LOCUS       NM_001004462            3301 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 10 subfamily G member 4
            (OR10G4), mRNA.
ACCESSION   NM_001004462 XM_372436
VERSION     NM_001004462.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Mainland,J.D., Keller,A., Li,Y.R., Zhou,T., Trimmer,C.,
            Snyder,L.L., Moberly,A.H., Adipietro,K.A., Liu,W.L., Zhuang,H.,
            Zhan,S., Lee,S.S., Lin,A. and Matsunami,H.
  TITLE     The missense of smell: functional variability in the human odorant
            receptor repertoire
  JOURNAL   Nat Neurosci 17 (1), 114-120 (2014)
   PUBMED   24316890
  REMARK    GeneRIF: This study verified that variations in OR10G4 genotype
            explain over 15% of the observed variation in perceived intensity
            and over 10% of the observed variation in perceived valence for the
            high-affinity in vitro agonist guaiacol.
REFERENCE   3  (bases 1 to 3301)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001884.4.
            
            On Jul 28, 2020 this sequence version replaced NM_001004462.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2163459
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641722.1/ ENSP00000493036.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AP001884.4         64743-64858
            117-3301            AP001884.4         67294-70478
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..3301
                     /gene="OR10G4"
                     /gene_synonym="OR11-278"
                     /note="olfactory receptor family 10 subfamily G member 4"
                     /db_xref="GeneID:390264"
                     /db_xref="HGNC:HGNC:14809"
     exon            1..116
                     /gene="OR10G4"
                     /gene_synonym="OR11-278"
                     /inference="alignment:Splign:2.1.0"
     exon            117..3301
                     /gene="OR10G4"
                     /gene_synonym="OR11-278"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1079
                     /gene="OR10G4"
                     /gene_synonym="OR11-278"
                     /note="olfactory receptor OR11-278"
                     /codon_start=1
                     /product="olfactory receptor 10G4"
                     /protein_id="NP_001004462.1"
                     /db_xref="CCDS:CCDS31702.1"
                     /db_xref="GeneID:390264"
                     /db_xref="HGNC:HGNC:14809"
                     /translation="MSNASLVTAFILTGLPHAPGLDALLFGIFLVVYVLTVLGNLLIL
                     LVIRVDSHLHTPMYYFLTNLSFIDMWFSTVTVPKMLMTLVSPSGRAISFHSCVAQLYF
                     FHFLGSTECFLYTVMSYDRYLAISYPLRYTSMMSGSRCALLATGTWLSGSLHSAVQTI
                     LTFHLPYCGPNQIQHYFCDAPPILKLACADTSANVMVIFVDIGIVASGCFVLIVLSYV
                     SIVCSILRIRTSDGRRRAFQTCASHCIVVLCFFVPCVVIYLRPGSMDAMDGVVAIFYT
                     VLTPLLNPVVYTLRNKEVKKAVLKLRDKVAHPQRK"
ORIGIN      
        1 ccggttgttt gagtgatatc ttgcaaacta gtgcctatac gtagtgggta gaaagtgaaa
       61 aattggggga aaaagttaga tgagttttac tactgagaag aatcacatac tgcaagaggg
      121 agagagacca agggtgagaa gaaatgtcca acgccagcct cgtgacagca ttcatcctca
      181 caggccttcc ccatgcccca gggctggacg ccctcctctt tggaatcttc ctggtggttt
      241 acgtgctcac tgtgctgggg aacctcctca tcctgctggt gatcagggtg gattctcacc
      301 tccacacccc catgtactac ttcctcacca acctgtcctt cattgacatg tggttctcca
      361 ctgtcacggt gcccaaaatg ctgatgacct tggtgtcccc aagcggcagg gctatctcct
      421 tccacagctg cgtggctcag ctctattttt tccacttcct ggggagcacc gagtgtttcc
      481 tctacacagt catgtcctat gatcgctact tggccatcag ttacccgctc aggtacacca
      541 gcatgatgag tgggagcagg tgtgccctcc tggccaccgg cacttggctc agtggctctc
      601 tgcactctgc tgtccagacc atattgactt tccatttgcc ctactgtgga cccaaccaga
      661 tccagcacta cttctgtgac gcaccgccca tcctgaaact ggcctgtgca gacacctcag
      721 ccaacgtgat ggtcatcttt gtggacattg ggatagtggc ctcaggctgc tttgtcctga
      781 tagtgctgtc ctatgtgtcc atcgtctgtt ccatcctgcg gatccgcacc tcagatggga
      841 ggcgcagagc ctttcagacc tgtgcctccc actgtattgt ggtcctttgc ttctttgttc
      901 cctgtgttgt catttatctg aggccaggct ccatggatgc catggatgga gttgtggcca
      961 ttttctacac tgtgctgacg ccccttctca accctgttgt gtacaccctg agaaacaagg
     1021 aggtgaagaa agctgtgttg aaacttagag acaaagtagc acatcctcag aggaaataaa
     1081 tactaggaag taaatacact agtttgttta aaaatagtaa tctaatttag ttattcatgt
     1141 gaaattgatt atatgtatag ttctcagtgt taaactttat tccaaaacac ctgcacagtt
     1201 ataattcttc cacagattgt ctaagacagt tttaacctca cagctagact tatatttatg
     1261 atgaacatga ttatattctg aattattgac tcatttctca tcaataggtt tatattaagt
     1321 ttaaaacata ttttaatcaa atctcaggga tagatgatta attcatgttt ataaattgat
     1381 aaacggtttt tgtgttttgt ttgatttcat atacacataa acttaagaat ttaccatcat
     1441 ggagacatag ttcaaaacca gcaacaaata ttattcaaaa ccagcaaaaa atatcatttt
     1501 tctaattgtg gctgttcaaa tttgtttttg gttttaacgt atctatatat ttgtatgtgt
     1561 atatactatt ccaaacatgt atacaaaaga aagtacatga catttagcat atttaacata
     1621 taggttttca tatatttatg tatgtgtatg tatttgccta tttacatata tatctgaaaa
     1681 catttctaga aacactattt taattggcaa gaatagctag ctattaatat ttaaaatatt
     1741 accaatgaat caattagaaa ttgtatactc acagaataga ttactatcca gcaatgataa
     1801 cgaatgatct aacaactaca tatataattg tttacgcact ttatacattt gcacccattt
     1861 ttaatgtttg ttaagatcca atataaaaaa ttaaatctct taaatatcta gattacttgg
     1921 ggctgttttg tctcctagtt cacttggcaa tgtctggaaa tattcttgct tgtcacaggc
     1981 actggcgtct attggctata ggtcaggagt gttaaacatt ccacaatgca caggagagac
     2041 cctcacaaca aaacttacca tggccaaatg ccgatagtgc tgaggatgag aacccggagc
     2101 tgaatttaat tttaagcgac atgtgtaaga ccacgacaat agaaataaaa tattttcaga
     2161 taaatataaa atttgctgaa tgaatctagg attataaagt gcacatggag actcatattt
     2221 ttaaaatgcc aattccattc aaattgatct atagatttga tgctattcca agtaaaatcc
     2281 cagcgtttga ttttgcagct atggacatgt ggatcttaaa gtgcggattg aaatggaatg
     2341 agtcccaaaa tggtcaagaa tctcttgaag aaataaagga taactgaaag attgacaaca
     2401 ctagttatca caacttatgg caaagctcta gtaactcaga gagtgttgca tttgtatgag
     2461 actagacaaa tagaaaaacg gaactgaata cagagtaaag aaatagactg atacatattc
     2521 gtatgacaaa gatgacactg caaagcaata aagcatgatt gctttcttga ataaattatt
     2581 ttggggtatc tgggtattca gaataaaaaa aattagtctc gatcctattt catactatac
     2641 acataaaaaa ctcaattata gtagataaga gatataaatg tggtggactg tatgacactt
     2701 ctttaggtaa gacacttttt agtgatgcaa aaccttcttg gaaaaaaatt aattaaaata
     2761 cttttttaaa tttatttttt attattatac tttaagttct ggcatacatg tgcacaacgt
     2821 gcaggtttgt tatgtagcaa tacatgtgcc atgttggttt gctgcaccca tcaactcatc
     2881 ggttacatta ggtatttccc ctaatgctat ccctccccca gccccccacc ccccaaaagg
     2941 cccccttgtg tgatgttccc ctccctgtgt ccatgtgttc tcattgttca actcccactt
     3001 atgagtgaga acatgtggtg ttggttttct cttcttgtgt tactttgctg gaagatatta
     3061 gtttccagtt tcatcaatgt ccctacaaag aacatgaact catcctttct tatggctgca
     3121 tagtattcca tggtgtatat gtgccacatt ttctttatcc agtctatcat tgatggacat
     3181 ttgggtgggt tccaagtctt tgctattgtg aacaatgctg caataaacat acatgtgcat
     3241 gtgtctttat agtagcatga tttataatcc tttgggtata tacccagtaa cgggattgct
     3301 g
//
