LOCUS       NM_001004450            1941 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily B member 1
            (OR1B1), transcript variant 1, coding, mRNA.
ACCESSION   NM_001004450 XM_017014695 XM_294534
VERSION     NM_001004450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1941)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1941)
  AUTHORS   Koyano,S., Emi,M., Saito,T., Makino,N., Toriyama,S., Ishii,M.,
            Kubota,I., Kato,T. and Kawata,S.
  TITLE     Common null variant, Arg192Stop, in a G-protein coupled receptor,
            olfactory receptor 1B1, associated with decreased serum
            cholinesterase activity
  JOURNAL   Hepatol Res 38 (7), 696-703 (2008)
   PUBMED   18328065
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1941)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1941)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   5  (bases 1 to 1941)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162254.17.
            
            On Jul 21, 2022 this sequence version replaced NM_001004450.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Transcript Variant: This variant (1, coding) represents the
            protein-coding allele encoded by the GRCh38 reference genome.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000623530.2/
                                                ENSP00000485577.2
            polymorphic pseudogene           :: based on alignments, homology
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AL162254.17        76012-76107         c
            97-1941             AL162254.17        46605-48449         c
FEATURES             Location/Qualifiers
     source          1..1941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..1941
                     /gene="OR1B1"
                     /gene_synonym="OR9-26; OR9-B"
                     /note="olfactory receptor family 1 subfamily B member 1"
                     /db_xref="GeneID:347169"
                     /db_xref="HGNC:HGNC:8181"
     exon            1..96
                     /gene="OR1B1"
                     /gene_synonym="OR9-26; OR9-B"
                     /inference="alignment:Splign:2.1.0"
     exon            97..1941
                     /gene="OR1B1"
                     /gene_synonym="OR9-26; OR9-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..1487
                     /gene="OR1B1"
                     /gene_synonym="OR9-26; OR9-B"
                     /note="olfactory receptor OR9-26; olfactory receptor 9-B"
                     /codon_start=1
                     /product="olfactory receptor 1B1"
                     /protein_id="NP_001004450.2"
                     /db_xref="GeneID:347169"
                     /db_xref="HGNC:HGNC:8181"
                     /translation="MSFAPNASHSPVFLLLGFSRANISYTLLFFLFLAIYLTTILGNV
                     TLVLLISWDSRLHSPMYYLLRGLSVIDMGLSTVTLPQLLAHLVSHYPTIPAARCLAQF
                     FFFYAFGVTDTLVIAVMALDRYVAICDPLHYALVMNHQRCACLLALSWVVSILHTMLR
                     VGLVLPLCWTGDAGGNVNLPHFFCDHRPLLRASCSDIHSNELAIFFEGGFLMLGPCAL
                     IVLSYVRIGAAILRLPSAAGRRRAVSTCGSHLTMVGFLYGTIICVYFQPPFQNSQYQD
                     MVASVMYTAITPLANPFVYSLHNKDVKGALCRLLEWVKVDP"
ORIGIN      
        1 aggtctggag gtttgctatg tttttgtgtt ccgtgagtgc aaatatcaat ctgatctcaa
       61 gactactatt gctggtaaag cagaatggac attgcagttc agagagaaga catcatgagg
      121 attgcagttg ggtgaggtgt gaatggaagg taaggaactg gagacagtga atatagataa
      181 ttctttcatg aagtcggcca ctggaaaaag ataagaaata gttggatgaa aagacaagaa
      241 tgaatgaaga gtttttcact gtgggaggga ctttagtagg gcttgtgaat tagatggaac
      301 aagtcactag ggtgggtgaa aaggaagaaa taaaggagaa aataaataca tattaaggaa
      361 gcgaaatcct agaccttagg gagggagagt agatggtcaa gttcgaatct aggtctttaa
      421 cgatctttag taacgtaata taattaacta gaaatgctat gatccctaac atcagaccca
      481 tgactttctt tttgacttaa actgtctttc aggcaggctg actgtcactc atgatgagct
      541 ttgcccctaa tgcttcacac tctccggttt ttttgctcct tgggttctcg agagctaaca
      601 tctcctacac tctcctcttc ttcctgttcc tggctattta cctgaccacc atactgggga
      661 atgtgacact ggtgctgctc atctcctggg actccagact gcactcaccc atgtattatc
      721 tgcttcgtgg cctctctgtg atagacatgg ggctatccac agttacactg ccccagttgc
      781 tggcccattt ggtctctcat tacccaacca ttcctgctgc ccgctgcttg gctcagttct
      841 ttttcttcta tgcatttggg gttacagata cacttgtcat tgctgtcatg gctctggatc
      901 gctatgtggc catctgtgac cccctgcact atgctttggt aatgaatcac caacggtgtg
      961 cctgcttact agccttgagc tgggtggtgt ccatactgca caccatgttg cgtgtgggac
     1021 tcgtcctgcc tctttgctgg actggggatg ctgggggcaa cgttaacctt cctcacttct
     1081 tttgtgacca ccggccactt ctgcgagcct cttgttctga catacattct aatgagctgg
     1141 ccatattctt tgagggtggc ttccttatgc tgggcccctg tgccctcatt gtactctctt
     1201 atgtccgaat tggggccgct attctacgtt tgccttcagc tgctggtcgc cgccgagcag
     1261 tctccacctg tggatcccac ctcaccatgg ttggtttcct ctacggcacc atcatttgtg
     1321 tctacttcca gcctcccttc cagaactctc agtatcagga catggtggct tcagtaatgt
     1381 atactgccat tacacctttg gccaacccat ttgtgtatag cctccacaat aaggatgtca
     1441 agggtgcact ctgcaggctg cttgaatggg tgaaggtaga cccctgatta gcctgctgtg
     1501 ggccatattg aataggtgag aaaagtcatg ggcatattct gagcagagtt ggttttgggg
     1561 agatcagagg ggtggagggc ctagataact taaggaactc cagatttggc tcttgtcaat
     1621 gttgtgcttt gatggagcca tgaacattcc acattcatag acacataaga tcagggctcc
     1681 cttatcagca tacctctggg caccctccat caggcctttt attttatcaa agtggatgaa
     1741 aaagaattac caagtctggg tagttttaat tttagagttc tgagggaata tgaggatagg
     1801 attgtgaaac tatgaactaa acgaagagca gtagagttaa tcatcatcat cacatttagg
     1861 ttggtgtgtg ttcttgtggg agtgtgtttg tgtatatcag aaagtaaggg aagatgacag
     1921 tttagacaaa tagggctaag t
//
