LOCUS       NM_003553               1307 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily E member 1
            (OR1E1), mRNA.
ACCESSION   NM_003553
VERSION     NM_003553.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1307)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   2  (bases 1 to 1307)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   3  (bases 1 to 1307)
  AUTHORS   Rouquier,S., Blancher,A. and Giorgi,D.
  TITLE     The olfactory receptor gene repertoire in primates and mouse:
            evidence for reduction of the functional fraction in primates
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2870-2874 (2000)
   PUBMED   10706615
REFERENCE   4  (bases 1 to 1307)
  AUTHORS   Glusman,G., Sosinsky,A., Ben-Asher,E., Avidan,N., Sonkin,D.,
            Bahar,A., Rosenthal,A., Clifton,S., Roe,B., Ferraz,C., Demaille,J.
            and Lancet,D.
  TITLE     Sequence, structure, and evolution of a complete human olfactory
            receptor gene cluster
  JOURNAL   Genomics 63 (2), 227-245 (2000)
   PUBMED   10673334
REFERENCE   5  (bases 1 to 1307)
  AUTHORS   Rouquier,S., Taviaux,S., Trask,B.J., Brand-Arpon,V., van den
            Engh,G., Demaille,J. and Giorgi,D.
  TITLE     Distribution of olfactory receptor genes in the human genome
  JOURNAL   Nat Genet 18 (3), 243-250 (1998)
   PUBMED   9500546
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   6  (bases 1 to 1307)
  AUTHORS   Ben-Arie,N., Lancet,D., Taylor,C., Khen,M., Walker,N.,
            Ledbetter,D.H., Carrozzo,R., Patel,K., Sheer,D., Lehrach,H. et al.
  TITLE     Olfactory receptor gene cluster on human chromosome 17: possible
            duplication of an ancestral receptor repertoire
  JOURNAL   Hum Mol Genet 3 (2), 229-235 (1994)
   PUBMED   8004088
REFERENCE   7  (bases 1 to 1307)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087498.8.
            
            On May 17, 2019 this sequence version replaced NM_003553.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322608.2/ ENSP00000313384.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1307              AC087498.8         16121-17427
FEATURES             Location/Qualifiers
     source          1..1307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..1307
                     /gene="OR1E1"
                     /gene_synonym="HGM071; OR13-66; OR17-2; OR17-32; OR1E5;
                     OR1E6; OR1E8P; OR1E9P; OST547"
                     /note="olfactory receptor family 1 subfamily E member 1"
                     /db_xref="GeneID:8387"
                     /db_xref="HGNC:HGNC:8189"
     exon            1..1307
                     /gene="OR1E1"
                     /gene_synonym="HGM071; OR13-66; OR17-2; OR17-32; OR1E5;
                     OR1E6; OR1E8P; OR1E9P; OST547"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..945
                     /gene="OR1E1"
                     /gene_synonym="HGM071; OR13-66; OR17-2; OR17-32; OR1E5;
                     OR1E6; OR1E8P; OR1E9P; OST547"
                     /note="olfactory receptor, family 1, subfamily E, member 9
                     pseudogene; olfactory receptor, family 1, subfamily E,
                     member 8 pseudogene; olfactory receptor, family 1,
                     subfamily E, member 5; olfactory receptor, family 1,
                     subfamily E, member 6; olfactory receptor OR17-4;
                     olfactory receptor OR17-18; OR5-85; olfactory receptor
                     1E5; olfactory receptor 1E6; olfactory receptor 5-85;
                     olfactory receptor 13-66; olfactory receptor 17-2/17-32;
                     olfactory receptor-like protein HGMP07I"
                     /codon_start=1
                     /product="olfactory receptor 1E1"
                     /protein_id="NP_003544.2"
                     /db_xref="CCDS:CCDS11024.1"
                     /db_xref="GeneID:8387"
                     /db_xref="HGNC:HGNC:8189"
                     /translation="MMGQNQTSISDFLLLGLPIQPEQQNLCYALFLAMYLTTLLGNLL
                     IIVLIRLDSHLHTPMYLFLSNLSFSDLCFSSVTIPKLLQNMQNQDPSIPYADCLTQMY
                     FFLLFGDLESFLLVAMAYDRYVAICFPLHYTAIMSPMLCLALVALSWVLTTFHAMLHT
                     LLMARLCFCADNVIPHFFCDMSALLKLAFSDTRVNEWVIFIMGGLILVIPFLLILGSY
                     ARIVSSILKVPSSKGICKAFSTCGSHLSVVSLFYGTVIGLYLCSSANSSTLKDTVMAM
                     MYTVVTPMLNPFIYSLRNRDMKGALSRVIHQKKTFFSL"
ORIGIN      
        1 atgatgggac aaaatcaaac cagcatctca gacttcctgc tcctgggcct gcccatccaa
       61 ccagagcagc aaaacctgtg ctatgccctg ttcttggcca tgtatcttac caccctcctg
      121 gggaacctcc tcatcattgt cctcattcga ctggactccc atctccacac gcctatgtat
      181 ttgtttctca gcaacttgtc cttctctgac ctctgcttct cttccgtgac cattcccaag
      241 ttgttacaga acatgcagaa ccaggaccca tccatcccct atgcggactg cctgacccaa
      301 atgtacttct tcctgttatt tggagacctg gagagcttcc tccttgtggc catggcctat
      361 gaccgctatg tggccatctg cttccccctg cactacaccg ccatcatgag ccccatgctc
      421 tgtctcgccc tggtggcgct gtcctgggtg ctgaccacct tccatgccat gttacacact
      481 ttactcatgg ccaggttgtg tttttgtgca gacaatgtga tcccccactt tttctgtgat
      541 atgtctgctc tgctgaagct ggccttctct gacactcgag ttaatgaatg ggtgatattt
      601 atcatgggag ggctcattct tgtcatccca ttcctactca tccttgggtc ctatgcaaga
      661 attgtctcct ccatcctcaa ggtcccttct tctaagggta tctgcaaggc cttctctact
      721 tgtggctccc acctgtctgt ggtgtcactg ttctatggaa ccgttattgg tctctactta
      781 tgctcatcag ctaatagttc tactctaaag gacactgtca tggctatgat gtacactgtg
      841 gtgaccccca tgctgaaccc cttcatctac agcctgagga acagagacat gaagggagcc
      901 ctgagcagag tcattcatca gaagaaaact ttcttctctc tctgatgata acacttggag
      961 ctattacata gtttatccag taaaatattg atattaatat tggaatatta ttctaaatta
     1021 tttcctcacc atccttttgt tgaaatggca tcgtacataa tttttcaata tgtagtggag
     1081 atgaagcata gctgagtagt tgaactaggg aagagggtct tggtgacctg gctaagactt
     1141 cctgtttgtc ttcccaaggt gatcttggaa aaatgtagtt taagaacaac tgttttaaat
     1201 ggtcttcatg ccccacattc ttaaattatc acaggatttt gttatgttac tcagaatttt
     1261 gctttgattg tagaatcatt tttgtttaat taaaaaaatt tttaaat
//
