LOCUS       NM_030959               1869 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 12 subfamily D member 3
            (OR12D3), mRNA.
ACCESSION   NM_030959
VERSION     NM_030959.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1869)
  AUTHORS   St Pourcain,B., Whitehouse,A.J., Ang,W.Q., Warrington,N.M.,
            Glessner,J.T., Wang,K., Timpson,N.J., Evans,D.M., Kemp,J.P.,
            Ring,S.M., McArdle,W.L., Golding,J., Hakonarson,H., Pennell,C.E.
            and Smith,G.D.
  TITLE     Common variation contributes to the genetic architecture of social
            communication traits
  JOURNAL   Mol Autism 4 (1), 34 (2013)
   PUBMED   24047820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1869)
  AUTHORS   Jensen,R.A., Sim,X., Li,X., Cotch,M.F., Ikram,M.K., Holliday,E.G.,
            Eiriksdottir,G., Harris,T.B., Jonasson,F., Klein,B.E., Launer,L.J.,
            Smith,A.V., Boerwinkle,E., Cheung,N., Hewitt,A.W., Liew,G.,
            Mitchell,P., Wang,J.J., Attia,J., Scott,R., Glazer,N.L., Lumley,T.,
            McKnight,B., Psaty,B.M., Taylor,K., Hofman,A., de Jong,P.T.,
            Rivadeneira,F., Uitterlinden,A.G., Tay,W.T., Teo,Y.Y.,
            Seielstad,M., Liu,J., Cheng,C.Y., Saw,S.M., Aung,T., Ganesh,S.K.,
            O'Donnell,C.J., Nalls,M.A., Wiggins,K.L., Kuo,J.Z., van Duijn,C.M.,
            Gudnason,V., Klein,R., Siscovick,D.S., Rotter,J.I., Tai,E.S.,
            Vingerling,J. and Wong,T.Y.
  CONSRTM   Blue Mountains Eye Study GWAS Team; CKDGen Consortium
  TITLE     Genome-wide association study of retinopathy in individuals without
            diabetes
  JOURNAL   PLoS One 8 (2), e54232 (2013)
   PUBMED   23393555
REFERENCE   3  (bases 1 to 1869)
  AUTHORS   McElroy,J.P., Cree,B.A., Caillier,S.J., Gregersen,P.K., Herbert,J.,
            Khan,O.A., Freudenberg,J., Lee,A., Bridges,S.L. Jr., Hauser,S.L.,
            Oksenberg,J.R. and Gourraud,P.A.
  TITLE     Refining the association of MHC with multiple sclerosis in African
            Americans
  JOURNAL   Hum Mol Genet 19 (15), 3080-3088 (2010)
   PUBMED   20466734
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1869)
  AUTHORS   Pelak,K., Goldstein,D.B., Walley,N.M., Fellay,J., Ge,D.,
            Shianna,K.V., Gumbs,C., Gao,X., Maia,J.M., Cronin,K.D.,
            Hussain,S.K., Carrington,M., Michael,N.L. and Weintrob,A.C.
  CONSRTM   Infectious Disease Clinical Research Program HIV Working Group;
            National Institute of Allergy and Infectious Diseases Center for
            HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Host determinants of HIV-1 control in African Americans
  JOURNAL   J Infect Dis 201 (8), 1141-1149 (2010)
   PUBMED   20205591
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[J Infect Dis. 2010 Aug 15;202(3):501]
REFERENCE   5  (bases 1 to 1869)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1869)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   7  (bases 1 to 1869)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1869)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL662781.4.
            
            On May 17, 2019 this sequence version replaced NM_030959.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ459858.1, BC103892.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396806.3/ ENSP00000380023.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1869              AL662781.4         87320-89188         c
FEATURES             Location/Qualifiers
     source          1..1869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1869
                     /gene="OR12D3"
                     /gene_synonym="hs6M1-27"
                     /note="olfactory receptor family 12 subfamily D member 3"
                     /db_xref="GeneID:81797"
                     /db_xref="HGNC:HGNC:13963"
     exon            1..1869
                     /gene="OR12D3"
                     /gene_synonym="hs6M1-27"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..955
                     /gene="OR12D3"
                     /gene_synonym="hs6M1-27"
                     /note="olfactory receptor OR6-27"
                     /codon_start=1
                     /product="olfactory receptor 12D3"
                     /protein_id="NP_112221.1"
                     /db_xref="CCDS:CCDS4658.1"
                     /db_xref="GeneID:81797"
                     /db_xref="HGNC:HGNC:13963"
                     /translation="MENVTTMNEFLLLGLTGVQELQPFFFGIFLIIYLINLIGNGSIL
                     VMVVLEPQLHSPMYFFLGNLSCLDISYSSVTLPKLLVNLVCSRRAISFLGCITQLHFF
                     HFLGSTEAILLAIMAFDRFVAICNPLRYTVIMNPQVCILLAAAAWLISFFYALMHSVM
                     TAHLSFCGSQKLNHFFYDVKPLLELACSDTLLNQWLLSIVTGSISMGAFFLTLLSCFY
                     VIGFLLFKNRSCRILHKALSTCASHFMVVCLFYGPVGFTYIRPASATSMIQDRIMAIM
                     YSAVTPVLNPLIYTLRNKEVMMALKKIFGRKLFKDWQQHH"
ORIGIN      
        1 agcaatggag aatgtcacta caatgaatga gtttcttcta cttggcctga ctggtgttca
       61 ggagctgcag cctttcttct ttgggatttt cttaatcatt tacctgataa acttgattgg
      121 aaatggatct atattggtga tggttgtttt ggaaccacaa ctccactccc ctatgtattt
      181 ttttctggga aacctttctt gtctggatat ttcttattct tcagtgacac tgcccaagct
      241 gctcgtaaac ctcgtgtgca gtcgcagggc tatatctttt ctaggctgta tcacccagct
      301 acacttcttc cactttttgg gaagcacaga ggccatttta ctggctatca tggcctttga
      361 ccgttttgtt gccatctgca atcctcttcg ctacactgtc atcatgaacc cccaggtgtg
      421 tattctgttg gcagctgcgg cctggctcat cagcttcttt tacgctctga tgcattctgt
      481 catgactgca cacctgagtt tttgtggctc tcagaaactc aatcacttct tctacgatgt
      541 caagccgctc ttagaattgg cctgtagtga cacattactc aatcaatggc ttctttccat
      601 tgtcacaggc agcatatcca tgggagcttt ctttctgact cttctctcct gcttctatgt
      661 aattggcttc cttctgttta agaacaggtc ctgcagaata ctccacaagg ctctgtccac
      721 ttgtgcctcc cattttatgg tggtatgtct tttctatgga cctgtgggct tcacatatat
      781 tcgtcctgct tcagccacct ccatgattca ggaccggata atggccatca tgtatagcgc
      841 cgtcacccct gtactgaatc cactaatcta cacccttagg aacaaagaag tgatgatggc
      901 tctgaagaaa atctttggta ggaagttgtt taaagactgg cagcaacacc actaggacta
      961 atgagggata tctgatttct attaagactg atttccatca cttcactgta agaaatgatt
     1021 tgtttacctg gtttatattt ttctttcaaa aattttgagc acatattata ttaggcagtg
     1081 tagtaggttc aagaaacaca ggagcaagca aaacaaattc cataatgtca tcaaacataa
     1141 agtttaatgt gatggaggcc ccaaataacc aaacgcgtaa gtacatatgt caggataatt
     1201 cggtggcaag gagaactaag gaggtaggaa gtatggggag ggttagagta ggaatctgct
     1261 gtgtaaaaaa gaatgtggca tttctcctag gacaaaaacc tttggaattt tccaagtaat
     1321 agaagtatct tactgaaatt ccatatgaga taatctttat ttttgcctat tttttttcct
     1381 tttgtgtttc cttcagcagg aaagtactga tgataatttt tctcacaaca gtttttatct
     1441 agaatatcat ttttgttaat cttaattctt gaagagaatt tttaatgggt atttaatttt
     1501 agggagagat ttttctagcc attgaaaata tcttgttttt ccccagctta ttgaagtata
     1561 attaacaaat aaaaattgca tatatttagg cttcacaaca tgatgcttta gtatatgtat
     1621 acattgtgaa gagactacca caatcaagct aaacctacat tactgtccct gcattagttt
     1681 actgttgaat actagaagtt cttcattcta tctaactgca ttttcatacc cattaagcca
     1741 atgtgacaag ctctttgttt cagttggagt gtttgcacaa tttaaatttg ataaattttt
     1801 gatagaatta aatttaaatt tatcctccaa ctaaattttt gatagaatta aatttaaatt
     1861 tgtcctcca
//
