LOCUS       NM_017570               4020 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens 5-oxoprolinase, ATP-hydrolysing (OPLAH), mRNA.
ACCESSION   NM_017570 XM_291266
VERSION     NM_017570.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Sass,J.O., Gemperle-Britschgi,C., Tarailo-Graovac,M., Patel,N.,
            Walter,M., Jordanova,A., Alfadhel,M., Baric,I., Coker,M.,
            Damli-Huber,A., Faqeih,E.A., Garcia Segarra,N., Geraghty,M.T.,
            Jatun,B.M., Kalkan Ucar,S., Kriewitz,M., Rauchenzauner,M.,
            Bilic,K., Tournev,I., Till,C., Sayson,B., Beumer,D., Ye,C.X.,
            Zhang,L.H., Vallance,H., Alkuraya,F.S. and van Karnebeek,C.D.
  TITLE     Unravelling 5-oxoprolinuria (pyroglutamic aciduria) due to
            bi-allelic OPLAH mutations: 20 new mutations in 14 families
  JOURNAL   Mol Genet Metab 119 (1-2), 44-49 (2016)
   PUBMED   27477828
  REMARK    GeneRIF: An autosomal recessive mode of inheritance for
            5-oxoprolinase deficiency is further supported by the
            identification of a single mutation in all 9/14 parent sample sets
            investigated (except for the father of one patient whose result
            suggests homozygosity), and the absence of 5-oxoprolinuria in all
            tested heterozygotes
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Li,X., Ding,Y., Liu,Y., Ma,Y., Song,J., Wang,Q. and Yang,Y.
  TITLE     Five Chinese patients with 5-oxoprolinuria due to glutathione
            synthetase and 5-oxoprolinase deficiencies
  JOURNAL   Brain Dev 37 (10), 952-959 (2015)
   PUBMED   25851806
  REMARK    GeneRIF: In this study, clinical, biochemical, and genetic aspects
            of five Chinese 5-oxoprolinuria patients with OPLAH or GSS gene
            mutations were investigated.
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Calpena,E., Casado,M., Martinez-Rubio,D., Nascimento,A.,
            Colomer,J., Gargallo,E., Garcia-Cazorla,A., Palau,F., Artuch,R. and
            Espinos,C.
  TITLE     5-Oxoprolinuria in Heterozygous Patients for 5-Oxoprolinase (OPLAH)
            Missense Changes
  JOURNAL   JIMD Rep 7, 123-128 (2013)
   PUBMED   23430506
REFERENCE   6  (bases 1 to 4020)
  AUTHORS   Almaghlouth,I.A., Mohamed,J.Y., Al-Amoudi,M., Al-Ahaidib,L.,
            Al-Odaib,A. and Alkuraya,F.S.
  TITLE     5-Oxoprolinase deficiency: report of the first human OPLAH mutation
  JOURNAL   Clin Genet 82 (2), 193-196 (2012)
   PUBMED   21651516
REFERENCE   7  (bases 1 to 4020)
  AUTHORS   Suhre,K., Shin,S.Y., Petersen,A.K., Mohney,R.P., Meredith,D.,
            Wagele,B., Altmaier,E., Deloukas,P., Erdmann,J., Grundberg,E.,
            Hammond,C.J., de Angelis,M.H., Kastenmuller,G., Kottgen,A.,
            Kronenberg,F., Mangino,M., Meisinger,C., Meitinger,T., Mewes,H.W.,
            Milburn,M.V., Prehn,C., Raffler,J., Ried,J.S., Romisch-Margl,W.,
            Samani,N.J., Small,K.S., Wichmann,H.E., Zhai,G., Illig,T.,
            Spector,T.D., Adamski,J., Soranzo,N. and Gieger,C.
  CONSRTM   CARDIoGRAM
  TITLE     Human metabolic individuality in biomedical and pharmaceutical
            research
  JOURNAL   Nature 477 (7362), 54-60 (2011)
   PUBMED   21886157
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4020)
  AUTHORS   Kumar,A. and Bachhawat,A.K.
  TITLE     A futile cycle, formed between two ATP-dependant gamma-glutamyl
            cycle enzymes, gamma-glutamyl cysteine synthetase and
            5-oxoprolinase: the cause of cellular ATP depletion in nephrotic
            cystinosis?
  JOURNAL   J Biosci 35 (1), 21-25 (2010)
   PUBMED   20413906
  REMARK    GeneRIF: the cause of cellular ATP depletion in nephrotic
            cystinosis may be the futile cycle, formed between two
            ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine
            synthetase and 5-oxoprolinase
REFERENCE   9  (bases 1 to 4020)
  AUTHORS   Watanabe,T., Abe,K., Ishikawa,H. and Iijima,Y.
  TITLE     Bovine 5-oxo-L-prolinase: simple assay method, purification, cDNA
            cloning, and detection of mRNA in the coronary artery
  JOURNAL   Biol Pharm Bull 27 (3), 288-294 (2004)
   PUBMED   14993790
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC142672.1 and AC109322.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017570.4.
            
            Summary: The protein encoded by this gene acts as a homodimer,
            using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline
            to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase
            deficiency (OPLAHD). [provided by RefSeq, Jun 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142672.1, SRR9304715.461662.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618853.5/ ENSP00000480476.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3119              BC142672.1         12-3130
            3120-3120           AC109322.16        38268-38268
            3121-4020           BC142672.1         3132-4031
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..4020
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /note="5-oxoprolinase, ATP-hydrolysing"
                     /db_xref="GeneID:26873"
                     /db_xref="HGNC:HGNC:8149"
                     /db_xref="MIM:614243"
     exon            1..40
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            41..264
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3960
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /EC_number="3.5.2.9"
                     /note="pyroglutamase; 5-oxo-L-prolinase"
                     /codon_start=1
                     /product="5-oxoprolinase"
                     /protein_id="NP_060040.1"
                     /db_xref="CCDS:CCDS75802.1"
                     /db_xref="GeneID:26873"
                     /db_xref="HGNC:HGNC:8149"
                     /db_xref="MIM:614243"
                     /translation="MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYA
                     DAPTEGIRRILEQEAGMLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTR
                     GFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDL
                     LEVQQPVDLGALRGKLEGLLSRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSL
                     SSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAP
                     MDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFE
                     ASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVT
                     DANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASPLSL
                     EEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTV
                     HIHRHSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQG
                     FPRSQISTESFLHLRYQGTDCALMVSAHQHPATARSPRAGDFGAAFVERYMREFGFVI
                     PERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVDKMTQCYFEGGYQETPVYLLAEL
                     GYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSI
                     FSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQE
                     TVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHH
                     ADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKVPNCSGTR
                     NLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFG
                     TSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEVFGNLNAPRAV
                     TLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQRVVD
                     VILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRIT
                     DPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPY
                     GLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPP
                     PGSPPQALAFPEHGSVYEYRRAQEAV"
     exon            265..456
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            457..556
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            557..680
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            681..876
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1042
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1181
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1249
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1515
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1628
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1799
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1937
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2076
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2189
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..2341
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2502
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2604
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2779
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2964
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3111
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3246
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3396
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3554
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3715
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3813
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     exon            3814..4020
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3970..3975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /note="hexamer: AATAAA"
     polyA_site      4020
                     /gene="OPLAH"
                     /gene_synonym="5-Opase; OPLA; OPLAHD"
                     /note="major polyA site"
ORIGIN      
        1 agagccgacc gcgagcgacc gagccggagc cgagcgccag tttttccagg gctaccagct
       61 gaagagctcc tgtgggactc cagccccacc accatgggca gccccgaggg ccgcttccac
      121 tttgccatcg accgtggggg taccttcaca gacgtctttg cccagtgccc aggggggcac
      181 gtgcgggtct taaaactgct ctcagaggac cctgccaact atgcggacgc gccaaccgaa
      241 ggcatccgcc gcatcctgga gcaggaggcc ggcatgctcc tgccccggga ccagccgctg
      301 gactccagtc atatcgccag catccgcatg ggcaccacag tggccaccaa cgcactgctg
      361 gagcggaagg gggagcgggt ggcgctgctg gtgacacgtg gcttccgaga cctgctgcac
      421 attggcaccc aagcccgtgg ggacctcttt gacctggccg tgcccatgcc tgaggtgctg
      481 tatgaagagg tgctggaggt ggacgaacgc gtggtgctgc accgtggaga ggcgggcacc
      541 gggacgcctg tgaaaggccg cacgggggac ctgctggaag tgcagcagcc tgtggacctg
      601 ggggccctgc gtgggaagct ggaggggctg ctatctcgag gcatccgcag cctggctgtg
      661 gtgctcatgc actcgtacac gtgggcccag catgagcagc aggtgggtgt gctggcccgg
      721 gagctgggct tcacgcacgt gtcactgtcc tcggaggcca tgcccatggt gcgcatcgtc
      781 cctcgggggc acacggcctg tgccgacgcc tacctcacgc ccgccatcca gcgctacgtg
      841 cagggcttct gccgtggctt ccagggccaa ctcaaggatg tgcaggtgtt gttcatgcgc
      901 tccgatggcg gcctggcgcc catggacacc ttcagcggct ccagtgctgt gctctcgggc
      961 ccggccggcg gcgtggtggg ctactcagcc accacctacc agcaggaggg tggccagcct
     1021 gtcatcggct ttgacatggg aggcacgtcc acggatgtga gccgctatgc tggggaattc
     1081 gagcacgtct tcgaggccag cacagctggc gtcaccctcc aggccccgca gctggacatc
     1141 aacaccgtgg cagcgggagg gggttcccgc ctcttcttca ggtctggcct ctttgtggtt
     1201 gggcccgagt cagcaggagc ccacccagga cccgcctgct accgcaaagg gggccctgtg
     1261 acagtgacgg atgctaatct ggtcctgggt cgcctgctgc ctgcctcctt cccctgcatt
     1321 tttgggccgg gagagaacca accactttcc cctgaggcct cccgcaaagc cctggaggct
     1381 gtggccactg aggtcaacag cttcctgacc aacgggccct gcccggcctc cccgctgagc
     1441 ctggaggagg tggccatggg gttcgtgcgc gtggccaacg aggccatgtg ccggcccatc
     1501 cgtgcactca cgcaggcaag aggccatgac ccctcagccc atgtgctggc ctgctttggg
     1561 ggagctggtg ggcagcatgc atgtgccatc gcccgggccc tgggcatgga cacggtgcac
     1621 atccacaggc acagtgggct gctgtcggcc ctggggctgg ccctggctga cgtggtgcat
     1681 gaggcacagg aaccctgctc cctgctctac gcgcctgaga ccttcgtgca gctggaccag
     1741 aggctgagcc gcctggagga gcagtgtgtg gatgctctgc aggcccaggg cttccccagg
     1801 tcccagatca gcactgagag cttcctgcac ctgcgctacc agggcacgga ctgtgctctg
     1861 atggtgtctg cccaccagca cccagccaca gcccgctcgc cccgtgcggg ggacttcggg
     1921 gcagcctttg tggagcggta catgagggag tttggctttg tcatacctga gcggccggtg
     1981 gtcgtggacg atgtgcgagt gcggggcacc ggccgcagtg gtcttcgcct cgaggatgcc
     2041 cccaaagccc agaccgggcc tccccgggtg gacaagatga cccagtgcta ctttgagggg
     2101 ggctaccagg agacccctgt gtacctgctg gcagagctgg gctatgggca caagctccat
     2161 gggccctgcc tcatcatcga cagtaacagc accatcctgg tggagccagg ttgccaggca
     2221 gaggtgacca agacagggga catctgcatc tccgtggggg ccgaagtccc cggcacagtg
     2281 ggcccccagc tggaccctat ccagctgtcc atcttctcac accgcttcat gagcattgct
     2341 gagcagatgg gccgcatcct gcagcgcaca gccatctcca ccaacatcaa ggagcgtctg
     2401 gacttctcct gtgccctctt tgggcccgat ggggggctgg tgtccaatgc cccccacatc
     2461 cctgtgcacc tgggtgccat gcaggagacg gtgcagttcc agattcagca cctgggggcc
     2521 gatctccacc ctggcgacgt gctactgagc aaccatccca gtgccggggg cagccacctg
     2581 ccagacctga ctgttatcac accggtgttt tggccgggtc agacgcggcc tgtgttctat
     2641 gtggccagcc gagggcacca cgcagacatc gggggcatca caccaggctc catgcccccc
     2701 cactccacca tgctgcaaca ggagggtgcc gtctttctgt ccttcaaact tgtccagggg
     2761 ggcgtcttcc aggaggaggc ggtgacggag gccctgcggg cgccaggcaa ggtccccaac
     2821 tgcagcggaa ccagaaacct gcacgacaac ctgtcggacc tccgtgccca ggtggcagcc
     2881 aaccagaagg gcatccagct ggtgggggag ctcattgggc agtacggcct ggacgtggtg
     2941 caggcctaca tgggccatat tcaggcaaac gctgagctgg ccgtgcgaga catgttgcgt
     3001 gcctttggaa cctcccggca ggcccggggc ctgcccctgg aggtgtcctc ggaagaccac
     3061 atggacgacg gttcccccat ccgcctccgt gtgcagatca gcctgagtca gggcagcgcc
     3121 gtgtttgact tcagcggcac tgggccggag gtgtttggta atctcaacgc accgcgggcc
     3181 gtaaccctgt ccgccctcat ctactgcctg cgctgtctgg tgggccgcga catcccactc
     3241 aaccagggct gcctggcgcc agtgcgcgtg gtcattcccc gaggctccat cctggacccg
     3301 tcgcccgagg cggcggtggt gggcggcaac gtgctcacgt cgcagcgcgt ggtggatgtc
     3361 atcctggggg cctttggggc ctgcgccgcc tcccagggct gcatgaacaa cgtgaccctg
     3421 ggcaacgccc acatgggcta ctacgagacg gtggcgggcg gcgcgggcgc gggtcccagc
     3481 tggcacgggc gcagcggtgt gcacagccac atgaccaaca cacgcatcac cgaccctgag
     3541 atcctggaga gccggtaccc ggtcatcctg cgccgcttcg agctgcggcg gggctcgggg
     3601 ggcagaggcc gcttccgagg cggcgacggc gtcacccgcg agctgctctt tcgtgaggag
     3661 gcgctgctgt cagtgctgac cgagcgccgc gccttccggc catacgggct ccacgggggc
     3721 gagcctggcg cccgcggcct aaacctgctg atccgcaaaa acggccggac ggtgaatctg
     3781 ggcggcaaga cgtcggtgac cgtgtacccc ggggatgtgt tctgtctcca cacgcccggc
     3841 ggcggtggct atggggaccc ggaggacccc gccccaccgc cggggtcgcc cccgcaagca
     3901 ctggcctttc ccgagcacgg cagcgtctat gagtatcgcc gggcccagga ggccgtgtga
     3961 ggatcccgca ataaagatgc cttaagtctc ccggttctgg ggacgcagct acggcgccta
//
