LOCUS       NM_001004492            6349 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily B member 11
            (OR2B11), transcript variant 1, mRNA.
ACCESSION   NM_001004492 XM_060580
VERSION     NM_001004492.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6349)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   2  (bases 1 to 6349)
  AUTHORS   Villani,A.C., Lemire,M., Fortin,G., Louis,E., Silverberg,M.S.,
            Collette,C., Baba,N., Libioulle,C., Belaiche,J., Bitton,A.,
            Gaudet,D., Cohen,A., Langelier,D., Fortin,P.R., Wither,J.E.,
            Sarfati,M., Rutgeerts,P., Rioux,J.D., Vermeire,S., Hudson,T.J. and
            Franchimont,D.
  TITLE     Common variants in the NLRP3 region contribute to Crohn's disease
            susceptibility
  JOURNAL   Nat Genet 41 (1), 71-76 (2009)
   PUBMED   19098911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606804.11.
            
            On Jan 8, 2021 this sequence version replaced NM_001004492.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641149.2/ ENSP00000492892.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AL606804.11        15579-16044         c
            467-6349            AL606804.11        7122-13004          c
FEATURES             Location/Qualifiers
     source          1..6349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..6349
                     /gene="OR2B11"
                     /note="olfactory receptor family 2 subfamily B member 11"
                     /db_xref="GeneID:127623"
                     /db_xref="HGNC:HGNC:31249"
     exon            1..466
                     /gene="OR2B11"
                     /inference="alignment:Splign:2.1.0"
     exon            467..6349
                     /gene="OR2B11"
                     /inference="alignment:Splign:2.1.0"
     CDS             3549..4502
                     /gene="OR2B11"
                     /note="novel 7 transmembrane receptor (rhodopsin family)
                     protein"
                     /codon_start=1
                     /product="olfactory receptor 2B11"
                     /protein_id="NP_001004492.1"
                     /db_xref="CCDS:CCDS31090.1"
                     /db_xref="GeneID:127623"
                     /db_xref="HGNC:HGNC:31249"
                     /translation="MKSDNHSFLGDSPKAFILLGVSDRPWLELPLFVVLLLSYVLAML
                     GNVAIILASRVDPQLHSPMYIFLSHLSFLDLCYTTTTVPQMLVNMGSSQKTISYGGCT
                     VQYAVFHWLGCTECIVLAAMALDRYVAICKPLHYAVLMHRALCQQLVALAWLSGFGNS
                     FVQVVLTVQLPFCGRQVLNNFFCEVPAVIKLSCADTAVNDTILAVLVAFFVLVPLALI
                     LLSYGFIARAVLRIQSSKGRHKAFGTCSSHLMIVSLFYLPAIYMYLQPPSSYSQEQGK
                     FISLFYSIITPTLNPFTYTLRNKDMKGALRRLLARIWRLCG"
ORIGIN      
        1 gagaatgagg tcaagttaaa tctgagggat aattttgaaa tgaacagaga gcgtgacacg
       61 ggcaaggtgt gttgcctgaa agccttatcc tcggaagtaa cctccaccat gtcaaggtac
      121 ctataggcac tctgggggac taaggttaag gcagttccac cgacctcacg tactgccaag
      181 ggagagtccg ggaaaccctg agtctcccca gcaagcctgt tgcaacggac agcagactcc
      241 ttctagactg agaataatct ctcagacttg ctcagagggt tgggttccag taaatggtaa
      301 ggtcccagca gcccatcaga ggaaatgtgc tgtgtgttcc tggaatatga agagcatttc
      361 tagtaagtcc atccttaaat gtccctccgc gactaaggcc aacacagact gcaatatagc
      421 cttcagtcct aaagcaagtc ttctgtagga gccaggaacc ctggagggaa tgatatatat
      481 ctaagggtgt atcacagcct gcgtgttcac agcctagcct gccagcagcc cccagaagaa
      541 actgcgggaa ttcagcgtga acatgataca atcagcaggt aactcttgag cgacgggttc
      601 ttacgttttt ggtaattgaa acacctaaag atatctttgc cttaaggcct gagtctcaga
      661 aagatgactt cgtgtgaggg tgagtgaggg gttgaaactg cctgcagaga ggcaggtagc
      721 aagttccaag aggggtcctg gtgggcgttt ctgcccagga cggcagtggt gaggatacag
      781 acagtgcgtg cctgcaacga tgcaacattg tggtgggatc acagcattgt gtgggtgttg
      841 aattctttaa cttcggtgct gaactagagt gaatgaggag tagaacatga atagaaagaa
      901 cctcagtact tggcatcacg gtgactgaag ggaactcagc cagaattaag atgaaggaga
      961 tggtttgagt ctggggggat ggctgccagg tgaaatttgg gatgcctcag ttcacaatgt
     1021 caaaaagggg gttagaggtc agtgaggaac tgacaactgt agatacagcc tgagggattc
     1081 cgtctgaatg cgatggcgat gtttgtggga actactgtgt ccatccaggg aagcaaggct
     1141 gtgccttgag ggggcacctg tacttgggta gtgggaagat gaaagaaggt caaggagtgc
     1201 agaggctaga cacctacgaa agctccgtgt ggaaacacct gaacagaagg gcatcagatc
     1261 cagggcatga ggggcagggc tgggcagtgt ccagctttgc cattgagaaa ccgtgtgtgt
     1321 gtgcgtgtgt gtgtgtgtgt gtgtgtgtgc gtgtgcacgt gcatgcatgt gtgtgcacgt
     1381 gtgtacgtaa gtgtgcacat gtacagtgga ctataattac aagaaaacca ctcctctcta
     1441 atccctgccc ctttctatcc tgtgaccttc ctctccctca tctccccttc ccaggaactt
     1501 cttttgtctc agtcgtttac gcgactgccc ttgctgctcc ccatgtcacc agctgctctt
     1561 tttttaaagc aaagttctgg agagaatagt agtgaagagc aggagtttgg ctttcagtcc
     1621 tggctttacc atttgctgcc gtgtaactaa ggtagaccag ctgtcctccc gagtcgctca
     1681 gtcaattagg ggtgaaaaca tggaccttgc tgagatatta aggcaacatc aagttattat
     1741 tacagtacct ggctcacagt gagtggtaaa taacttgtct ttattataaa ttgccgcata
     1801 catttacccc tctatctttc ttgcttcctt cattctctca tttctttctt cactatccct
     1861 acaacttctc ccttttctcc cagtttaggc tctgaaaaga aactctggaa tcagaaatct
     1921 cagaaagaga aatgtcataa ttcctttact tcttaataat tagacttaaa aatgtgctag
     1981 cttgactttg ctcggccaca gctcactgtt ttgacaggca tcttgagctc gttagagata
     2041 agatcacatt ctgtgaagtt tatttcataa gtattgttga tagaatctgg gaggagatac
     2101 gataattgaa tgtttcacaa gaatattggc aactttctga caaaacgtgt gtggttttga
     2161 aactagagaa gcaggaggga aaaactgaac ttattcctcc attgaaaccc tggagtttga
     2221 gttgttttcc agtaacagta gagttcttca gaacatcaac tggggcagca gggaacacct
     2281 gttgcaacat gtaagctgag cagatctccg ttagttttac agtctatgca taaggtacca
     2341 aatcaagaat aaaaatcctt cataaattat ctgcttacag gatttattat gaataatgat
     2401 taattaatta ttgtttatta ataatatttt tcaatcctat catggagcat aacatcccca
     2461 tcaggaactg gaaggtgtgc aatgcttgag cgattgtagg aggtgagaag ccaatggtgc
     2521 agtcgaaagg acccacgaat cagcaggtgg caacccagtt gcttcctaac agcaatggtt
     2581 tcagaaatca aattggctgt tttctatcac tgagaggtga cagctgctcg gcaaagaaat
     2641 tgtgcaggaa attggaatgt cactcaagcc atcagataaa acctagccct agagggcagt
     2701 ctgatctttc cgtagacaat tccaggggct acctttctca cgccaatcaa gagctttctc
     2761 cctgtgctca aaattccatg gtctggggtc tcattaacta ccatgaccta ttcaggggct
     2821 gaagtaacgt ataccttggc tcttccactc cagagactca caggacctag aattgtgctg
     2881 cttttactgc cagtgtgagt gacagggctg cctgtgcgtg tgtggtcatg acagcggaga
     2941 tcagcatgaa tccgggagct ggatgcaagc gtgagccagt gacggggggt ggtcctatca
     3001 atacagcccc cagctgctca caaagccctt ctgcttgctt tatgtcaccg cctgcctccc
     3061 tcctaccact acctcccaaa atgggaaagc ctaagaaggt ggacaattcc ttgtcgatgt
     3121 ggatgtagag agaaatcaaa cactctgacg gtgatgggag ctgcagcacg cttcgctcta
     3181 cctggaacat aattgtcatt cgtgaggtat tcttctcaca tacttaatgt ctctatcgtc
     3241 cccaagtctt ggcaattgaa ggaggtattt ctccccattt tacagatgca gaagttcagg
     3301 aatattaaat ggtttagttg cggccactga gtaggaagga gagcaaagac acagaggctg
     3361 ctactggggc tcctggttct gacccttccg catcccagcg tctccacaga ggtaaggaga
     3421 atcaaacagg ctatcacctg ggaaaggaag agtggatgca agagggagga aagtgatcaa
     3481 ttcctcttct caggtattat tcattccaat tttctcaatt tgccacaagt gccagaaaat
     3541 gccgcaacat gaaaagtgac aaccatagct tcttagggga ctcccctaaa gccttcatcc
     3601 ttctgggtgt gtctgacagg ccgtggctgg aactccctct ctttgtggtc ctcctgctgt
     3661 cctatgtgct ggccatgttg gggaacgtcg ccatcatcct ggcatcccgg gtggatcctc
     3721 aactccacag ccccatgtac atcttcctca gtcacctgtc cttcctggac ctctgctaca
     3781 ccaccacgac agtccctcag atgctggtca acatgggcag ttcccagaag accatcagct
     3841 atggaggctg cactgtgcaa tatgcagtct tccactggct gggatgcacg gagtgcatcg
     3901 tcctggccgc catggccctg gaccgctacg tggccatctg caagcccctg cactatgccg
     3961 ttctcatgca ccgtgctctc tgtcagcagc tcgtggctct ggcctggctc agtggcttcg
     4021 gcaactcctt cgtgcaggtg gtcctgacgg tgcaattgcc attctgcggg cggcaggtgc
     4081 tgaacaactt tttctgtgag gtgccggccg tgatcaagct gtcgtgtgct gacaccgctg
     4141 tgaatgacac catactggct gtgctggtgg ccttcttcgt gttggtgccc ctggctctca
     4201 tccttctctc ctatggcttt attgcccggg cagtgctcag gatccagtcc tccaagggac
     4261 gacacaaggc ctttgggacg tgttcctccc acctgatgat cgtctccctc ttctacctac
     4321 ctgcgattta catgtatctg cagccccctt ccagctactc ccaagagcag ggcaaattta
     4381 tttctctctt ctattccata atcaccccca ctctcaatcc cttcacctac accctgagaa
     4441 ataaagatat gaagggggct ctgaggagac ttctggccag gatctggagg ctctgtggat
     4501 gatgaggaca tgagatgtag catctccatc aattaaagaa cacagcacaa gtctattgtg
     4561 cactcagagc atctttcact taaggagtta atacccagag agctcaaaaa ccctgtcttc
     4621 aaacatctca cttcctgtta taatgcccca aatcccatag cgacaaagtt cattttaaac
     4681 gtataattct aagaggccat atatttttaa gcattgttta aatagacttc aataagtatg
     4741 tgtggaatta tttcacttcc aatttcctga ttcttttctc ttttcctctt cctatatttc
     4801 ttttattctc tccccatttg tctcttttct attactccta agtatacaca agatgaagct
     4861 gaaatacaat cttattttac ttacaatgaa taagtgtttt tctccatata cttaaatctc
     4921 cacaaatttt acacgacttt ttcagacaat tccaggaatg aagtagattg ctatcttctt
     4981 cctgtgattt tgattttttt ttctctgtag ttcacatttt cttctataga aagtttttcc
     5041 atgaaatgta aactagtaca aacactagta caaccacgat ggaaaacatt gtggatcctt
     5101 aaagaacaaa aagtagatct accatttgat ccagcaatcc cactacgggg catctaccca
     5161 gaggaaaata agtcattata cgaaaaagat acttgctcat gcgtgtttat agcagcacaa
     5221 tttgcaattg gaaaaatatg gaaccatctg ggcgcagtgg ctcatgcctg taatcccagc
     5281 actttgggag gccgaggcgg gtgaatcaca aggtcaggag ttcaagacca gcctggccaa
     5341 gatggtgaaa ccccatctct actaaaaata caaaaattag ctgggcatgg tggcacacgc
     5401 ctgtaatccc agctactcag gaggctgagg cagagaattg cttgaacccg ggaggcggag
     5461 gttgcagtga gccgagatcg cgcctctgca ctccagactg ggcgacagag caagactcca
     5521 tctcaaaaaa aaaagaaaaa gaaaatgtga gatatatacc atggaaaaat actattcagc
     5581 cataaaaagg aatgaaataa tggcattctc agcaacctgg ccagttttaa tgtcctaatg
     5641 cccaaaggtt ctctttctct ctttcaagct cagctatgtg tttctgatta cattatttat
     5701 ataggttatc aaagtgtttg tagcaggaag gcagtcggta atagttcacc aagatgcaga
     5761 aacccagtct ccagttggtg ctgctcagaa gtgctaacaa gacagagttt gcaacagaat
     5821 gtaaatctca tactgtttcc cttataaaaa tagtcttcag ggtttttttt aaatgtcagc
     5881 tcatctaaaa ggtatgttta ataatgtgat tgttttacat tcttatacaa gctccttata
     5941 tcgacagttc atagactaca ctttgagtag caaagtgtgg ctactttgat ggctaattgt
     6001 acagaggaaa tagtatttcc atcctgagca attccatgcg gtttaagagt tgtccatgtg
     6061 tagagaagca attagtaaat atttccttat aacttaatgc tctgtgaagt ataatagatg
     6121 aactgttcct cggatgggat aaatccaaaa taagctgtta tcaactgaaa gcaagatgca
     6181 tcttctacat aatacttcta gttaggagcg caggctctga tactctcaaa cctttccctc
     6241 cacgattttc aatctcctat cctatcaaag atgaaattcc actcattaca gttagagtga
     6301 ggtaacgttt taaaaattat ctacaatgga atcatttgcc aaagtgact
//
