LOCUS       NM_012352                930 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily A member 2
            (OR1A2), mRNA.
ACCESSION   NM_012352
VERSION     NM_012352.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Schmiedeberg,K., Shirokova,E., Weber,H.P., Schilling,B.,
            Meyerhof,W. and Krautwurst,D.
  TITLE     Structural determinants of odorant recognition by the human
            olfactory receptors OR1A1 and OR1A2
  JOURNAL   J Struct Biol 159 (3), 400-412 (2007)
   PUBMED   17601748
  REMARK    GeneRIF: Evolutionary conserved amino acid residues to be necessary
            for specific responsiveness of OR1A1 to odorants were identified.
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Glusman,G., Sosinsky,A., Ben-Asher,E., Avidan,N., Sonkin,D.,
            Bahar,A., Rosenthal,A., Clifton,S., Roe,B., Ferraz,C., Demaille,J.
            and Lancet,D.
  TITLE     Sequence, structure, and evolution of a complete human olfactory
            receptor gene cluster
  JOURNAL   Genomics 63 (2), 227-245 (2000)
   PUBMED   10673334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090282.6.
            
            On Nov 17, 2020 this sequence version replaced NM_012352.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC106733.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381951.1/ ENSP00000371377.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               AC090282.6         93775-94704
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..930
                     /gene="OR1A2"
                     /gene_synonym="OR17-6"
                     /note="olfactory receptor family 1 subfamily A member 2"
                     /db_xref="GeneID:26189"
                     /db_xref="HGNC:HGNC:8180"
                     /db_xref="MIM:618047"
     CDS             1..930
                     /gene="OR1A2"
                     /gene_synonym="OR17-6"
                     /note="olfactory receptor OR17-10; olfactory receptor
                     17-6"
                     /codon_start=1
                     /product="olfactory receptor 1A2"
                     /protein_id="NP_036484.1"
                     /db_xref="CCDS:CCDS11021.1"
                     /db_xref="GeneID:26189"
                     /db_xref="HGNC:HGNC:8180"
                     /db_xref="MIM:618047"
                     /translation="MKKENQSFNLDFILLGVTSQQEQNNVFFVIFLCIYPITLTGNLL
                     IILAICADIRLHNPMYFLLANLSLVDIIFSSVTIPKVLANHLLGSKFISFGGCLMQMY
                     FMIALAKADSYTLAAMAYDRAVAISCPLHYTTIMSPRSCILLIAGSWVIGNTSALPHT
                     LLTASLSFCGNQEVANFYCDIMPLLKLSCSDVHFNVKMMYLGVGVFSLPLLCIIVSYV
                     QVFSTVFQVPSTKSLFKAFCTCGSHLTVVFLYYGTTMGMYFRPLTSYSPKDAVITVMY
                     VAVTPALNPFIYSLRNWDMKAALQKLFSKRISS"
     exon            1..930
                     /gene="OR1A2"
                     /gene_synonym="OR17-6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagaaag aaaatcaatc ctttaacctg gattttattc tcctgggagt tactagtcag
       61 caagaacaga ataatgtctt ctttgtgatt tttttgtgca tttaccccat cacactgact
      121 ggaaatctgc tcatcatctt ggccatctgt gctgacattc gccttcacaa ccccatgtat
      181 tttctccttg ccaacctctc cttggttgac atcatcttct catccgtaac catccctaag
      241 gtgctggcca accatctctt ggggagcaag ttcatctcct ttgggggatg cctaatgcag
      301 atgtatttca tgatagcctt ggccaaggca gacagctata ccttggctgc aatggcatac
      361 gatcgagctg tggccatcag ctgcccactt cattacacaa caattatgag tccacggtct
      421 tgtatcctgc ttattgctgg gtcttgggtg attggaaaca ccagtgctct cccccacact
      481 ctgctcacag ctagtttgtc cttctgtggc aaccaggaag tagccaattt ctactgtgac
      541 attatgcctt tgctgaagtt gtcctgttct gacgtccact ttaatgtgaa gatgatgtac
      601 ctaggggtcg gcgttttctc tttgccatta ctatgcatca ttgtctccta tgttcaggtc
      661 ttttccacag tcttccaagt tccatctacc aagagtctat tcaaagcctt ctgcacctgt
      721 ggctcccacc tcacagttgt ttttttatat tatggtacaa cgatgggcat gtatttccgc
      781 cctctgacca gttacagccc caaagatgca gtgataactg tgatgtatgt ggcagtgacc
      841 ccagcattaa atcctttcat ctatagtctg agaaattggg atatgaaggc agccctacag
      901 aaactcttca gcaagagaat ctcctcatag
//
