LOCUS       NM_001004490            4224 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily AG member 2
            (OR2AG2), transcript variant 1, mRNA.
ACCESSION   NM_001004490 XM_291980
VERSION     NM_001004490.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4224)
  AUTHORS   Chakraborty,S., Dakle,P., Sinha,A., Vishweswaraiah,S., Nagori,A.,
            Salimath,S., Prakash,Y.S., Lodha,R., Kabra,S.K., Ghosh,B.,
            Faruq,M., Mahesh,P.A. and Agrawal,A.
  TITLE     Genetic variations in olfactory receptor gene OR2AG2 in a large
            multigenerational family with asthma
  JOURNAL   Sci Rep 9 (1), 19029 (2019)
   PUBMED   31836740
  REMARK    GeneRIF: Genetic variations in olfactory receptor gene OR2AG2 in a
            large multigenerational family with asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4224)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 4224)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087280.11 and AC091564.12.
            
            On Aug 5, 2020 this sequence version replaced NM_001004490.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000641124.1/
                                                ENSP00000493362.1
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AC087280.11        2115-2469           c
            356-4224            AC091564.12        163124-166992       c
FEATURES             Location/Qualifiers
     source          1..4224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4224
                     /gene="OR2AG2"
                     /gene_synonym="OR11-76; OR2AG2P"
                     /note="olfactory receptor family 2 subfamily AG member 2"
                     /db_xref="GeneID:338755"
                     /db_xref="HGNC:HGNC:15143"
     exon            1..355
                     /gene="OR2AG2"
                     /gene_synonym="OR11-76; OR2AG2P"
                     /inference="alignment:Splign:2.1.0"
     exon            356..4224
                     /gene="OR2AG2"
                     /gene_synonym="OR11-76; OR2AG2P"
                     /inference="alignment:Splign:2.1.0"
     CDS             893..1843
                     /gene="OR2AG2"
                     /gene_synonym="OR11-76; OR2AG2P"
                     /note="olfactory receptor, family 2, subfamily AG, member
                     2 pseudogene; olfactory receptor OR11-76 pseudogene"
                     /codon_start=1
                     /product="olfactory receptor 2AG2"
                     /protein_id="NP_001004490.1"
                     /db_xref="CCDS:CCDS31413.1"
                     /db_xref="GeneID:338755"
                     /db_xref="HGNC:HGNC:15143"
                     /translation="MELRNSTLGSGFILVGILNDSGSPELLYATFTILYMLALTSNGL
                     LLLAITIEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMF
                     LALTMGSAEDLLLAFMAYDRYVAICHPLKYMTLMSPRVCWIMVATSWILASLIAIGHT
                     MYTMHLPFCVSWEIRHLLCEIPPLLKLACADTSRYELIIYVTGVTFLLLPISAIVASY
                     TLVLFTVLRMPSNEGRKKALVTCSSHLIVVGMFYGAATFMYVLPSSFHSPKQDNIISV
                     FYTIVTPALNPLIYSLRNKEVMRALRRVLGKYILLAHSTL"
     regulatory      4079..4084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR2AG2"
                     /gene_synonym="OR11-76; OR2AG2P"
                     /note="hexamer: AATAAA"
     polyA_site      4097
                     /gene="OR2AG2"
                     /gene_synonym="OR11-76; OR2AG2P"
                     /note="major polyA site"
ORIGIN      
        1 atgaaacaca gcatgagggg aatatatgaa atctgaggac ctggacttaa gaactcagct
       61 agaaccattc caaagcagta aggactttct cgcaaggaca gtgaatgaga gaactttgga
      121 agagattcag ctcctcactt ctgcaggatc ctgccctagg ttctcagctg cctgtctgca
      181 tctatctcta cttccagaga ggacttgcag tgccagtgac tggaggagcc tttgatctct
      241 gatcctagag acagccatac acacacctac attcatcctg gccagaagaa gcaacttttc
      301 tttctttggc ttcttgaacc tctttacctg gaagctatgc cccttcccat atgagcagag
      361 cagcacttga agagtccagg tgatcaagca gcccaagaac ccagagattc tcctactgag
      421 gaaagtaatc aacaacaatg agactggttt aagggagaag acagcaaaga ggttttttat
      481 aaataaaatt ttaaaaactg aattggaatt ccaactacat tttaagcaga aaaatagcta
      541 gatcttaaac caatccccag tatatttgtt cattgtgaag aaagagatgc tttcatctat
      601 ctacaaagat gtttgcttgg gcttattctt caggatacct tatttgaagg gatttctaaa
      661 tgattactat taacaacatg tcaaaatacc tgataccagt ttagctgatg gtttatttca
      721 ataaaagcat tcagaaatca gaggcatact aagaaatgga aaatatatca tattatggga
      781 ttcctattgg ccaatgcaca gtgacctaga acaatccaaa gctagagtga acacctttag
      841 aaaagcttcc actgataata tatttggttc taggcaacta aaaaaacaca tcatggagct
      901 ccggaactcc accttgggaa gcggcttcat cttggtgggg attctgaatg acagtgggtc
      961 tcctgaactg ctctatgcta catttacaat cctatacatg ttggcactga ccagcaatgg
     1021 tctgctgctc ctggccatca ccatagaagc ccggctccac atgcccatgt acctcctgct
     1081 tgggcagctc tctctcatgg acctcctgtt cacatctgtt gtcactccca aggcccttgc
     1141 ggactttctg cgcagagaaa acactatctc ctttggaggc tgtgcacttc agatgttcct
     1201 ggcactgaca atgggtagcg ctgaggacct cctactggcc ttcatggcct atgacaggta
     1261 tgtggccatt tgtcatcctc tgaaatacat gaccctcatg agcccaagag tctgctggat
     1321 catggtggcc acatcctgga tcctggcatc cctgattgct ataggacata ccatgtacac
     1381 tatgcacctc cctttctgtg tgtcctggga aatcaggcat ctgctctgtg agatcccacc
     1441 cttgctgaag ttggcctgtg ctgatacctc caggtatgag cttataatat acgtgacagg
     1501 tgtgactttc ctcttgctcc ccatttctgc cattgtggcc tcctacacac tagtcctatt
     1561 cactgtgctt cgtatgccat caaatgaggg gaggaagaaa gcccttgtca cctgctcttc
     1621 ccacctgatt gtggtcggga tgttctatgg agctgccaca ttcatgtatg tcttgcccag
     1681 ttccttccac agccccaaac aagacaacat catctctgtt ttctacacaa ttgtcactcc
     1741 agccctgaat ccactcatct acagcctgag gaataaggag gtcatgcggg ccttgaggag
     1801 ggtcctggga aaatacatac tgctggcaca ttccacgctc tagggaagga tcatggcttg
     1861 cctctcacca ttcctcctcc agataaaatt ctctactcac tcattcctgc tccaaataaa
     1921 attctctact cactcattct tcaatactgt actctgagat gatagataca ttttttaaat
     1981 tttactttta ttttcaactg tgaatctggt gtgtacaatg atcttgagtt aaactcattt
     2041 ggcacacatc atcctgactt tggaaaccca tgttataaaa ataaccagat gggggaaaag
     2101 ccttgaatgg gtgttgtaga ctcactctgt ggtaggcatc gtcctgacac attaccaagt
     2161 agacatggta ggggattagc tttccatttt aacatcacat agcagtgaga agcagcagta
     2221 gttttggact gaccaaattc caatagcctc tcagcatcag aggaggacta ctccctttga
     2281 agcagattct taaactacta atagagggaa gaattttcag aagatatatt agacttcctg
     2341 tttattaagt agatgattat ttgagcagtt agtggaaatg aataagagtt atgtgactgc
     2401 atttgtactc tagacctaag ggaccttcac attggttact tgagtaatga taaataatta
     2461 cattgaaaga gtgtggccag gcgcagtagc tcacgcctgt aatccaagca ctttgggagg
     2521 ctgaggtggg cagatcacct gaggtaagga gttcaagacc agcctggcca acgtgtggaa
     2581 cccgggtctc tactaaaaat acaaaaatga gcggggcata gttgtgggtg cctgtaatcc
     2641 cagctactcg ggaggctgag gcaggagaat tgcttgaccc tgggaggcgg aggtcgcagt
     2701 gagctgagat cgcgccactg cactccagcc tgagcaacag agagagactc cgtttcaata
     2761 aataaataaa taaatagaaa gaaagaatgg aaaaggataa agaaagatat ttctacttgg
     2821 aaattttgac agtctttttg aaaatgggca tttttacatt gcctaaaatt aaaactaaaa
     2881 taaagaatga ataaaataga attgaaagta ccagttttaa agtgagtaca ataacaatga
     2941 gagaaatttg ttgggaatat tgtctaagtt ttttaaaatg tggacttgca gatatgtgaa
     3001 tgtgttttta aacattaaaa caattgaaag aggttatatt cttgaggtga gtgtatgtac
     3061 atgtgtgttt ccatagaaaa ggaagtataa aatttataat ttgctttcta gctagcctaa
     3121 ataagcctta ttttttttat tctactcatc agtgtgggaa gatttatagc aaaatttggg
     3181 aacttaaatt tgttgaatgc agaattccca aaatatcttg gcttacatag gtgttattat
     3241 tcttgagaat agtgctttgt caaaacacaa taattcttgt tttctttata gaaataatat
     3301 tacattattt aatctataaa gctaaaccat aaaaaataaa agataaagct aatctataaa
     3361 attaatccaa ctttgttata aaaactgaga aaattaaaaa aattagaata aatcaaaaat
     3421 cacttataaa tttttctttt ttgttgcaca tatatgcatt ttactgaatt taaatgtcca
     3481 tgatgatgaa ggtcctgtgt tttttccatt tgaaatttgg tgaatcttct tccttgctat
     3541 gagggaatat tttagagtag tgatgagaaa gcagaccaga gtgcccgcat ttgaatccct
     3601 ctcttccttt ggtcatctat gcatctttga acgctaaatt aaactctttg taccttagtc
     3661 tgctgatgtt aaaagtggtg atatttactg gcctgctctt gtgatattgt tgggtagatt
     3721 aaataagata attaatatca ggtactgaga ccacagctta gtaaactgtg cttaaaacat
     3781 tttggctgct atatggataa atagtaaaaa gcctttttaa aaaatcttat tttattattt
     3841 ccttttagaa atgaaacatt tgtttattat ttttattgac aaaatatgta tgtcttaatg
     3901 tagtaaaaca tgatgttttg aaatatgtat actttatgga attgctaaat caagccaact
     3961 aacatatgct ttactccaca tacttatctt ttttgcatta ggaaaagtta aaatctactt
     4021 tctcagcaat tttcaagcac acaatataat ctgattaact ataattgcca tgatctacaa
     4081 taaatctctt gaacttattc ctcctgtcta actgaagttt tgtgtccttt caccagcatc
     4141 tcccaaatcc ccctacctca acatttggta accaccattt tactctctgt ttctgtaaat
     4201 tcagcttaca ggttctgcat ataa
//
