LOCUS       NM_003555                942 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily G member 1
            (OR1G1), mRNA.
ACCESSION   NM_003555
VERSION     NM_003555.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 942)
  AUTHORS   Topin,J., de March,C.A., Charlier,L., Ronin,C., Antonczak,S. and
            Golebiowski,J.
  TITLE     Discrimination between olfactory receptor agonists and non-agonists
  JOURNAL   Chemistry 20 (33), 10227-10230 (2014)
   PUBMED   25043138
REFERENCE   2  (bases 1 to 942)
  AUTHORS   Albertsen,H.M., Chettier,R., Farrington,P. and Ward,K.
  TITLE     Genome-wide association study link novel loci to endometriosis
  JOURNAL   PLoS One 8 (3), e58257 (2013)
   PUBMED   23472165
REFERENCE   3  (bases 1 to 942)
  AUTHORS   Charlier,L., Topin,J., Ronin,C., Kim,S.K., Goddard,W.A. 3rd,
            Efremov,R. and Golebiowski,J.
  TITLE     How broadly tuned olfactory receptors equally recognize their
            agonists. Human OR1G1 as a test case
  JOURNAL   Cell Mol Life Sci 69 (24), 4205-4213 (2012)
   PUBMED   22926438
  REMARK    GeneRIF: Or1g1 is examined within a model for recognition of
            broadly tuned olfactory receptors.
REFERENCE   4  (bases 1 to 942)
  AUTHORS   Sanz,G., Thomas-Danguin,T., Hamdani el,H., Le Poupon,C., Briand,L.,
            Pernollet,J.C., Guichard,E. and Tromelin,A.
  TITLE     Relationships between molecular structure and perceived odor
            quality of ligands for a human olfactory receptor
  JOURNAL   Chem Senses 33 (7), 639-653 (2008)
   PUBMED   18603653
  REMARK    GeneRIF: OR1G1 recognizes a group of odorants that share both 3D
            structural and perceptual qualities.
REFERENCE   5  (bases 1 to 942)
  AUTHORS   Matarazzo,V., Clot-Faybesse,O., Marcet,B., Guiraudie-Capraz,G.,
            Atanasova,B., Devauchelle,G., Cerutti,M., Etievant,P. and Ronin,C.
  TITLE     Functional characterization of two human olfactory receptors
            expressed in the baculovirus Sf9 insect cell system
  JOURNAL   Chem Senses 30 (3), 195-207 (2005)
   PUBMED   15741602
REFERENCE   6  (bases 1 to 942)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   7  (bases 1 to 942)
  AUTHORS   Matarazzo,V., Zsurger,N., Guillemot,J.C., Clot-Faybesse,O.,
            Botto,J.M., Dal Farra,C., Crowe,M., Demaille,J., Vincent,J.P.,
            Mazella,J. and Ronin,C.
  TITLE     Porcine odorant-binding protein selectively binds to a human
            olfactory receptor
  JOURNAL   Chem Senses 27 (8), 691-701 (2002)
   PUBMED   12379593
  REMARK    GeneRIF: OR17-209 fails to bind to the pig odorant-binding protein,
            while OR17-201 exhibits specific saturable binding
REFERENCE   8  (bases 1 to 942)
  AUTHORS   Glusman,G., Sosinsky,A., Ben-Asher,E., Avidan,N., Sonkin,D.,
            Bahar,A., Rosenthal,A., Clifton,S., Roe,B., Ferraz,C., Demaille,J.
            and Lancet,D.
  TITLE     Sequence, structure, and evolution of a complete human olfactory
            receptor gene cluster
  JOURNAL   Genomics 63 (2), 227-245 (2000)
   PUBMED   10673334
REFERENCE   9  (bases 1 to 942)
  AUTHORS   Rouquier,S., Taviaux,S., Trask,B.J., Brand-Arpon,V., van den
            Engh,G., Demaille,J. and Giorgi,D.
  TITLE     Distribution of olfactory receptor genes in the human genome
  JOURNAL   Nat Genet 18 (3), 243-250 (1998)
   PUBMED   9500546
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   10 (bases 1 to 942)
  AUTHORS   Ben-Arie,N., Lancet,D., Taylor,C., Khen,M., Walker,N.,
            Ledbetter,D.H., Carrozzo,R., Patel,K., Sheer,D., Lehrach,H. et al.
  TITLE     Olfactory receptor gene cluster on human chromosome 17: possible
            duplication of an ancestral receptor repertoire
  JOURNAL   Hum Mol Genet 3 (2), 229-235 (1994)
   PUBMED   8004088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF087928.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069379.1, BC095520.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328890.3/ ENSP00000331545.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..942
                     /gene="OR1G1"
                     /gene_synonym="OR17-130; OR17-209; OR1G2"
                     /note="olfactory receptor family 1 subfamily G member 1"
                     /db_xref="GeneID:8390"
                     /db_xref="HGNC:HGNC:8204"
     CDS             1..942
                     /gene="OR1G1"
                     /gene_synonym="OR17-130; OR17-209; OR1G2"
                     /note="olfactory receptor, family 1, subfamily G, member
                     2; olfactory receptor OR17-8; olfactory receptor 1G2;
                     olfactory receptor 17-209"
                     /codon_start=1
                     /product="olfactory receptor 1G1"
                     /protein_id="NP_003546.1"
                     /db_xref="CCDS:CCDS11020.1"
                     /db_xref="GeneID:8390"
                     /db_xref="HGNC:HGNC:8204"
                     /translation="MEGKNLTSISECFLLGFSEQLEEQKPLFGSFLFMYLVTVAGNLL
                     IILVIITDTQLHTPMYFFLANLSLADACFVSTTVPKMLANIQIQSQAISYSGCLLQLY
                     FFMLFVMLEAFLLAVMAYDCYVAICHPLHYILIMSPGLCIFLVSASWIMNALHSLLHT
                     LLMNSLSFCANHEIPHFFCDINPLLSLSCTDPFTNELVIFITGGLTGLICVLCLIISY
                     TNVFSTILKIPSAQGKRKAFSTCSSHLSVVSLFFGTSFCVDFSSPSTHSAQKDTVASV
                     MYTVVTPMLNPFIYSLRNQEIKSSLRKLIWVRKIHSP"
     exon            1..942
                     /gene="OR1G1"
                     /gene_synonym="OR17-130; OR17-209; OR1G2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagggga aaaatctgac cagcatctca gaatgtttcc tcctggggtt ctctgagcag
       61 ctggaggagc agaagcccct ctttgggtcc ttcctgttca tgtacttggt cacggtggca
      121 ggcaacctcc tcatcattct agtcatcatt actgacactc aactccatac ccccatgtac
      181 ttctttctag ccaacctctc ccttgcagat gcctgctttg tgtccaccac agtccctaag
      241 atgctggcaa acatacagat ccagagtcag gccatctcct actcagggtg tctactacag
      301 ttgtattttt tcatgttatt tgtgatgctg gaggcattcc tcttggcggt catggcctat
      361 gactgctacg tggccatatg ccacccactt cattacattc tgatcatgag ccctgggctc
      421 tgcatcttcc tcgtgtctgc atcctggatc atgaatgccc tccactccct tctacacaca
      481 cttctgatga acagcctgtc cttctgcgca aaccatgaga tcccacactt cttctgtgac
      541 atcaatcccc tcctgagtct gtcctgcaca gaccccttca ccaatgagct ggtgatcttc
      601 atcactgggg gtctcacagg actcatttgt gtgctttgcc tgattatctc ttacacgaac
      661 gttttctcga ccatcctgaa gatcccatca gctcagggga agcggaaagc cttttccacc
      721 tgcagctctc atctctccgt ggtctctctc ttctttggga cttctttttg tgttgatttc
      781 agttctccct caacccactc ggcccagaag gacacagttg catcagtgat gtacacagtg
      841 gtaactccaa tgttgaatcc ctttatctac agtttgagga accaagaaat aaagtcttcc
      901 ctgagaaagt taatctgggt tcggaaaatt cattcccctt ag
//
