LOCUS       NM_001405852            8661 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily AT member 4
            (OR2AT4), transcript variant 2, mRNA.
ACCESSION   NM_001405852
VERSION     NM_001405852.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8661)
  AUTHORS   Piccini,I., Cheret,J., Tsutsumi,M., Sakaguchi,S., Ponce,L.,
            Almeida,L., Funk,W., Kuckelhaus,M., Kajiya,K., Paus,R. and
            Bertolini,M.
  TITLE     Preliminary evidence that Merkel cells exert chemosensory functions
            in human epidermis
  JOURNAL   Exp Dermatol 32 (10), 1848-1855 (2023)
   PUBMED   37587642
  REMARK    GeneRIF: Preliminary evidence that Merkel cells exert chemosensory
            functions in human epidermis.
REFERENCE   2  (bases 1 to 8661)
  AUTHORS   Shi,J., Lu,D., Gu,R., Xu,Y., Pan,R., Bo,F. and Zhang,Y.
  TITLE     Identification of Key Biomarkers and Immune Infiltration in
            Sporadic Vestibular Schwannoma Basing Transcriptome-Wide Profiling
  JOURNAL   World Neurosurg 160, e591-e600 (2022)
   PUBMED   35092815
  REMARK    GeneRIF: Identification of Key Biomarkers and Immune Infiltration
            in Sporadic Vestibular Schwannoma Basing Transcriptome-Wide
            Profiling.
REFERENCE   3  (bases 1 to 8661)
  AUTHORS   Cheret,J., Bertolini,M., Ponce,L., Lehmann,J., Tsai,T., Alam,M.,
            Hatt,H. and Paus,R.
  TITLE     Olfactory receptor OR2AT4 regulates human hair growth
  JOURNAL   Nat Commun 9 (1), 3624 (2018)
   PUBMED   30228264
  REMARK    GeneRIF: Study shows that human hair follicles (HF) can engage in
            chemosensation and that the specific activation of OR2AT4 is
            required to sustain HF growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8661)
  AUTHORS   Busse,D., Kudella,P., Gruning,N.M., Gisselmann,G., Stander,S.,
            Luger,T., Jacobsen,F., Steinstrasser,L., Paus,R., Gkogkolou,P.,
            Bohm,M., Hatt,H. and Benecke,H.
  TITLE     A synthetic sandalwood odorant induces wound-healing processes in
            human keratinocytes via the olfactory receptor OR2AT4
  JOURNAL   J Invest Dermatol 134 (11), 2823-2832 (2014)
   PUBMED   24999593
  REMARK    GeneRIF: OR2AT4 is involved in human keratinocyte
            re-epithelialization during wound-healing processes
REFERENCE   5  (bases 1 to 8661)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001972.4 and AP003175.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN03267769,
                              SAMN03267782 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641504.1/ ENSP00000493318.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AP001972.4         238-286             c
            50-8661             AP003175.2         63458-72069         c
FEATURES             Location/Qualifiers
     source          1..8661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..8661
                     /gene="OR2AT4"
                     /gene_synonym="OR11-265"
                     /note="olfactory receptor family 2 subfamily AT member 4"
                     /db_xref="GeneID:341152"
                     /db_xref="HGNC:HGNC:19620"
     exon            1..49
                     /gene="OR2AT4"
                     /gene_synonym="OR11-265"
                     /inference="alignment:Splign:2.1.0"
     exon            50..8661
                     /gene="OR2AT4"
                     /gene_synonym="OR11-265"
                     /inference="alignment:Splign:2.1.0"
     CDS             701..1663
                     /gene="OR2AT4"
                     /gene_synonym="OR11-265"
                     /note="isoform 1 is encoded by transcript variant 2;
                     olfactory receptor OR11-265 pseudogene; olfactory receptor
                     2AT4"
                     /codon_start=1
                     /product="olfactory receptor 2AT4 isoform 1"
                     /protein_id="NP_001392781.1"
                     /db_xref="GeneID:341152"
                     /db_xref="HGNC:HGNC:19620"
                     /translation="MDATACNESVDGSPVFYLLGIPSLPETFFLPVFFIFLLFYLLIL
                     MGNALILVAVVAEPSLHKPMYFFLINLSTLDILFTTTTVPKMLSLFLLGDRFLSFSSC
                     LLQMYLFQSFTCSEAFILVVMAYDRYVAICHPLHYPVLMNPQTNATLAASAWLTALLL
                     PIPAVVRTSQMAYNSIAYIYHCFCDHLAVVQASCSDTTPQTLMGFCIAMVVSFLPLLL
                     VLLSYVHILASVLRISSLEGRAKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFH
                     IMGNVVYAILTPILNPLIYTLRNRDVKAAITKIMSQDPGCDRSI"
     regulatory      5989..5994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2AT4"
                     /gene_synonym="OR11-265"
                     /note="hexamer: ATTAAA"
     polyA_site      6008
                     /gene="OR2AT4"
                     /gene_synonym="OR11-265"
                     /note="major polyA site"
ORIGIN      
        1 aggccaactg tgacgactct acacaagaca tcaaggcgga ccaggattgg agcagaagtc
       61 cagacaccta gcttaaatgg agtcagaaag aaccactagt caaggcatac aagaaagaaa
      121 cttaataaga gtgtgagcag ctgcatagta cacacagcct tggagaaaga agcccctcaa
      181 tggaacatga tggaactttg agtgagtaca aaagtagaga catgagctta aggacttgat
      241 ttatgagatc tgacatcaac ttaaaccaca cagcatggaa actaagatga agaccagaag
      301 aagcctttcc aaagcacttt cacaattata attcaacaat caactgttta gatctgattt
      361 tcccagtaaa atataaactc tgggaagaca ggaactttgc ctgccttctt caatttgatc
      421 acttcatcac ctaaacaaag catacagact tctatttggt tggttattaa ttaattaata
      481 atcaatattt gacaaatttt gcgttcacat ggcaaaagtc aataccatag cccctcatca
      541 gtcctctaca gttggttgta aataattctg cttatattac ctacagagta aacattatag
      601 cattatcact ccagaatcct ttgtttctat ggtttccaga tgtttccaat gtctagatgt
      661 tccagctgcc catctctgag aaatccagct gtgtctcaca atggatgcca cagcctgtaa
      721 tgaatcagtg gatggctcac ccgtcttcta tctattgggc atcccctctc tgccagagac
      781 cttcttcctc cctgtgtttt ttattttcct cctcttctac cttctcatcc tgatgggtaa
      841 tgccctgatc ctggtggccg tggtggcaga gcccagcctc cacaagccca tgtacttctt
      901 tctgatcaat ctctccacct tggacatcct tttcaccaca accactgtcc ccaagatgct
      961 gtccttattc ttgcttgggg accgcttcct cagcttttct tcctgcttac tgcagatgta
     1021 cctcttccaa agttttacat gttcagaagc cttcatcctg gtggtcatgg cctatgaccg
     1081 ctatgtggct atctgccacc cactgcacta ccctgtcctc atgaacccac agaccaatgc
     1141 taccttggca gccagtgcct ggctaactgc cctcctcctg cccatcccag cagtagtaag
     1201 gacctcccag atggcatata acagcattgc ctacatctac cactgcttct gtgatcatct
     1261 ggctgtggtc caggcctcct gctctgacac caccccccag accctcatgg gcttctgcat
     1321 cgccatggtg gtgtccttcc tcccccttct cctggtgctt ctctcctatg tccacatcct
     1381 ggcctcagtg cttcgcatca gttccctaga aggacgggca aaagccttct ccacctgcag
     1441 ctcccacctt ctggtcgtgg gcacctacta ctcatctatt gccatagcct acgtggccta
     1501 cagggctgac ctgccccttg acttccatat catgggcaat gtggtatatg ccattctcac
     1561 accaattctc aaccccctca tttacacgct gagaaacagg gatgtaaagg cagccatcac
     1621 caaaatcatg tctcaagacc caggctgtga caggagcatt tgacctttaa atgcagctaa
     1681 ctctgcttcc aggacaccaa ataacagtgc ttagcacaga gaaaggactc aatacatgat
     1741 aatgaaataa tgttaatttt tattggaatc ttaagttgtt gtataaaatt ttactactta
     1801 gtaattcaag aaacctttac taaaataaaa aaaaaatctt catggcaaaa aattcttaaa
     1861 agcaaagtca aaaaacaaat aaaaaacgta tcacagggaa aggcaaatat tcatattata
     1921 caaagaatgt agaagattga aataaacatt tcaataaaaa catgggcaaa atatatgtgt
     1981 agacaaataa aaaaaaatgc agtggccttt aaataatgag tatttactat ataaaaagaa
     2041 tacgaattta aattgtgctg aaatgttatt tttcacttaa tcagattagc agattagcaa
     2101 aaatccaata ttttgacaat atgcatgtag aaaaacagaa cttttataac ttgcttgtga
     2161 ggatgcaaac tggtataaca ctaccgcaat acctaccaaa attacatatg catttaccct
     2221 ttgactcagc agtatcactt ctagggatct atcccgagga gtcaccatca atcattcatt
     2281 aggttacgta ttcatcacta tacagggaac tgattgaata aaccataaaa atgcatgatg
     2341 cagtaataaa aaggaaataa ggaagctctc tactgatatg atatcatctc taggatatgt
     2401 gttaagtgaa aaaaagcaag ctgcagaaaa gtgtttttgt aagaaaggag atagtttgct
     2461 taaaatttca ggaaaaaact agagggaaaa tgtgaactca taaagatggt tatctataag
     2521 gagaggcaag gaacaggaag gagaggacca gaatggaagc aagtctagac atatgtaatt
     2581 atttttacat agttcaaaga aatcagaaag aaaaacccca caattccctc aatttaaaat
     2641 aaacagaagc acttgaccct ggctgtctct caagttagtg gcatgaccac aaagaaaatt
     2701 actgtaagtg acttttacac aatgttttga ctatacatcc taaaagggat gtattaaaag
     2761 gacaagaaaa atcacatctt aaactacatt gaggagtttt tgttgttgtt gttgtttgtc
     2821 tgttctgaga agaggccttg ctctgtcacc caggctggag tgcagtggcg ctatctcggc
     2881 tcattgcagc cttgaccgct agggctcaag tgatcctccc acctcagctc cctgagtagc
     2941 tgggaccaca ggcacatgca ccactacccc cagctagagt agttttaaaa acatgaatat
     3001 tatagtttta cttctttaat atatattaga taaattatat gttcgtataa ccaaaaccat
     3061 ttttatcatt ttattttacc atgcatggtt ttatatttac agagagtttc aaagatagta
     3121 tgagagttcc catatatcct tcacctaact tcctctgtgt caacatctta cataaccatg
     3181 atacatttat caaaagtaag aagttaacat ttgtaaaata cgtactatta attatactag
     3241 agactttatt caaatttctc cagtttttcc agtaatgtct tctttccatt ccaggatcca
     3301 atcagaatgc cacattgcat tttattatat cttcttagtt gcctgacatt ttattggtct
     3361 ttccttatct ttcatgacct tgacactttt gaagagtcaa tagtaaattt aaatgcatat
     3421 ggctaagtga aagaagccaa tctaaaaagg ttacataatg tatgatttta actgtatgac
     3481 attctggaaa aggcaaaact atgaagacag taaagagctc aggggctgcc agggagacta
     3541 ggagaaggga gggattaata ggcagaacac ggagggcttt taggacagtg aaactattct
     3601 gtatgatact ataatggtgg atacatgtta tatatttgtc aagactcata gaatgtacta
     3661 caccaagtgt atactatggg ctttgggtca taatgatgtg tcaatgtagg cttgaatgta
     3721 acaaatgtaa ccactctggt gggggatgtc attctaacag gtatgtagtg gtatcttatt
     3781 gtggttgtaa tttaatttaa ttacatttcc ctatgactaa ttgtgttgac catctttcat
     3841 gtgctcattt tctatccata tatctttttt ggtgaagtct gtccagatct tttgcctgct
     3901 ttttaatcca ggttgtttgt tttcatacca ttgaatttca agtgttcttt gtatattcta
     3961 ggtacaaatt cattattaga tatttgatat acaagtagtt tccccagtca atgactagcc
     4021 tttgaattcg cttacagtgt cttttgcaga gcagaggttt tcaattttga taaagcctaa
     4081 cttatcattt ttcccttatg gattatgctg tttgataaca tatctaaata ctcatcacca
     4141 aaccaaaggt catgcagatt ttgccctata gaaaacgaag tttctagaag ttttctattt
     4201 ttgatttcat tctatgaaca attttgagtt aattcttggg taaggtgtga ggtttaggtt
     4261 gagattcttt ttttgtgtgc atatgaacat acaatcattc cagcaccatt tgttataaac
     4321 cattctttat ctatcaaatt gcctttacac ttttgtcaaa tatcagttga ttatatttgt
     4381 gtgtatctat ttgtgggctc tctattctgt tccactgata tatatgtcta tcctttaccg
     4441 ataccacacg gtcttgaata ctgtagcttt atagtcaatg ttgaaattcc ataatgtgac
     4501 tcctctgact ttattaattt ttttgcagtt gtttggttat tctagttcct ttgctttttg
     4561 atataaattt tagaaccaag ttactgggat ttggggaggg gagggactat gttaaatcta
     4621 tagattaaat ttgggacagt tgtcatttta acaatgtcga gtcttccatt ccatgaatat
     4681 aatatatctc tccatttact tagctcttta attttattca ttacaaactg cattcctggg
     4741 atgaacccca tttggttgtg acatgttttg ccctttatat attactagat ttgacttgtg
     4801 aatattttgt tcaggatttt tgcatcaata tttatgagag ataccagagt gtagttttct
     4861 tgtaatttct ttgtctggtt tggtattaga taaatgctgg cctcataaaa tgaattagga
     4921 agctttcccg tctcttctac attctcaaaa acattgtata gaattggtgc tatttcttcc
     4981 ttaaatattt ggtagaattt gcctgtaaaa tttccagggc ctggaatttt ctttcaggaa
     5041 gtttttaact acaaaattaa ctatttaata gatatagaaa tttttccatt atctatttct
     5101 ttttgaatga actttataat ttctgccttt taagaaattt gtccattttg tccaaatttt
     5161 agaatttata aacatagagt tgtttgtact gttcccttat tatcctttta atgtctgtga
     5221 tgtctcctct ttcattccta atattggcaa tttgtgtttt ctgtgatttt ttcttggtca
     5281 gtttagctat aggtttacca atttactgat ttttcaaaga atcagcattt agtttgtttc
     5341 ttctcatttt cctgttttca attttattga ttcttcctct aatctttata ttttttttcc
     5401 ttctacatac tttgggttta atttgatcat ttttctaatt tcctgacatg ggagattaga
     5461 tcattgatac gagactttta tttttcaatg taagcattga agtctgtaca tttcccaata
     5521 gctcctgcat tagcaacttc acacgaattt taatatgttg catttttatt ttcattttat
     5581 tccaaatgta ttttaaattt cccctaaaac atcctaattg acccatgctt atttcaaagt
     5641 gtttttattt aatttcagaa tatttggaag attttcccaa tcactttctg ttactcctgt
     5701 ctagtttaat tcccttatgg ttcaagaata tgctttgtat gattactatt gtttaaaaag
     5761 cttttctatt cttttaaatt tttttaatgg cctattcttt taaatttttt agtggcctaa
     5821 aatatgacct accttggtga atgttctgtg cacccttgga agtgtattct gctattatgt
     5881 ggagtgttct ataaatgtca attaggtcta gttgtttgat agtgctgttt agaccttcta
     5941 tatcttaact gattttctat ctgcttgatc aattcctgaa agggaaatat taaagtttct
     6001 aacaataatt atggatttgt ccatttctcc cttcaatttc accagtttgt aagaaaattt
     6061 ccacttttta gattcagggg gtacacatgc aggtttgtga catgggtaca tttcatgatg
     6121 ctgaggtttg ggatatgaat gatcccgtca cccagatagt gagcatagta cgcagcaggt
     6181 agttttacaa acctcgctac cctccctcca ccctctatta gtccccagtg tctattgttg
     6241 ccatctttat gagcataagt acccaatgtt tagctcccac ttataagtga gaacatgcag
     6301 tacatggttt tctgatcctg tgttaattcg cttaggataa tgggctccag ctgcatccat
     6361 gatttcattc ttttttatgg ctatgtagca tttcatgctg tatatggacc aattttctcc
     6421 tttttttttc tttttttttt tttgagacgg agtttcgcct tgttgcccag gctggagtgc
     6481 aatggcacga tctcagctca ccacagcctc cgcctcccag gttcaagtga ttctcctgcc
     6541 tcagcctccc aagtagctgg gattacaggc atgtgccacc atgcccagct aattttgtag
     6601 ttttagtaaa gacggggttt ctctgtgttg gtcaggctgg tctcgaactc ctgaactcag
     6661 gtgatccacc agcctcggcc tcccaaagtg ctgggattac aggcgtgaga cactgcgcct
     6721 ggccatattt ggaccaattt tctttaccca gcccaccgct gatgggcacc taggttgaat
     6781 ccatgttttt actattgtga atactaatgc aatgaacata tgagtgcatg tgtcttttga
     6841 tagaataacg tattttcttt tggatatata cccagtaatg agattgctgg gtcaaatgat
     6901 agctctattt tatgttcttt gagaaattgc caaaccactt tccacagtgg ctgaactaat
     6961 ttacattctc accaacagtg tataagcatt ccattttctc tacagcctgg tcagcacctg
     7021 ttcttctttg actttaatga tagccattct gactggtatg agataatatc tcatggtttt
     7081 gatttgcact tctctgatga ttagtgatgt tgagcatttt ttcatgtctg ttggctgctt
     7141 atatgtcttc tttttagaag tgtctgttta tgtgttttgc ccacttttta atggtattat
     7201 ttggtttttg cttattgaat taagttcctt atagattctg aatactagac ctttgtcaga
     7261 tacatagttt gcaaatattc tctttctttt ctttcttttc cttctctctc cccacccctc
     7321 ccccaccctc cttttttgag acagtcttat tctgtcgccc aggctggaag gcagtggcgt
     7381 gatctcagtt cactgcaacc ttgacctcct gggcctaagc aatcttccca ccccagcctc
     7441 ccgagtagct ggagctacag gcatgtgcca ccacacctgg ctaattttta aatttctgta
     7501 gagacaggtt ctctctatgt tgcccaagtg tctcaaactc ctgagctcaa gggatccttc
     7561 cacctccgcc tcccaaagtt ctgggattac aggcgtgagt cactgcaccc ggcagtttac
     7621 aaatattttc tcccattctg taggttgtct gtttactctt ttgatagttt ctttcgctgt
     7681 gcagaaactg tttagtttaa ttaggttcca cttgtcaatt ttcgtttttg ttgcagttgt
     7741 ttttcaggac ttagtcataa attctttccc aaggccaata tttagaatgg tgtttcctag
     7801 gttttcttct aggattctta tactttgaga tctttacatt taaatcttta atctatcttg
     7861 agttaatttt tgtttatggt gaaaggtagg ggtgcagttt cattcttctg catatggcta
     7921 gccagctatc ctagcactat ttatttattt atttatttat tttattatac tttaagtttt
     7981 agggtacatg tgcaaaacgt gcaggtttgt tacatatgta tacgtgtgcc atgttggtgt
     8041 gctgcaccca ctaactcatc atttacatta gatatatctc ctaatgctat ccctccccac
     8101 tcccccaccc cagcactatt tattgaagag ggagtccttt tcccatactt atttttgctg
     8161 acttttttga agatcatatg gctgtaggta tgcagcttta tttctgggtt ctgtattctg
     8221 ttccattggt ctatgtgtct gttcttatgc caatatcatg ctgttttgat tactgtagcc
     8281 ttagagtttc aagtcaggta atgtgatgcc tccagctttg ttctttttgc ttaggattgc
     8341 tttggctatt tgggctcttt tttggttcca tgtgaattta agaatagctt tttttctaat
     8401 tctgtgaaaa aaatgatgtt ggtagtttga gaggaatagc attcaatctg tatattgctg
     8461 tgggcagtat ggtcatttta gtgttgttga ttcttccaat tcatgagcat ggaatgtttg
     8521 tccatttctt tgtttcatct atagtttttt cagcaatgtt ttgagttctt cttgtagaga
     8581 tctttcacct ctttggttag gtgtattcct aggtttcttg tgcttgtgtg tggctattat
     8641 aaatgggatt gtgtatttaa a
//
