LOCUS       NM_182647               3402 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens opioid related nociceptin receptor 1 (OPRL1),
            transcript variant 1, mRNA.
ACCESSION   NM_182647 XM_940657
VERSION     NM_182647.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3402)
  AUTHORS   Chen,J., Wang,Z., Zhang,R., Yin,H., Wang,P., Wang,C. and Jiang,Y.
  TITLE     Heterodimerization of apelin and opioid receptor-like 1 receptors
            mediates apelin-13-induced G protein biased signaling
  JOURNAL   Life Sci 328, 121892 (2023)
   PUBMED   37364634
  REMARK    GeneRIF: Heterodimerization of apelin and opioid receptor-like 1
            receptors mediates apelin-13-induced G protein biased signaling.
REFERENCE   2  (bases 1 to 3402)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3402)
  AUTHORS   Narendran,R., Tollefson,S., Fasenmyer,K., Paris,J., Himes,M.L.,
            Lopresti,B., Ciccocioppo,R. and Mason,N.S.
  TITLE     Decreased Nociceptin Receptors Are Related to Resilience and
            Recovery in College Women Who Have Experienced Sexual Violence:
            Therapeutic Implications for Posttraumatic Stress Disorder
  JOURNAL   Biol Psychiatry 85 (12), 1056-1064 (2019)
   PUBMED   30954231
  REMARK    GeneRIF: Decreased Nociceptin Receptors Are Related to Resilience
            and Recovery in College Women Who Have Experienced Sexual Violence.
            Decreased midbrain and cerebellum nociceptin receptors are
            associated with less severe PTSD symptoms. Medications that target
            nociceptin should be explored to prevent and treat PTSD.
REFERENCE   4  (bases 1 to 3402)
  AUTHORS   Loughran,G., Chou,M.Y., Ivanov,I.P., Jungreis,I., Kellis,M.,
            Kiran,A.M., Baranov,P.V. and Atkins,J.F.
  TITLE     Evidence of efficient stop codon readthrough in four mammalian
            genes
  JOURNAL   Nucleic Acids Res 42 (14), 8928-8938 (2014)
   PUBMED   25013167
REFERENCE   5  (bases 1 to 3402)
  AUTHORS   Beier,H. and Grimm,M.
  TITLE     Misreading of termination codons in eukaryotes by natural nonsense
            suppressor tRNAs
  JOURNAL   Nucleic Acids Res 29 (23), 4767-4782 (2001)
   PUBMED   11726686
  REMARK    Review article
REFERENCE   6  (bases 1 to 3402)
  AUTHORS   Ito,E., Xie,G., Maruyama,K. and Palmer,P.P.
  TITLE     A core-promoter region functions bi-directionally for human
            opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP
  JOURNAL   J Mol Biol 304 (3), 259-270 (2000)
   PUBMED   11090272
REFERENCE   7  (bases 1 to 3402)
  AUTHORS   Meunier,J.C., Mollereau,C., Toll,L., Suaudeau,C., Moisand,C.,
            Alvinerie,P., Butour,J.L., Guillemot,J.C., Ferrara,P., Monsarrat,B.
            et al.
  TITLE     Isolation and structure of the endogenous agonist of opioid
            receptor-like ORL1 receptor
  JOURNAL   Nature 377 (6549), 532-535 (1995)
   PUBMED   7566152
REFERENCE   8  (bases 1 to 3402)
  AUTHORS   Wick,M.J., Minnerath,S.R., Roy,S., Ramakrishnan,S. and Loh,H.H.
  TITLE     Expression of alternate forms of brain opioid 'orphan' receptor
            mRNA in activated human peripheral blood lymphocytes and
            lymphocytic cell lines
  JOURNAL   Brain Res Mol Brain Res 32 (2), 342-347 (1995)
   PUBMED   7500847
REFERENCE   9  (bases 1 to 3402)
  AUTHORS   Mollereau,C., Parmentier,M., Mailleux,P., Butour,J.L., Moisand,C.,
            Chalon,P., Caput,D., Vassart,G. and Meunier,J.C.
  TITLE     ORL1, a novel member of the opioid receptor family. Cloning,
            functional expression and localization
  JOURNAL   FEBS Lett 341 (1), 33-38 (1994)
   PUBMED   8137918
REFERENCE   10 (bases 1 to 3402)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF285093.1, BC038433.1,
            R17579.1 and CB048300.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182647.3.
            
            Summary: The protein encoded by this gene is a member of the 7
            transmembrane-spanning G protein-coupled receptor family, and
            functions as a receptor for the endogenous, opioid-related
            neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system
            modulates a variety of biological functions and neurobehavior,
            including stress responses and anxiety behavior, learning and
            memory, locomotor activity, and inflammatory and immune responses.
            A promoter region between this gene and the 5'-adjacent RGS19
            (regulator of G-protein signaling 19) gene on the opposite strand
            functions bi-directionally as a core-promoter for both genes,
            suggesting co-operative transcriptional regulation of these two
            functionally related genes. Alternatively spliced transcript
            variants have been described for this gene. A recent study provided
            evidence for translational readthrough in this gene, and expression
            of an additional C-terminally extended isoform via the use of an
            alternative in-frame translation termination codon. [provided by
            RefSeq, Dec 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes two isoforms, which result from the use of
            alternative in-frame translation termination codons. The shorter
            isoform (1) results from translation termination at the upstream
            UGA stop codon, while the longer isoform (1x) results from UGA stop
            codon readthrough to the downstream UAG termination codon. This
            RefSeq represents the shorter isoform (1). Variants 1, 2, and 3
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.209984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336866.7/ ENSP00000336843.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AF285093.1         1-271
            272-2093            BC038433.1         229-2050
            2094-2094           R17579.1           110-110
            2095-2982           BC038433.1         2052-2939
            2983-2983           CB048300.1         73-73
            2984-3402           BC038433.1         2941-3359
FEATURES             Location/Qualifiers
     source          1..3402
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..3402
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /note="opioid related nociceptin receptor 1"
                     /db_xref="GeneID:4987"
                     /db_xref="HGNC:HGNC:8155"
                     /db_xref="MIM:602548"
     exon            1..271
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /inference="alignment:Splign:2.1.0"
     exon            272..422
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /inference="alignment:Splign:2.1.0"
     exon            423..688
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..1568
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     orphanin FQ receptor; nociceptin receptor; kappa3-related
                     opioid receptor; kappa-type 3 opioid receptor; opiate
                     receptor-like 1; nociceptin/orphanin FQ receptor"
                     /codon_start=1
                     /product="nociceptin receptor isoform 1"
                     /protein_id="NP_872588.1"
                     /db_xref="CCDS:CCDS13556.1"
                     /db_xref="GeneID:4987"
                     /db_xref="HGNC:HGNC:8155"
                     /db_xref="MIM:602548"
                     /translation="MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGA
                     FLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLL
                     TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALD
                     VRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAIC
                     IFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCW
                     TPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC
                     CASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA"
     exon            689..1044
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..3402
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3376..3381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /note="hexamer: AATAAA"
     polyA_site      3402
                     /gene="OPRL1"
                     /gene_synonym="KOR-3; KOR3; NOCIR; NOP; NOPr; OOR; OPRL;
                     ORL1; PNOCR"
                     /note="major polyA site"
ORIGIN      
        1 acccgccccg cccgcgcgtc ggcccccaca gtcgcctggg ggtggcccgg agagtcgagg
       61 tgctcatagt ggagccctgg ctcccgggcg gacggagccg cacggtagta gatgggggtg
      121 tggccgtggc ccccgactct gctcggcggg gccgttcctg ctttgccatc cgtgtgggac
      181 ttccacgaca gtggaggcac gagagctggg ccccatatgc tgcttgccca gcttgggaaa
      241 gaggaggctg ctgcaaagga ccgatcggcg gcttcgggct gccggctcac tcggctgctg
      301 cgtctggtct ggcgtctgct gagaagatcc tcttctaccc tgctctgcac ctgtgctcga
      361 ctgccagccg gctgagggcg ggggtctcca cggtggtccc agctcccaag gaggttgcag
      421 aagtaccgta cagagtggat ttgcagggca gtggcatgga gcccctcttc cccgcgccgt
      481 tctgggaggt tatctacggc agccaccttc agggcaacct gtccctcctg agccccaacc
      541 acagtctgct gcccccgcat ctgctgctca atgccagcca cggcgccttc ctgcccctcg
      601 ggctcaaggt caccatcgtg gggctctacc tggccgtgtg tgtcggaggg ctcctgggga
      661 actgccttgt catgtacgtc atcctcaggc acaccaaaat gaagacagcc accaatattt
      721 acatctttaa cctggccctg gccgacactc tggtcctgct gacgctgccc ttccagggca
      781 cggacatcct cctgggcttc tggccgtttg ggaatgcgct gtgcaagaca gtcattgcca
      841 ttgactacta caacatgttc accagcacct tcaccctaac tgccatgagt gtggatcgct
      901 atgtagccat ctgccacccc atccgtgccc tcgacgtccg cacgtccagc aaagcccagg
      961 ctgtcaatgt ggccatctgg gccctggcct ctgttgtcgg tgttcccgtt gccatcatgg
     1021 gctcggcaca ggtcgaggat gaagagatcg agtgcctggt ggagatccct acccctcagg
     1081 attactgggg cccggtgttt gccatctgca tcttcctctt ctccttcatc gtccccgtgc
     1141 tcgtcatctc tgtctgctac agcctcatga tccggcggct ccgtggagtc cgcctgctct
     1201 cgggctcccg agagaaggac cggaacctgc ggcgcatcac tcggctggtg ctggtggtag
     1261 tggctgtgtt cgtgggctgc tggacgcctg tccaggtctt cgtgctggcc caagggctgg
     1321 gggttcagcc gagcagcgag actgccgtgg ccattctgcg cttctgcacg gccctgggct
     1381 acgtcaacag ctgcctcaac cccatcctct acgccttcct ggatgagaac ttcaaggcct
     1441 gcttccgcaa gttctgctgt gcatctgccc tgcgccggga cgtgcaggtg tctgaccgcg
     1501 tgcgcagcat tgccaaggac gtggccctgg cctgcaagac ctctgagacg gtaccgcggc
     1561 ccgcatgact aggcgtggac ctgcccatgg tgcctgtcag cccgcagagc ccatctacgc
     1621 ccaacacaga gctcacacag gtcactgctc tctaggcgga cacaccctgg gccctgagca
     1681 tccagagcct gggatgggct tttccctgtg ggccagggat gctcggtccc agaggaggac
     1741 ctagtgacat catgggacag gtcaaagcat tagggccacc tccatggccc cagacagact
     1801 aaagctgccc tcctggtgca gggccgaggg gacacaagga cctacctgga agcagctgac
     1861 atgctggtgg acggccgtga ctggagcccg tgcccctccc tccccgtgct tcatgtgact
     1921 cttggcctct ctgctgctgc gttggcagaa ccctgggtgg gcaggcaccc ggaggaggag
     1981 cagcagctgt gtcatcctgt gccccccatg tgctgtgtgc tgtttgcatg gcagggctcc
     2041 agctgccttc agccctgtga cgtctcctca gggcagctgg acaggcttgg cactgcccgg
     2101 gaagtgcagc aggcagcttt tctttggggt gggacttgcc ctgagcttgg agctgccacc
     2161 tggaggactt gcctgttccg actccacctg tgcagccggg gccaccccag gagaaagtgt
     2221 ccaggtgggg gctggcagtc cctggctgca gaccccgagc tggccctggg ccagccgcac
     2281 ctctgaaggt tttctgtgtg ctgcacggtg caggcctcat ccctgactgc agcttgactc
     2341 tgggcccaac ccccatttcc cttcaggaga ccagcgagag gccctggccc attccctcca
     2401 gcggtgcaat gaactatcat gctgtggacc gtcaacccag ccctgcttct cagtgtgggg
     2461 caggtgtctc aggacgaagg cgccgcgtga ccacatgggc agctctgttc acaaagtgga
     2521 ggcctcgttt tcctggtctt gactgctctg tttgggtggg agaagattct ctgggggtcc
     2581 ccacatcctc ccaaggctcc cctcacagcc tctcctttgc ttgaagccag aggtcagtgg
     2641 ccgtgctgtg ttgcggggga agctgtgtgg aaggagaagc tggtggccac agcagagtcc
     2701 tgctctgggg acgcctgctt catttacaag cctcaagatg gctctgtgta gggcctgagc
     2761 ttgctgccca acgggaggat ggcttcacag cagagccagc atgaggggtg gggcctggca
     2821 gggcttgctt gagccaaact gcaaaggctg tggtggctgt gaggacactg cgggggttgg
     2881 ggggggggcg tctgtacctc aggggatgcc ccgctgtggt cacccagaga atcacccttc
     2941 ctggtctaca gatggaagct gcaggttggt gactttgcaa atgcacttcc tacagatgaa
     3001 ctattaaaag acctgcaaca ttgaaaaaac tcattttttc caccaaaacc ttggccaggt
     3061 aacctacctt aggcacctgc aaagaacagg aagtgatggc tgtctcgcaa cagagcctgg
     3121 gctgctcctc ctgctctggg gagtctaggc cgtggggact gttctgggga ggctcatgct
     3181 gtctccatga cgtctgtggc aggagtccct gaggacggga gctgcctagc tacagttttc
     3241 ttgccaaggc gaggtgtttt gtgaatctgt gctgatgtaa tgtgcacctt cacgtattta
     3301 tgcatgtggc aagcgttact tcctgtgcac gtagccagcc ctgggtctgt ctctggggta
     3361 atgaaaaagg accctaataa acacctgctc actggctggg ta
//
