LOCUS       NM_001386096            1741 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily A member 25
            (OR2A25), transcript variant 2, mRNA.
ACCESSION   NM_001386096
VERSION     NM_001386096.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091768.4.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641663.1/ ENSP00000493343.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC091768.4         24385-24470
            87-1741             AC091768.4         28790-30444
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..1741
                     /gene="OR2A25"
                     /gene_synonym="OR2A24P; OR2A25P; OR2A27"
                     /note="olfactory receptor family 2 subfamily A member 25"
                     /db_xref="GeneID:392138"
                     /db_xref="HGNC:HGNC:19562"
     exon            1..86
                     /gene="OR2A25"
                     /gene_synonym="OR2A24P; OR2A25P; OR2A27"
                     /inference="alignment:Splign:2.1.0"
     exon            87..1741
                     /gene="OR2A25"
                     /gene_synonym="OR2A24P; OR2A25P; OR2A27"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1023
                     /gene="OR2A25"
                     /gene_synonym="OR2A24P; OR2A25P; OR2A27"
                     /note="olfactory receptor, family 2, subfamily A, member
                     25 pseudogene; olfactory receptor, family 2, subfamily A,
                     member 27; olfactory receptor, family 2, subfamily A,
                     member 24 pseudogene; olfactory receptor 2A27"
                     /codon_start=1
                     /product="olfactory receptor 2A25"
                     /protein_id="NP_001373025.1"
                     /db_xref="CCDS:CCDS43669.1"
                     /db_xref="GeneID:392138"
                     /db_xref="HGNC:HGNC:19562"
                     /translation="MGGNQTSITEFLLLGFPIGPRIQMLLFGLFSLFYIFILLGNGTI
                     LGLISLDSRLHTPMYFFLSHLAVVDIACACSTVPQMLVNLLHPAKPISFAGCMTQMFL
                     FLSFAHTECLLLVVMSYDRYVAICHPLRYSTIMTWKVCITLALTSWILGVLLALVHLV
                     LLLPLSFCGPQKLNHFFCEIMAVLKLACADTHINEVMVLAGAVSVLVGAFFSTVISYV
                     HILCAILKIQSGEGCQKAFSICSSHLCVVGLFYGTAIIMYVEPQYESPKEQKKYLLLF
                     HSLFNPMLNPLIYSLRNKEVQGTLKRMLEKKRTS"
ORIGIN      
        1 cctgccctga aacaagtgat tctatttgga aggttgaatc tatatgagtt ccacctgccc
       61 taaaaacaag tgaatctatt tggaagggaa atggggggaa atcagacttc catcacagag
      121 ttcctcctac tgggatttcc cattggccca aggattcaga tgctcctctt tgggctcttc
      181 tccctgttct acatcttcat tctgttgggg aacgggacaa tcctggggct catctcactg
      241 gactccagac tccacacccc catgtacttc ttcctctcac acctggcggt cgtcgacatc
      301 gcctgtgctt gcagcacggt gccccagatg ctggtgaacc tcctgcatcc agccaagccc
      361 atctcctttg ctggctgcat gacccagatg tttctgtttt tgagttttgc acatacagaa
      421 tgtctcctcc tggtggtgat gtcctatgat cggtacgtgg ccatctgcca ccctctccga
      481 tattctacca tcatgacctg gaaagtctgc atcactttgg cattgacttc ctggatttta
      541 ggagtcttat tggcccttgt ccatctagtg ttactgctac cactgtcctt ctgtggaccc
      601 cagaaactta atcacttttt ctgtgaaatt atggctgttc tcaaacttgc ctgtgcggat
      661 acccacatta atgaggtaat ggttttggca ggggcagtgt ctgtgctggt gggagccttc
      721 ttttccactg taatatctta tgttcatatt ctatgtgcca ttctaaagat ccagtcagga
      781 gaggggtgcc agaaagcctt ctccatctgc tcctcccacc tctgtgtggt tggactcttt
      841 tatggcacag ccatcatcat gtatgttgag ccccagtatg agagccccaa ggagcagaag
      901 aaatatctcc tgctgtttca cagcctcttc aatcccatgc ttaatcccct aatttatagt
      961 cttaggaaca aggaagtcca aggtactcta aagaggatgc ttgaaaagaa gagaacttca
     1021 tgaaagcctg aaagaatagt aaaatagctg gcttcaaagg gctttgagat tacatctgaa
     1081 cccatcccta ctcaggatac ataatcacac tctagagaac cctttccatc ttcttgaaat
     1141 tttcctatga ctacctcccg agaaagccca ttctgctttc ctctctccag cattgaaggt
     1201 cggagctgca caattaataa aaatatgttt atactagctg tatagtgtac acacttttaa
     1261 tataattatg tgaaatattc tgaaagttgg aaataaatgt gtatcttttt gttctgtaaa
     1321 taagacttga aggcgaattt ttgtagaata aggatatggg agttaggaga gactgataac
     1381 aaagtcatta tttaattatt cttaatttag aacgtgccgg ccagacacgg tggctcacgc
     1441 ctgtaatccc agcactttgg gaggccgaga caggtggatc acgcggtcag gagaccgaga
     1501 ccatcttggc taacacggtg aaaccccgtt tctactaaaa atacaaaaaa ttagccgggc
     1561 gtgttggcgg gcgcctgtag tcccagctac tcgggaggct gaggcaggag aatggcgcga
     1621 accctggaga ggcggagctt gcagtgagct gagatggcgc cactgcactc caacctgggg
     1681 gacacagcga gactccgtct caaaaaaaaa aaaaagaaag tgtcatattt aggccaggcg
     1741 t
//
