LOCUS       NM_014565               4166 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 1 subfamily A member 1
            (OR1A1), transcript variant 1, mRNA.
ACCESSION   NM_014565
VERSION     NM_014565.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4166)
  AUTHORS   Shim,T., Pacalon,J., Kim,W.C., Cong,X., Topin,J., Golebiowski,J.
            and Moon,C.
  TITLE     The Third Extracellular Loop of Mammalian Odorant Receptors Is
            Involved in Ligand Binding
  JOURNAL   Int J Mol Sci 23 (20), 12501 (2022)
   PUBMED   36293357
  REMARK    GeneRIF: The Third Extracellular Loop of Mammalian Odorant
            Receptors Is Involved in Ligand Binding.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4166)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4166)
  AUTHORS   Ahmed,L., Zhang,Y., Block,E., Buehl,M., Corr,M.J., Cormanich,R.A.,
            Gundala,S., Matsunami,H., O'Hagan,D., Ozbil,M., Pan,Y.,
            Sekharan,S., Ten,N., Wang,M., Yang,M., Zhang,Q., Zhang,R.,
            Batista,V.S. and Zhuang,H.
  TITLE     Molecular mechanism of activation of human musk receptors OR5AN1
            and OR1A1 by (R)-muscone and diverse other musk-smelling compounds
  JOURNAL   Proc Natl Acad Sci U S A 115 (17), E3950-E3958 (2018)
   PUBMED   29632183
  REMARK    GeneRIF: Molecular mechanism of activation of human musk receptors
            OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling
            compounds.
REFERENCE   4  (bases 1 to 4166)
  AUTHORS   Wu,C., Jia,Y., Lee,J.H., Kim,Y., Sekharan,S., Batista,V.S. and
            Lee,S.J.
  TITLE     Activation of OR1A1 suppresses PPAR-gamma expression by inducing
            HES-1 in cultured hepatocytes
  JOURNAL   Int J Biochem Cell Biol 64, 75-80 (2015)
   PUBMED   25817041
  REMARK    GeneRIF: OR1A1 activation suppresses hepatic triglyceride
            metabolism by modulating HES-1, PPARG, and mtGPAT expression.
REFERENCE   5  (bases 1 to 4166)
  AUTHORS   Schmiedeberg,K., Shirokova,E., Weber,H.P., Schilling,B.,
            Meyerhof,W. and Krautwurst,D.
  TITLE     Structural determinants of odorant recognition by the human
            olfactory receptors OR1A1 and OR1A2
  JOURNAL   J Struct Biol 159 (3), 400-412 (2007)
   PUBMED   17601748
  REMARK    GeneRIF: Evolutionary conserved amino acid residues to be necessary
            for specific responsiveness of OR1A1 to odorants were identified.
REFERENCE   6  (bases 1 to 4166)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   7  (bases 1 to 4166)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   8  (bases 1 to 4166)
  AUTHORS   Glusman,G., Sosinsky,A., Ben-Asher,E., Avidan,N., Sonkin,D.,
            Bahar,A., Rosenthal,A., Clifton,S., Roe,B., Ferraz,C., Demaille,J.
            and Lancet,D.
  TITLE     Sequence, structure, and evolution of a complete human olfactory
            receptor gene cluster
  JOURNAL   Genomics 63 (2), 227-245 (2000)
   PUBMED   10673334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090282.6.
            
            On Aug 7, 2020 this sequence version replaced NM_014565.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641732.2/ ENSP00000493179.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               AC090282.6         103923-104256
            335-752             AC090282.6         104837-105254
            753-885             AC090282.6         108723-108855
            886-4166            AC090282.6         111872-115152
FEATURES             Location/Qualifiers
     source          1..4166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4166
                     /gene="OR1A1"
                     /gene_synonym="OR17-7"
                     /note="olfactory receptor family 1 subfamily A member 1"
                     /db_xref="GeneID:8383"
                     /db_xref="HGNC:HGNC:8179"
                     /db_xref="MIM:618046"
     exon            1..334
                     /gene="OR1A1"
                     /gene_synonym="OR17-7"
                     /inference="alignment:Splign:2.1.0"
     exon            335..752
                     /gene="OR1A1"
                     /gene_synonym="OR17-7"
                     /inference="alignment:Splign:2.1.0"
     exon            753..885
                     /gene="OR1A1"
                     /gene_synonym="OR17-7"
                     /inference="alignment:Splign:2.1.0"
     exon            886..4166
                     /gene="OR1A1"
                     /gene_synonym="OR17-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             891..1820
                     /gene="OR1A1"
                     /gene_synonym="OR17-7"
                     /note="olfactory receptor OR17-11; olfactory receptor
                     17-7"
                     /codon_start=1
                     /product="olfactory receptor 1A1"
                     /protein_id="NP_055380.2"
                     /db_xref="CCDS:CCDS11022.1"
                     /db_xref="GeneID:8383"
                     /db_xref="HGNC:HGNC:8179"
                     /db_xref="MIM:618046"
                     /translation="MRENNQSSTLEFILLGVTGQQEQEDFFYILFLFIYPITLIGNLL
                     IVLAICSDVRLHNPMYFLLANLSLVDIFFSSVTIPKMLANHLLGSKSISFGGCLTQMY
                     FMIALGNTDSYILAAMAYDRAVAISRPLHYTTIMSPRSCIWLIAGSWVIGNANALPHT
                     LLTASLSFCGNQEVANFYCDITPLLKLSCSDIHFHVKMMYLGVGIFSVPLLCIIVSYI
                     RVFSTVFQVPSTKGVLKAFSTCGSHLTVVSLYYGTVMGTYFRPLTNYSLKDAVITVMY
                     TAVTPMLNPFIYSLRNRDMKAALRKLFNKRISS"
ORIGIN      
        1 ctcttgtccc ttcggctccc ctgttgggaa actggggact cctccttcta aaccatccca
       61 ttcctgtgtc ctccacctca ggaacagagg attgttcccc atcctgccac tgcttctcca
      121 gcatggctgc cctcaaacgg gatgctagca ggtgctagat gaactaactg caaacttcct
      181 ttctgtggag gagaagtgaa ggccacaggg ccaggaccct ttttaaaagc atctgaactg
      241 actccacaga tagggactta gacattggaa gagactgtat cacagcaaca tcaaagggta
      301 gacagccagc aactgtaggc tacttgccca agagaattgt tctcagcacc accccattca
      361 catggctgat atctcagagg atgacgcttt ccaggaaagt gggtattaaa ggcgccgcaa
      421 tgttcaaggc cctgacgtca tcccagtgaa ctcaaggccc gctacgtctc cagcatgcat
      481 gttgaggcac ctcctggctt ctcttcttgg tggtagaggg tctttttacc tctttcccct
      541 agtctgatat atggcccctg ggtccctctt ccagtataaa taaacctcca tttattctca
      601 acctctttac aaggaacatt ctatctccta ccttaaatga aacatgaact tgagccaccc
      661 agctccatcg ctgtcctctg gaccaaatca tcacagaaca tgtgaaataa caacagaagc
      721 tcatcatcta gattatacaa atggaacatt agcaatggga actgtcaaca tcaacttagt
      781 ctgccatgat gccaagagct ccacctctga actcacatat ccgtaccata tgagctaacc
      841 atgctctctg cctctccaga tttactgaac gatttgacac ctgagaagcc atgagggaaa
      901 ataaccagtc ctctacactg gaattcatcc tcctgggagt tactggtcag caggaacagg
      961 aagatttctt ctacatcctc ttcttgttca tttaccccat cacattgatt ggaaacctgc
     1021 tcatcgtcct agccatttgc tctgatgttc gccttcacaa ccccatgtat tttctccttg
     1081 ccaacctctc cttggttgac atcttcttct catcggtaac catccctaag atgctggcca
     1141 accatctctt gggcagcaaa tccatctctt ttgggggatg cctaacgcag atgtatttca
     1201 tgatagcctt gggtaacaca gacagctata ttttggctgc aatggcatat gatcgagctg
     1261 tggccatcag ccgcccactt cactacacaa caattatgag tccacggtct tgtatctggc
     1321 ttattgctgg gtcttgggtg attggaaatg ccaatgccct cccccacact ctgctcacag
     1381 ctagtctgtc cttctgtggc aaccaggaag tggccaactt ctactgtgac attaccccct
     1441 tgctgaagtt atcctgttct gacatccact ttcatgtgaa gatgatgtac ctaggggttg
     1501 gcattttctc tgtgccatta ctatgcatca ttgtctccta tattcgagtc ttctccacag
     1561 tcttccaggt tccttccacc aagggcgtgc tcaaggcctt ctccacctgt ggttcccacc
     1621 tcacggttgt ctctttgtat tatggtacag tcatgggcac gtatttccgc cctttgacca
     1681 attatagcct aaaagacgca gtgatcactg taatgtacac ggcagtgacc ccaatgttaa
     1741 atcctttcat ctacagtctg agaaatcggg acatgaaggc tgccctgcgg aaactcttca
     1801 acaagagaat ctcctcgtaa ccaatgtgag ggcctacatt ggataccgta gtcaccagtt
     1861 acggtatatt ggaaatccag ttctgatgtc atcctcctac gagaggcagt ctctgatctt
     1921 tctagcctga aattcctaat ctcagaactc ttataacatt ttaataagtt aataataagt
     1981 gattattgaa attaccactt tcaactcatt gctgctcttt ttggcagagt ggcagcacag
     2041 ggatataggg catatgtcct gatgagcaga gtcaagttgg gaagatctga gcctcagctt
     2101 tcacatctac atgttaggaa taataagtgc cctacatggg tcacatggtg tgttgattac
     2161 aatagctcat gcttccaaga ttataaatca ctattcatgt gtccattttt atttgactgt
     2221 taagtttaat cacccttatt aggcttgcaa gcctctgagg gcaggagttg tttttacaca
     2281 tcactgtacc ttcccaatct tggtcagata aagtgcatcc aataaatact ggtggaagtg
     2341 gaatgaataa gatattaata tctgaaacgt aatattataa ttagggataa tcaaaccaga
     2401 cattattttc tcatccttta aacctttcaa gaaactccca ttcacaaatg ctacaaaggg
     2461 aataaaatac ctaggaatac agcttacaag ggacatgaag gaactcttca aggaaaacta
     2521 aaacccactg ctcaaggaaa taagagagga caaaaacaaa tggaaaaaca ttccatcctc
     2581 ttttatacaa agaatcaata tcatgaaaat ggccatactg cccaaagtaa tttatagatt
     2641 caatgctatt cccatcaaac taccattgac attcttcaca gaattagaaa acacttcttt
     2701 aaatttcgta tggaactaaa aaagagcccg tatatccaag acaatcataa gcaaaaagaa
     2761 caaagctaca ggcatcatgc tacttgactt caaactatac tacaaggcta cagtaaccaa
     2821 aacagcatgg tactggtacc aaaacagaca tgtagcccag tggaacagaa cagagacctc
     2881 acaaataaca ccacacatct acaaccatct gatctttgac aaacctgaca aaaacaagaa
     2941 atggggaaag gattccctat ttaataaatg gtgttgggaa aactggctag ccatatgcag
     3001 aaaaatgaaa ctggacccct ttcttacatc ttatacaaaa attaactcaa gatggattaa
     3061 aggcttaaac gtaagaccta aaaccataaa aaccttagaa gaaaacgtag gcaataccat
     3121 tcaggacata ggcatgggca aacttcatgt ttaaaacacc aaaagcaatg gcaacaaaag
     3181 ccaaaattga caaatgggat ctaattaaac taaagagctt ctgcacagca aaagaaacta
     3241 tcatcagagt gaacaggcaa cctacagaat gggagaaaat ttttgccatc tatccatctg
     3301 acaaagggct aatatctaga atctacaaag aacttaaatt tacaggaaaa aaaccacccc
     3361 atgaaaaagt gggcgaagga tatgaacaga cacttctcaa aagaagacat ttatgcagcc
     3421 aataaacata tgaaaaaaag ctcaacatca ctggtcgtta gagaaatgca aatcaaaacc
     3481 acaatgagac accatctcat gccagttgga atggcgatca ttaaaaagta aggaaacaac
     3541 atatgctgga gaggatgtgg agaaatagga aggtttttac actgttggtg ggagtgtaaa
     3601 ttagttcaac tatcatggaa gacagtgtgg tgactcctca aggatctaga accacaaata
     3661 ccatttgatc cagtgatccc attactgggt atatacctaa aggattataa atcattctac
     3721 tataaagaca catgcacaag tatatttatt gtggcactgt tcacagtagc aaagacttgg
     3781 aaccaaccca aatgcccatc aatgatagac tggatgaaga aaatgtggca catatacacc
     3841 atggaatact acgcagtcat aaaaaaggat gagttcatgt cctttgcagg gacatggatc
     3901 aagctggaaa ccatcattct cagcaaacta acacaagaaa agaaaaccaa acactgcacg
     3961 ttctcactca taagtgtgag ttaaacaatg agaacacatg gacacaagga agggcacatc
     4021 acacaccagg gcctgtcagc gggttggggg caagaggagg gatagcatta ggagaaatac
     4081 ctaatgcaga tgtcaggctg atggatgcag caaaccacca tggcacgtgt atacctatgt
     4141 aacaaacctg catgttctgc acatgt
//
