LOCUS       NM_030908               1758 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily A member 4
            (OR2A4), mRNA.
ACCESSION   NM_030908
VERSION     NM_030908.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Tsai,T., Veitinger,S., Peek,I., Busse,D., Eckardt,J.,
            Vladimirova,D., Jovancevic,N., Wojcik,S., Gisselmann,G.,
            Altmuller,J., Stander,S., Luger,T., Paus,R., Cheret,J. and Hatt,H.
  TITLE     Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect
            epidermal proliferation and differentiation
  JOURNAL   Exp Dermatol 26 (1), 58-65 (2017)
   PUBMED   27315375
  REMARK    GeneRIF: Proliferation tests, ELISA and kinase array indicated that
            OR2A4/7 and CHS play important roles in the proliferation of HaCaT
            cells and keratinocytes.
REFERENCE   2  (bases 1 to 1758)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   3  (bases 1 to 1758)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   4  (bases 1 to 1758)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC120953.2, BI020419.1, CB852924.1, AW863744.1, DA927334.1 and
            BF848491.1.
            
            On Feb 22, 2014 this sequence version replaced NM_030908.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315453.4/ ENSP00000319546.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-933               BC120953.2         1-933
            934-1073            BI020419.1         302-441
            1074-1121           CB852924.1         386-433             c
            1122-1195           AW863744.1         306-379             c
            1196-1710           DA927334.1         31-545              c
            1711-1758           BF848491.1         253-300
FEATURES             Location/Qualifiers
     source          1..1758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..1758
                     /gene="OR2A4"
                     /gene_synonym="OR2A10; OR2A7"
                     /note="olfactory receptor family 2 subfamily A member 4"
                     /db_xref="GeneID:79541"
                     /db_xref="HGNC:HGNC:14729"
     exon            1..1758
                     /gene="OR2A4"
                     /gene_synonym="OR2A10; OR2A7"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..933
                     /gene="OR2A4"
                     /gene_synonym="OR2A10; OR2A7"
                     /note="olfactory receptor, family 2, subfamily A, member
                     10; olfactory receptor OR6-37; olfactory receptor 2A10"
                     /codon_start=1
                     /product="olfactory receptor 2A4"
                     /protein_id="NP_112170.1"
                     /db_xref="CCDS:CCDS5149.1"
                     /db_xref="GeneID:79541"
                     /db_xref="HGNC:HGNC:14729"
                     /translation="MGDNITSIREFLLLGFPVGPRIQMLLFGLFSLFYVFTLLGNGTI
                     LGLISLDSRLHAPMYFFLSHLAVVDIAYACNTVPRMLVNLLHPAKPISFAGRMMQTFL
                     FSTFAVTECLLLVVMSYDLYVAICHPLRYLAIMTWRVCITLAVTSWTTGVLLSLIHLV
                     LLLPLPFCRPQKIYHFFCEILAVLKLACADTHINENMVLAGAISGLVGPLSTIVVSYM
                     CILCAILQIQSREVQRKAFRTCFSHLCVIGLVYGTAIIMYVGPRYGNPKEQKKYLLLF
                     HSLFNPMLNPLICSLRNSEVKNTLKRVLGVERAL"
ORIGIN      
        1 atgggagaca atataacatc catcagagag ttcctcctac tgggatttcc cgttggccca
       61 aggattcaga tgctcctctt tgggctcttc tccctgttct acgtcttcac cctgctgggg
      121 aacgggacca tactggggct catctcactg gactccagac tgcacgcccc catgtacttc
      181 ttcctctcac acctggcggt cgtcgacatc gcctacgcct gcaacacggt gccccggatg
      241 ctggtgaacc tcctgcatcc agccaagccc atctcctttg cgggccgcat gatgcagacc
      301 tttctgtttt ccacttttgc tgtcacagaa tgtctcctcc tggtggtgat gtcctatgat
      361 ctgtacgtgg ccatctgcca ccccctccga tatttggcca tcatgacctg gagagtctgc
      421 atcaccctcg cggtgacttc ctggaccact ggagtccttt tatccttgat tcatcttgtg
      481 ttacttctac ctttaccctt ctgtaggccc cagaaaattt atcacttttt ttgtgaaatc
      541 ttggctgttc tcaaacttgc ctgtgcagat acccacatca atgagaacat ggtcttggcc
      601 ggagcaattt ctgggctggt gggacccttg tccacaattg tagtttcata tatgtgcatc
      661 ctctgtgcta tccttcagat ccaatcaagg gaagttcaga ggaaagcctt ccgcacctgc
      721 ttctcccacc tctgtgtgat tggactcgtt tatggcacag ccattatcat gtatgttgga
      781 cccagatatg ggaaccccaa ggagcagaag aaatatctcc tgctgtttca cagcctcttt
      841 aatcccatgc tcaatcccct tatctgtagt cttaggaact cagaagtgaa gaatactttg
      901 aagagagtgc tgggagtaga aagggcttta tgaaaaggat tatggcattg tgactgacag
      961 tgacctagga agttacatca ttgagcggtt cttaacccat ctctgcactg gtgggacctc
     1021 tgccctcaat ggacatgaga attatctgag acatttattt aaaatggagc tatctcctgc
     1081 cctaccttta aatgactgat ttcagcagat gtgggatgaa attctagaaa ttgatctctt
     1141 caagttgtgc tgcagccact ccacaccagg acaatacccc ttacaatatc ctcattagct
     1201 tttgatccag tcccatacct cccataatgt tttcctcaaa acactggtcc cttcagagga
     1261 ctttaaaaat aagttctata gtcaaataag tttgagactt acttcacatc agatgcctct
     1321 gtctagggat cacaattcat attagcatag tgaatgctgt aaatatttct ctaggaaaga
     1381 ataattctat accagcttta agccagtgtt ttctaaactt atgtgagcac ataaaatttc
     1441 ctttgtaata cttagtaaca gtttcctgga acaggagatc ttgatattaa ttgactcatt
     1501 gtgaatactt cctacagccc ccttctaggg cagaatgatt tcttttttcc ttgcaaagtg
     1561 agcctctaaa gagatgtagt tctgagcatt atgcctcgat cagtctgtaa aaatccgggt
     1621 tctgtttgga tacagaccgt gagggaccct gtctctactg ttcaatggta gatcatctaa
     1681 agaaaataaa tgcaatcctg tccttcatca tggatcggca ttcctgctat agaagcttca
     1741 ggagatgacc tcattcaa
//
