LOCUS       NM_001319106            6991 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens opioid binding protein/cell adhesion molecule like
            (OPCML), transcript variant 6, mRNA.
ACCESSION   NM_001319106 XM_005271574
VERSION     NM_001319106.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6991)
  AUTHORS   Khamko,R., Wasenang,W., Daduang,J., Settasatian,C. and
            Limpaiboon,T.
  TITLE     Combined OPCML and AXL Expression as a Prognostic Marker and OPCML
            Enhances AXL Inhibitor in Cholangiocarcinoma
  JOURNAL   In Vivo 36 (3), 1168-1177 (2022)
   PUBMED   35478117
  REMARK    GeneRIF: Combined OPCML and AXL Expression as a Prognostic Marker
            and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma.
REFERENCE   2  (bases 1 to 6991)
  AUTHORS   Khamko,R., Daduang,J., Settasatian,C. and Limpaiboon,T.
  TITLE     OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3
            Inactivation and Rho GTPase Down-regulation
  JOURNAL   Cancer Genomics Proteomics 18 (6), 771-780 (2021)
   PUBMED   34697068
  REMARK    GeneRIF: OPCML Exerts Antitumor Effects in Cholangiocarcinoma via
            AXL/STAT3 Inactivation and Rho GTPase Down-regulation.
REFERENCE   3  (bases 1 to 6991)
  AUTHORS   Lian,B., Li,H., Liu,Y., Chai,D., Gao,Y., Zhang,Y., Zhou,J. and
            Li,J.
  TITLE     Expression and promoter methylation status of OPCML and its
            functions in the inhibition of cell proliferation, migration, and
            invasion in breast cancer
  JOURNAL   Breast Cancer 28 (2), 448-458 (2021)
   PUBMED   33108608
  REMARK    GeneRIF: Expression and promoter methylation status of OPCML and
            its functions in the inhibition of cell proliferation, migration,
            and invasion in breast cancer.
REFERENCE   4  (bases 1 to 6991)
  AUTHORS   Antony,J., Zanini,E., Birtley,J.R., Gabra,H. and Recchi,C.
  TITLE     Emerging roles for the GPI-anchored tumor suppressor OPCML in
            cancers
  JOURNAL   Cancer Gene Ther 28 (1-2), 18-26 (2021)
   PUBMED   32595215
  REMARK    GeneRIF: Emerging roles for the GPI-anchored tumor suppressor OPCML
            in cancers.
            Review article
REFERENCE   5  (bases 1 to 6991)
  AUTHORS   Fang,X., Dong,Y., Yang,R. and Wei,L.
  TITLE     LINC00619 restricts gastric cancer progression by preventing
            microRNA-224-5p-mediated inhibition of OPCML
  JOURNAL   Arch Biochem Biophys 689, 108390 (2020)
   PUBMED   32359894
  REMARK    GeneRIF: LINC00619 restricts gastric cancer progression by
            preventing microRNA-224-5p-mediated inhibition of OPCML.
REFERENCE   6  (bases 1 to 6991)
  AUTHORS   Li,C., Tang,L., Zhao,L., Li,L., Xiao,Q., Luo,X., Peng,W., Ren,G.,
            Tao,Q. and Xiang,T.
  TITLE     OPCML is frequently methylated in human colorectal cancer and its
            restored expression reverses EMT via downregulation of smad
            signaling
  JOURNAL   Am J Cancer Res 5 (5), 1635-1648 (2015)
   PUBMED   26175934
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6991)
  AUTHORS   Shark,K.B. and Lee,N.M.
  TITLE     Cloning, sequencing and localization to chromosome 11 of a cDNA
            encoding a human opioid-binding cell adhesion molecule (OBCAM)
  JOURNAL   Gene 155 (2), 213-217 (1995)
   PUBMED   7721093
REFERENCE   8  (bases 1 to 6991)
  AUTHORS   Struyk,A.F., Canoll,P.D., Wolfgang,M.J., Rosen,C.L., D'Eustachio,P.
            and Salzer,J.L.
  TITLE     Cloning of neurotrimin defines a new subfamily of differentially
            expressed neural cell adhesion molecules
  JOURNAL   J Neurosci 15 (3 Pt 2), 2141-2156 (1995)
   PUBMED   7891157
REFERENCE   9  (bases 1 to 6991)
  AUTHORS   Smith,M.W., Clark,S.P., Hutchinson,J.S., Wei,Y.H., Churukian,A.C.,
            Daniels,L.B., Diggle,K.L., Gen,M.W., Romo,A.J., Lin,Y. et al.
  TITLE     A sequence-tagged site map of human chromosome 11
  JOURNAL   Genomics 17 (3), 699-725 (1993)
   PUBMED   8244387
REFERENCE   10 (bases 1 to 6991)
  AUTHORS   Lane,C.M., Elde,R., Loh,H.H. and Lee,N.M.
  TITLE     Regulation of an opioid-binding protein in NG108-15 cells parallels
            regulation of delta-opioid receptors
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11234-11238 (1992)
   PUBMED   1333602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP005122.2, AK314077.1,
            BX537377.1, BC143946.1, AP000843.5 and DA247864.1.
            
            On Nov 19, 2020 this sequence version replaced NM_001319106.1.
            
            Summary: This gene encodes a member of the IgLON subfamily in the
            immunoglobulin protein superfamily of proteins. The encoded
            preprotein is proteolytically processed to generate the mature
            protein. This protein is localized in the plasma membrane and may
            have an accessory role in opioid receptor function. This gene has
            an ortholog in rat and bovine. The opioid binding-cell adhesion
            molecule encoded by the rat gene binds opioid alkaloids in the
            presence of acidic lipids, exhibits selectivity for mu ligands and
            acts as a GPI-anchored protein. Since the encoded protein is highly
            conserved in species during evolution, it may have a fundamental
            role in mammalian systems. Alternative splicing results in multiple
            transcript variants, at least one of which encodes an isoform that
            is proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (6) uses an alternate in-frame
            splice site in the 5' coding region and lacks an alternate in-frame
            exon in the 3' coding region compared to variant 3. The encoded
            isoform (f) may undergo proteolytic processing similar to isoform
            a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143945.1, SRR1803615.74755.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AP005122.2         97319-97517         c
            200-1779            AK314077.1         1-1580
            1780-2060           BX537377.1         1154-1434
            2061-3515           BC143946.1         1370-2824
            3516-6721           AP000843.5         74983-78188         c
            6722-6991           DA247864.1         1-270
FEATURES             Location/Qualifiers
     source          1..6991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..6991
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="opioid binding protein/cell adhesion molecule like"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
     exon            1..911
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             745..1779
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="isoform f precursor is encoded by transcript
                     variant 6; IgLON family member 1; opioid binding
                     protein/cell adhesion molecule-like preprotein"
                     /codon_start=1
                     /product="opioid-binding protein/cell adhesion molecule
                     isoform f precursor"
                     /protein_id="NP_001306035.1"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
                     /translation="MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDN
                     VTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMI
                     QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAI
                     GRPEPTVTWRHLSVKGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKIT
                     VNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKGR
                     MSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAVIDGVNSASRALACLWLSG
                     TLLAHFFIKF"
     exon            912..1144
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1270
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1405
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1526
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1678
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..6991
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6969..6974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="hexamer: AATAAA"
     polyA_site      6991
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="major polyA site"
ORIGIN      
        1 gtctcgtgcc gcgtccccgg aggaggcggg ggccgccgtc cgcccagctc cccgtgcgcc
       61 cggagcctgc gccgggcggc gctcccccgg ctggccgcga gtcgccgacc gggctgcaga
      121 ggacggccac cgaccggacg accctggctg cgccggctgc gcgtccccgc cttggaactt
      181 tttgccgcct tggggttcca gatgcgagac ctggggctgg gggacacgta catctgtcca
      241 tgtgtgtgat ctaataaacc atttcctcct ctccttgaag ccgcagcttt ttatgacagc
      301 tcctgtatgt cagagacact tgccttcttc tttgggttat aaacttttga tgccagagct
      361 ctgcagaacg tgcccaactg aatcttaaag tagcgtctcg aagagagagg cagagaaagc
      421 gcaatctgtg accttcatcc ccgcaccttg cttcttcctc tcccctcctg gccgcctccc
      481 tcctccccag gggagcgtca agaaagctct ttttggatgc aggagggggc atctggttct
      541 gctaggctgg aaagctgagg caggatctga ggaagaattc tcagactccg gagagcccgg
      601 actcctctct tctccttccc cctgctcctg gcgaactctg ccccttccct cctccccgca
      661 ccgcttcccg agcccgctgg tgcgcggggc gggggaccag gactgtgcgg ctgccggagt
      721 cctgggaagt tgtggctgtc gagaatgggg gtctgtgggt acctgttcct gccctggaag
      781 tgcctcgtgg tcgtgtctct caggctgctg ttccttgtac ccacaggagt gcccgtgcgc
      841 agcggagatg ccaccttccc caaagctatg gacaacgtga cggtccggca gggggagagc
      901 gccaccctca ggtgtaccat agatgaccgg gtaacccggg tggcctggct aaaccgcagc
      961 accatcctct acgctgggaa tgacaagtgg tccatagacc ctcgtgtgat catcctggtc
     1021 aatacaccaa cccagtacag catcatgatc caaaatgtgg atgtgtatga cgaaggtccg
     1081 tacacctgct ctgtgcagac agacaatcat cccaaaacgt cccgggttca cctaatagtg
     1141 caagttcctc ctcagatcat gaatatctcc tcagacatca ctgtgaatga gggaagcagt
     1201 gtgaccctgc tgtgtcttgc tattggcaga ccagagccaa ctgtgacatg gagacacctg
     1261 tcagtcaagg gccagggctt tgtaagtgag gatgagtacc tggagatctc tgacatcaag
     1321 cgagaccagt ccggggagta cgaatgcagc gcgttgaacg atgtcgctgc gcccgatgtg
     1381 cggaaagtaa aaatcactgt aaactatcct ccctatatct caaaagccaa gaacactggt
     1441 gtttcagtcg gtcagaaggg catcctgagc tgtgaagcct ctgcagtccc catggctgaa
     1501 ttccagtggt tcaaggaaga aaccaggtta gccactggtc tggatggaat gaggattgaa
     1561 aacaaaggcc gcatgtccac tctgactttc ttcaatgttt cagaaaagga ttatgggaac
     1621 tatacttgtg tggccacgaa caagcttggg aacaccaatg ccagcatcac attgtatggg
     1681 cctggagcag tcattgatgg tgtaaactcg gcctccagag cactggcttg tctctggcta
     1741 tcagggaccc tcttagccca cttcttcatc aagttttgat aagaaatcct aggtcctctg
     1801 agcaacgcct gcttctccat atcacagact ttaatctaca ctgcggagag caaaccagct
     1861 tgggcttctt tttgtttttt tctgttattc tagatttgtt ttctttttgt ttttgtttat
     1921 ttgtttgttt gcttttattt ccagcttgaa tgagtggggt tgggggcggg gtgggcaggg
     1981 ttctaccacg tgtaggataa tcattcattg gtgtgtccaa aaatggggtc tgctcctgct
     2041 accttgaccc ttccctttcc tctgcttctc tcctcatcat cattcccaac aacatcctct
     2101 gccacacaca acaaaacgta agtttcattt gggcaaaaat tgagcctcac aataaacacc
     2161 ctgaagacac aacttgactt ataacatagt gcacagcaag agctacatcc aagtgtccta
     2221 ttatctgtga ttattttctt aatgacaatg tacatatgcc cccatccatg ttaattatta
     2281 tctaattcca ttagggttca cgtcttttct ttctgggaca ctatcctact atatccatat
     2341 ctatagattt caatatagat gattgtgcca tcttctgtag cccctccgct ctactcattc
     2401 cttccaccat ctgcagagat ttgaagtttg gggctatgca tgaaacccaa cactaaattt
     2461 tgcaagtcaa gtaaccaaaa aagggggagg cattttgaag atagaacctc tattttaaaa
     2521 agagaagttc aactcataaa cgtgattgat aggtggctga tttatttagg ttttgtcaag
     2581 ctatctatca aagtaatggt acagttaccc atctactcaa atatctgatt tatctcacca
     2641 tccaattatc tacccacctg tcttcctctc tagcaatcta tttactgttt atcaatctat
     2701 caatgtaatt gtctaacact cctttctatt ctctccctac tactcactat caattcatcc
     2761 ccatatgaat ctctaaccat attgtatctc tcccactgta ttcatttata caccatcagc
     2821 agacattggc atcttcaaaa ttatctttca acttctgtga aagccaacga tctcacaggt
     2881 taacaaaata caaaagcaat accctgtgtt gtggactctt taaaatctgg tatcctatcc
     2941 acccaaggga gacactaaca gataggccaa agtagcaagc taatgatcag tcactcacta
     3001 ttcccagaag agcctgtgtt ttctaaaaca ctttcttggg aagcagatca gcctagaaaa
     3061 gttttgatta gcactgtggt tttccttttg cacttgaagg acaaaggtgc cagcctttat
     3121 gcttctctca acccttcaag aaagtacatg tcaggaacct atggctggct ttccttagca
     3181 gcaagaactt gagagaaaaa cacatctgtc tctgcaatgc aaagtgaaga gtccacccgc
     3241 ctgagtggga tgacttcagc tagagtctcc tttctgctcc agttctggtt taatctgttt
     3301 gaaaactatc cagtaaaaag ctgatggagg ccaattacat ggcgggtgta ttgacaactc
     3361 tggtatttgt ttcaggaagc tcttctaagc tgagggcact tgagcaactg acttaatttt
     3421 caagcacttg attaacacaa cactgcaaac agaagggaga aagtgtcagt gacacagttt
     3481 cctctgatgc agctgcttct ccaatggctt tggggaagaa cttcaccagc tcttcaggtt
     3541 caaagcagac ccagcataca aacaagagct gagccacctt tgctgtcttg tctcctggga
     3601 cgagaaggac tcatccagca aagttgcctg ggattcaaaa taaaggcatt gcagaccgca
     3661 caggtgtgct gcagggactg atccacagag aggatgagaa tgcagcatca atcgcagacc
     3721 tgccctgcct cagttggaaa accttttcag gccctcagtc taaaaaataa aaaatatgag
     3781 caccattgaa ttctgtgccc ttaatgctta actggtcttc ttcctctggt atcagtgtcc
     3841 tctttgtttt tgtccatcaa ggcacatgag tgtgacctct gccatgggga aacacacaca
     3901 gagatatcta tacatatata catacataca aacataggct atcttggcac actaaatgct
     3961 aagcactgtc ttaagaggta gagctggtgt gagtgaaatt aatgttacat tttccagctg
     4021 taaacagaca tctgcatttc ctagtgagct gccaggagcc agattcggga accgtaactg
     4081 atgtgccagg aatggtgcat tgattcccag ttccagggat gatcatgagc aggcgcaaaa
     4141 tcagaattaa aggtcgcaca tagacgtttc agatctgtca ccaccttcag catctggagt
     4201 tgagttggtg tcagatagtg tatgagaatt aaatgtgtca tctgagcatg ctactgatga
     4261 taaatttgtt actttggagt tgaataaatg tgaaggctgt gaagagtgga cagtcttgga
     4321 gaacacagtg cttgaaatgg acaagctgga cctattcctc actccaagac ttgttctaca
     4381 ggaaagggtc catgctcctt tggccaagat catcagaacc tctcaaccca acaaggctgg
     4441 cttcagggcc actatggaac cctgctgttc ccccttccaa aggatactaa gatgcccctc
     4501 tggtgggtac ctatcccagc cacgtttcag agggagagaa atgctacagt tgatcctcat
     4561 ctgtctgggg taaagacaac aaagtaaata caacccaagg caactggggt actcactggg
     4621 agtgaaaatg acttcttcac aacagacata tttctgcttc tgtgtttttg tgtttctttg
     4681 gtggggatgg cttcatggga gagtggctgt cacccatcat tttgaagcat atagaacaac
     4741 aaatgcttac acaagacaat atccacactt ttccaacttc acacacggag agtacatgga
     4801 gaatgcctac aggctagatt tgttcagggt gccagtagtg ggcatggggt gggggcaagg
     4861 caggacaaaa catacaagtc tgagcaagta catctcttgc aggttttcca catgaaaagg
     4921 aagccaaata agtcctgtta ggagattagg tgagaggaat tagcaatgta gggactctga
     4981 aacccttccc cttcccaaaa cagagttcat atgcacttcc accaaagtaa tgccaatgaa
     5041 agtgctcgtg ttaaggctgc agccaagctt gtttttcagt agtttaatgt caagtgcctg
     5101 atacagtcga ctgcaagtct aaacaagcat gtttagtttt tctcattctt gctttaattc
     5161 agggaggggg agatgtagag aagtggttgt gaaaacatgt acaggcttta tgcagagcac
     5221 tgcgcatggc tgttctgctg caactgtgct ccacgaaaca gaagaaaagg taaggtgttg
     5281 tgtcacaaag aggccccagt ctctttcttc ttacatccat gcctcttact agatgataca
     5341 tttacagatt gggcagtttg ttctcaaaac ctgggtgaga agactattcc tggactctag
     5401 caacttcaaa actgaggctg ggtttcagaa tctttttctg catcaattca gtcaatttgc
     5461 cttcaacaaa gagaagtcag caagttctat ttatgctgaa agaactattc catgagaaaa
     5521 gcagagaacc ccaaagtggg caggcaaccc cgacgagagc ttatccctgt ggcggcatca
     5581 ggagtggctg tacattgaat tttcaagtgc tggttggctg tcgccagccc atggtaggag
     5641 gggaggaatg gcttaagatg aggtaagatc tggtggtggg gcatctttcc tcaattccat
     5701 actgactttg atcttgagaa agaaaaactg gctatgcatt acctaaaacc agtccaaaat
     5761 gaaacagacc aacacacaca caaaagcaaa ttgtcaatcc ctttggaatt aagggaagca
     5821 gcataaggtt tttctttttg gaaaaaatgc atttattttc tttttctcca acagcaagaa
     5881 tcttttgttt tcattttgca cgtgacctta tcttggaaac tcttataccc aattgcctcc
     5941 cctcctatta ttcagagctt ccctgtcttt ttacttgaag acaaataagt ttgagcactt
     6001 gagtaaaact tcacaggtgt gtaagtagga aggcaacatt ttcaaaaaga gaccatatga
     6061 tgagaacgcc taatgatcac cacatgcaaa caaacaaaac tgccagtctc atttcccaca
     6121 tttcttactt aagagaagag aagtaaatga aaggaagaag aaatagattt gtaattaaag
     6181 atgtggcaaa aaagataggg ctgagccagt tcaatttagc cttcaggtgc agaatactta
     6241 gagtccaaag aaatgtggag tggacttaat tagatgcagt tgtctttatc ctgaaagtag
     6301 tgagctaagc ctaatttcca gcattttgaa agagattcct ttttgtttct ttccatggtg
     6361 ccctctttaa ggcacagagt tgctccacac cactgggtgg agaaagaaag attgcgaacc
     6421 ctcgaccatc cttttgaggc tacattctat gttatttggc agatttataa agctatcagt
     6481 aataacaatg ctatgtactg caagctgccc ttgtgttagt taaagggagc atttttaatc
     6541 gttcggaaat tttcgtgaca tgtcaagtgc agttgtgagg actgtgtggg tgaacgaaaa
     6601 tgtgtctgtc aagttcagag tcctttagat ttaaaaaaaa attatgactt atcaatggtg
     6661 ccgttatagc tgtgtcagac aatgggtgtg cccattctca caattatcct tcaaaaaaaa
     6721 tctatgttca aatgctttaa aaatttatca cacgatacaa gagtatgact ttgtcagcct
     6781 tctagagttc tttttttctt ttattttctt tcgtattttt tccttcaaaa aatcaatgaa
     6841 gacttgattt ctgtcaataa ttgtatcaag ggtgaatata ctacctgaat tttgtgcatg
     6901 ttacattgta gttgtaacct tttctaattc aggatgaata cgagatggtt gtgattgtgc
     6961 agtgtaccaa taaagttcga gaaatttgta a
//
