LOCUS       NM_012365               8681 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily A member 5
            (OR2A5), mRNA.
ACCESSION   NM_012365 XM_069619 XM_374683
VERSION     NM_012365.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8681)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 8681)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   3  (bases 1 to 8681)
  AUTHORS   Rouquier,S., Taviaux,S., Trask,B.J., Brand-Arpon,V., van den
            Engh,G., Demaille,J. and Giorgi,D.
  TITLE     Distribution of olfactory receptor genes in the human genome
  JOURNAL   Nat Genet 18 (3), 243-250 (1998)
   PUBMED   9500546
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091768.4.
            
            On Jul 22, 2020 this sequence version replaced NM_012365.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641693.1/ ENSP00000493295.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AC091768.4         3522-3707
            187-8681            AC091768.4         4925-13419
FEATURES             Location/Qualifiers
     source          1..8681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..8681
                     /gene="OR2A5"
                     /gene_synonym="OR2A11P; OR2A26; OR2A8; OR7-138; OR7-141"
                     /note="olfactory receptor family 2 subfamily A member 5"
                     /db_xref="GeneID:393046"
                     /db_xref="HGNC:HGNC:8232"
     exon            1..186
                     /gene="OR2A5"
                     /gene_synonym="OR2A11P; OR2A26; OR2A8; OR7-138; OR7-141"
                     /inference="alignment:Splign:2.1.0"
     exon            187..8681
                     /gene="OR2A5"
                     /gene_synonym="OR2A11P; OR2A26; OR2A8; OR7-138; OR7-141"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1173
                     /gene="OR2A5"
                     /gene_synonym="OR2A11P; OR2A26; OR2A8; OR7-138; OR7-141"
                     /note="olfactory receptor, family 2, subfamily A, member
                     8; olfactory receptor, family 2, subfamily A, member 26;
                     olfactory receptor, family 2, subfamily A, member 11
                     pseudogene; olfactory receptor 2A8; olfactory receptor
                     2A26; olfactory receptor 7-138/7-141"
                     /codon_start=1
                     /product="olfactory receptor 2A5"
                     /protein_id="NP_036497.1"
                     /db_xref="CCDS:CCDS43668.1"
                     /db_xref="GeneID:393046"
                     /db_xref="HGNC:HGNC:8232"
                     /translation="MTKNQTWVTEFILLGFPLSLRIQMLLSGLFSLLYVFTLLGNGAI
                     LGLIWLDSRLHTPMYFFLSHLAIIDISYASNNVPKMLTNLGLNKRKTISFVPCTMQTF
                     LYMAFAHTECLILVMMSYDRYMAICHPLQYSVIMRWGVCTVLAVTSWACGSLLALVHV
                     VLILRLPFCGPHEINHFFCEILSVLKLACADTWLNQVVIFAASVFILVGPLCLVLVSY
                     SRILAAILRIQSGEGRRKAFSTCSSHLCMVGLFFGSAIVMYMAPKSRHPEEQQKVLSL
                     FYSLFNPMLNPLIYSLRNAEVKGALKRVLWKQRSK"
ORIGIN      
        1 ggctgcagtc tgcatcagcc tatgctaaga aaagagagac aactcctgca tctggaaatt
       61 ccttctctca ggggctgctg gtgggagcaa gatcctcagc tctggccttc aaaagctcct
      121 gtgatctctg cacaatttct ctaaatagaa ttatatttct gagacaagac caggcctgat
      181 accacacaca tagctcattg ccacagcaga gtccaacgca ggtactgtca caagggcatg
      241 acaaaaaatc agacatgggt cacagaattc attctcctgg gatttccact cagcctaagg
      301 attcagatgc tcctctctgg gcttttctcc ctgttatacg tcttcaccct gctgggaaat
      361 ggggccatcc tggggctcat ctggctggac tccagactgc acacccccat gtacttcttt
      421 ctctcacacc tggccatcat tgatatttcg tatgcttcca acaatgtccc caagatgctg
      481 acaaaccttg gcttgaacaa gagaaaaaca atctcctttg tcccatgcac aatgcagacc
      541 tttttataca tggcttttgc tcacactgag tgtctcatct tggtaatgat gtcctacgat
      601 cggtacatgg ctatctgcca ccctctgcaa tattctgtca tcatgagatg gggagtgtgc
      661 acagtcctgg ctgtcacttc ttgggcatgt ggttcccttc tggccctggt ccatgtggtt
      721 ctcatcctga ggctgccctt ctgtgggccc catgaaatca accacttctt ctgtgaaatc
      781 ctgtctgtcc tcaagttggc ctgtgctgac acctggctca accaggtggt catctttgct
      841 gcttcagtgt tcatcctggt ggggccgctc tgcctggtgc tggtctccta ctcgcgcatc
      901 ctggcggcca tcttgaggat ccagtctggg gagggccgca gaaaggcctt ctccacctgc
      961 tcctcccacc tttgcatggt gggactcttc tttggcagcg ccattgtcat gtacatggcc
     1021 cccaagtccc gccaccctga ggagcagcag aaggtccttt ccctgtttta cagccttttc
     1081 aacccgatgc tgaacccctt gatctatagc ctgaggaacg cagaggtcaa gggtgccctg
     1141 aaaagagtgt tgtggaaaca gagatcaaag tgagggatgc cagggaaagt ctagagggtt
     1201 gaagatttgc tcccaatgag atttgtagga acagtggtgt aaatgcctta cagtctcatc
     1261 tcttagattt ctgatatcaa gaatgtatat tgattggatt ctatccctaa acgtggagta
     1321 ccatgcagat cacaaagcac atgcagacag gcgctgagcc gtgtggtgca gcagaggtgc
     1381 aaagtgccat gaactcctac tcccaggtcc cacccctacc caggatctgc tttctgttct
     1441 tttgaggctt agttctctca agcttcctct taaattcctc tattatttcc atctcttttt
     1501 gccataagta tatgctggta atcccatacc atatgctact ataagagagt acttgtaatc
     1561 acacagaata aatactgacc ttggttaagc agccctctac tgggaatgta acaacaacta
     1621 agagtataga aaatgcctgg tttggaacct aaagcctaag gatgatgata ttagtactgg
     1681 aagttcatct aaatcaccct aacaaatcta attctgtaaa aagcaaagtt taattgtata
     1741 gattttttta tataaaaggc agagaaatat caggatcttt gtttcatttc acttaattct
     1801 gcaccattta attagaaaga gtttggaaag attttgcatt taaaataaat atgagagaat
     1861 gttattaggg atagttacct ttttcataat tcagatcgca aagccgggtg taggtgacaa
     1921 tttatcatta cggtgattac ataaaatatt gtagtagtaa gaaaatactg caaaggaaga
     1981 aagcatcaag ggaaactgac agcttgatgt aacatcatag accaccgctt agaaccaaga
     2041 acatgtcaag tcttgataaa gactttcagg aacctcaaca aaattccaaa gagaagctat
     2101 tccaggtgac ataaatcact tttcctggac ccaagtggtc agaatgacat ggacaggtaa
     2161 tttgttttat tttaacacaa gtctgagtcc taaatgatca gcataatatg ataatatgat
     2221 ttctttaaca cattgagtat ggtacctttt ggaattctct cttttttctc tcaacccttg
     2281 tagtattgtg tgaattcaac tgtatgaccc atgatgttat tacattatct gctgcctgta
     2341 ccttttctat ttttacaatt ttaaaatata ttcttatcac ttcatatatt tcttcttcca
     2401 tgaaagaaag aagcaaaggg ggaactcttt cctcccaccc cctctccaaa tgcactgttt
     2461 tcttttcagt tctcaaaaag cctagttgct gactattctg ctcatccatt catctcggtt
     2521 aaacattctg cctctggtga tggtctttgt tttcatatct ccatactgtg aggacatttt
     2581 ttggcctgca gaaattcaca aaccttgctc tgcccctccc aaagagagca atttgaattt
     2641 aaaaaaaaat actggatcta aatttaacta tcaaccacta tggaattatt gtgtgcacta
     2701 ctctgaagct agaaagagaa aacaggcagt attttcatat agaaaggact ttctaactat
     2761 atctgaaaaa aattattaca ttccctaaaa tatgtatact tcatgttctg cttaaaacct
     2821 ttaaaagaaa agggaaagag gaaacatata gaatagttca tctcatataa aacataagca
     2881 atagatttgg attcagaatt tttttaccta gggtacagtg gaaaaatcag ggggtataat
     2941 tcatcctatg tcagttctaa gtgattggga aagaatagac caaaaagact acatttctac
     3001 agaaagtgac aaatatagat aaattataaa gaaatgttct ctagcaggtc ttaatagtgg
     3061 ctctaatttt atatatatat atatattgaa tacattacag aaaatacctg agtatatgaa
     3121 aaatttctat taattgtttc catatttgag ttgtaggatt ttaacaaact aattaaatgt
     3181 tggtgttatg accgctttat atatacatat tttcaacatt aatcagtttt taaaggtctg
     3241 ggggaaagtg aaagaaacaa ttgcattgtt ttaggctgca agttctactg actgcttcac
     3301 aaatgttacc ccgtttatct tgcataaaca tcacaatgga gtcgctatta ttttctccac
     3361 ttaatagata agtaaacaaa gttcagaatg atttaataac ttatcctata ctatgcaacc
     3421 agtaatagaa ctgagtgtta tggatcgtac tgattgcaaa cccaagctgc ttcttagcag
     3481 ctttctgccc aaaacattac aaattttagc tcaacagggg ttagactcaa catccacatg
     3541 atggggcaga gtctggaaca aaacggagtt tacagtatta tagccaaagt cttaacacca
     3601 gaaagaatac atcctgtagc caacccatct ttggaggatt cattaccacc tttgggaaga
     3661 gtagaaacac tcacattagc agcatcatca ttttccaata gtaactccct cctaatgcct
     3721 gtctgcaaaa tcacatggcc tcataaggca ttgccccaaa gggacaatct gaacgagaga
     3781 caccctgctg ttctcagtga tcatcttacc tatgattctg gtcttctttc tatcattagg
     3841 tgtacccacc tgtgttcttt acctttatga tgtgattaat gcttttccag gaagtgtccc
     3901 catctctcct gtgtacagat ccgtgatgga cctaccttac cagtgctcta ggctgctagg
     3961 actgagaaag ggggaaccca gcacaggtgc aagctgagat gcttgctatg ttagattcac
     4021 atctcaattg tgctacaact tgctaaatag gtctgcttct aggaataata tagcctcctc
     4081 aatcctgagt tttattttag gtcagatgtg gctaacaagg tttcagctag gtgccttata
     4141 taacttttat gaatgctaaa tgaaagactt tatgtgactc tgatttgaag tgatgtattt
     4201 ttgtgagaag gatataagga caatgaaaat gaaaaatgat tacatagtaa gactaagagc
     4261 tggtaaaatt catgactaaa caactataaa actacaaaat ccaattttat tttaatgatt
     4321 cataaattat tatgatactt actgaacaat ggaagtttct caaaaaatct cagctctttg
     4381 tgtttgcaac tttctgtgcc tgtctttgtt tttatttggt tggtgatatt ggggaaggtc
     4441 tccaccaaag gaggttgaag gttagtacac aggaggttgg gtatgaaatg gtgttcattg
     4501 ttcctgctag tagacaaaac tgtaagaaga atcctacata aaattttaca ttctctatat
     4561 agcttcaatt cgaaaaggat tcttgagata gcatccagat aggaaatata tacaaaaata
     4621 attagtccat agctttgtta cgttcattct cctacccaca cactaagaat tctcatcaac
     4681 tgtgtatcta gaatagctcc tctaggaaat ctcagtctct gtatgtagag atagaaactc
     4741 accctggtga caccttgtta gttggctgaa attttggcac tcatagtagc caactcctta
     4801 tattggtctc cctggcctta ctattgccct ggatactaat catattagga aagaaatata
     4861 tagatgagca aataaatgag tgcatagcca taaataattt ttgaaatgac tgtgtttcca
     4921 tagcccggaa aaaaggagga ataaagcaaa caggataatt gtcttcatat gtcccatcga
     4981 gaatcttgca ggaggcaaac atagttgttt attgccttcc acaaagtggg gaaaaatacc
     5041 ctagaatcaa aaagtaggtt tacataaaag tggaattaac atcaatatga gaaaatattt
     5101 ttgaacatta taagttatgc aacaatgagg tcttgtgaat tattgtgcag ccttactata
     5161 aatagaaaca taaaggttga gtaaaatata aatacgttga acaggcattt gcaatagagt
     5221 ctttccaatg tctcttcaat cttgaaaatt taagatttca taataaactt tttcatcttt
     5281 ttaatgaggg gcggagttta acctgatttt aaacaaactt acagtcattt aaagattttt
     5341 aaatggtaat tctaagataa tcttttttct gtcaaaatcc cgtcttgttc ttccgaggat
     5401 tcagcagagt catcaaaaga aaatattcaa gtaggaaaaa attgttgtat aagcttcata
     5461 cttgtggttc tcatactttt attcccacaa tgccatcaca actttatttc tagatataca
     5521 tggtttcaca ttttaaaata ttagcctgat attcagtgat agtggctcaa tgacttttgc
     5581 cttaaacaca ggcacagggg cttgcacatg taatcccaaa aactgaagag attgaggtgg
     5641 gaggatcgct tgagccccgt agtttgaggc tgcagtgagc tatgaccatg ctactgcatt
     5701 ccagcctggg caacagagtg ggaccccatc tttgaaaaaa caaacaaaca aacaaacaaa
     5761 aaaccccaca gagcagtgac agattaaacc acaaggagag gaaatgaaaa agacaaaatt
     5821 agcccccaag gcaagataaa catctctgtg gatcagaaac aaaacataaa atcagatgtg
     5881 tgagtgatgc agaagccacg ggttagccga ctgtttgtaa gctggcctga gtggagatag
     5941 ctttgctctt aggaactaaa tatattaaag ttcttcatgc aataatgggg aactgaggct
     6001 tagcaccttc cttgaaaata aggtatggag gagggtggga gggactgact tcctttgctt
     6061 actaatgaag accaaaaaat gtactgtgct gtactgcttc cctatgtagc tagctgaaga
     6121 cttgtgagaa cccaggccct gcgctgcaac caaatgtgga atccagacac ccactctggg
     6181 tgctgggatt cccaatatac tcagtctcac tataggtaca taattctaaa ccatttacgt
     6241 aagatccagg tctggatagg aagcccaaag agctgggcca agacaacccc tgagcttcta
     6301 gatgagagaa gagggaggga gagagacaga cagagagaaa tggagagaga actgggtttt
     6361 taaatctatt ttcagaagct gccaagagaa gcagcccaaa atatcaacaa ctggaaaata
     6421 aattcacttc tgatgatgtc ccttgtgcat gttcaggaat gaacaattga taaatattta
     6481 tgtttatgtt taaatgcata aaagatttct taaagatatg ctaactattt tagatggcca
     6541 gggattaaga cggaaaataa ttagaaaata acagatggat cccaaaagat aacaattaca
     6601 gagcttagaa ataaaacacg cattccctga aataaggact aactcttgtt tttttttttt
     6661 ttttttttga gacggagtct cgctctgtcg cccaggctgg agtgcagtgg cacaatctcg
     6721 gttcactgca agctctgcct cctggtttca tgccattctc ctgcctcagc ctcccgagta
     6781 gctgggacta caggcgtctg ccaccatgcc cggctaattt tttgcatttt tagtagagac
     6841 ggggtttcac tgtgttagcc aggatggtct cgatctgctg acctcgtgat ccacccacct
     6901 cggcctccca aagtgctggg attacaggcg tgagccaccg cgcccggcca actcttctta
     6961 aatatgaaaa aaattcaact aacaggataa attctagatg gagtacatta tgggaaaaaa
     7021 tgtgaaatag aacatggaat gcataatttt cccaaaatgc aacagagact attttttaag
     7081 aaaatggaat aaaaagcaca tagaatctag actcagatat aatatctatt tattttataa
     7141 ggacgtaaaa ataatgatga aaataggata ggacattatt gctgaaattt ttttcctgat
     7201 ggctaaacac atgaattctc agaacaaaag atactctgag tatcaagcta catgaataaa
     7261 aataaattaa tatctagaca tatcataatg aaagcacaga acattaagga ggaaaagaaa
     7321 ataataaaac cttcagagaa taaaagaata gctacaaaag aataacaaat aatagtggac
     7381 ttcccctcag caaaacagat gccaaaagag aatattcaaa aggattagga aaactgttac
     7441 tctacaattt cacacacagt taaactgtaa ttcaagaaaa agagaaaaat gaaaatgttt
     7501 tcaaacaaag tctaaggaaa attacctccc ttaggtcttc aacagaatta ttaataaata
     7561 tattggatag aaaaaaagat gaaaacagaa taaaagtata tagggtacat gcgaagcata
     7621 cgagttgata aagaataata gtaaatataa ttgttgaatg taaacaaaat agctttttat
     7681 atgaaataat aaaagctctt agcagctgta acaggttgat gtaaataata ccaatgaata
     7741 attaaatcac ggtaaagctc ttgacttgac tagaaaggtg aaaatgctga ataattgtag
     7801 attgcattag aaaaatttat aatttagtgt gtgttaaaaa ttcaaaagta gatcacattt
     7861 gccatctttg agccccccac ctctgctgca gttgtagcag gcaatacgtc tgtcatccac
     7921 tcctcagtgg cttcaccagc ctttcagcca gatacaaggc tgttgtccta gtgattacag
     7981 ccacatgagt cactggtcag ctcagcggct atcccgacct gctgcctgac tcccataatc
     8041 ttcacccatt tatgagtgag aacatgcaat atttgtcttt ctgtgcctgg cttgtttcac
     8101 ttaagataat gatctctagt ttcatccatc ttgttgtaaa atacataatt tcatagtttt
     8161 ttaatggctg aatagtattc cattacatat gtataatact tttttttata ctttcattta
     8221 ttgatggaca catgttgtat tagtctgttc tcatgctgct aataaagaca tacctgagac
     8281 tgggcaattt atttttaaaa cagggtttag ttgactcaca gttcagcatg gctgaggagg
     8341 cctcaggaaa cttacaatca tggcggaagt ggaagcaaac acatccttct tcacacggtg
     8401 gccagaagaa ctgccaagca aagcagggaa agccttttaa aaaaccatca gatcagcctg
     8461 gcatggtgac tcacacctgt aatcccagca ctttgggagg ccgaggtggg tggatcgcga
     8521 gatcaggagt tcaagacaag cctggccaat atggtgaaac cccatctctt ctaaaataca
     8581 aaaattaccg ggcatggtgg cacgtgcttg tagtcccagc tacctgggag gctgaggcag
     8641 aagaatcgct tgaacccagg aggcggaggt tgcagtgagc c
//
