LOCUS       NM_001048181            1261 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens opsin 1, medium wave sensitive 2 (OPN1MW2), mRNA.
ACCESSION   NM_001048181 XM_001127499
VERSION     NM_001048181.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Hofmann,L., Alexander,N.S., Sun,W., Zhang,J., Orban,T. and
            Palczewski,K.
  TITLE     Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin
            Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of
            Monostable Visual G Protein-Coupled Receptors
  JOURNAL   Biochemistry 56 (17), 2338-2348 (2017)
   PUBMED   28402104
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Zhang,X., Bedigian,A.V., Wang,W. and Eggert,U.S.
  TITLE     G protein-coupled receptors participate in cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 69 (10), 810-818 (2012)
   PUBMED   22888021
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   Gardner,J.C., Webb,T.R., Kanuga,N., Robson,A.G., Holder,G.E.,
            Stockman,A., Ripamonti,C., Ebenezer,N.D., Ogun,O., Devery,S.,
            Wright,G.A., Maher,E.R., Cheetham,M.E., Moore,A.T., Michaelides,M.
            and Hardcastle,A.J.
  TITLE     X-linked cone dystrophy caused by mutation of the red and green
            cone opsins
  JOURNAL   Am J Hum Genet 87 (1), 26-39 (2010)
   PUBMED   20579627
REFERENCE   4  (bases 1 to 1261)
  AUTHORS   Tsutsumi,M., Ikeyama,K., Denda,S., Nakanishi,J., Fuziwara,S.,
            Aoki,H. and Denda,M.
  TITLE     Expressions of rod and cone photoreceptor-like proteins in human
            epidermis
  JOURNAL   Exp Dermatol 18 (6), 567-570 (2009)
   PUBMED   19493002
  REMARK    GeneRIF: Immunoreactivity to anti-OPN1LW antibodies was seen in the
            basal layer of human epidermis & reconstructed skin. The opsin mRNA
            was seen in total RNA from human skin. Neither immunoreactivity nor
            mRNA expression was seen in cultured human keratinocytes.
REFERENCE   5  (bases 1 to 1261)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   6  (bases 1 to 1261)
  AUTHORS   Hayashi,T., Motulsky,A.G. and Deeb,S.S.
  TITLE     Position of a 'green-red' hybrid gene in the visual pigment array
            determines colour-vision phenotype
  JOURNAL   Nat Genet 22 (1), 90-93 (1999)
   PUBMED   10319869
REFERENCE   7  (bases 1 to 1261)
  AUTHORS   Asenjo,A.B., Rim,J. and Oprian,D.D.
  TITLE     Molecular determinants of human red/green color discrimination
  JOURNAL   Neuron 12 (5), 1131-1138 (1994)
   PUBMED   8185948
REFERENCE   8  (bases 1 to 1261)
  AUTHORS   Winderickx,J., Sanocki,E., Lindsey,D.T., Teller,D.Y., Motulsky,A.G.
            and Deeb,S.S.
  TITLE     Defective colour vision associated with a missense mutation in the
            human green visual pigment gene
  JOURNAL   Nat Genet 1 (4), 251-256 (1992)
   PUBMED   1302020
REFERENCE   9  (bases 1 to 1261)
  AUTHORS   Nathans,J., Thomas,D. and Hogness,D.S.
  TITLE     Molecular genetics of human color vision: the genes encoding blue,
            green, and red pigments
  JOURNAL   Science 232 (4747), 193-202 (1986)
   PUBMED   2937147
REFERENCE   10 (bases 1 to 1261)
  AUTHORS   Applebury,M.L. and Hargrave,P.A.
  TITLE     Molecular biology of the visual pigments
  JOURNAL   Vision Res 26 (12), 1881-1895 (1986)
   PUBMED   3303660
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244097.3.
            
            On Nov 20, 2020 this sequence version replaced NM_001048181.2.
            
            Summary: This gene encodes for a light absorbing visual pigment of
            the opsin gene family. The encoded protein is called green cone
            photopigment or medium-wavelength sensitive opsin. Opsins are
            G-protein coupled receptors with seven transmembrane domains, an
            N-terminal extracellular domain, and a C-terminal cytoplasmic
            domain. The long-wavelength opsin gene and multiple copies of the
            medium-wavelength opsin gene are tandemly arrayed on the X
            chromosome and frequent unequal recombination and gene conversion
            may occur between these sequences. X chromosomes may have fusions
            of the medium- and long-wavelength opsin genes or may have more
            than one copy of these genes. Defects in this gene are the cause of
            deutanopic colorblindness. [provided by RefSeq, Mar 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369929.8/ ENSP00000358945.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC244097.3         151262-151433
            173-469             AC244097.3         156414-156710
            470-638             AC244097.3         158698-158866
            639-804             AC244097.3         160334-160499
            805-1044            AC244097.3         162054-162293
            1045-1261           AC244097.3         164576-164792
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..1261
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /note="opsin 1, medium wave sensitive 2"
                     /db_xref="GeneID:728458"
                     /db_xref="HGNC:HGNC:26952"
     exon            1..172
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1155
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /note="green-sensitive opsin; green cone photoreceptor
                     pigment; opsin 1 (cone pigments), medium-wave-sensitive 2;
                     opsin 1 cone pigments medium-wave-sensitive 2"
                     /codon_start=1
                     /product="medium-wave-sensitive opsin 1"
                     /protein_id="NP_001041646.1"
                     /db_xref="CCDS:CCDS35447.1"
                     /db_xref="GeneID:728458"
                     /db_xref="HGNC:HGNC:26952"
                     /translation="MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPN
                     YHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAE
                     TVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFG
                     NVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS
                     YMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLA
                     FCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCIL
                     QLFGKKVDDGSELSSASKTEVSSVSSVSPA"
     exon            173..469
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /inference="alignment:Splign:2.1.0"
     exon            470..638
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /inference="alignment:Splign:2.1.0"
     exon            639..804
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /inference="alignment:Splign:2.1.0"
     exon            805..1044
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1261
                     /gene="OPN1MW2"
                     /gene_synonym="GOP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgaccctc aggtgacgca ccagggccgg ctgccgtcgg ggacagggct ttccatagcc
       61 atggcccagc agtggagcct ccaaaggctc gcaggccgcc atccgcagga cagctatgag
      121 gacagcaccc agtccagcat cttcacctac accaacagca actccaccag aggccccttc
      181 gaaggcccga attaccacat cgctcccaga tgggtgtacc acctcaccag tgtctggatg
      241 atctttgtgg tcattgcatc cgtcttcaca aatgggcttg tgctggcggc caccatgaag
      301 ttcaagaagc tgcgccaccc gctgaactgg atcctggtga acctggcggt cgctgacctg
      361 gcagagaccg tcatcgccag cactatcagc gttgtgaacc aggtctatgg ctacttcgtg
      421 ctgggccacc ctatgtgtgt cctggagggc tacaccgtct ccctgtgtgg gatcacaggt
      481 ctctggtctc tggccatcat ttcctgggag agatggatgg tggtctgcaa gccctttggc
      541 aatgtgagat ttgatgccaa gctggccatc gtgggcattg ccttctcctg gatctgggct
      601 gctgtgtgga cagccccgcc catctttggt tggagcaggt actggcccca cggcctgaag
      661 acttcatgcg gcccagacgt gttcagcggc agctcgtacc ccggggtgca gtcttacatg
      721 attgtcctca tggtcacctg ctgcatcacc ccactcagca tcatcgtgct ctgctacctc
      781 caagtgtggc tggccatccg agcggtggca aagcagcaga aagagtctga atccacccag
      841 aaggcagaga aggaagtgac gcgcatggtg gtggtgatgg tcctggcatt ctgcttctgc
      901 tggggaccct acgccttctt cgcatgcttt gctgctgcca accctggcta ccccttccac
      961 cctttgatgg ctgccctgcc ggccttcttt gccaaaagtg ccactatcta caaccccgtt
     1021 atctatgtct ttatgaaccg gcagtttcga aactgcatct tgcagctttt cgggaagaag
     1081 gttgacgatg gctctgaact ctccagcgcc tccaaaacgg aggtctcatc tgtgtcctcg
     1141 gtatcgcctg catgaggtct gcctcctacc catcccgccc accggggctt tggccacctc
     1201 tcctttcccc ctccttctcc atccctgtaa aataaatgta atttatcttt gccaaaacca
     1261 a
//
