LOCUS       NM_002548               4887 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily D member 2
            (OR1D2), transcript variant 1, mRNA.
ACCESSION   NM_002548
VERSION     NM_002548.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4887)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4887)
  AUTHORS   Ottaviano,G., Zuccarello,D., Menegazzo,M., Perilli,L., Marioni,G.,
            Frigo,A.C., Staffieri,A. and Foresta,C.
  TITLE     Human olfactory sensitivity for bourgeonal and male infertility: a
            preliminary investigation
  JOURNAL   Eur Arch Otorhinolaryngol 270 (12), 3079-3086 (2013)
   PUBMED   23525651
  REMARK    GeneRIF: The present preliminary study seems to confirm the
            important role of OR1D2 both in nose and spermatozoa and may
            explain the idiopathic infertility of the study group.
REFERENCE   3  (bases 1 to 4887)
  AUTHORS   Albertsen,H.M., Chettier,R., Farrington,P. and Ward,K.
  TITLE     Genome-wide association study link novel loci to endometriosis
  JOURNAL   PLoS One 8 (3), e58257 (2013)
   PUBMED   23472165
REFERENCE   4  (bases 1 to 4887)
  AUTHORS   Wade,F., Espagne,A., Persuy,M.A., Vidic,J., Monnerie,R., Merola,F.,
            Pajot-Augy,E. and Sanz,G.
  TITLE     Relationship between homo-oligomerization of a mammalian olfactory
            receptor and its activation state demonstrated by bioluminescence
            resonance energy transfer
  JOURNAL   J Biol Chem 286 (17), 15252-15259 (2011)
   PUBMED   21454689
  REMARK    GeneRIF: the homo-oligomerization status of the human OR1740
            receptor and its involvement in receptor activation upon odorant
            ligand binding were addressed
REFERENCE   5  (bases 1 to 4887)
  AUTHORS   Cook,B.L., Steuerwald,D., Kaiser,L., Graveland-Bikker,J.,
            Vanberghem,M., Berke,A.P., Herlihy,K., Pick,H., Vogel,H. and
            Zhang,S.
  TITLE     Large-scale production and study of a synthetic G protein-coupled
            receptor: human olfactory receptor 17-4
  JOURNAL   Proc Natl Acad Sci U S A 106 (29), 11925-11930 (2009)
   PUBMED   19581598
REFERENCE   6  (bases 1 to 4887)
  AUTHORS   Ben-Arie,N., Lancet,D., Taylor,C., Khen,M., Walker,N.,
            Ledbetter,D.H., Carrozzo,R., Patel,K., Sheer,D., Lehrach,H. et al.
  TITLE     Olfactory receptor gene cluster on human chromosome 17: possible
            duplication of an ancestral receptor repertoire
  JOURNAL   Hum Mol Genet 3 (2), 229-235 (1994)
   PUBMED   8004088
REFERENCE   7  (bases 1 to 4887)
  AUTHORS   Schurmans,S., Muscatelli,F., Miot,F., Mattei,M.G., Vassart,G. and
            Parmentier,M.
  TITLE     The OLFR1 gene encoding the HGMP07E putative olfactory receptor
            maps to the 17p13-->p12 region of the human genome and reveals an
            MspI restriction fragment length polymorphism
  JOURNAL   Cytogenet Cell Genet 63 (3), 200-204 (1993)
   PUBMED   8097991
REFERENCE   8  (bases 1 to 4887)
  AUTHORS   Selbie,L.A., Townsend-Nicholson,A., Iismaa,T.P. and Shine,J.
  TITLE     Novel G protein-coupled receptors: a gene family of putative human
            olfactory receptor sequences
  JOURNAL   Brain Res Mol Brain Res 13 (1-2), 159-163 (1992)
   PUBMED   1315913
REFERENCE   9  (bases 1 to 4887)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
REFERENCE   10 (bases 1 to 4887)
  AUTHORS   Buck,L. and Axel,R.
  TITLE     A novel multigene family may encode odorant receptors: a molecular
            basis for odor recognition
  JOURNAL   Cell 65 (1), 175-187 (1991)
   PUBMED   1840504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097370.10.
            
            On Aug 6, 2020 this sequence version replaced NM_002548.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641833.1/ ENSP00000493103.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC097370.10        50469-50792
            325-4887            AC097370.10        61845-66407
FEATURES             Location/Qualifiers
     source          1..4887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4887
                     /gene="OR1D2"
                     /gene_synonym="OLFR1; OR17-4"
                     /note="olfactory receptor family 1 subfamily D member 2"
                     /db_xref="GeneID:4991"
                     /db_xref="HGNC:HGNC:8183"
                     /db_xref="MIM:164342"
     exon            1..324
                     /gene="OR1D2"
                     /gene_synonym="OLFR1; OR17-4"
                     /inference="alignment:Splign:2.1.0"
     exon            325..4887
                     /gene="OR1D2"
                     /gene_synonym="OLFR1; OR17-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..1313
                     /gene="OR1D2"
                     /gene_synonym="OLFR1; OR17-4"
                     /note="olfactory receptor OR17-6; olfactory receptor 17-4;
                     olfactory receptor-like protein HGMP07E"
                     /codon_start=1
                     /product="olfactory receptor 1D2"
                     /protein_id="NP_002539.2"
                     /db_xref="CCDS:CCDS11019.1"
                     /db_xref="GeneID:4991"
                     /db_xref="HGNC:HGNC:8183"
                     /db_xref="MIM:164342"
                     /translation="MDGGNQSEGSEFLLLGMSESPEQQRILFWMFLSMYLVTVVGNVL
                     IILAISSDSRLHTPVYFFLANLSFTDLFFVTNTIPKMLVNLQSHNKAISYAGCLTQLY
                     FLVSLVALDNLILAVMAYDRYVAICCPLHYTTAMSPKLCILLLSLCWVLSVLYGLIHT
                     LLMTRVTFCGSRKIHYIFCEMYVLLRMACSNIQINHTVLIATGCFIFLIPFGFVIISY
                     VLIIRAILRIPSVSKKYKAFSTCASHLGAVSLFYGTLCMVYLKPLHTYSVKDSVATVM
                     YAVVTPMMNPFIYSLRNKDMHGALGRLLDKHFKRLT"
ORIGIN      
        1 aaaatggata agcagacctg atgtgctccc tgttcatccc gtttcttcat gaatctagga
       61 tccaagactc agttctcata tcccacaaat ctcattgggg catcaatagc ctgaaatcct
      121 gtctcctttt ttacagaagc tgaagaccca ggcaacaagt tctctgctct gtacctttag
      181 ccaataggat gagtctccaa gacctattca gaaaataatg cattctggtc ttttatgacc
      241 tgaatgtgtt ttcatcctgt agaacaggaa cgtggaggaa gctgaaccag tgaactctga
      301 gagcagcaca gagcagtggg taaggacttt tggtaaacat ttgctggtgt taatgttaaa
      361 agagagttgg ggaaatggat ggaggcaacc agagtgaagg ttcagagttc cttctcctgg
      421 ggatgtcaga gagtcctgag cagcagcgga tcctgttttg gatgttcctg tccatgtacc
      481 tggtcacggt ggtgggaaat gtgctcatca tcctggccat cagctctgat tcccgcctgc
      541 acacccccgt gtacttcttc ctggccaacc tctccttcac tgacctcttc tttgtcacca
      601 acacaatccc caagatgctg gtgaacctcc agtcccataa caaagccatc tcctatgcag
      661 ggtgtctgac acagctctac ttcctggtct ccttggtggc cctggacaac ctcatcctgg
      721 ctgtgatggc atatgaccgc tatgtggcca tctgctgccc cctccactac accacagcca
      781 tgagccctaa gctctgtatc ttactccttt ccttgtgttg ggtcctatcc gtcctctatg
      841 gcctcataca caccctcctc atgaccagag tgaccttctg tgggtcacga aaaatccact
      901 acatcttctg tgagatgtat gtattgctga ggatggcatg ttccaacatt cagattaatc
      961 acacagtgct gattgccaca ggctgcttca tcttcctcat tccctttgga ttcgtgatca
     1021 tttcctatgt gctgattatc agagccatcc tcagaatacc ctcagtctct aagaaataca
     1081 aagccttctc cacctgtgcc tcccatttgg gtgcagtctc cctcttctat gggacacttt
     1141 gtatggtata cctaaagccc ctccatacct actctgtgaa ggactcagta gccacagtga
     1201 tgtatgctgt ggtgacaccc atgatgaatc ccttcatcta cagcctgagg aacaaggaca
     1261 tgcatggggc tctgggaaga ctcctagata aacactttaa gaggctgaca tgagggcaat
     1321 ttggaaagac agcattaaag tggagactag gaatatcctt caccctatgt aagggattgt
     1381 cctgtgtgtt atacagcagt gattgggaca tggctccagc tcagagacag catatagata
     1441 tgtggtgata aaaaagacat atttgtaacc tggtgtcccc caggtctcat cagccttggc
     1501 cgtaaataag gtcacactaa caccaacact agaatgttgc agggtcaaat tcttcaatgt
     1561 acttgactac agggccacat tcttggcctt atctgactat atccagttta aacctagaag
     1621 tgtctctcat ctagcacaca tccaaagtac agaaagtaaa tagtagctga taagaaagtt
     1681 agtcacatgg ctgtggaggt ttgaaagaga ttgcaatcat acatatttgt atcagctgat
     1741 ccagcacgtg atatagacct cgacaggtgg tgttcaattc atttgacatt catgcagtca
     1801 ttcatcaact cattctattc ataatgacag tgtacagagg cctcaaactg ggttacaaat
     1861 gtgaggtcac agtctactcg gggaagtaca taaatttaca ttaaacataa atggacctaa
     1921 ctcatcaatt aaaaagtaat gttcaacata ctgattaaaa aataaaatat agatagatgt
     1981 atttaaagag acacgatgaa agcacaggaa tatataaagc ttgaaattaa aaagagaaac
     2041 agacatattt ggaaaatact aaatatttta agtgaaatat tgctgcaatg acatcaggta
     2101 aaagatattt caaaacgggt gaaaggagtg atgtcaacaa gatggtggaa tcgacagttg
     2161 tatctctcat ccaccaacat acagactaat ttatcaacca tccacagatg aaaatacctt
     2221 tgtgagagct ccagaatcca agtgaaagtt tatagcaccc tggtagtaca cagaagtaga
     2281 aaaaacacca tattgaacat tgtagaaaaa actctgtcac attacctgaa tcacccctca
     2341 cccaagccag cacagagtag cacaaagaga gatcccctca tctcatgagt tcttccataa
     2401 gtaaaaaaga aaataaaaca tatgtacaac ttcccctgac tttcaggatg ctaaccaaga
     2461 ggaccacttc tgtcatgcct caccaagaat actgaggcaa ttcacatggc cagacccctc
     2521 tgagtagcta agaacaagaa aaaaaaaaaa taagaaaatg gttgggagct cttaatagtc
     2581 agtatgtgta ttttaacaac tggggccttg caccctacag tgggcctgtg catggtgccc
     2641 agaagctggc ccatccaccc acatccccaa gcactaggcc tgcctgccca tagaccctgc
     2701 caactggcca gcccagaata tctggctaag ctgactggtg aaaaacagtt cctatcaaat
     2761 tggactttcc ctatcaaaac cagcctgtaa agactaaaag agatgactgc ttcttcaaat
     2821 gtgcaaacac aaatgtgaag ctacaggaaa cacaaggaat caaggaaact tagcaaagcc
     2881 aaaggaacaa aataaagctt cagaaaccat caaagaaatg gagaaatatg aactgcctga
     2941 caaagaattc aagtgatcat ttgaagaaac atggtgaccc acacaaaaac acaggtaaac
     3001 tactaaacaa aatcaggaaa tcaatacata aataaaatgt aaatttcaac aaacagaaac
     3061 cacaaaaaag aaacagtaat tctggagcta aataatacaa tgactaaact ttaaaaaact
     3121 caaaagagct tcagcagcag atatgaagaa acagaagaaa gaattcacta ctcaaaaaca
     3181 ggtcatttga aagtactagt aagagaaaca aatggaaaaa gagtgaagaa agcctatggg
     3241 acatatggga cccatcaaac aaatacacac attacataag tatcagaagg aaaagtgaaa
     3301 gaaaaggagg cagaaaactt atttttctaa aaatggctat tcacagcagc caccacaggc
     3361 aggaaaacag aaacctgaaa gtgctgcttg ctttctcaac agggagactt gcagcctgga
     3421 acaagttttc agccctgctc accagctacc cggaaataaa ctcagcactg ttaggggtag
     3481 ggcacattgg gagtgacatg gccacttgga cagcatggga gctgggtgag gcctatcact
     3541 gctggctttc caccacttcc ctggcaacct gtatgacaca gcagaggcag ccataatccc
     3601 catgggaaca taacttcatt ggcctgttaa ccacaccccc atccctcaca gtggccacag
     3661 caagccccac cgaaggagag tcggagctca cacatgccta accctgcccc aacctaatgg
     3721 tctttctcta cgcaccctgg tagccgaaga caaagggcat aatctcttgg gagctctatg
     3781 gtcccactca ccacctgaga aactggaata cttatccagg ccaccttagg gcaagtttgt
     3841 atccccccta tgctaccaca gctggtgcac tcttgaaagg accacctctt ggctggaggc
     3901 caactagtac actaaacaaa acttcaacca aggaccatag actcctagat aaacacttgg
     3961 accatgagag ttcactttac tccactgcta cctccactgg accaggcact ggtatccatg
     4021 cctgagggac tgaagacaga tcacatcaca ggactcttca cagacacccc ccagtaccag
     4081 ctcagagccc agaagctctg ttggatggct agaccagcag agaaataaca atcattgcag
     4141 tttggctctc aggaagcccc atccccagga gatggggtag agccccatat caagggggga
     4201 tcccatggac aaaaacaatc tgataagtag cccttgagcc ccagatcttc cttctgacat
     4261 agtctaccca aatgagaagg aaccagaaaa acaaatctgg taatatgaca aaacaaggtt
     4321 ctttaacacc cttgaaagat cacactagct caccagcaat ggatccaaac caagaagaaa
     4381 tctctgaatt gccagaaaaa gaattcagaa agttgagtat taagctaatc aaggaggtgc
     4441 ccgagaaagg tgaagttcaa cttaaattaa aaaaaaaaaa agtaagggtg gagaccaccc
     4501 ctcatattgt cttatgccca atttctgcct ccaaagaaag aagtaaaaac taaaaggcag
     4561 aaatgaaatc taaaggcaga cagcctgtca ccacgccctg ggcctggtag ttaaagatcg
     4621 acccctgacc taactggtta tgttatctat agattacaga cattgtatgg aaaagcattg
     4681 taaaaatccc tgtcctgttc tgttttgttc tgattactgg tgcatgcagc ccccagtcac
     4741 gtaccccctg cttgctcaat tgatcatgac tctctcacgc agaccccctt agagttgtga
     4801 gcccttaaaa gggacaggaa ttgctcactg ggggagctca gctcttgaga caggagtctt
     4861 gccgatgctc ctggccaaat aaacccc
//
