LOCUS       NM_001355292            1791 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 14 subfamily A member 2
            (OR14A2), mRNA.
ACCESSION   NM_001355292
VERSION     NM_001355292.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118470.2.
            
            On Jul 14, 2022 this sequence version replaced NM_001355292.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            CDS exon combination :: AA954584.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366485.2/ ENSP00000355441.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AC118470.2         50982-51252         c
            272-344             AC118470.2         38595-38667         c
            345-584             AC118470.2         37297-37536         c
            585-685             AC118470.2         36394-36494         c
            686-1791            AC118470.2         26068-27173         c
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1791
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /note="olfactory receptor family 14 subfamily A member 2"
                     /db_xref="GeneID:388761"
                     /db_xref="HGNC:HGNC:15024"
     exon            1..271
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /inference="alignment:Splign:2.1.0"
     exon            272..344
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /inference="alignment:Splign:2.1.0"
     exon            345..584
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /inference="alignment:Splign:2.1.0"
     exon            585..685
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1791
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /inference="alignment:Splign:2.1.0"
     CDS             705..1649
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /note="olfactory receptor, family 5, subfamily AX, member
                     1 pseudogene; olfactory receptor 5AX1; olfactory receptor
                     OR1-31"
                     /codon_start=1
                     /product="olfactory receptor 14A2"
                     /protein_id="NP_001342221.1"
                     /db_xref="CCDS:CCDS86063.1"
                     /db_xref="GeneID:388761"
                     /db_xref="HGNC:HGNC:15024"
                     /translation="MANVTLVTGFLLMGFSNIQKLRILYGVLFLLIYLAALMSNLLII
                     TLITLDVKLQTPMYFFLKNLSFLDVFLVSVPIPKFIVNNLTHNNSISILGCAFQLLLM
                     TSFSAGEIFILTAMSYDRYVAICCPLNYEVIMNTGVCVLMASVSWAIGGLFGTAYTAG
                     TFSMPFCGSSVIPQFFCDVPSLLRISCSETLMVIYAGIGVGACLSISCFICIVISYIY
                     IFSTVLKIPTTKGQSKAFSTCFPHLTVFTVFIITAYFVYLKPPSNSPSVIDRLLSVIY
                     TVMPPVFNPVTYSLRNNDMKCALIRLLQKTYGQEAYFI"
     regulatory      1771..1776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /note="hexamer: AATAAA"
     polyA_site      1791
                     /gene="OR14A2"
                     /gene_synonym="OR5AX1; OR5AX1P"
                     /note="major polyA site"
ORIGIN      
        1 aattagaaat atcagttata ttactcaggt tttgaatgga atgtcatatt tgaaaatgac
       61 attcatagaa tcagatatga tcagacagtt ttaaggaact atgctgactt tatgaggtca
      121 aggcttacaa aatcctcttg aaaaaattag cctggtacct ggcttatagc atgcttagcc
      181 ttacagtgag tatagaaggt cactttccgg tactctcagg aaccatagga tattttggag
      241 acctcaagaa gagaggcagt cattcaattc tgttttaagc cctggagacc cagctcttca
      301 ctctcacctc agatctgaga cgtgatgcca caccttttcc tccagctgcc atgacaaaat
      361 actacagatg gggtagctta aacacgtcgt ctgtgagtgg gtgtttctca cgattctgga
      421 ggctgcacat ctgagatcaa gacgtcagct gccttggttt cctctgaatc ttctcctcgg
      481 gctgcagatg gacactgtct tgctgcctct tcctctggtc gtctctgtgc atgcgtgccc
      541 ccagggtctc tgcgtgccct aatccctgtt ctaataaggc atcaatgcct tttatcagtt
      601 taagaggtta ccttcaatac caggttactg aggatttttg tcacaaattt cttcaaatct
      661 ttcaaatcag ttttctgata atgaggcact gaagagaatc tagtatggcc aatgtcacct
      721 tggtgacagg atttcttctt atggggtttt ctaatatcca gaagctgcgg attttatatg
      781 gtgtgctctt cctactgatt tacctggcag ccctaatgag taaccttctc atcattactc
      841 tcattaccct ggacgtaaag ctccaaacac ccatgtactt cttcctgaag aacttatcct
      901 ttttggatgt cttcctggtg tctgttccaa tcccaaaatt cattgtcaac aacctaaccc
      961 acaacaattc catttccatt ctaggatgtg ccttccagct acttttaatg acttccttct
     1021 cagcaggaga gatatttatc ctcactgcca tgtcctatga ccgctatgta gccatctgct
     1081 gtcccctgaa ctacgaggta atcatgaata ctggagtctg tgtgttaatg gcaagtgttt
     1141 cctgggccat tggagggctc tttggtactg cgtacacagc tggcacattt tccatgcctt
     1201 tctgtggctc cagtgtgatt ccacagtttt tctgtgatgt tccttcatta ctaaggattt
     1261 cctgttctga aacactaatg gtaatttatg caggtattgg agttggtgca tgtttaagca
     1321 tttcttgttt catctgtatt gtgatctctt acatttatat cttctccact gtactgaaga
     1381 tccctaccac taaaggtcag tccaaagctt tttccacatg cttcccccat ctcactgttt
     1441 tcactgtttt tatcataact gcttattttg tttatcttaa gccaccttca aattcaccat
     1501 ctgttattga caggctgctt tctgtgatct acactgtgat gcctccagta tttaaccctg
     1561 taacctacag cctgcggaac aatgacatga aatgtgctct gataaggttg ctgcagaaaa
     1621 catatggtca ggaggcttac ttcatttaac actttcaagt tctgtcagtg atacagtgcc
     1681 ttacagatca caagaaactt tccttatttg taactttgga aagacctgag aaaagaaagc
     1741 aatatactca aattattttt tccctgaaga aataaatact caagagccta a
//
