LOCUS       NM_012353               3719 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily C member 1
            (OR1C1), mRNA.
ACCESSION   NM_012353 XM_291437
VERSION     NM_012353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   5  (bases 1 to 3719)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Specific repertoire of olfactory receptor genes in the male germ
            cells of several mammalian species
  JOURNAL   Genomics 39 (3), 239-246 (1997)
   PUBMED   9119360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450999.5 and AC118470.2.
            
            On Aug 3, 2020 this sequence version replaced NM_012353.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000641256.1/
                                                ENSP00000493457.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL450999.5         6408-6552           c
            146-2570            AL450999.5         1991-4415           c
            2571-3719           AC118470.2         57957-59105         c
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..3719
                     /gene="OR1C1"
                     /gene_synonym="HSTPCR27; OR1-42; OR1.5.10; ORL211; TPCR27"
                     /note="olfactory receptor family 1 subfamily C member 1"
                     /db_xref="GeneID:26188"
                     /db_xref="HGNC:HGNC:8182"
     exon            1..145
                     /gene="OR1C1"
                     /gene_synonym="HSTPCR27; OR1-42; OR1.5.10; ORL211; TPCR27"
                     /inference="alignment:Splign:2.1.0"
     exon            146..3719
                     /gene="OR1C1"
                     /gene_synonym="HSTPCR27; OR1-42; OR1.5.10; ORL211; TPCR27"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1103
                     /gene="OR1C1"
                     /gene_synonym="HSTPCR27; OR1-42; OR1.5.10; ORL211; TPCR27"
                     /note="olfactory receptor OR1-42; olfactory receptor
                     TPCR27"
                     /codon_start=1
                     /product="olfactory receptor 1C1"
                     /protein_id="NP_036485.2"
                     /db_xref="CCDS:CCDS41481.1"
                     /db_xref="GeneID:26188"
                     /db_xref="HGNC:HGNC:8182"
                     /translation="MEKRNLTVVREFVLLGLPSSAEQQHLLSVLFLCMYLATTLGNML
                     IIATIGFDSHLHSPMYFFLSNLAFVDICFTSTTVPQMVVNILTGTKTISFAGCLTQLF
                     FFVSFVNMDSLLLCVMAYDRYVAICHPLHYTARMNLCLCVQLVAGLWLVTYLHALLHT
                     VLIAQLSFCASNIIHHFFCDLNPLLQLSCSDVSFNVMIIFAVGGLLALTPLVCILVSY
                     GLIFSTVLKITSTQGKQRAVSTCSCHLSVVVLFYGTAIAVYFSPSSPHMPESDTLSTI
                     MYSMVAPMLNPFIYTLRNRDMKRGLQKMLLKCTVFQQQ"
ORIGIN      
        1 gaaagaaaca cacttgtcta tatctcattc ttctcttttt cactcttgac tagaaatctg
       61 aatcaatgca taggtccatc tatgcttttg tgattggata ttcaggaaag agaaaagtca
      121 taggtggcaa aggtctcaga aaaggatttg ttgggaatat ggaaaaaaga aatctaacag
      181 ttgtcaggga attcgtcctt ctgggacttc ctagctcagc agagcagcag cacctcctgt
      241 ctgtgctctt tctctgtatg tatttagcca ccaccttggg gaacatgctc atcattgcga
      301 cgattggctt tgactctcac ctccattccc ctatgtactt cttccttagt aacttggcct
      361 ttgttgacat ctgctttacg tcgactacag tcccccaaat ggtagtgaat atcttgactg
      421 gcaccaagac tatctctttt gcaggctgcc tcacccagct cttcttcttc gtttcttttg
      481 tgaatatgga cagcctcctt ctgtgtgtga tggcgtatga tagatatgtg gcgatttgcc
      541 accccttaca ttacaccgcc agaatgaacc tgtgcctttg tgtccagcta gtggctggac
      601 tgtggcttgt tacttacctc cacgccctcc tgcatactgt cctaatagca cagctgtcct
      661 tctgtgcctc caatatcatc catcatttct tctgtgatct caatcctctc ctgcagctct
      721 cttgctctga cgtctccttc aatgtaatga tcatttttgc agtaggaggt ctattggctc
      781 tcacgcccct tgtctgtatc ctcgtatctt atggacttat cttctccact gttctgaaga
      841 tcacctctac tcagggcaag cagagagctg tttccacctg cagctgccac ctgtcagtgg
      901 tggtgttgtt ttacggcaca gccatcgccg tctatttcag cccttcatcc ccccatatgc
      961 ctgagagcga cactctgtca accatcatgt attcaatggt ggctccgatg ctgaatcctt
     1021 tcatctatac cctaaggaac agggatatga agaggggact tcagaaaatg cttctcaagt
     1081 gcacagtctt tcagcagcaa taatgacctc agtgactgaa ttaaataata ctaatgtggt
     1141 gataagaaag tgtgactaga tgctcacaat aacagtgaga agagaaacca actgctatta
     1201 aatgtctccc ttatgctgga aatcgtgtta agcactttat atgaattatc acattaaatc
     1261 ctctgagtaa atatataaaa accatatagc attctttata cagaaagtga atcttaggga
     1321 agttaaatag tctgcataca acccatagct gataaatagt ttctgactcc agtacaaata
     1381 taccttagtg atgagaatct ctgtgatata gttcccaaat gctacatatt aagataaatt
     1441 ttcctaaact tcttgtctgt gagttcagat ttagaattaa aggggcataa attctaatgt
     1501 taattcgaca atgtggtaga acacatttta aatagtgagt cttcttaaaa atcactaaaa
     1561 taatttattc aagttttaaa gtatgtatgc tttcctccaa tcccctctca cttcaaatac
     1621 agtcaatgat tttattctat tgacacatgt ccttgtcatg tgtgtcccta actgatctca
     1681 ggcatggagg aactcagaat ctcccagcca tctttatagg gcagaggcta actgatctcc
     1741 cccaacaact aggagtgctt tgggtataca atatctttag agaagagatc aggttctcag
     1801 ctgcattttt catatgggga atacattaac ttctttcaaa acaaagcctc atgcccaatc
     1861 ccttgggttt tattttatct tgctttccta acaaaaaatt aacatactgt atgcaaaaat
     1921 aattatattt gaggtcattc aattaaatag actccattta agatattaac catccaatcc
     1981 aatctaattg tttattcaac ctattccggt tcctttctac aattttacat ctgagaatga
     2041 actaagatca tttctgcttg tccttttcta gaattaaaat gtctgctcac agacctctgt
     2101 aatttcttga acgaacacat gtataatatt taaaacctta taaacacaca cgtgcaccct
     2161 ttctcaagga agaccaaata catacataca taagaaaatt taaatccatt cagggaaaaa
     2221 aagtttcttc aaaaaagcaa caatgttgat atagatattt tagctcttct aacatgtata
     2281 cctaatttat aataccaaat agggtttaaa aaatacctat taggagctat gtttattaca
     2341 taggtgatga aataatatgt ataccaaact cctgtgacat gcaatttacc tgtgcaaatc
     2401 tgcacatgta cccctgaatc taaaataaca gtttaaaaat gtagattctc agaatataaa
     2461 taaataaata aaagcattgg tgaagtaaat tgtaacttca gttttaccca ataaaaatgg
     2521 gtaagacgtg tctgtagtta aaagattatg tcacaaaagt gaattcaatc cttcactaga
     2581 gtgtaggtgt agaaaactgt ttaagcttag aagtttcggt gcaggacact gctagggttt
     2641 agagaccatc catgttaggc tttcaaatat cccccaggcc agtttcaggt tgggcagcct
     2701 actaccccat gacatccaat attatattga catactgatt tcatttctct tggatgtata
     2761 cccaatagtg attgctggat cgtacagtag ttctattttt aattttttga gtaaacgtca
     2821 tactgttttc cataagggct atactaatct acattcccac cgatagtgaa gaaagattct
     2881 ttttcctcca taccctcatc aaactttttt atcttttgac ttttttcata gccactcaga
     2941 caagtgtgag gtgcatctca cggtggtttt aattggcatt tcccttatga ataacgattt
     3001 tgagcatttt ttcatatctg ttggcaattt gaatgtcttc ttgtgagaaa tgtctattca
     3061 agtactttgc tctttttaaa aattgtgtta tttggcagtt ttttgctact gagttatttg
     3121 aactccttat atactttgaa tattaactcc ttatcagatg tatgatttgc aaatattttc
     3181 tcccattttg taggtcatct cttcattctg ttggttgtta cctttgctgt aaaagacttt
     3241 tagtttaatt tactagcgct tgttaatttt agttttgtca attgtgggag tcatatctaa
     3301 aagattatca tgcataccaa tgtcatagag ctttccccct gtgctttctt ctattagttt
     3361 tatagtttct ggtcttctgt ttatgtgttt aatatatttt gtgttgattt ttgtatatgg
     3421 tgtcagataa gggtccaatt ccattcatct ccatatggat attcagttgt tctaaaacca
     3481 cttattgaag agatggtcca ttccatattg tgtgtcccta ccacctttgt caaagatcaa
     3541 ttgaccatga atgtatcaat ttatttctat gtgtctattt ttatgccagt accatgccat
     3601 ttttgattac tgtatctttt tattgcattt taaaatttaa ttggcataaa ataatcatac
     3661 acacttatgg agtacacagg gatgttttga taaatataat gtacaggtat cagatcaag
//
