LOCUS       NM_001004135            4163 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 2 subfamily A member 12
            (OR2A12), mRNA.
ACCESSION   NM_001004135 XM_294316 XM_380063
VERSION     NM_001004135.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4163)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   2  (bases 1 to 4163)
  AUTHORS   Gilad,Y. and Lancet,D.
  TITLE     Population differences in the human functional olfactory repertoire
  JOURNAL   Mol Biol Evol 20 (3), 307-314 (2003)
   PUBMED   12644552
REFERENCE   3  (bases 1 to 4163)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091768.4.
            
            On Jul 22, 2020 this sequence version replaced NM_001004135.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641592.1/ ENSP00000493157.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC091768.4         40852-41117
            267-4163            AC091768.4         49631-53527
FEATURES             Location/Qualifiers
     source          1..4163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..4163
                     /gene="OR2A12"
                     /gene_synonym="OR2A12P; OR2A16P"
                     /note="olfactory receptor family 2 subfamily A member 12"
                     /db_xref="GeneID:346525"
                     /db_xref="HGNC:HGNC:15082"
     exon            1..266
                     /gene="OR2A12"
                     /gene_synonym="OR2A12P; OR2A16P"
                     /inference="alignment:Splign:2.1.0"
     exon            267..4163
                     /gene="OR2A12"
                     /gene_synonym="OR2A12P; OR2A16P"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..1250
                     /gene="OR2A12"
                     /gene_synonym="OR2A12P; OR2A16P"
                     /note="olfactory receptor, family 2, subfamily A, member
                     12 pseudogene; olfactory receptor, family 2, subfamily A,
                     member 16 pseudogene; olfactory receptor OR7-10"
                     /codon_start=1
                     /product="olfactory receptor 2A12"
                     /protein_id="NP_001004135.1"
                     /db_xref="CCDS:CCDS43670.1"
                     /db_xref="GeneID:346525"
                     /db_xref="HGNC:HGNC:15082"
                     /translation="MESNQTWITEVILLGFQVDPALELFLFGFFLLFYSLTLMGNGII
                     LGLIYLDSRLHTPMYVFLSHLAIVDMSYASSTVPKMLANLVMHKKVISFAPCILQTFL
                     YLAFAITECLILVMMCYDRYVAICHPLQYTLIMNWRVCTVLASTCWIFSFLLALVHIT
                     LILRLPFCGPQKINHFFCQIMSVFKLACADTRLNQVVLFAGSAFILVGPLCLVLVSYL
                     HILVAILRIQSGEGRRKAFSTCSSHLCVVGLFFGSAIVMYMAPKSSHSQERRKILSLF
                     YSLFNPILNPLIYSLRNAEVKGALKRVLWKQRSM"
ORIGIN      
        1 gcatgccaag attctcctgg gtaggaacaa ccttgccatt cttcctgagt tctcacttct
       61 ttgcataagc aggaacacaa gtgcacatgc gtgcacacac acacaaacag aggcatacac
      121 acctgcccca cacctacaca cgctgacact catacgaata acaaagctgg aggatagaga
      181 ggagagggga aggtgttaca ctgctcagta gggaagacat aggatggtgg gaagacgctt
      241 catatgttgt tctctggact ccacagctgt gaaatttctg tcttaagtac atcacaagat
      301 ttttctgtca cgagaacatg gaaagcaatc agacctggat cacagaagtc atcctgttgg
      361 gattccaggt ggacccagct ctggagttgt tcctctttgg gtttttcttg ctattctaca
      421 gcttaaccct gatgggaaat gggattatcc tggggctcat ctacttggac tctagactgc
      481 acacacccat gtatgtcttc ctgtcacacc tggccattgt ggacatgtcc tatgcctcga
      541 gtactgtccc taagatgcta gcaaatcttg tgatgcacaa aaaagtcatc tcctttgctc
      601 cttgcatact tcagactttt ttgtatttgg cgtttgctat tacagagtgt ctgattttgg
      661 tgatgatgtg ctatgatcgg tatgtggcaa tctgtcaccc cttgcaatac accctcatta
      721 tgaactggag agtgtgcact gtcctggcct caacttgctg gatatttagc tttctcttgg
      781 ctctggtcca tattactctt attctgaggc tgcctttttg tggcccacaa aagatcaacc
      841 actttttctg tcaaatcatg tccgtattca aattggcctg tgctgacact aggctcaacc
      901 aggtggtcct atttgcgggt tctgcgttca tcttagtggg gccgctctgc ctggtgctgg
      961 tctcctactt gcacatcctg gtggccatct tgaggatcca gtctggggag ggccgcagaa
     1021 aggccttctc tacctgctcc tcccacctct gcgtggtggg gcttttcttt ggcagcgcca
     1081 ttgtcatgta catggccccc aagtcaagcc attctcaaga acggaggaag atcctttccc
     1141 tgttttacag ccttttcaac ccgatcctga accccctcat ctacagcctt aggaatgcag
     1201 aggtgaaagg ggctctaaag agagtccttt ggaaacagag atcaatgtga agaatcattt
     1261 gagatatcct gagtgtgtaa gcatggttct catgaccctg ggtcctgaaa tttccttttt
     1321 aattctttaa tttaccacac ccaatactgt ttatctttag acttcttata aaaagagaaa
     1381 ctggcctggc gtggtggctg aagcctgtaa tcccaacact ttgggaggct gacctgggcg
     1441 gattacctga ggtcaggagt tcgagaccag cctaaccaac atggcgaaac actgtctcta
     1501 ttaaaaatac aaaaattagc cgggcgtgct ggtgggcgcc tgtaatccca gctctacttg
     1561 ggaggctgag gcaggagaat cgtttgaacc caggaggcgg aggttgcact gagccgagat
     1621 tgtaccactg cactccagcc tgggcgacag agcaagactc cctctcaaaa ataaataaat
     1681 aaataaataa agagagagaa actaattact tttactattt aaggcattga taccaaacct
     1741 gagataaact tatgaaacag aaaatcacaa tctaatccta ctcatgaaca tagatgcaaa
     1801 cctcttaaag aaaatattaa tgaaacaagt ccatcagaat gaagtaagga tgtattataa
     1861 tgaaactatg tataccctta aaatgcagca ataatttaac attaaaacaa acaacaaaaa
     1921 taacttcccc acattaacaa attaaagaat acatttcata tgaacatctc agtagatcca
     1981 agaaagtgtt tgacaagatt taagatcaat tctttataag ctaatatcgc agtaagactt
     2041 tctaaacaga atctaccaaa aacaaaacaa aaataaaaac aaagcagacg tcatggttaa
     2101 tggtgaaatg ttagcatctg tccttttcgg gtaaagaatc agacacaaaa aaaatcactt
     2161 gtttttcttg atttcacttt ttactagaga tcctaaccaa tacagttaga caaaaagaac
     2221 aaatacaccc atgcatgcgc acacacgcac acacgcacac acacacacac tcacacgtgc
     2281 acacacattt gagaaagaag aaacaaactg taattacata caaatgacat tactgtatat
     2341 gtaggaaatt caaaagaatt ataagaaatt ttaaagtagc ttgatacaaa atcaatataa
     2401 aaatatatta tatttttaaa gcagtaacaa acaattaaaa tgaaacttga aaaaacgcta
     2461 ccatacacaa caggatttaa ttctcaaatg cttaggaata attataacaa agattataca
     2521 aaagctctaa agagacaatt aaaaatttat tgagagacta tggtaaataa atagatacac
     2581 aatgtgtggt atgccaagtt cttggactga aaaacataat attacaaaga ttcaatctcc
     2641 ttaaattgat tattagattt aatacaatcc caatcaatat cgcagcaggg tgtgtggatg
     2701 tgtgcagaac tcaacaaact aatcttaaaa ttcaagggac caaggctagc tcaaactcta
     2761 ttaaaagaga aagagtacaa cgtgggagga tttgatcctt cagatatcaa aacacactat
     2821 atagtgctaa taaacagaac agtgtggtat ttatacacag atagaccaaa aaacaaacag
     2881 aatagaaaga aaattagtgt atatttgctt ttattagcac ttgctatatt agaggtgtgg
     2941 catggcatat cactggggaa tgaaaaagct ttgaagtaaa tggtgttggg acaaccaagt
     3001 ctttataaag atattcaaat catgcagaaa attcaacttc tggtgtattc aagatttaag
     3061 tgtcaaaggc agaactctaa agcttttaga agatatacaa gagaaggatt ttttaaacaa
     3121 tacacataat tgctattgtg aaataatatc tgatattata aaatctttaa gctgcattaa
     3181 ataaaaatat tagtgtatgt gactgggttg aaattaagaa cttatgttaa tcaaaacagg
     3241 gcataaaaag tgaaaggaca agccacaaaa tcttctggaa gactttctga tttatcagct
     3301 ctcaagcagt acatccccaa agaccagcat atttcagagt ctcatgcatt gtcttgacta
     3361 ggtgactttc aatcatatct cttcagtctg tctttttatg gcattattaa gtacttgaag
     3421 tttttccctt tatatatttt tttcacatgt gtgttgtcag tttacaatca gtaatataca
     3481 agatcgtcgt acacatcaat tttgtcttgt catagctgtg tctctagtat ctagagcaga
     3541 gctaggtaca gagaagattc tcaacaatta tctgttgaca gacgaccaat aggtatcccc
     3601 aggaaagtgt aagcctatcc acattcttcc tgaaaccaag aagcaaccaa gttaggggga
     3661 gagagatgca tttttatgtt ctatttatta ataatttcta ttttgcacat gagaagatcg
     3721 aggaacacag aggttgagta acttaccctg agtcattgag ttagcataat caatggaaaa
     3781 tatagagttt aaaaaaatag gttctctggc tccagagctg gtattctttt attgttaaac
     3841 aatagaaatt tatgtccaag atcaggtgcc aagcatcgtc gagctctagt ggggactttc
     3901 ttctggcttt cagagagtgt cttcccactg tgtctacaca tggcagagag agagagagcc
     3961 catattctca atacaatact aactctatgt acaactgtag cttacaccaa tgacccattg
     4021 attcaagaca aaagataaac atatctccct tctaccacca ggaaggaaag ttatcaggat
     4081 cattgaagga ggactttctt tctctctttc ttcctttctt tcttctttct ttccttcctt
     4141 ccttcctttc tctttctctt cct
//
