggca ttccacacaa
     6181 tttctggctc cacatccagt agaactattg gaatcctcca acataaccat cttgaggcag
     6241 taaatcctga aagaaagtga aagaagacct ttctaaatag agggaagtcc catcttactt
     6301 ggatttaagt tatagtaaat gaagaggaaa atgctaacat gccatattgg acaccacttg
     6361 tctttcgatg ccaggtccct tttcagccga atatgtcaga attttctagg ctccatcttt
     6421 tcttttattc ctcttgcagc aaccataggc tttgatggct tctcacagga cagaaaacct
     6481 ggatcatccc aaacctgctc tgtgaaccct ctacttcatg tatgggtttc ctcccatgct
     6541 gcacactgtg agggtcatgc atcaccacag catgcacagc tgagaaatgt ggagagtgaa
     6601 ggacccaggc cacattgact gtggggatgt aagccagtgg agacacactt cctgaagtaa
     6661 gatgcatttc acaaagctcc cagtttccag aaggatggag caccagtcac ccttggtcat
     6721 ggccaaaccc tctttgtcct tgccctttcc tgctctctgg gatcacagaa catgtgcact
     6781 ggacacagct tctgccttgg aaacacccag actaaggtaa tttctcacac accagtttat
     6841 cttccagctt ctgtcagaac tttaggtcag gtattatgag ccagatagag taaaaaatat
     6901 aaactttaaa aattataatc accctcaaca tggcaagctt ctcatggtaa gaaaggaatg
     6961 caagaattca gaaactaacc cagggaatag caggctcaag atttcttggc aaataaattc
     7021 acttaataga tcacagatat tttctcatct caacacatgc tgtgcacagg tatatttcaa
     7081 acctaatcac cgtggaattt ctcattttca ttattacaaa caaagctaca ataagttcat
     7141 gtgtattgaa atccttgcaa acttgactag tagctcaaga taaattttag aataaaaaat
     7201 caaatggtat tcacatgtat atactctgaa gcatatattt ggtcttcaac aggtttccag
     7261 gcatacaact actaaaatcc ttggattcct taaagtggta cttgtatgtt aatgagttga
     7321 caaatggcta gtagtcccta cgtagcttca ggatgggagc tgggcacctg aaagaccaag
     7381 gcagaattag agaattaaga tagtcagacc cagcccccaa cctccatgga gggaagaagg
     7441 gatgaatgtt aagcagaaca ccaatggcca gtgatttaat cagtcatgcc tacagaatga
     7501 tgcctccata aaaaccctca aggactgggt tcagagggct tccagatagc tgaagacgtg
     7561 gaggttcctg gaaggtggtg aacctggaga gagcatgcaa gctccacagc ctttccctat
     7621 acctcaccct atgcatctct tcatctgcat ctcttgcgat atcctttaca ataaactgct
     7681 aaatgtagat gcctccatga gttctgtggg ctgctctagc aaattaattg aacccaagaa
     7741 gggggctgtg gtaacccaga cttacagctg attgactggt cagacacaca ggtaaaaaga
     7801 acttgaggct tataattggt attggaaacg gggatgtctt atgagactta gccctcaccc
     7861 agcagacctg gcgttatttc caggtagata gtgtcaaaac tgaattgaag gacacccagc
     7921 tggtgtctgc cataggattg attgtttgct tggtgtatgg gcttaacccc atcaccttta
     7981 gtcacagaag tcttctgtgt tgattgttga gtgagagaat agaaaaagcg ctttagtttg
     8041 tttttcctta tagaacatgt tgacattatg tggacatatt taaatttccc ttcagacacc
     8101 aaattcgtac ttttgccaat aatgtgtaca aaggcatata ttctcacagt ttcactaaca
     8161 tttgattttg ttagtaactt tagttttact tgcaaatctt acctcagtat cattttattt
     8221 ggcattgatt taatcattag tgaggtttaa catcttctgg tatgttttgg ggctatttgt
     8281 gtttcttcaa taaattgttt ttttcttaaa ttttcattgt tttacctttt tgcttactga
     8341 tttgtagcgg tagttgacat gattctacac atctttgtca tcatataagt gttgaatcgt
     8401 ttttctagtg ggacgtttta tccttttgct atgttttgtt tgtttccttt gtggtacaaa
     8461 agttttaaat gttatatgta ttaaataaac tatcaatcat gcctttatg
//
