LOCUS       NM_001004489            6993 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily AG member 1
            (OR2AG1), mRNA.
ACCESSION   NM_001004489 XM_090203
VERSION     NM_001004489.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6993)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6993)
  AUTHORS   Dooley,R., Baumgart,S., Rasche,S., Hatt,H. and Neuhaus,E.M.
  TITLE     Olfactory receptor signaling is regulated by the post-synaptic
            density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold
            multi-PDZ domain protein 1
  JOURNAL   FEBS J 276 (24), 7279-7290 (2009)
   PUBMED   19909339
REFERENCE   3  (bases 1 to 6993)
  AUTHORS   Mashukova,A., Spehr,M., Hatt,H. and Neuhaus,E.M.
  TITLE     Beta-arrestin2-mediated internalization of mammalian odorant
            receptors
  JOURNAL   J Neurosci 26 (39), 9902-9912 (2006)
   PUBMED   17005854
  REMARK    GeneRIF: OR2AG1 binds beta-arrestin2 with high affinity and is
            internalized via a clathrin-dependent mechanism.
REFERENCE   4  (bases 1 to 6993)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6993)
  AUTHORS   Neuhaus,E.M., Mashukova,A., Zhang,W., Barbour,J. and Hatt,H.
  TITLE     A specific heat shock protein enhances the expression of mammalian
            olfactory receptor proteins
  JOURNAL   Chem Senses 31 (5), 445-452 (2006)
   PUBMED   16565291
  REMARK    GeneRIF: The Hsc70t helps expression of OR2AG1 in heterologous cell
            systems and helped the characterization of an 'orphan' human
            olfactory receptor.
REFERENCE   6  (bases 1 to 6993)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   7  (bases 1 to 6993)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   8  (bases 1 to 6993)
  AUTHORS   Lane,R.P., Cutforth,T., Young,J., Athanasiou,M., Friedman,C.,
            Rowen,L., Evans,G., Axel,R., Hood,L. and Trask,B.J.
  TITLE     Genomic analysis of orthologous mouse and human olfactory receptor
            loci
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7390-7395 (2001)
   PUBMED   11416212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087280.11.
            
            On Aug 21, 2020 this sequence version replaced NM_001004489.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jul 2015].
            
            CCDS Note: This olfactory receptor gene is a segregating pseudogene
            (PMID:22908908), where some individuals have an allele that encodes
            a functional olfactory receptor, while other individuals have an
            allele that is predicted to be non-functional. This CCDS is being
            retained because the Classifier for Olfactory Receptor Pseudogenes
            (CORP) predicts the reference genome allele to be functional.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2467148
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641258.1/ ENSP00000493074.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               AC087280.11        13513-13964
            453-6993            AC087280.11        15511-22051
FEATURES             Location/Qualifiers
     source          1..6993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6993
                     /gene="OR2AG1"
                     /gene_synonym="OR11-79; OR2AG3"
                     /note="olfactory receptor family 2 subfamily AG member 1"
                     /db_xref="GeneID:144125"
                     /db_xref="HGNC:HGNC:15142"
     exon            1..452
                     /gene="OR2AG1"
                     /gene_synonym="OR11-79; OR2AG3"
                     /inference="alignment:Splign:2.1.0"
     exon            453..6993
                     /gene="OR2AG1"
                     /gene_synonym="OR11-79; OR2AG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..1423
                     /gene="OR2AG1"
                     /gene_synonym="OR11-79; OR2AG3"
                     /note="olfactory receptor, family 2, subfamily AG, member
                     3; olfactory receptor OR11-79; hT3 olfactory receptor;
                     olfactory receptor 2AG3"
                     /codon_start=1
                     /product="olfactory receptor 2AG1"
                     /protein_id="NP_001004489.1"
                     /db_xref="CCDS:CCDS31414.1"
                     /db_xref="GeneID:144125"
                     /db_xref="HGNC:HGNC:15142"
                     /translation="MELWNFTLGSGFILVGILNDSGSPELLCATITILYLLALISNGL
                     LLLAITMEARLHMPMYLLLGQLSLMDLLFTSVVTPKALADFLRRENTISFGGCALQMF
                     LALTMGGAEDLLLAFMAYDRYVAICHPLTYMTLMSSRACWLMVATSWILASLSALIYT
                     VYTMHYPFCRAQEIRHLLCEIPHLLKVACADTSRYELMVYVMGVTFLIPSLAAILASY
                     TQILLTVLHMPSNEGRKKALVTCSSHLTVVGMFYGAATFMYVLPSSFHSTRQDNIISV
                     FYTIVTPALNPLIYSLRNKEVMRALRRVLGKYMLPAHSTL"
ORIGIN      
        1 tatctttgct ccctgacccc agcaagaatg aaggaaagtc tgagtatctg aacccaagaa
       61 ctcagtctgg taactgctct agggctagag gggctctctc cctggcaacc tgtatgaaag
      121 tagttgctac tagttcttca caggcgtgag aacaagaaag taatcttctt cctatatagg
      181 aaactaccca aattctgtat tagctgtctg cctgcatcca ctgctatctc tagggtagac
      241 ctgcagataa gtggaaggaa tagaagggcc ctgacatctg atctcactag tacttttcag
      301 acacttaacc caacttggca atattaaacc aactgaacac tgctgaagaa agccacgtcc
      361 tttcttccca tttcgactgg aacatccttg aacttcaaac aatccctagg aaagtctgag
      421 tggtcggaca gctaagcttc tcacaacctg aggtgatgaa agaaaccaca gcatggagct
      481 ctggaacttc accttgggaa gtggcttcat tttggtgggg attctgaatg acagtgggtc
      541 tcctgaactg ctctgtgcta caattacaat cctatacttg ttggccctga tcagcaatgg
      601 cctactgctc ctggctatca ccatggaagc ccggctccac atgcccatgt acctcctgct
      661 tgggcagctc tctctcatgg acctcctgtt cacatctgtt gtcactccca aggcccttgc
      721 ggactttctg cgcagagaaa acaccatctc ctttggaggc tgtgcccttc agatgttcct
      781 ggcactgaca atgggtggtg ctgaggacct cctactggcc ttcatggcct atgacaggta
      841 tgtggccatt tgtcatcctc tgacatacat gaccctcatg agctcaagag cctgctggct
      901 catggtggcc acgtcctgga tcctggcatc cctaagtgcc ctaatatata ccgtgtatac
      961 catgcactat cccttctgca gggcccagga gatcaggcat cttctctgtg agatcccaca
     1021 cttgctgaag gtggcctgtg ctgatacctc cagatatgag ctcatggtat atgtgatggg
     1081 tgtgaccttc ctgattccct ctcttgctgc tatactggcc tcctatacac aaattctact
     1141 cactgtgctc catatgccat caaatgaggg gaggaagaaa gcccttgtca cctgctcttc
     1201 ccacctgact gtggttggga tgttctatgg agctgccaca ttcatgtatg tcttgcccag
     1261 ttccttccac agcaccagac aagacaacat catctctgtt ttctacacaa ttgtcactcc
     1321 agccctgaat ccactcatct acagcctgag gaataaggag gtcatgcggg ccttgaggag
     1381 ggtcctggga aaatacatgc tgccagcaca ctccacgctc tagggaagga tcatggctag
     1441 cttccagaat tccttctcct gagagtcaaa agattcatgt tatgaatcaa atactaatgg
     1501 taaaaccaat acagtgcaga gtatagcatt taatagaaaa gtgaaggaat gtaactggat
     1561 ttgtcaaatg ctctttaaat cttctctcca tgaagtaatt tatagggcat gatttacact
     1621 atctaaaatt actcttcact ctatttaaaa tttaatcttt attttcccag gaaggtattt
     1681 agttaaatgg gttcccacct tgggacatga cccctaacct tcgaagttta tattggatca
     1741 gggaaaggaa aagaaccaga gaaaggaaag tttcaagtgg gtggtgtaag taaaacccag
     1801 acatcaaagg gggagatgtc ttgagatttg cacaaattta gaccaactga ccttattaaa
     1861 aggttatata gacttcttgt ctaatgcccc aactggtagt agtttgcttg tatttgcatt
     1921 gtacttgctc ttttttttct ttctaaacat cagccatatg aaacactcta acaagtgtct
     1981 ttgcttgttt gtttttgttt gttggttttt gacatggaga tactttatag ttcctaaaat
     2041 gcaattatta ataaaatgaa gaaaatagga ggtgaaggta gtccataagc aaggttcatg
     2101 ataaacaact ttgcttattt cttgctaata caaaaacaaa caagcaaaat agtgattttc
     2161 cattatccaa ggctatcttg taacattcca accattgcag tgttcacatg catggtgggt
     2221 gtggatattt aagtcagtgt gtctgtgtgt ttgtgctaaa gatggagagg acaacataat
     2281 gcattttctc accagcttaa ttatgctgca ctactattag tttgtctata agtctgagaa
     2341 tattgaaaac aaaagatgtg aacaaaagct gtgagttgca ttttgaagat taaaaataat
     2401 ataaaatgat atggctaatt acatgacact cttttggggg atattgctgt ttgaagattc
     2461 gctaacgctt tttaaatcaa ttcctatagt aatttaaaac agtaactgag actaggttca
     2521 gaaagtatag tagtagtata tcatgtttgg aaggcaaggc tgagtagaga taattcctac
     2581 acgtatttat atgaatttcc ttccatttta atacaggcat gcattttact gagttgatgt
     2641 gtgtgtgtaa aacagatttt tttaacctac aagcatatag ttatttttcc tatattatat
     2701 agtggcagta tacagcactg caaagagtct agggtcagct atcagcgtac agaagttaga
     2761 attgaataca ccccacttat ttctataact tttagcatat tacttaacct gtttgtgccc
     2821 aagtctgcaa gtttgcaaag tgtaagttga cattaacaat aagacctact ttgtagtgtt
     2881 gtgaggatga aacaagttag taaatataaa tataaagaca tctttatact tgtaatcagc
     2941 atgtgtcgta taataagtat ttaataaatt taacacctac agaataaatg gccctgaaaa
     3001 tactgttgag tgatggtata atgttacatc atatgggtgt tttgtaacat tattagctat
     3061 tttatcattg ttttaccttt aacattgtcg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta
     3121 tgtctctgtg tgtgtgtgta tgtgtgtgtg aaatcaataa tgtcaatctc ttggatgtgt
     3181 gacttttttt ctatagaaaa ttcctatgag tgaaattact cgaaccaagg ttaaaaatct
     3241 gtttaatact cttcatatga aaagacaaat tgttttctta aaatgttaaa tattttgcat
     3301 tcttaccagc aacatataag tgtacttagc ccactacata ttttttcatg ttaaatttta
     3361 catataagta gtcttcacta attgataagg tataaaattt gcctatttta atttgcttaa
     3421 gtaacttgtc cacagttttc ttattgattt gttgaagttt ttttacaggt taggaacacg
     3481 gagactttgt tatatttgtg gtaataactt cttttcaatt tgttatttgg cttctaatat
     3541 ctgcatggca gagattttta gaaagagaaa tatttaaaat atttgtatag tgaaggatat
     3601 cttttatttt tttttccagt gatttttact gttaggatat aattttctat tctcattgac
     3661 gtctttgctg tgcatcatac agttcaattt aggtaacaat ttatatattt tatgtgtttt
     3721 gtcactctat atgtttaact ttaacaataa atgtcaaact tatctttaca tgtgaaaatg
     3781 atgatatttc aacttttgtc aaaggtacca tttttctagc aatattttaa agtaatcctt
     3841 tcattttcta ttattttact accttcatca gacatgttct agtaagctat attttggcta
     3901 actcttcagt tctagcttct ttctcctctt tactcttttg gaagacattt gattctatca
     3961 ttcacatctt aatagctcac ttgtaatttg attgtgaata tatttaactg ataaattaat
     4021 ttgtaatttg agcatttttt acaatactca gccttgcctt cctgaacatg gtgcatgact
     4081 atacttctgg aacctagtct cagtcagttt taaaatgaac attccacacc atcattctaa
     4141 gctgatgcct tgcctcacac ttcactagaa cagaagcagt tggctacaaa gccctcttca
     4201 aatcctccac atatctgtgc ctgcgtgtac acttcctgtt ttccctcatt ataactgctt
     4261 gaacccggga ggcagagact gcagtgagcc gagattgcac cactgcactc cagcctgggc
     4321 aacagagtga gattctgtca caaaataaat aaataaataa ataaataaat aaataaataa
     4381 ataaataaag taagaagtct ttgcatgact ccaatccccc tcagtaactg tagcattatt
     4441 ttcagcttct cttcacagga aaaaaaaaaa atacaaaggg aacacttatg cccattttct
     4501 cctctgctga tcttctattc gcatcttaac acactttcaa tcaagctctg gtctctttct
     4561 atggacctgt tctttgtgaa aattatcatt aatgtgctaa ataaaatgtc tacctccata
     4621 ttctccttca tcaacctttc agcaacattg atataattga cctcaccctt ctgttgggaa
     4681 atttttcttc ttttggcttc cagacaccac acaactctgg cttgcttctt taatccctaa
     4741 ccttttttgc cttattggat tcgtttttct ttctgaatgt ttccacattc agatgataca
     4801 aacatggact tccctgtctt ctcaatcaag aatctcttcc tgagtaattt catccactta
     4861 catagattta agttctgtcc atatgctttt gagtcccaaa gacctcacta cttgtataat
     4921 ccacagactc aaaaaattag ccgggtgtga tggtggatgc ctgtaattcc agctacacag
     4981 gaggctgagg caggagaatc gcttgaacct gggaggagga ggttgcagtg aggcaagatc
     5041 gcgccattgc actccagctt gggcaacaag agcgaaaccc catctcagaa aacaaacaaa
     5101 caaacaaaca aaaaaacaaa aaacaacgag atatcacgtc ttgcctgtta gtattatttt
     5161 tgaaaaccaa aaaagtcaaa gcaaaacaag tgttggtagg tatggggaga aaatggaacc
     5221 tgtgtacaca attcatggga atgtaaaatg gtacagccat tatggaaaac agtatggagg
     5281 tctaaagatt caaactatta ctactgtatg atccaagatt cccacttctg actatatatc
     5341 caaaggtaat taaatcgctg tttccaagac atatttgcac tccatgttta ttgcagcatg
     5401 attcacaata gacaaaatat tggaaacaac ctaagagtct atcaacagac caatggataa
     5461 agaaaatgtg gtctatttat acaatagaat attatttacc cttaaaaggg aaggacactc
     5521 tgtcatttgc aatgaaatag accaacctgg aggacattat gctatgtgga ataagcccaa
     5581 cacagaaata caaatgctgt ctaattttgc ttaatgcgga agctagaaaa gagtctaact
     5641 cagtaataga gagtacagtg gtgtttgcca agggtttggg gtgactgtgg gaggaaatga
     5701 aaaatattag tcaacagata caaactttta tttttaagat gaataatttc tgaggttcca
     5761 acatatagca tggtgactga agttaataaa aatgtgtact tgaaatttgc tgcagaagta
     5821 gatgtcacgt gttctcacaa cacacacgca cagagggtaa gtatgtaagg tgattgatat
     5881 gttgctctgt taattagctt gcatgtggtc atcatttcac agggtatacg tatatcaaat
     5941 catcacactg tataccttaa atacattcta gtcatatttg tcaaccatat ctcaataaag
     6001 ttggaaaaaa aagaaaacta tgggcaaatt atacataata ataaacataa aaaatcattt
     6061 gaaaacattt ctaaagctgc tttgtcttca ttataggaat gtaaaatatt acctctgctg
     6121 gaatatgaac tacacccagg atttgaatag tacaaattag atgagacgac ttgcagtgta
     6181 gagccctcta ggctttcagc ctagaacagg aaggaacgca gagtaatgac agcaaacagt
     6241 gaagctatag gataataatt cctcctcagt gacaagaggc cccaccactg ctttggactc
     6301 caggaagcac tcagacatta acatctgtga agtgtgccct gcatgctaag aaaagggtga
     6361 actgacagac ccttctgtcc atcaagtcat ccacagccta gttatttctg tctctgctgc
     6421 taattgtgcc aaaagtaacc ataaaatctg gagtcaactg ctagaagttt tgcaagaaca
     6481 aaggccaagg agatgcactt gtgtcttggt gagtagccaa agttagctgc agggagctga
     6541 agcaagggac tgaaaaaatg agaagtctta gaaaatgttc tccagtcctt gaggatctga
     6601 aggcctatgt gtgactgata tttggtggag aagaacggac ctagctcttt ccccactcca
     6661 accaaccaaa atctttgttg aaaggcatat tgtgtattgt cactaattct gggaaggcgg
     6721 gggccattgg ttttcatgaa gtgtgactat gaaacatgaa aatcacacaa ggcaatcttg
     6781 atctgaggaa tgcttctaag agaaaatgaa tacacctgcc ctataggccc gcttctctac
     6841 caagcacacg gagatgtcca cttattcttg ctggcaccaa atggtgatat tcaaaagagc
     6901 tggcataatt ttttagagtt gctaagtata taaagcacta actttatcaa ttttgttaat
     6961 tatacttcac ttcatctctg tcttatcaat tag
//
