LOCUS       NM_181744               3490 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens opsin 5 (OPN5), transcript variant 1, mRNA.
ACCESSION   NM_181744 XM_166440
VERSION     NM_181744.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3490)
  AUTHORS   Bukowski,L., Chernomorchenko,A.M.F., Starnawska,A., Mors,O.,
            Staunstrup,N.H., Borglum,A.D. and Qvist,P.
  TITLE     Neuropsin in mental health
  JOURNAL   J Physiol Sci 70 (1), 26 (2020)
   PUBMED   32414324
  REMARK    GeneRIF: Neuropsin in mental health.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3490)
  AUTHORS   Lan,Y., Wang,Y. and Lu,H.
  TITLE     Opsin 3 is a key regulator of ultraviolet A-induced photoageing in
            human dermal fibroblast cells
  JOURNAL   Br J Dermatol 182 (5), 1228-1244 (2020)
   PUBMED   31380578
REFERENCE   3  (bases 1 to 3490)
  AUTHORS   Wang,Y., Lan,Y. and Lu,H.
  TITLE     Opsin3 Downregulation Induces Apoptosis of Human Epidermal
            Melanocytes via Mitochondrial Pathway
  JOURNAL   Photochem Photobiol 96 (1), 83-93 (2020)
   PUBMED   31730232
REFERENCE   4  (bases 1 to 3490)
  AUTHORS   Castellano-Pellicena,I., Uzunbajakava,N.E., Mignon,C., Raafs,B.,
            Botchkarev,V.A. and Thornton,M.J.
  TITLE     Does blue light restore human epidermal barrier function via
            activation of Opsin during cutaneous wound healing?
  JOURNAL   Lasers Surg Med 51 (4), 370-382 (2019)
   PUBMED   30168605
REFERENCE   5  (bases 1 to 3490)
  AUTHORS   Bobinska,K., Mossakowska-Wojcik,J., Szemraj,J., Galecki,P.,
            Zajaczkowska,M. and Talarowska,M.
  TITLE     Human neuropsin gene in depression
  JOURNAL   Psychiatr Danub 29 (2), 195-200 (2017)
   PUBMED   28636578
  REMARK    GeneRIF: Expression of the hNP gene on the mRNA level, evaluated
            based on peripheral blood, is significantly higher in the patients
            with MRD than in the healthy subjects.
REFERENCE   6  (bases 1 to 3490)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   7  (bases 1 to 3490)
  AUTHORS   Terakita,A.
  TITLE     The opsins
  JOURNAL   Genome Biol 6 (3), 213 (2005)
   PUBMED   15774036
  REMARK    Review article
REFERENCE   8  (bases 1 to 3490)
  AUTHORS   Tarttelin,E.E., Bellingham,J., Hankins,M.W., Foster,R.G. and
            Lucas,R.J.
  TITLE     Neuropsin (Opn5): a novel opsin identified in mammalian neural
            tissue
  JOURNAL   FEBS Lett 554 (3), 410-416 (2003)
   PUBMED   14623103
REFERENCE   9  (bases 1 to 3490)
  AUTHORS   Fredriksson,R., Hoglund,P.J., Gloriam,D.E., Lagerstrom,M.C. and
            Schioth,H.B.
  TITLE     Seven evolutionarily conserved human rhodopsin G protein-coupled
            receptors lacking close relatives
  JOURNAL   FEBS Lett 554 (3), 381-388 (2003)
   PUBMED   14623098
REFERENCE   10 (bases 1 to 3490)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356421.10 and AL161622.12.
            
            On Jul 16, 2021 this sequence version replaced NM_181744.3.
            
            Summary: Opsins are members of the guanine nucleotide-binding
            protein (G protein)-coupled receptor superfamily. This opsin gene
            is expressed in the eye, brain, testes, and spinal cord. This gene
            belongs to the seven-exon subfamily of mammalian opsin genes that
            includes peropsin (RRH) and retinal G protein coupled receptor
            (RGR). Like these other seven-exon opsin genes, this family member
            may encode a protein with photoisomerase activity. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY377391.1, BC126198.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371211.7/ ENSP00000360255.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AL356421.10        157721-157885
            166-285             AL356421.10        162204-162323
            286-456             AL356421.10        167491-167661
            457-791             AL161622.12        486-820
            792-1033            AL161622.12        13411-13652
            1034-1091           AL161622.12        16931-16988
            1092-3490           AL161622.12        29240-31638
FEATURES             Location/Qualifiers
     source          1..3490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.3"
     gene            1..3490
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /note="opsin 5"
                     /db_xref="GeneID:221391"
                     /db_xref="HGNC:HGNC:19992"
                     /db_xref="MIM:609042"
     exon            1..165
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1100
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /note="transmembrane protein 13; neuropsin; G-protein
                     coupled receptor 136"
                     /codon_start=1
                     /product="opsin-5"
                     /protein_id="NP_859528.1"
                     /db_xref="CCDS:CCDS4923.1"
                     /db_xref="GeneID:221391"
                     /db_xref="HGNC:HGNC:19992"
                     /db_xref="MIM:609042"
                     /translation="MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIG
                     ILSTFGNGYVLYMSSRRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFG
                     WIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYA
                     SFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFS
                     YVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSA
                     FGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRL
                     HTVTTVRKSSAVLEIHEEWE"
     exon            166..285
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            286..456
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            457..791
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1033
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1091
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..3490
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1978..1983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /note="hexamer: AATAAA"
     polyA_site      1999
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /note="major polyA site"
     regulatory      3468..3473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /note="hexamer: AATAAA"
     polyA_site      3490
                     /gene="OPN5"
                     /gene_synonym="GPR136; GRP136; PGR12; TMEM13"
                     /note="major polyA site"
ORIGIN      
        1 tttgcttttc agatccctcg tggttcgaga acagaatggc gttaaatcac actgccctgc
       61 ctcaggacga gcgcctgccc cattaccttc gagatgggga tccttttgct tccaaacttt
      121 cttgggaagc ggatttagtg gctggctttt acctaacaat aattgggatt ctgtccacat
      181 ttggaaatgg atatgtcctt tacatgtctt ctagacgaaa gaagaagctg agacccgctg
      241 aaataatgac tatcaattta gcagtctgtg atctggggat ttcagttgta ggcaagccgt
      301 tcaccatcat ctcttgcttt tgtcaccgct gggtgtttgg ctggatcggc tgccgctggt
      361 atggatgggc tggatttttc tttggctgtg gaagccttat caccatgact gctgtcagcc
      421 tggatcgata tttgaaaatc tgctatttat cttatggggt ttggctgaaa agaaagcacg
      481 cctacatctg cctggcagcc atctgggcct atgcttcctt ctggaccacc atgcccttgg
      541 taggtctggg ggactacgta cctgagccct tcggaacctc gtgcaccctg gactggtggc
      601 tggcccaggc ctcggtaggg ggccaggttt tcatcctgaa catcctcttc ttctgcctct
      661 tgctcccaac ggctgtgatc gtgttctcct acgtaaagat cattgccaag gttaagtcct
      721 cttccaaaga agtagctcat ttcgacagtc ggatccatag cagccatgtg ctggaaatga
      781 aactgacaaa ggtagcgatg ttgatttgtg ctggattcct gattgcctgg attccttatg
      841 cagtggtgtc tgtgtggtca gcttttggaa ggccagactc cattcccata cagctctctg
      901 tggtgccaac cctacttgca aaatctgcag cgatgtacaa tcccatcatt taccaagtta
      961 ttgattacaa atttgcctgt tgccaaactg gtggtttgaa agcaaccaag aagaagtctc
     1021 tggaaggctt caggctgcac accgtaacca cagtcaggaa gtcttctgct gtgctggaaa
     1081 ttcatgaaga gtgggaataa caaatgttct ggttgtgaag agtgcatctg aagtgcttac
     1141 acggcgtctg gcatatgcag agaaattagc ttacaaatgt tatttttctg acttctcgcc
     1201 tccactccac ttaccctgtc aggaaaaaat aattcacaag gaatatcaaa acaatgatgc
     1261 accctaggag tatccaagta tcttaactga gttatctcat tctggtatag tggcagagtt
     1321 ataactaaag agtgccagaa acccacgctt taaacatcct gcagtgcaca cctcggtctc
     1381 gtcagtaagg acttcacttt cttctgaact ggggcttgtg aaagctggcc tgaaaagcct
     1441 gattcaagga gatcaggctg tgtctctgac tggagcagct acactcccca tctgtaattt
     1501 gatttgttct attgcagatg atgtactggg cagaggtgag tgtggattgg tgaaaatctg
     1561 tttttatgac tggcaaagca gtgcaggggg gtctttcact gataagaagc atcatcagta
     1621 gggtttgtcc ctgatgcctt tacaacagca tctgagcacc tctcaagttt ttccaggcca
     1681 gctccagttt cagtgaggag agtgtgggct ttctattccc caaatattct tactacagtt
     1741 aatatgtagg ttactgcccc agcccaactg caggttccca gatgtgagtt ccatgtaggc
     1801 agaaactgtc cagttcttga aattgaatta cttccttgtg tatgtgtttt tttcctactt
     1861 aaagctcctc gggatgcttc ctctcaaaag tctttgaaga ataagaggtt aagctaagac
     1921 aacctgaatc aatttttttt tttttgtcaa atgcgattga aattatcccc ataattcaat
     1981 aaaatagctt tttcccttct ttctttttac tttgttggaa actatgcaac agaaacaaag
     2041 taagaagact ctaccttaat tttaaaggta actcttacat aaagaagaaa gtcattatgc
     2101 caggccaggg ggagagtgga aaggggaaat ttagagaata gaaacaaact taagcatctt
     2161 gtaaattttg agtgaattgt aaacacataa tgaatgaatg agaagggcca gccaggagtc
     2221 tgtgaaatgg tccagttggg aaatgcctaa tgcataaaca caaatcttgg tgacaggtag
     2281 gttagttatc tgtgaacttt ctaaagatta aataaacaat aataggattt tgttaatgtg
     2341 ccaaagtgag tttaaaccat gaaagacacg atgcaaatat gcaagtacct ttaattgggc
     2401 ataataaaaa gtagtgaggt atggttaaaa taacatttag aacaagagag aagttaggga
     2461 gaatttttgt ctaaaaagcc aaaaagtgat agttgattgg tgattttgtt gttatcagga
     2521 gagagaattt tcttaatgta ataagttagg tactttggca agtgaaatgg gttctaggcc
     2581 aattgcaagt ccttaggatt ccctggcagc tagaaacctt ggcactccca aaagacagct
     2641 tcagttaaaa tgacagatga acatgagtct tcaagtcaaa actactgttg taccacgtcc
     2701 attgaatgtt tggtgattca agtctctgtt attcaagaac tgattctgtt tttcctcctg
     2761 tcaaaacctt ggttgatttt gactgtagta gcacatctgg caggaatatg acagaaaaaa
     2821 attaagttaa aaatataatt tctattcccc tattttttct gtaaaaggct ttatggggaa
     2881 gaagggaaga aggttgacat gagtagagat gatacttgcc tctggatgac ccagttgggt
     2941 tctcctttga ctgccattca ccacagttga cctcattagg ctccgaagta tgagaagagc
     3001 ttcattgcca agttagtgaa agaagcagat gatttacttt tgctcgagtg ggtctgtaga
     3061 cctcgggagg ttagccattt ctcttagagt ttggtgtatg tattaagata cagcatgtat
     3121 gtaggtatat ataatacata tatgtgtgta tacatatata tatatttctg gtttgtttaa
     3181 tatcttttaa aaaattttaa tggaattttt tgaacatgta caaaagagaa agaatcctac
     3241 gatgaactcc catgtatcca tcatccagcc tcaatagtga tcaacccata gcatattgtg
     3301 gttcatgttg acactcatcc acctctttcc ttccccatct ctccccatta ttttgagacg
     3361 aatgagatcc tgggatttcg tgaaaatatt atgaatatct tatttgtgag aacaagattt
     3421 cccaaagcat gatccccaga aacctagtcc tgcaaaacta ctgcaaaaat aaagtgttct
     3481 aatctccaaa
//
