LOCUS       NM_000911               9317 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens opioid receptor delta 1 (OPRD1), mRNA.
ACCESSION   NM_000911
VERSION     NM_000911.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9317)
  AUTHORS   Bigliardi,P.L., Lo,S., Bigliardi,E., Dancik,Y., Leblanc-Noblesse,E.
            and Bigliardi-Qi,M.
  TITLE     Delta opioid receptor expression correlates to skin ageing and
            melanin expression in Asian women
  JOURNAL   Exp Dermatol 33 (6), e15096 (2024)
   PUBMED   38922774
  REMARK    GeneRIF: Delta opioid receptor expression correlates to skin ageing
            and melanin expression in Asian women.
REFERENCE   2  (bases 1 to 9317)
  AUTHORS   Ying,Y., Li,X. and Chen,Y.
  TITLE     Hypomethylation of the opioid receptor delta 1 gene combined with
            high opioid receptor delta 1 protein levels indicates increased
            risk of gout
  JOURNAL   J Clin Lab Anal 36 (9), e24634 (2022)
   PUBMED   35908776
  REMARK    GeneRIF: Hypomethylation of the opioid receptor delta 1 gene
            combined with high opioid receptor delta 1 protein levels indicates
            increased risk of gout.
REFERENCE   3  (bases 1 to 9317)
  AUTHORS   Miyano,K., Yoshida,Y., Hirayama,S., Takahashi,H., Ono,H.,
            Meguro,Y., Manabe,S., Komatsu,A., Nonaka,M., Mizuguchi,T.,
            Fujii,H., Higami,Y., Narita,M. and Uezono,Y.
  TITLE     Oxytocin Is a Positive Allosteric Modulator of kappa-Opioid
            Receptors but Not delta-Opioid Receptors in the G Protein Signaling
            Pathway
  JOURNAL   Cells 10 (10), 2651 (2021)
   PUBMED   34685631
  REMARK    GeneRIF: Oxytocin Is a Positive Allosteric Modulator of
            kappa-Opioid Receptors but Not delta-Opioid Receptors in the G
            Protein Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9317)
  AUTHORS   Wu,B., Hand,W. and Alexov,E.
  TITLE     Opioid Addiction and Opioid Receptor Dimerization: Structural
            Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling
            Pathways
  JOURNAL   Int J Mol Sci 22 (19), 10290 (2021)
   PUBMED   34638633
  REMARK    GeneRIF: Opioid Addiction and Opioid Receptor Dimerization:
            Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its
            Signaling Pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9317)
  AUTHORS   Crist,R.C., Arauco-Shapiro,G., Zhang,A., Reiner,B.C.,
            Berrettini,W.H. and Doyle,G.A.
  TITLE     Differential expression and transcription factor binding associated
            with genotype at a pharmacogenetic variant in OPRD1
  JOURNAL   Am J Drug Alcohol Abuse 47 (5), 581-589 (2021)
   PUBMED   34407719
  REMARK    GeneRIF: Differential expression and transcription factor binding
            associated with genotype at a pharmacogenetic variant in OPRD1.
REFERENCE   6  (bases 1 to 9317)
  AUTHORS   Simonin,F., Befort,K., Gaveriaux-Ruff,C., Matthes,H., Nappey,V.,
            Lannes,B., Micheletti,G. and Kieffer,B.
  TITLE     The human delta-opioid receptor: genomic organization, cDNA
            cloning, functional expression, and distribution in human brain
  JOURNAL   Mol Pharmacol 46 (6), 1015-1021 (1994)
   PUBMED   7808419
REFERENCE   7  (bases 1 to 9317)
  AUTHORS   Befort,K., Mattei,M.G., Roeckel,N. and Kieffer,B.
  TITLE     Chromosomal localization of the delta opioid receptor gene to human
            1p34.3-p36.1 and mouse 4D bands by in situ hybridization
  JOURNAL   Genomics 20 (1), 143-145 (1994)
   PUBMED   8020949
REFERENCE   8  (bases 1 to 9317)
  AUTHORS   Evans,C.J., Keith,D.E. Jr., Morrison,H., Magendzo,K. and
            Edwards,R.H.
  TITLE     Cloning of a delta opioid receptor by functional expression
  JOURNAL   Science 258 (5090), 1952-1955 (1992)
   PUBMED   1335167
REFERENCE   9  (bases 1 to 9317)
  AUTHORS   Offermanns,S., Schultz,G. and Rosenthal,W.
  TITLE     Evidence for opioid receptor-mediated activation of the G-proteins,
            Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15)
            hybrid cells
  JOURNAL   J Biol Chem 266 (6), 3365-3368 (1991)
   PUBMED   1671672
REFERENCE   10 (bases 1 to 9317)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF434068.1, U10504.1 and AL009181.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000911.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U07882.2, U10504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMN03465403
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234961.7/ ENSP00000234961.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               BF434068.1         61-274
            215-1134            U10504.1           1-920
            1135-1746           AL009181.1         94896-95507         c
            1747-9317           AL009181.1         87325-94895         c
FEATURES             Location/Qualifiers
     source          1..9317
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..9317
                     /gene="OPRD1"
                     /gene_synonym="DOP; DOR; DOR1; OPRD"
                     /note="opioid receptor delta 1"
                     /db_xref="GeneID:4985"
                     /db_xref="HGNC:HGNC:8153"
                     /db_xref="MIM:165195"
     exon            1..441
                     /gene="OPRD1"
                     /gene_synonym="DOP; DOR; DOR1; OPRD"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1333
                     /gene="OPRD1"
                     /gene_synonym="DOP; DOR; DOR1; OPRD"
                     /note="delta opioid receptor 1; DOR-1; D-OR-1"
                     /codon_start=1
                     /product="delta-type opioid receptor"
                     /protein_id="NP_000902.3"
                     /db_xref="CCDS:CCDS329.1"
                     /db_xref="GeneID:4985"
                     /db_xref="HGNC:HGNC:8153"
                     /db_xref="MIM:165195"
                     /translation="MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSAS
                     SLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTL
                     PFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFR
                     TPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVF
                     LFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAP
                     IHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCR
                     KPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA"
     exon            442..791
                     /gene="OPRD1"
                     /gene_synonym="DOP; DOR; DOR1; OPRD"
                     /inference="alignment:Splign:2.1.0"
     exon            792..9317
                     /gene="OPRD1"
                     /gene_synonym="DOP; DOR; DOR1; OPRD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9287..9292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPRD1"
                     /gene_synonym="DOP; DOR; DOR1; OPRD"
                     /note="hexamer: AATAAA"
     polyA_site      9317
                     /gene="OPRD1"
                     /gene_synonym="DOP; DOR; DOR1; OPRD"
                     /note="major polyA site"
ORIGIN      
        1 acagcgctcc gggcgaggag agcgggcgga cgccgggggc tgggccggtg cgggcggcga
       61 ggcaggcgga cgaggcgcag agacagcggg gcggccgggg cgcggcagcc ggcggcgtcg
      121 gggccgcggc ctctgccttg ccgctcccct cgcgtcggat ccccgcgccc agggcgcacg
      181 gtggagaggg acgcggcgga gccggccggc agccatggaa ccggccccct ccgccggcgc
      241 cgagctgcag cccccgctct tcgccaacgc ctcggacgcc taccctagcg cctgccccag
      301 cgctggcgcc aatgcgtcgg ggccgccagg cgcgcggagc gcctcgtccc tcgccctggc
      361 aatcgccatc accgcgctct actcggccgt gtgcgccgtg gggctgctgg gcaacgtgct
      421 tgtcatgttc ggcatcgtcc ggtacactaa gatgaagacg gccaccaaca tctacatctt
      481 caacctggcc ttagccgatg cgctggccac cagcacgctg cctttccaga gtgccaagta
      541 cctgatggag acgtggccct tcggcgagct gctctgcaag gctgtgctct ccatcgacta
      601 ctacaatatg ttcaccagca tcttcacgct caccatgatg agtgttgacc gctacatcgc
      661 tgtctgccac cctgtcaagg ccctggactt ccgcacgcct gccaaggcca agctgatcaa
      721 catctgtatc tgggtcctgg cctcaggcgt tggcgtgccc atcatggtca tggctgtgac
      781 ccgtccccgg gacggggcag tggtgtgcat gctccagttc cccagcccca gctggtactg
      841 ggacacggtg accaagatct gcgtgttcct cttcgccttc gtggtgccca tcctcatcat
      901 caccgtgtgc tatggcctca tgctgctgcg cctgcgcagt gtgcgcctgc tgtcgggctc
      961 caaggagaag gaccgcagcc tgcggcgcat cacgcgcatg gtgctggtgg ttgtgggcgc
     1021 cttcgtggtg tgttgggcgc ccatccacat cttcgtcatc gtctggacgc tggtggacat
     1081 cgaccggcgc gacccgctgg tggtggctgc gctgcacctg tgcatcgcgc tgggctacgc
     1141 caatagcagc ctcaaccccg tgctctacgc tttcctcgac gagaacttca agcgctgctt
     1201 ccgccagctc tgccgcaagc cctgcggccg cccagacccc agcagcttca gccgcgcccg
     1261 cgaagccacg gcccgcgagc gtgtcaccgc ctgcaccccg tccgatggtc ccggcggtgg
     1321 cgctgccgcc tgaccaggcc atccggcccc cagagcgccc ctccctagtg acccggaggc
     1381 cacatgagtc ccagtgggag gcgcgagcca tgatgtggag tggggcagta gaaggtcgga
     1441 ggcttgggac cgccagatgg ggcctctgtt tcggagacgg gaccgggccg ctagatgggc
     1501 atggggtggg cctctggttt ggggcgaggc agaggacaga tcaatggcgc agtgcctctg
     1561 gtctgggtgc cccgtccacg gctctaggtg gggcgggaaa gccagtgact ccaggagagg
     1621 agcgggacct gtggctctac aactgagtcc ttaaacaggg catctccagg aaggcggggc
     1681 ttcaaccttg agacagcttc ggtttctaac ttggagccgg actttcggag ttgggggtcc
     1741 gggcccagga cccagaaagg gcagtggtgg ggacagttgc ttgaaaactg agctgcaaga
     1801 ctgggcctct gtgtagtagg gaggagcctc ctgtgagggg agacccagag acaggacagc
     1861 tgggtgtggc tacagctgaa gatttggtca ccagataggg cgcctgtgca aagggcctgt
     1921 ggcctcatct ttggatacgg gatacagtcc cagccctgag ttctagcaag gggcaaggct
     1981 cgctgaggtc caggtccgac ttgacacctt tataaataga atataaaaga ctgaggggcc
     2041 aggcgtggtg gctcaagcct gtaatcccag cactttggga ggccgaggca ggtggatgga
     2101 catgagccca ggagttcgag actagtctgg gcaacatggg agaccctgtc gctacaaaaa
     2161 atacaaaatt agccaggcat ggtggtgtgt acctgcaggc ctagctcctt ggaaggtgag
     2221 aggatcactt gatcccagga gtttgaagct gcagtgagct atggtggtgc cactgcactc
     2281 cagcctgggg gacagagtaa gactctgtct ctcaaaaagg agagagaggg agaatgaggg
     2341 aagaagagat aggaagagag agaaacagta taccttttat ctctttgaca ggcatgtatt
     2401 tccttggaat gggcaggaat ccctcagaat cggtggccac agtggggctt gggacaggac
     2461 agcagagcgg ggggcagcca ctccaggata gggtaataag acaggacctt ggttggagta
     2521 gggtccccag aactgagtac taatgggggc ccagaggctt gggaaggaga aggcttccaa
     2581 aaccagttcg aaaacccaga cccggagtgg acctccgtgc caaggggtgg tggtgggtgg
     2641 gtggaggaag aggtgggctc ctgcttcaag gttaggtctt ccagtggaag gtggatgctt
     2701 tctgtgagtc cccagggccc tagtttctct ggcccagata ctggaggaca gaggaccacc
     2761 tacttagatc ccgtagatgg taagtggtgc ctgggactct tgagggcggg gggcggggta
     2821 tgagaagcat cagttcgcac ttggtgctgg gtcctgggcc ctgataagaa cctggatgaa
     2881 atcctcttcc attctcccaa catctggctg catccatgtg tctggtgtca atgactccag
     2941 tgaactggaa ctgcccatat ggggacctga ccttgaagga actgggggga gaagcttttg
     3001 taactgcaat gccggcatca gtgtgtgtcc ccctctgcct ttccccccag gctccccagg
     3061 tcccccacct gctccagccc agctgtcccc ttcacgctgc tgagagtgat atccacctgg
     3121 agttgggtgt agaagttttt cttttcattg gttcggcatt ttattcaggc actcctggat
     3181 ctttgcttcc cagaatatca gtgtctgtcc ttgttctctg tacctccccc gtgcctcatc
     3241 tcctctccct ccgctgctgt cccctccctc accaacactg cctcagtaat gcacccctga
     3301 ctccctattg aagcagtgtg ctgacatcct tgtaaaaaca aatttaattt tcttcctttt
     3361 ttgggacaga tggaaagaaa ttgacgtctt tgtctcaaac aaaagaaaaa agaaaaagaa
     3421 acaatatact tcttttccct ttgacagcca tgtctttgga acaaaagctg ggaggctgtc
     3481 actccagcag ggactgaata gcatgcaggg ggctggggac ttaggcacca agaggggctt
     3541 tgggcacatt agggggaagg gatgctctca gagggcaaag cacagccccc ttctcagggt
     3601 gaggctccca gcagccccag acccggggat gtgcctcctt tgggaaatgg ctaccccggg
     3661 tcctggaaag atgtggggcc atgcccagca ctcacatcca gcctgccaag ccattgtgac
     3721 ctggggtccc aagccaccta gatcactctc actaccttgt gaccacagag acccctgtgt
     3781 ctgagggtgg gaggtcgtca gcatggcagg agacacttct cctcatcagg ggtcctcctg
     3841 tgaatgcttt gggggtatgg cagaaaaagg gacaatctag gaactgggga agactcctga
     3901 aggaggtgac attggagcca ggctgtttac tctccctgca ggacctgtgt cccctcccag
     3961 gataggcctg tttcaaggct gcttgaagcc cactcactgc catctcctgt gtctgtaaca
     4021 gatctggctg ttttttgccc cttctgatat gtaaatctgt cctgaggtca gcagggcccg
     4081 ggtccggacc acgtgtgttt aaggtagtgc aaacttgtat tgaaatctac ttcatgccaa
     4141 gcatgcactc tgggcatcag gactcggaat gagtcagcct tggccctgcc ctcagaaagc
     4201 ctgagccagt gttgggagat aaagcatcaa cagatgattg cacctcagtg tgatgagtgc
     4261 ggtgacaggg agccccaggg agggtgtcac agggaagtgc cttttctagc ttttcactaa
     4321 aacacatgtt tgtcgcagtt ctgtaagagg tggaaaaggg tcggggaccc tgaaggatga
     4381 ataggagttg gccaccaaaa agaggaaata gcgtgtgcgg aggcatgggg atgtttaaat
     4441 gcttggcaaa cccaacaagt tgggtgcagc tggagcatgg ggcttaacta agctcttctg
     4501 tgtgccaggc tctctgccag gtgtcttgtg tgcatcagcc cacctgatcc tcaggacagc
     4561 ctggtgagga agtagtgtta tccccattga ggacaaagag agctgaggct gagagaggtc
     4621 aggctacttg ctcctaagtc acagggcctg ttcgtagtgg cagaacttgg gtccctggaa
     4681 ttccagggtc catgtttcca gttaattcca ggcatcagtg aagtagaaag gccttagaag
     4741 ctggaacccc agaatgaggt tttgaagacc taaaaccaaa tggaaaaatc taaaggaaac
     4801 gagcaatttt ccatgaactt ttgttcctcc tgaagctctc caaatcttca cgtttcagaa
     4861 tgtactgtgc atggtgcatt ttaaagctct aaattgacag tgtaattcta gatcgtcaca
     4921 gggttctcaa aactgcagag taggtctgtt tcccccaaaa tttccattta tctccctcca
     4981 ggaggaggga gggaagtttt tgcccctgat ttcaaaatgt cctactgttt cagatctctt
     5041 cttcttcatc atcttttttt tttttttttc agccagtgtc ttgctctgtt gcccagtctg
     5101 gagtgcaagt gcagtggtgc agtcatagct cactgcagtc tcaaactcct gggctcaagt
     5161 gatcttccca cctcagcctc ctgagaatct gggacgacgg gtgtgtgaca ccatgcccag
     5221 caattttatt tttattttta ttcatttatt ttgtttgggt tttttttttt ctgagacagg
     5281 gtctccctct gtcgcatagg ctggagtgca gtggcaccat ctcggctcat tgcaacctcc
     5341 gcctcctggg ttcaagtcat cctcccgcct cagcctcctg agtagctggg attacaggtg
     5401 tgcaccacca taacccagct aatattttta tttttagtag agacggggtt tcaccatttg
     5461 gccaaactgg tctcgaactc ctgacctcag gggatctgcc cgcctcagct tcccaaagtg
     5521 ctgggattac aggcgtgagc caccaagccc ggccaatttt tttttttttc aatagagacc
     5581 agagtgtctc tgtgttgccc agactggtct tgaacttctg tcctcaagca attctcctgc
     5641 cttggcctcc caaagtactg ggtttacagg tgtgagccac tgtgcccagc tctcatacct
     5701 cgtcttgatg cagtagaagt agtggttaag cctggaatca gatcttggtt ttccctctct
     5761 gagcctcagt ttcctcatct gtagagtaga cttccttcac gggtggttgt gaggatttaa
     5821 tgtatgtata gggataaggc ccagaacgta agtaaactct aagtacatgg taagtggcag
     5881 tcactgctta caagtggagc cagggttcag ggtcagagct agagacctac agggaagagt
     5941 aggtgagctg tcggggctag tgatggagag agagaagaga ctggagatcc agcttgggga
     6001 tccccttgct tcctggccca ggagccacca tggagagtga gaagctgcca gagaagcagg
     6061 aggaggatgg agagaatgtg ctaccatgga aactggagga ggagggcgtt cccaggagga
     6121 gggagtgatg gataatgtca agtgtcataa gagaggatgc gagtagggag ggcaggaggg
     6181 tgatgggagc tctccaattt agttttttac atggcccagg cagcccccaa gcctggatca
     6241 aatcccagct ctcaagctaa ctggctgtgt gacctagaca agggatttgc cttctctgag
     6301 cttcagtttc cttctagagt tgagatgtgg gaattggtcc atctctaata cgatcatcag
     6361 cctcacttaa taagagtcct agctttgccg aattcttggc cacgtgctag cagtgtgatc
     6421 ttaggcaagt cacttcacct ccacgagagc actctctgaa agctagagat atggtaagca
     6481 aagtgccacc aaagtgcctg gcacatagtg gggcctcgat acaggcttat tctctgataa
     6541 ttacacgtgt gccagaggca gctgctctaa ggaggcttgc tgggcttgga attagaaatg
     6601 ctcctcaagg gctgggtgca gtggctcacg cctgtaatcc tagcactttg ggaggccaag
     6661 gcgggtggat catgaggtca ggagttcaac accagcctga ccaacatggt gaaaccctgt
     6721 ctgtactaaa aacacaaaaa ttagccaggc gtggtggcgt gcacctgtaa tcccagctac
     6781 tcaggaggct gaggcgggag aatcgcctga acccaggaag cagaggttac agtgagccaa
     6841 gatcttgcca ctgtactcca gcctgggcga cagagcgaga ctctgtctga aaaaaaaaaa
     6901 aaattaaaaa gaaatgctcc tcaagttgga gagggcccac tagcatcctg agaggacttg
     6961 gaagaacaac agtccaggct gggcacctgc tgggtctctg tccaaaggcc agccctctct
     7021 ttgtgtcagc cgcagatccc tcacctaggg catgactact ggctgccagc tcccactaac
     7081 acctgctgca gatccagact gaagccggcc ccagcggccc caaagcccct aggaagtgac
     7141 caccccccat ccctggcacc cagatcctgg cccctgcact cacacacaaa acacatacag
     7201 atgcctctct ttcatcatgt atttattcct ttatttctgg gagccgggag gagtgacggg
     7261 agcaaatcag gacctggccg ccccacgctg agcttgcaga tattgagagt tgggtgacag
     7321 atggctgtgt ggttcaggct gcaggcagct tgggaattca aaatggggct tagagaggag
     7381 ctggaggggg ccctcgaggt ggacgtagtg atgcagtagg gcatggcact gcgaggttgc
     7441 ccgggttcta gtcccagcac catcaccggg gatgagccgt ttcagagtgt ggcactctgt
     7501 cacactccat ttcattgaga ggccactgag acattatcaa tgggtaatgt acagcacttc
     7561 catggcataa ctcatttaat cttcacagca tgatgatgag gtaggcatag tatcattacc
     7621 tccattttac agatggggaa actgaggctc agagaaggga atgacttgcc caagaccaca
     7681 tggcttctca gtgattggct cagctaggat cccacctttg gtccttcaag tccacttcct
     7741 ctgctttcct cttcctgcac cctgagagga aatgctctga gtataccgag ggtcctcagg
     7801 agactctcac atccagctca cagtcacagg ctgagcattc cctgtgctgg gttctgtacc
     7861 tcatcatgtt ggcagcagag gcacgtgcca gctgctcaaa aaactgctgt aaccttggta
     7921 gatccctctc cccatccatt tcttccttgc cttggaagtc ctgcttgttt gataattttc
     7981 tgactgactg ccatgttgtt gccttgtgac cttgggcatg tcatttcact ctgagccatt
     8041 tctcagtcat ggatgacagc acttagctga tgagaagttg agaagattca gaaagaggct
     8101 atgagtgaag gaccttgtct gttttggtca tgaaagtgtt cccaggaaat gcaaatggac
     8161 acacagtagt tatctactga gctaatgaac aatgtccctg gtgcatagta agtgcccaat
     8221 aaaatgcagc ttttttcata ttatctaatg ttttaggcca tgcctgcacc aacccatgct
     8281 tctttttttt tttctttctt tctttctttt ttttttttta agacagagtc tcactctgtc
     8341 acccaggctg aagtgcaatg gcgagatctc ggctcactgc aacctccgcc gcccgggttc
     8401 aagcaattct cctgcctcag cctgctgagt agctgggatt acaggcacgt gcccggctaa
     8461 ttttgtattt ttagtagaga cggggtttcg ccgtgttggc caggctggtc tcgaactcct
     8521 gacctcaact gatccaccca cctcggcctc ccaaagtgct aggattacag gcatgagcca
     8581 ccgtgcccag cccaacccat ggttcttaat gctgcaggtg ggtccggaga aaggcttttc
     8641 tcttttaacc atctccttga atttcagaag gtgggacaac atgtgctgga aagcagttct
     8701 taagaggaca tcttttccca agctccttag ccttagctgt cctctcctgc cctcaccagg
     8761 actgccctct cagggaccca agaggaaggg acagcctgga aaggaagaag gtcccgggcc
     8821 atctgcgtca tggggatgga gtcccttggc gtgtgccggt gcaaatacac tcctgtaacg
     8881 gggctcatct agaatctcct ctcggaatga ggagaccgca aatgtggttt tgaatcttca
     8941 ttgtccactt cattgctgtg gtgttgggca ggtctctgtc cctctctggg cctctgcacg
     9001 atggaggggt aggagttgat ggttctgaag gctctgccat cctggaaaag aactgagaca
     9061 cttccctcat gttcctgggt cccagaaaca gacatctgtt ggtaaaatct actgggcatt
     9121 tgcccagaga cagggaaaag aatgcctggg ggtctgtaat aggagctgcc ccaattaggg
     9181 gcagggaggc gggcatgtaa aaaaggaagc ttaaagcttt gttttcaggc tttttgccta
     9241 ccccaggctc catcttggta ccaagtactc aaccttctgt tttctcaata aagtgagccc
     9301 tcttctcggt gtctgca
//
