LOCUS       NM_001004460            5390 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 10 subfamily A member 2
            (OR10A2), mRNA.
ACCESSION   NM_001004460 XM_291981
VERSION     NM_001004460.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5390)
  AUTHORS   Bernstein,J.A., Zhang,G., Jin,L., Abbott,C. and Nebert,D.W.
  TITLE     Olfactory receptor gene polymorphisms and nonallergic vasomotor
            rhinitis
  JOURNAL   J Asthma 45 (4), 287-292 (2008)
   PUBMED   18446592
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   2  (bases 1 to 5390)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   3  (bases 1 to 5390)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   4  (bases 1 to 5390)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   5  (bases 1 to 5390)
  AUTHORS   Lane,R.P., Cutforth,T., Young,J., Athanasiou,M., Friedman,C.,
            Rowen,L., Evans,G., Axel,R., Hood,L. and Trask,B.J.
  TITLE     Genomic analysis of orthologous mouse and human olfactory receptor
            loci
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7390-7395 (2001)
   PUBMED   11416212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087280.11.
            
            On Aug 6, 2020 this sequence version replaced NM_001004460.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641461.1/ ENSP00000493131.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AC087280.11        93550-93844
            296-5390            AC087280.11        100116-105210
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..5390
                     /gene="OR10A2"
                     /gene_synonym="OR10A2P; OR11-82; OR11-86; OST363"
                     /note="olfactory receptor family 10 subfamily A member 2"
                     /db_xref="GeneID:341276"
                     /db_xref="HGNC:HGNC:8161"
     exon            1..295
                     /gene="OR10A2"
                     /gene_synonym="OR10A2P; OR11-82; OR11-86; OST363"
                     /inference="alignment:Splign:2.1.0"
     exon            296..5390
                     /gene="OR10A2"
                     /gene_synonym="OR10A2P; OR11-82; OR11-86; OST363"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..1339
                     /gene="OR10A2"
                     /gene_synonym="OR10A2P; OR11-82; OR11-86; OST363"
                     /note="olfactory receptor, family 10, subfamily A, member
                     2 pseudogene; olfactory receptor OR11-86; olfactory
                     receptor OR11-82 pseudogene; hP4 olfactory receptor"
                     /codon_start=1
                     /product="olfactory receptor 10A2"
                     /protein_id="NP_001004460.1"
                     /db_xref="CCDS:CCDS31415.1"
                     /db_xref="GeneID:341276"
                     /db_xref="HGNC:HGNC:8161"
                     /translation="MSFSSLPTEIQSLLFLTFLTIYLVTLMGNCLIILVTLADPMLHS
                     PMYFFLRNLSFLEIGFNLVIVPKMLGTLLAQDTTISFLGCATQMYFFFFFGVAECFLL
                     ATMAYDRYVAICSPLHYPVIMNQRTRAKLAAASWFPGFPVATVQTTWLFSFPFCGTNK
                     VNHFFCDSPPVLRLVCADTALFEIYAIVGTILVVMIPCLLILCSYTHIAAAILKIPSA
                     KGKNKAFSTCSSHLLVVSLFYISLSLTYFRPKSNNSPEGKKLLSLSYTVMTPMLNPII
                     YSLRNNEVKNALSRTVSKALALRNCIP"
ORIGIN      
        1 actagcccca agaacaaaag aggcacaggt gggaacaact ctcccaaaac caggactggg
       61 agcatggcca aacttcatag tgagcttact tgcctctgac acacaaggca gcagtgagct
      121 ggctacagct ccagccatta atagctcagc caggacaggg aataagactt ccctggttct
      181 tcttttggct ttgctgaaac agaaatagag ctgttatatt acatgcatga aggacatgca
      241 tgaagcatgg atgtcagcca gagttgaaca aggcagatgt tcctgttgga cacagtaaga
      301 acgagtctga aaaacaaatt gagaatctga cttccaatca ataatctttc tccatgacca
      361 cagttgggga cttctgccca cacttatagc tacaggaaac tggacaagaa taagtgagtt
      421 tatcctcatg agcttctctt ccctgcctac tgaaatacag tcattactct ttctgacatt
      481 tctaaccatc tacctggtca ccctgatggg aaactgcctc atcattctgg ttaccctagc
      541 tgaccccatg ctacacagcc ccatgtactt cttcctcaga aacttatctt tcctggagat
      601 tggcttcaac ctagtcattg tgcccaaaat gctggggacc ctgcttgccc aggacacaac
      661 catctccttc cttggctgtg ccactcagat gtatttcttc ttcttctttg gagtggctga
      721 atgcttcctc ctggctacca tggcatatga ccgctatgtg gccatctgca gtcccttgca
      781 ctacccagtc atcatgaacc aaaggactcg tgccaaactg gctgctgcct cctggttccc
      841 aggctttcct gtagctactg tgcagaccac atggctcttc agttttccat tctgtggcac
      901 caacaaggtg aaccacttct tctgtgacag cccacctgtg ctgaggctgg tctgtgcaga
      961 cacagcactc tttgagatct acgccatcgt cggaaccatt ctggtggtca tgatcccctg
     1021 cttgctgatc ttgtgttcct atactcacat tgctgctgcc atcctcaaga tcccatcagc
     1081 taaagggaag aataaagcct tttctacatg ttcctcacac ctccttgttg tctctctttt
     1141 ctatatatca ttaagcctca cctacttccg gcctaaatca aataattcac ctgagggcaa
     1201 gaagctgcta tcattgtcct acactgttat gactcccatg ttgaacccca ttatctacag
     1261 cctgagaaat aacgaggtga agaatgccct cagcaggacg gtctctaagg ccctagccct
     1321 cagaaactgt atcccataga ccttaggaag taaggctaca ttttactgga tgagaaacaa
     1381 tcagtcccag atttgagatt cctctctgca tctttccaca tctccaataa gatgaagtcc
     1441 tgttgctgaa atggcttttg gaaagctgag tggagagaaa ggagcagaga agtagtttcg
     1501 acctagcacc accaactatg aaaactcctc tgcctgccca ttgtagactt acattgtttt
     1561 ccttgtttca actggtatga cagcacttct gtggccaact atttccaggt gttatatttc
     1621 tttttttttt tttttttgag acggagtctc gctctgtccc ccaggctgga gtgcagtggc
     1681 gcatctctgc tcactgcaag ctccgcctcc tgggttcacg ctgttctcct gcctcagcct
     1741 cccaagtagc tgggactaca ggtgcccgcc accatgcccg gctaattttt tgtatttttt
     1801 tagtagagac agggtttcac cgtgttagcc aggatggtct cgatctcctg acctcgtgat
     1861 ccacccgcct cggcctccca aagtgctggg attacaggcg tgagccaccg cgcctggccg
     1921 gtgtttatat ttctgtgtga cgtgcattgt gcacaatatg aaactgctag tcattataac
     1981 atgggggcac acatagtaac agagggtaaa acccaataaa aatcatcttg tcacttttcc
     2041 tcttctgggc agatctgact ctacattcat gacagaaaat ctcatgatct ttcccaacac
     2101 ataactctcc tcaccatctt acttcattct catgccctta agcagtgtta gttcttttaa
     2161 gcttactggt atgcagtatg catgtatgag agtagatcaa aagttcacat gcatatgcct
     2221 ttataacccc aataattatt tccttcacac tagattcttc ccaagaaaaa caacctgagc
     2281 ttccctaaga tctctattcc atattcaggt tcttatgttt tgttgaagta atatcgtaaa
     2341 tttcagtcat agctttgctt tgatgagaac aaagctccag aataagtctt ctttaaccac
     2401 aagatttctc cttcttataa tctggtagta ctctatttgt agatgtgccc taatttattt
     2461 agccagtctt ttactactac aaatcatgct gtaaataatg gacttatcca tatatctgtt
     2521 tttatatttt tgctagtgta cctgacaaat agaaatctag aaattgagtt tcttgggcaa
     2581 aagttaaata catacataat gttgctatat atattgattg tctatctagc tcccctctga
     2641 acttattgca ccattttatg ctcccaccag caatttatga ggtgtttgtt tccccacaac
     2701 tcaacaataa catttctcat gaaatattta gaatttcgat tatttaatat tttataaaaa
     2761 ctcaatgaaa ttttaatttg aatgaaataa attttgaaga ataagaaaga aacagatgat
     2821 caaatcagag gaaaggtgtg catttcattg aaacttgagt tatagattag acgattagca
     2881 attggtgatg tcttggtgtt ttattttctc ttcttgaaag gttgtttttc acttttattt
     2941 tagccaaatc tatcccatct ctcaagaccc cactgtgatt cctcaagaag cagaaatcac
     3001 tctttctgta tgcacccatt tcaagtttat taataaatac attaaatttt gtatatacta
     3061 catgtagaaa ctgtacatgt acttattttt acatgtttgt cttcctccaa cttttctgta
     3121 actcttcaaa aataagaatt gttcaagtgt ttctggtgtt ttgttttgtg tttgagacag
     3181 ggtctctctc tctgtcaccc aggctggact gcggtagcag aattatggct cactgtagcc
     3241 tcaaacacct gggctcaggc catcttcctg cctcagtctc cctagtggct gggactatag
     3301 gcgtacatca ccatgcctgg ccatttaaaa attttttttt agtagagacg aggtcttgct
     3361 atgctaccca gtctggtatc gaacttctga gttcaagcaa tccttctgcc tgaacctctc
     3421 aaagtgctgg gattataagt gtgagccatt gcatgcaaca caagtgtttc tcttttcttt
     3481 tctttctttc tttttttttt tttttttgag acaaaggtct gctctattac tcaggctgct
     3541 ggggtgcaat ggcacaatct tggctcactg caacttctgc cttctgggtt caatcaattc
     3601 tcatgcctca gcctcttgag tagctgggat tacaggcgtg ccaagccatg cccaactaat
     3661 tttttttttg tattttttag tagagatgca gttttaccat gttggagctc ctggcctcaa
     3721 gtgatctgcc tgcctcagcc tcccaagggc tgggattaca gacgtgggcc accatgccag
     3781 gccaagtatt tcccttttaa tatgacgtag gcattcctga aaagcttatg taatgcaaac
     3841 ctttacatta aaaatattat ggggaagtag ggctagggtt agggctagac tcaaaataca
     3901 tgcaacttta aagacaaggc attagtagaa acaacatttg gttcccagag agacaatgta
     3961 gactgcccag gcaggcagct cattgaggct ggaggttgcc acagtagata tttaaaatat
     4021 acaacaacag tagaatgaaa ataccaacaa tgcttggatt agaacaatga tgcttgatgc
     4081 tgagacaatt tgtactgggg tagggggtag tccttagtat gggtaaagaa tttgaagtaa
     4141 agcaaacaag aataacccaa aacctaaaga aaaagttgta catagtttca gggaaaggat
     4201 tccaacagaa gagtgccaca tgcacaaaca caggagtgct gagagactat gatgtgtgta
     4261 aggaacacaa agcatttttg tgtcactgaa aaatcagcta cactggggat ttgaaactgg
     4321 aaaaataagc agagatcaca ggaaaagacc ttgttaaagg atttacttta tcccaggggc
     4381 catacggagt aattgaaaga cattaagcag gtaagtgact taaccagagt tgctggttaa
     4441 gacagcaact ggtaagacag ttgctgataa gacagatcac atacaaacca aggatggttt
     4501 gaagagaatg aaccagaagc aggttcctac catactctag gccagagaaa ataaatccag
     4561 aacctaaagg cagtggtggt agagctggag aaggtgacac tgaattagtg tttaggagta
     4621 aaaataatca aatttggggc acaaattaaa ggattatatc ccagttcctg gcttgtactt
     4681 tggggtggtg ccatttactg aaatggggta tctacaaaga ggaggtttga ggtggaggaa
     4741 gcagacaagc acatttatat ctcttatcat tgtttcagtc cgtgtgaatt gtatgatgct
     4801 atattatatt cttttgtgcc tttgtctaaa ttccttatga atggggctca ctgtacctac
     4861 tttgtgtctg tgtagatgtt tccctgatta tttaccacat tttcttcatt atctattaaa
     4921 ttattcaata acaatttact gggcatctac ctttctaggc attggggtaa aaaaatgaat
     4981 aacacaattt ctatttcaag gagcatgtca tctactgtat gagacaaata catacaataa
     5041 tgattattct aaaataagaa ctatgaaagt ggtattccag ttctccaatg ttactaatat
     5101 attgaaattt tctgcccatc tttagaaatt gtgttgcttt gttcttacta ccaccctgta
     5161 ctggatactg gcttgtcctc acctgtgggc tcagatttat tcccattctg aaaaaatgag
     5221 tgcaagtgtc acttgtcggc caaatccctg acttggactc agccacccag gattccaaca
     5281 cttgctgaaa aaactactca acttatctgt gtctcagatt ccttgactgt aaaatgggta
     5341 taatactatc tgtatcttca ggtgttgtga gaatcaaata agataataca
//
