LOCUS       NM_013941               1672 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 10 subfamily C member 1
            (OR10C1), mRNA.
ACCESSION   NM_013941 XM_498078
VERSION     NM_013941.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   Thompson,E.E., Haller,G., Pinto,J.M., Sun,Y., Zelano,B., Jacob,S.,
            McClintock,M.K., Nicolae,D.L. and Ober,C.
  TITLE     Sequence variations at the human leukocyte antigen-linked olfactory
            receptor cluster do not influence female preferences for male odors
  JOURNAL   Hum Immunol 71 (1), 100-103 (2010)
   PUBMED   19833159
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1672)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1672)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 1672)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
REFERENCE   6  (bases 1 to 1672)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645927.3.
            
            On Nov 17, 2020 this sequence version replaced NM_013941.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jul 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be functional according to the Classifier for
            Olfactory Receptor Pseudogenes.
            
            CCDS Note: This olfactory receptor gene is a segregating pseudogene
            (PMID:22908908), where some individuals have an allele that encodes
            a functional olfactory receptor, while other individuals have an
            allele that is predicted to be non-functional. This CCDS is being
            retained because the Classifier for Olfactory Receptor Pseudogenes
            (CORP) predicts the reference genome allele to be functional.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC136997.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444197.3/ ENSP00000419119.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1672              AL645927.3         48561-50232
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1672
                     /gene="OR10C1"
                     /gene_synonym="hs6M1-17; OR10C1P; OR10C2; OR6-31"
                     /note="olfactory receptor family 10 subfamily C member 1"
                     /db_xref="GeneID:442194"
                     /db_xref="HGNC:HGNC:8165"
     exon            1..1672
                     /gene="OR10C1"
                     /gene_synonym="hs6M1-17; OR10C1P; OR10C2; OR6-31"
                     /inference="alignment:Splign:2.1.0"
     CDS             711..1649
                     /gene="OR10C1"
                     /gene_synonym="hs6M1-17; OR10C1P; OR10C2; OR6-31"
                     /note="olfactory receptor OR6-31; olfactory receptor,
                     family 10, subfamily C, member 2; seven transmembrane
                     helix receptor; olfactory receptor 10C2"
                     /codon_start=1
                     /product="olfactory receptor 10C1"
                     /protein_id="NP_039229.3"
                     /db_xref="CCDS:CCDS34364.1"
                     /db_xref="GeneID:442194"
                     /db_xref="HGNC:HGNC:8165"
                     /translation="MSANTSMVTEFLLLGFSHLADLQGLLFSVFLTIYLLTVAGNFLI
                     VVLVSTDAALQSPMYFFLRTLSALEIGYTSVTVPLLLHHLLTGRRHISRSGCALQMFF
                     FLFFGATECCLLAAMAYDRYAAICEPLRYPLLLSHRVCLQLAGSAWACGVLVGLGHTP
                     FIFSLPFCGPNTIPQFFCEIQPVLQLVCGDTSLNELQIILATALLILCPFGLILGSYG
                     RILVTIFRIPSVAGRRKAFSTCSSHLIMVSLFYGTALFIYIRPKASYDPATDPLVSLF
                     YAVVTPILNPIIYSLRNTEVKAALKRTIQKTVPMEI"
ORIGIN      
        1 cagaaataag caattaagga agttcttgtc atcttttgcc tgagcatgtt ttaaaactag
       61 agaaatgctc acccctctaa atagttgaac tgtttaatgc tataggagct taaaaagaga
      121 ggatctttct catttttttt ctcctccttg aacactgtga aatttatggt aaaatgacag
      181 aaaaagaaga aagactaagt gaatctggta actaaagaaa gagctggaaa aaagaaaact
      241 agagggcaag aggtgataag agaggtcacc tcttatcaga caggagacaa gttgatggag
      301 aaaaagatct gctatgaggg aaaattctgt ctccagccct gcaggaagaa ttggaaaatc
      361 agaaaagagt gaaaagggag ctagactgac ttaatcttca gcccaggtaa aactggaaag
      421 acagtttaac atgttcttta gaatgatagg cactatcagg aagagatgaa gtcagggatt
      481 caggctcaga gagacaaata ctcatccagg atcccaagag tgagcaaggg tggaatatgg
      541 actccaggca aggctgccta atttcaaagt ccatgatatt ctaatagaaa gggagatcta
      601 gtgctgcgat cagatgcaga gagaggtcat ctttgcccat ttcacgattc catagttgtg
      661 atttttcctt gccatttctt ttgtcttcca gtcaaaggta tgcaggcagg atgagtgcaa
      721 acacctccat ggtgactgag tttcttcttc tcggcttctc ccacctggcc gacctccagg
      781 gcttgctctt ctctgtcttt ctcactatct acctgctgac cgtggcaggc aatttcctca
      841 ttgtggtgct ggtctccact gatgctgccc tccagtcccc tatgtacttc ttcctgcgca
      901 ccctctcggc cttggagatt ggctatacgt ctgtcacggt ccccctgcta cttcaccacc
      961 tccttactgg ccggcgccac atctctcgct ctggatgtgc tctccagatg ttcttcttcc
     1021 tcttctttgg cgccacggag tgctgcctcc tggcagccat ggcctatgac cgctatgcag
     1081 ccatctgtga acccctccgc tacccactgc tgctgagcca ccgggtgtgt ctacagctag
     1141 ctgggtcggc gtgggcctgt ggggtgctgg tggggctggg ccacacccct ttcatcttct
     1201 ctttgccctt ctgcggcccc aataccatcc cgcagttctt ctgtgagatc cagcctgtcc
     1261 tgcagctggt atgtggagac acctcgctta atgaactgca gattatcctg gcaacagccc
     1321 tcctcatcct ctgccccttt ggcctcatcc tgggctccta cgggcgtatc ctcgttacca
     1381 tcttccggat cccatctgtt gcgggccgcc gcaaggcctt ctccacctgc tcctcccacc
     1441 tgatcatggt ctccctcttc tatggcaccg cactctttat ctatattcgc cctaaggcca
     1501 gctacgatcc ggccactgac cctctggtgt ccctcttcta tgctgtggtc acccccatcc
     1561 tcaaccccat catctacagc ctgcggaaca cagaggtcaa agctgcccta aagagaacca
     1621 tccagaaaac ggtgcctatg gagatttgaa aagggggcga tagtgacttc tg
//
