LOCUS       NM_033282               2383 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens opsin 4 (OPN4), transcript variant 1, mRNA.
ACCESSION   NM_033282
VERSION     NM_033282.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Platzl,C., Kaser-Eichberger,A., Trost,A., Strohmaier,C., Stone,R.,
            Nickla,D. and Schroedl,F.
  TITLE     Melanopsin in the human and chicken choroid
  JOURNAL   Exp Eye Res 247, 110053 (2024)
   PUBMED   39151779
  REMARK    GeneRIF: Melanopsin in the human and chicken choroid.
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Adhikari,P., Uprety,S., Feigl,B. and Zele,A.J.
  TITLE     Melanopsin-mediated amplification of cone signals in the human
            visual cortex
  JOURNAL   Proc Biol Sci 291 (2023), 20232708 (2024)
   PUBMED   38808443
  REMARK    GeneRIF: Melanopsin-mediated amplification of cone signals in the
            human visual cortex.
REFERENCE   3  (bases 1 to 2383)
  AUTHORS   Rach,H., Kilic-Huck,U., Reynaud,E., Hugueny,L., Peiffer,E., Roy de
            Belleplaine,V., Fuchs,F., Bourgin,P. and Geoffroy,P.A.
  TITLE     The melanopsin-mediated pupil response is reduced in idiopathic
            hypersomnia with long sleep time
  JOURNAL   Sci Rep 12 (1), 9018 (2022)
   PUBMED   35637236
  REMARK    GeneRIF: The melanopsin-mediated pupil response is reduced in
            idiopathic hypersomnia with long sleep time.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2383)
  AUTHORS   de Assis,L.V.M., Lacerda,J.T., Moraes,M.N.,
            Dominguez-Amorocho,O.A., Kinker,G.S., Mendes,D., Silva,M.M.,
            Menck,C.F.M., Camara,N.O.S. and Castrucci,A.M.L.
  TITLE     Melanopsin (Opn4) is an oncogene in cutaneous melanoma
  JOURNAL   Commun Biol 5 (1), 461 (2022)
   PUBMED   35562405
  REMARK    GeneRIF: Melanopsin (Opn4) is an oncogene in cutaneous melanoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2383)
  AUTHORS   Sun,H., Wang,C., Hu,B., Gao,X., Zou,T., Luo,Q., Chen,M., Fu,Y.,
            Sheng,Y., Zhang,K., Zheng,Y., Ren,X., Yan,S., Geng,Y., Yang,L.,
            Dong,Q. and Qin,L.
  TITLE     Exosomal S100A4 derived from highly metastatic hepatocellular
            carcinoma cells promotes metastasis by activating STAT3
  JOURNAL   Signal Transduct Target Ther 6 (1), 187 (2021)
   PUBMED   34035222
  REMARK    GeneRIF: Exosomal S100A4 derived from highly metastatic
            hepatocellular carcinoma cells promotes metastasis by activating
            STAT3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2383)
  AUTHORS   Qiu,X., Kumbalasiri,T., Carlson,S.M., Wong,K.Y., Krishna,V.,
            Provencio,I. and Berson,D.M.
  TITLE     Induction of photosensitivity by heterologous expression of
            melanopsin
  JOURNAL   Nature 433 (7027), 745-749 (2005)
   PUBMED   15674243
REFERENCE   7  (bases 1 to 2383)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   8  (bases 1 to 2383)
  AUTHORS   Zhu,X., Brown,B., Li,A., Mears,A.J., Swaroop,A. and Craft,C.M.
  TITLE     GRK1-dependent phosphorylation of S and M opsins and their binding
            to cone arrestin during cone phototransduction in the mouse retina
  JOURNAL   J Neurosci 23 (14), 6152-6160 (2003)
   PUBMED   12853434
REFERENCE   9  (bases 1 to 2383)
  AUTHORS   Lerchl,A.
  TITLE     Biological rhythms in the context of light at night (LAN)
  JOURNAL   Neuro Endocrinol Lett 23 Suppl 2, 23-27 (2002)
   PUBMED   12163844
  REMARK    Review article
REFERENCE   10 (bases 1 to 2383)
  AUTHORS   Provencio,I., Rodriguez,I.R., Jiang,G., Hayes,W.P., Moreira,E.F.
            and Rollag,M.D.
  TITLE     A novel human opsin in the inner retina
  JOURNAL   J Neurosci 20 (2), 600-605 (2000)
   PUBMED   10632589
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC067750.5, CD634966.1, BC113558.1 and BM672338.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033282.3.
            
            Summary: Opsins are members of the guanine nucleotide-binding
            protein (G protein)-coupled receptor superfamily. This gene encodes
            a photoreceptive opsin protein that is expressed within the
            ganglion and amacrine cell layers of the retina. In mouse, retinal
            ganglion cell axons expressing this gene projected to the
            suprachiasmatic nucleus and other brain nuclei involved in
            circadian photoentrainment. In mouse, this protein is coupled to a
            transient receptor potential (TRP) ion channel through a G protein
            signaling pathway and produces a physiologic light response via
            membrane depolarization and increased intracellular calcium. The
            protein functions as a sensory photopigment and may also have
            photoisomerase activity. Experiments with knockout mice indicate
            that this gene attenuates, but does not abolish, photoentrainment.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113558.1, SRR1803611.159498.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241891.10/ ENSP00000241891.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC067750.5         156717-156726       c
            11-266              CD634966.1         422-677             c
            267-1919            BC113558.1         86-1738
            1920-1954           AC067750.5         145242-145276       c
            1955-2383           BM672338.1         14-442              c
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..2383
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /note="opsin 4"
                     /db_xref="GeneID:94233"
                     /db_xref="HGNC:HGNC:14449"
                     /db_xref="MIM:606665"
     exon            1..381
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1674
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     melanopsin"
                     /codon_start=1
                     /product="melanopsin isoform 1"
                     /protein_id="NP_150598.1"
                     /db_xref="CCDS:CCDS7376.1"
                     /db_xref="GeneID:94233"
                     /db_xref="HGNC:HGNC:14449"
                     /db_xref="MIM:606665"
                     /translation="MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPS
                     ISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRSRSLR
                     TPANMFIINLAVSDFLMSFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMIT
                     LTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVPEGLL
                     TSCSWDYMSFTPAVRAYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACK
                     GNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSV
                     PAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRST
                     LTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEA
                     KAPPRPQGHEAETPGKTKGLIPSQDPRM"
     exon            382..527
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            528..661
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            662..865
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1037
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1202
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1310
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1491
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1635
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..2383
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2352..2357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /note="hexamer: AATAAA"
     polyA_site      2383
                     /gene="OPN4"
                     /gene_synonym="MOP"
                     /note="major polyA site"
ORIGIN      
        1 gtgagtcacc ataactgcga cactcactca tttgcgcttc accagacaca gagcaaccgc
       61 cagccccaag agcagctcca ggctggatct gcgccggaca caggagaaag cagcgggtag
      121 gctaagcagg ggtgctgagg atggaggaaa gttgggaggc tgagcacagc tgaagtcctg
      181 agctccctgt gcccttgact tctctgtggg ctcgagcaag gaccatccca actcaggatg
      241 aaccctcctt cggggccaag agtcccgccc agcccaaccc aagagcccag ctgcatggcc
      301 accccagcac cacccagctg gtgggacagc tcccagagca gcatctccag cctgggccgg
      361 cttccatcca tcagtcccac agcacctggg acttgggctg ctgcctgggt ccccctcccc
      421 acggttgatg ttccagacca tgcccactat accctgggca cagtgatctt gctggtggga
      481 ctcacgggga tgctgggcaa cctgacggtc atctatacct tctgcaggag cagaagcctc
      541 cggacacctg ccaacatgtt cattatcaac ctcgcggtca gcgacttcct catgtccttc
      601 acccaggccc ctgtcttctt caccagtagc ctctataagc agtggctctt tggggagaca
      661 ggctgcgagt tctatgcctt ctgtggagct ctctttggca tttcctccat gatcaccctg
      721 acggccatcg ccctggaccg ctacctggta atcacacgcc cgctggccac ctttggtgtg
      781 gcgtccaaga ggcgtgcggc atttgtcctg ctgggcgttt ggctctatgc cctggcctgg
      841 agtctgccac ccttcttcgg ctggagcgcc tacgtgcccg aggggttgct gacatcctgc
      901 tcctgggact acatgagctt cacgccggcc gtgcgtgcct acaccatgct tctctgctgc
      961 ttcgtgttct tcctccctct gcttatcatc atctactgct acatcttcat cttcagggcc
     1021 atccgggaga caggacgggc tctccagacc ttcggggcct gcaagggcaa tggcgagtcc
     1081 ctgtggcagc ggcagcggct gcagagcgag tgcaagatgg ccaagatcat gctgctggtc
     1141 atcctcctct tcgtgctctc ctgggctccc tattccgctg tggccctggt ggcctttgct
     1201 gggtacgcac acgtcctgac accctacatg agctcggtgc cagccgtcat cgccaaggcc
     1261 tctgcaatcc acaaccccat catttacgcc atcacccacc ccaagtacag ggtggccatt
     1321 gcccagcacc tgccctgcct gggggtgctg ctgggtgtat cacgccggca cagtcgcccc
     1381 taccccagct accgctccac ccaccgctcc acgctgacca gccacacctc caacctcagc
     1441 tggatctcca tacggaggcg ccaggagtcc ctgggctcgg agagtgaggt gggctggaca
     1501 cacatggagg cagcagctgt gtggggagct gcccagcaag caaatgggcg gtccctctac
     1561 ggtcagggtc tggaggactt ggaagccaag gcacccccca gaccccaggg acacgaagca
     1621 gagactccag ggaagaccaa ggggctgatc cccagccagg accccaggat gtaggacgcc
     1681 cactggctct ccctttcttc tgagacacat ccagcccccc cacgtctccc tcatatacac
     1741 agacccagga ttatgctgtg agcctgcagg ctttggaagt ggccctgtca cccgtgctgc
     1801 acgggattca cagccccagc cccatggccc ctctccacac ctcaaaactc ctgccccata
     1861 acgtcctccg catccacttt ccagctcagc agccgcaccc gaggctcagc ctgaggggta
     1921 tgtgcccagg ccctcccact tcccgagttg tctgcctctc ctcaaatgct gtgtgctgca
     1981 attgtccagg cgatgacaat ggtgatggct ccagagaaca caccagctat ttatgagcct
     2041 ctgcccccag gctgggcctg tcactggcat aggaaggcca gccccgcatc tcccactgcc
     2101 aacagctgaa gccgagcaca gacctccctt tgcacgctgg aacagttact cacctgtggc
     2161 ttcttccccc agtgtaccgt tccactgtgg cccacattct tgtgcacgcg ggcatttgca
     2221 ggcacgctct cgcgtagtta cctatctgaa tgcacaccaa gcacatgcgt gcacactctg
     2281 cgtctgtgat tcatttcatg tagtggtcta agctcctccc agggctgtgt ggatctgaca
     2341 gggtatagga aaataaaaag cggagaaggt gtcttcagac aaa
//
