LOCUS       NM_013936               1496 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 12 subfamily D member 2
            (OR12D2), mRNA.
ACCESSION   NM_013936
VERSION     NM_013936.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Soler Artigas,M., Loth,D.W., Wain,L.V., Gharib,S.A., Obeidat,M.,
            Tang,W., Zhai,G., Zhao,J.H., Smith,A.V., Huffman,J.E., Albrecht,E.,
            Jackson,C.M., Evans,D.M., Cadby,G., Fornage,M., Manichaikul,A.,
            Lopez,L.M., Johnson,T., Aldrich,M.C., Aspelund,T., Barroso,I.,
            Campbell,H., Cassano,P.A., Couper,D.J., Eiriksdottir,G.,
            Franceschini,N., Garcia,M., Gieger,C., Gislason,G.K., Grkovic,I.,
            Hammond,C.J., Hancock,D.B., Harris,T.B., Ramasamy,A.,
            Heckbert,S.R., Heliovaara,M., Homuth,G., Hysi,P.G., James,A.L.,
            Jankovic,S., Joubert,B.R., Karrasch,S., Klopp,N., Koch,B.,
            Kritchevsky,S.B., Launer,L.J., Liu,Y., Loehr,L.R., Lohman,K.,
            Loos,R.J., Lumley,T., Al Balushi,K.A., Ang,W.Q., Barr,R.G.,
            Beilby,J., Blakey,J.D., Boban,M., Boraska,V., Brisman,J.,
            Britton,J.R., Brusselle,G.G., Cooper,C., Curjuric,I., Dahgam,S.,
            Deary,I.J., Ebrahim,S., Eijgelsheim,M., Francks,C., Gaysina,D.,
            Granell,R., Gu,X., Hankinson,J.L., Hardy,R., Harris,S.E.,
            Henderson,J., Henry,A., Hingorani,A.D., Hofman,A., Holt,P.G.,
            Hui,J., Hunter,M.L., Imboden,M., Jameson,K.A., Kerr,S.M.,
            Kolcic,I., Kronenberg,F., Liu,J.Z., Marchini,J., McKeever,T.,
            Morris,A.D., Olin,A.C., Porteous,D.J., Postma,D.S., Rich,S.S.,
            Ring,S.M., Rivadeneira,F., Rochat,T., Sayer,A.A., Sayers,I.,
            Sly,P.D., Smith,G.D., Sood,A., Starr,J.M., Uitterlinden,A.G.,
            Vonk,J.M., Wannamethee,S.G., Whincup,P.H., Wijmenga,C.,
            Williams,O.D., Wong,A., Mangino,M., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., North,K.E., Omenaas,E., Palmer,L.J.,
            Pietilainen,K.H., Pin,I., Pola Sbreve Ek,O., Pouta,A., Psaty,B.M.,
            Hartikainen,A.L., Rantanen,T., Ripatti,S., Rotter,J.I., Rudan,I.,
            Rudnicka,A.R., Schulz,H., Shin,S.Y., Spector,T.D., Surakka,I.,
            Vitart,V., Volzke,H., Wareham,N.J., Warrington,N.M., Wichmann,H.E.,
            Wild,S.H., Wilk,J.B., Wjst,M., Wright,A.F., Zgaga,L., Zemunik,T.,
            Pennell,C.E., Nyberg,F., Kuh,D., Holloway,J.W., Boezen,H.M.,
            Lawlor,D.A., Morris,R.W., Probst-Hensch,N., Kaprio,J., Wilson,J.F.,
            Hayward,C., Kahonen,M., Heinrich,J., Musk,A.W., Jarvis,D.L.,
            Glaser,S., Jarvelin,M.R., Ch Stricker,B.H., Elliott,P.,
            O'Connor,G.T., Strachan,D.P., London,S.J., Hall,I.P., Gudnason,V.
            and Tobin,M.D.
  CONSRTM   International Lung Cancer Consortium; GIANT consortium
  TITLE     Genome-wide association and large-scale follow up identifies 16 new
            loci influencing lung function
  JOURNAL   Nat Genet 43 (11), 1082-1090 (2011)
   PUBMED   21946350
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Thompson,E.E., Haller,G., Pinto,J.M., Sun,Y., Zelano,B., Jacob,S.,
            McClintock,M.K., Nicolae,D.L. and Ober,C.
  TITLE     Sequence variations at the human leukocyte antigen-linked olfactory
            receptor cluster do not influence female preferences for male odors
  JOURNAL   Hum Immunol 71 (1), 100-103 (2010)
   PUBMED   19833159
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Younger,R.M., Amadou,C., Bethel,G., Ehlers,A., Lindahl,K.F.,
            Forbes,S., Horton,R., Milne,S., Mungall,A.J., Trowsdale,J.,
            Volz,A., Ziegler,A. and Beck,S.
  TITLE     Characterization of clustered MHC-linked olfactory receptor genes
            in human and mouse
  JOURNAL   Genome Res 11 (4), 519-530 (2001)
   PUBMED   11282967
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645927.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 6, 2020 this sequence version replaced NM_013936.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be non-functional as an olfactory receptor
            according to the Classifier for Olfactory Receptor Pseudogenes.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000642051.1/
                                                ENSP00000493463.1
            polymorphic pseudogene           :: PMID: 22908908
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AL645927.3         4886-5070
            186-1496            AL645927.3         5953-7263
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1496
                     /gene="OR12D2"
                     /gene_synonym="DJ994E9.8; HS6M1-20"
                     /note="olfactory receptor family 12 subfamily D member 2"
                     /db_xref="GeneID:26529"
                     /db_xref="HGNC:HGNC:8178"
     exon            1..185
                     /gene="OR12D2"
                     /gene_synonym="DJ994E9.8; HS6M1-20"
                     /inference="alignment:Splign:2.1.0"
     exon            186..1496
                     /gene="OR12D2"
                     /gene_synonym="DJ994E9.8; HS6M1-20"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1111
                     /gene="OR12D2"
                     /gene_synonym="DJ994E9.8; HS6M1-20"
                     /note="olfactory receptor OR6-28"
                     /codon_start=1
                     /product="olfactory receptor 12D2"
                     /protein_id="NP_039224.2"
                     /db_xref="GeneID:26529"
                     /db_xref="HGNC:HGNC:8178"
                     /translation="MLNTTSVTEFLLLGVTDIQELQPFLFVVFLTIYFISVTGNGAVL
                     MIVISDPRLHSLMYFFLGNLSYLDICYSTVTLPKMLQNFLSTHKAISFLGCISQLHFF
                     HSLGSTESMLFAVMAFDLSVAICKPLRYTVIMNPQLCTQMAITIWVIGFFHALLHSVM
                     TSRLNFCGSNRIHHFLCDIKPLLKLACGNTELNQWLLSTVTGTIAMGPFFLTLLSYFY
                     IITYLFFKTRSCSMLCKALSTCASHFMVVILFYAPVLFTYIHPALESFMDQDRIVAIM
                     YTVVTPVLNPLIYTLRNKEVKGALGRVIRRL"
ORIGIN      
        1 agaagacaga actttcagtg gtctaaattc ttagatactt tagaagaaga cactattggg
       61 taaaatgaag gaagaattgt tgagtctatt ggaagagttt ttcttattca gagattcagg
      121 ggtgtgaaaa aggaaaaagt ctcagtgcaa ctggaaacta aaggaacaat aacatttgtc
      181 atcaatgatg ctgaatacaa cctcagtcac cgaatttctc ctcttgggag tgacagacat
      241 tcaagaactg cagccttttc tcttcgtggt tttcctcacc atctacttca tcagtgtgac
      301 tgggaatgga gccgttctga tgattgtcat ctccgatcct agactccatt cccttatgta
      361 tttcttcctg ggaaacctgt cctacctgga tatctgttac tctacggtga cactgccaaa
      421 aatgctgcag aactttctct ctacacacaa agcaatttct ttcttgggat gcataagcca
      481 gcttcatttc ttccactccc tgggcagcac ggagtccatg ttgttcgccg tgatggcatt
      541 tgacctctct gtggctatct gcaagccact tcgctacact gtcatcatga accctcagct
      601 ctgtacccag atggccatca caatctgggt cattggtttt ttccatgccc tgctgcactc
      661 cgtaatgact tctcgcttga acttctgtgg ttccaaccgt atccatcatt ttctctgtga
      721 tattaagcca ttgctaaagc tggcctgtgg gaacactgag cttaatcagt ggctactcag
      781 tactgtcacg gggacaattg ccatgggccc cttctttctg acacttctct cctatttcta
      841 cattatcact tatctcttct tcaagacccg ttcttgtagc atgctctgta aagcactgtc
      901 cacttgtgcc tcccacttca tggtagttat tcttttctat gcacctgttc ttttcaccta
      961 tatccatcct gcgttagaga gcttcatgga ccaggaccgg attgttgcca tcatgtacac
     1021 tgtggtcact cctgtactaa acccactgat ctatactttg aggaacaagg aagtgaaggg
     1081 ggccttgggt agagtgatca gaaggctttg atttgaataa accagagaac tctactgagg
     1141 cataaataac cagcaatgaa aaagtagaga tgtgtaattt tactgcttct cagatggttt
     1201 ataagtgtaa aatagaggca actggataaa agaaaaaaaa gtccaatcta gttgtagtaa
     1261 acaatacatt tctaagtaat atgaggaata cttgaaaatg caagacacta gccatggaac
     1321 cctaatgctg aaaatttttt ggaatatcag ttgatgtaat tgacttatta tgtattctaa
     1381 catgtacttg tatgcaattg catgtagaat tttgcctata ttgcccatgt attgtataga
     1441 tagatgatat ttaggactgt ttgtctgtga gatcctttta gtttaacaca ttttag
//
