LOCUS       NP_001316996             364 aa            linear   PRI 01-MAY-2025
DEFINITION  medium-wave-sensitive opsin 3 [Homo sapiens].
ACCESSION   NP_001316996 XP_003960138
VERSION     NP_001316996.1
DBSOURCE    REFSEQ: accession NM_001330067.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245140.2.
            
            On Aug 15, 2016 this sequence version replaced XP_003960138.1.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000599405.4/ ENSP00000469970.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     Protein         1..364
                     /product="medium-wave-sensitive opsin 3"
                     /note="green-sensitive opsin; green cone photoreceptor
                     pigment; opsin 1 cone pigments medium-wave-sensitive 3;
                     opsin 1 (cone pigments), medium-wave-sensitive 3;
                     Medium-wave-sensitive opsin 2; Opsin 1 cone pigments
                     medium-wave-sensitive 2"
                     /calculated_mol_wt=40453
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Region          17..43
                     /region_name="Required for 11-cis-retinal regeneration.
                     /evidence=ECO:0000250|UniProtKB:P04001"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Site            34
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (P0DN78.1)"
     Region          42..333
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Site            53..77
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Region          56..80
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:410628"
     Region          89..111
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:410628"
     Site            90..115
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Region          127..149
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:410628"
     Site            130..149
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Site            169..192
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Region          171..187
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:410628"
     Region          217..240
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:410628"
     Site            219..246
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Region          267..289
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:410628"
     Site            269..292
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     Region          301..326
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:410628"
     Site            301..325
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P0DN78.1)"
     CDS             1..364
                     /gene="OPN1MW3"
                     /gene_synonym="GCP; GOP; OPN1MW; OPN1MW2"
                     /coded_by="NM_001330067.2:39..1133"
                     /db_xref="CCDS:CCDS83509.1"
                     /db_xref="GeneID:101060233"
                     /db_xref="HGNC:HGNC:51831"
ORIGIN      
        1 maqqwslqrl agrhpqdsye dstqssifty tnsnstrgpf egpnyhiapr wvyhltsvwm
       61 ifvviasvft nglvlaatmk fkklrhplnw ilvnlavadl aetviastis vvnqvygyfv
      121 lghpmcvleg ytvslcgitg lwslaiiswe rwmvvckpfg nvrfdaklai vgiafswiwa
      181 avwtappifg wsrywphglk tscgpdvfsg ssypgvqsym ivlmvtccit plsiivlcyl
      241 qvwlairava kqqkesestq kaekevtrmv vvmvlafcfc wgpyaffacf aaanpgypfh
      301 plmaalpaff aksatiynpv iyvfmnrqfr ncilqlfgkk vddgselssa sktevssvss
      361 vspa
//
