LOCUS       NM_001004458            1474 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily S member 1
            (OR1S1), mRNA.
ACCESSION   NM_001004458 XM_166917
VERSION     NM_001004458.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP004247.2.
            
            On Jul 15, 2022 this sequence version replaced NM_001004458.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be non-functional as an olfactory receptor
            according to the Classifier for Olfactory Receptor Pseudogenes.
            This RefSeq was derived from genomic sequence to make the sequence
            consistent with the reference genome assembly. The genomic
            coordinates used for the transcript record were based on
            alignments.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000641544.1/
                                                ENSP00000493053.1
            polymorphic pseudogene           :: PMID: 22908908
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AP004247.2         174196-174313
            119-1474            AP004247.2         176205-177560
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1474
                     /gene="OR1S1"
                     /gene_synonym="OR11-232; OST034"
                     /note="olfactory receptor family 1 subfamily S member 1"
                     /db_xref="GeneID:219959"
                     /db_xref="HGNC:HGNC:8227"
     exon            1..118
                     /gene="OR1S1"
                     /gene_synonym="OR11-232; OST034"
                     /inference="alignment:Splign:2.1.0"
     exon            119..1474
                     /gene="OR1S1"
                     /gene_synonym="OR11-232; OST034"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1112
                     /gene="OR1S1"
                     /gene_synonym="OR11-232; OST034"
                     /note="olfactory receptor OR11-232"
                     /codon_start=1
                     /product="olfactory receptor 1S1"
                     /protein_id="NP_001004458.2"
                     /db_xref="GeneID:219959"
                     /db_xref="HGNC:HGNC:8227"
                     /translation="MHQGNQTTITEFILLGFFKQDEHQNLLFVLFLGMYLVTVIGNGL
                     IIVAISLDTYLHTPMYLFLANLSFADISSISNSVPKMLVNIQTKSQSISYESCITQMY
                     FSIVFVVIDNLLLGTMAYDHFVAICHPLNYTILMRPRFGILLTVISWFLSNIIALTHT
                     LLLIQLLFCNHNTLPHFFCDLAPLLKLSCSDTLINELVLFIVGLSVIIFPFTLSFFSY
                     VCIIRAVLRVSSTQGKWKAFSTCGSHLTVVLLFYGTIVGVYFFPSSTHPEDTDKIGAV
                     LFTVVTPMINPFIYSLRNKDMKGALRKLINRKISSL"
ORIGIN      
        1 agtaactttc tgagattttt accatcattc agaggtgaat ctcttcagaa tccagcattg
       61 gtcttgacca gctagacagt caccttaaga attcagaaca atttgtgcag gactactggt
      121 tttcttgtag gaatatgaag acttttagtt cctttcttca gatcggcaga aatatgcatc
      181 aaggaaacca aaccaccatc actgaattca ttctcctggg atttttcaag caggatgagc
      241 atcaaaacct cctctttgtg cttttcttgg gtatgtacct ggtcactgtg attgggaacg
      301 ggctcatcat tgtggctatc agcttggata cgtaccttca tacccccatg tatctcttcc
      361 ttgccaatct atcctttgct gatatttcct ccatttccaa ctcagtcccc aaaatgctgg
      421 tgaatattca aaccaagagt caatccatct cttatgagag ctgcatcaca cagatgtact
      481 tttctattgt gtttgtcgtc attgacaatt tgctcttggg gaccatggcc tatgaccact
      541 ttgtggcgat ctgccaccct ctgaattata caattctcat gcggcccagg ttcggcattt
      601 tgctcacagt catctcatgg ttcctcagta atattattgc tctgacacac acccttctgc
      661 tcattcaatt gctcttctgt aaccacaaca ctctcccaca cttcttctgt gacttggccc
      721 ctctgctcaa actgtcctgt tcagatacat tgatcaatga gcttgtgttg tttattgtgg
      781 gtttatcagt tatcatcttc ccctttacac tcagcttctt ttcctatgtc tgcatcatca
      841 gagctgtcct gagagtatct tccacacagg gaaagtggaa agccttctcc acttgtggct
      901 ctcacctgac agttgtatta ctgttctacg gaaccattgt aggcgtgtac tttttcccct
      961 cctccactca ccctgaggac actgataaga ttggtgctgt cctattcact gtggtgacac
     1021 ccatgataaa ccccttcatc tacagcttga ggaataagga tatgaaaggt gccctgagaa
     1081 agctcatcaa tagaaaaatt tcttcccttt gatgccctgg acctctacat tcttttagtc
     1141 cacataatca gataaatgat tcagcccaga gcgtatggca cagttgtgat ggttcaactt
     1201 ttgatgaact tgcaggtatc tgtctcctat tccaacctct gaaggggttg gagcttttcc
     1261 acttagctct tgtcttggaa acaaaacctg taactgccat ggtaagtcac aagaataaca
     1321 cgcatcctta gagagtagat tggtggttac cagggcccag gggtgggaag atggaatgga
     1381 ggtgatgagt tgttgattaa tgggtacaac aatacagtta gatagaagaa ataagaccta
     1441 ttgtttgata aatcattagg gggactatag taaa
//
