LOCUS       NM_001003745            2650 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 10 subfamily A member 3
            (OR10A3), mRNA.
ACCESSION   NM_001003745 XM_291986
VERSION     NM_001003745.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2650)
  AUTHORS   Kang,W., Choi,D., Son,B., Park,S. and Park,T.
  TITLE     Activation of OR10A3 by Suberic Acid Promotes Collagen Synthesis in
            UVB-Irradiated Dermal Fibroblasts via the cAMP-Akt Pathway
  JOURNAL   Cells 11 (24), 3961 (2022)
   PUBMED   36552724
  REMARK    GeneRIF: Activation of OR10A3 by Suberic Acid Promotes Collagen
            Synthesis in UVB-Irradiated Dermal Fibroblasts via the cAMP-Akt
            Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2650)
  AUTHORS   Hirota,T., Takahashi,A., Kubo,M., Tsunoda,T., Tomita,K.,
            Sakashita,M., Yamada,T., Fujieda,S., Tanaka,S., Doi,S.,
            Miyatake,A., Enomoto,T., Nishiyama,C., Nakano,N., Maeda,K.,
            Okumura,K., Ogawa,H., Ikeda,S., Noguchi,E., Sakamoto,T., Hizawa,N.,
            Ebe,K., Saeki,H., Sasaki,T., Ebihara,T., Amagai,M., Takeuchi,S.,
            Furue,M., Nakamura,Y. and Tamari,M.
  TITLE     Genome-wide association study identifies eight new susceptibility
            loci for atopic dermatitis in the Japanese population
  JOURNAL   Nat Genet 44 (11), 1222-1226 (2012)
   PUBMED   23042114
REFERENCE   3  (bases 1 to 2650)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   4  (bases 1 to 2650)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 2650)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   6  (bases 1 to 2650)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC044810.7.
            
            On Aug 5, 2020 this sequence version replaced NM_001003745.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642047.1/ ENSP00000493303.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC044810.7         162455-162576       c
            123-2650            AC044810.7         158039-160566       c
FEATURES             Location/Qualifiers
     source          1..2650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2650
                     /gene="OR10A3"
                     /gene_synonym="HSHTPCRX12; HTPCRX12"
                     /note="olfactory receptor family 10 subfamily A member 3"
                     /db_xref="GeneID:26496"
                     /db_xref="HGNC:HGNC:8162"
     exon            1..122
                     /gene="OR10A3"
                     /gene_synonym="HSHTPCRX12; HTPCRX12"
                     /inference="alignment:Splign:2.1.0"
     exon            123..2650
                     /gene="OR10A3"
                     /gene_synonym="HSHTPCRX12; HTPCRX12"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1245
                     /gene="OR10A3"
                     /gene_synonym="HSHTPCRX12; HTPCRX12"
                     /note="olfactory receptor OR11-97"
                     /codon_start=1
                     /product="olfactory receptor 10A3"
                     /protein_id="NP_001003745.1"
                     /db_xref="CCDS:CCDS31421.1"
                     /db_xref="GeneID:26496"
                     /db_xref="HGNC:HGNC:8162"
                     /translation="MKRQNQSCVVEFILLGFSNFPELQVQLFGVFLVIYVVTLMGNAI
                     ITVIISLNQSLHVPMYLFLLNLSVVEVSFSAVITPEMLVVLSTEKTMISFVGCFAQMY
                     FILLFGGTECFLLGAMAYDRFAAICHPLNYPVIMNRGVFMKLVIFSWISGIMVATVQT
                     TWVFSFPFCGPNEINHLFCETPPVLELVCADTFLFEIYAFTGTILIVMVPFLLILLSY
                     IRVLFAILKMPSTTGRQKAFSTCASHLTSVTLFYGTANMTYLQPKSGYSPETKKLISL
                     AYTLLTPLLNPLIYSLRNSEMKRTLIKLWRRKVILHTF"
ORIGIN      
        1 cagggacagt gaatagataa ggatctgaag attctgcttt ggtacttgtt ggtgggtttg
       61 ccttctgtag ttatcctcac tgataattgg agatacttat caagtgataa ctcaatgctc
      121 agattcacta ttacaagtca ttggccattc ttcaaaagtg ccaacctgaa gttctgtcaa
      181 aatgagcttg tcattacatc tgctgtcaag aattccagac ttgaactcac agctatggga
      241 ttacgacttc atactcgata taccaggtcc ataaaaacaa tataagtttc aactactgaa
      301 atgaaaagac aaaatcaaag ctgtgtggtt gaattcatcc tcctgggctt ttctaacttt
      361 cctgagctcc aggtgcagct ctttggggtt ttcctagtta tttatgtggt gaccctgatg
      421 ggaaatgcca tcattacagt catcatctcc ttaaaccaga gcctccacgt tcccatgtac
      481 ctgttcctcc tgaacctatc tgtggtggag gtgagtttca gtgcagtcat tacgcctgaa
      541 atgctggtgg tgctctctac tgagaaaact atgatttctt ttgtgggctg ttttgcacag
      601 atgtatttca tccttctttt tggtgggact gaatgttttc tcctgggagc gatggcttat
      661 gaccgatttg ctgcaatttg ccatcctctg aactacccag tgattatgaa cagaggggtt
      721 tttatgaaat tagtaatatt ctcatggatc tcagggatca tggtggctac tgtgcagacc
      781 acttgggtat ttagttttcc attttgtggc cccaatgaaa ttaatcatct cttctgtgag
      841 actcccccgg tactagagct tgtgtgtgca gacaccttct tatttgaaat ctatgccttc
      901 acaggcacca ttttgattgt tatggttcct ttcttgttga tcctcttgtc ttacattcga
      961 gttctgtttg ccatcctgaa gatgccatca actactggga gacaaaaggc cttttccacc
     1021 tgtgcctctc acctcacatc tgtgaccctg ttctatggca cagccaatat gacttattta
     1081 caacccaaat ctggctactc acccgaaacc aagaaactga tctcattggc ttacacgttg
     1141 cttacccctc tgctcaatcc gctcatctat agcttacgaa acagtgagat gaagaggact
     1201 ttgataaaac tatggcgaag aaaagtgatt ttacacacat tctgattgtg ttgagaagct
     1261 gagtaagatt tggccactgc ctgagtgaac tctatttaaa tttaataaag ggtgaaaaca
     1321 gactgcattt tttgtatgac tatgtaagtt tgttgagttt ttttattgga aaacgtatct
     1381 caataaagaa ctgctgtcac ttgtttttag tagatacata tgttctcata acatgacaca
     1441 acagtttatt catccatttc tctattatga acatccaagt agctactgga ttactgtcat
     1501 tttttttttt tttttttttg agatggagtt tcgctccagc ccaggctgga gtgcaatggc
     1561 acgatctggg ctcactgcaa cctccacctc ctgggttcta gcaattctcc tgcctcagcc
     1621 tcccgagtag ttgggattac aggcatgcgc caccacaccc agctaatttt tgtattttta
     1681 gtagagacgg ggtttcacca tgctggtcag gctggtctca aactcccaac cttagatgat
     1741 ccgcccacct cggcctccca aagcgctgtg attacaggtg tgagccacca cgcctggcct
     1801 ggattactgt cattaagaca gtgcttcaat aaatgccttg ttccatatgc tcatatgtac
     1861 tgatgtcatt atacctgtgt gatagatttg ctacagtgcg gctgatagga tgaggagtat
     1921 ctgtgtttac aaattttatt agctattgca gaattacttt tcaaaatgat tatagttctt
     1981 cagactggcc tgaaggctca ctgtgctttg gtaacagggt agagcttcaa gagaccaaca
     2041 aataaggtga tgatgtttct atttttggat tgaaaatttg ttccacggat gagtaaaaaa
     2101 aaagtgcatc tattttgggg ggccaaaaat ggttctactt catgacctta cacaaattat
     2161 aatcccaaac tggatttctc ttggtatctt tccaaatatt tatccaatgt tggtgaccag
     2221 agagctacat gggaagtttc tcaaattctc atttgataat atcagtatct ttttcattta
     2281 cagaccactg atttagaaac ttttatgaag tttccttttg tagtctgtga caggaaagta
     2341 aaatcttgga accccaaact cactatgcca aaagaaaagt taagcttgga aactggctca
     2401 ggcaaaaaaa ttgcctttcc ttttgttcct aaatagatag ctacaagata tccggtcacc
     2461 tatcttccca ggttacctcc ctcaattgtt cttaaaaata attggaataa aactgatact
     2521 gtgatgttaa gattagatat acatattctg ctaaatgaag gggtgtcatt ataatttgtg
     2581 tatattattt gggaataggc aatacatata tatatctgtg tgtctattta aactggtttt
     2641 aggtttataa
//
