LOCUS       NM_001319105            6409 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens opioid binding protein/cell adhesion molecule like
            (OPCML), transcript variant 5, mRNA.
ACCESSION   NM_001319105
VERSION     NM_001319105.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6409)
  AUTHORS   Khamko,R., Wasenang,W., Daduang,J., Settasatian,C. and
            Limpaiboon,T.
  TITLE     Combined OPCML and AXL Expression as a Prognostic Marker and OPCML
            Enhances AXL Inhibitor in Cholangiocarcinoma
  JOURNAL   In Vivo 36 (3), 1168-1177 (2022)
   PUBMED   35478117
  REMARK    GeneRIF: Combined OPCML and AXL Expression as a Prognostic Marker
            and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma.
REFERENCE   2  (bases 1 to 6409)
  AUTHORS   Khamko,R., Daduang,J., Settasatian,C. and Limpaiboon,T.
  TITLE     OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3
            Inactivation and Rho GTPase Down-regulation
  JOURNAL   Cancer Genomics Proteomics 18 (6), 771-780 (2021)
   PUBMED   34697068
  REMARK    GeneRIF: OPCML Exerts Antitumor Effects in Cholangiocarcinoma via
            AXL/STAT3 Inactivation and Rho GTPase Down-regulation.
REFERENCE   3  (bases 1 to 6409)
  AUTHORS   Lian,B., Li,H., Liu,Y., Chai,D., Gao,Y., Zhang,Y., Zhou,J. and
            Li,J.
  TITLE     Expression and promoter methylation status of OPCML and its
            functions in the inhibition of cell proliferation, migration, and
            invasion in breast cancer
  JOURNAL   Breast Cancer 28 (2), 448-458 (2021)
   PUBMED   33108608
  REMARK    GeneRIF: Expression and promoter methylation status of OPCML and
            its functions in the inhibition of cell proliferation, migration,
            and invasion in breast cancer.
REFERENCE   4  (bases 1 to 6409)
  AUTHORS   Antony,J., Zanini,E., Birtley,J.R., Gabra,H. and Recchi,C.
  TITLE     Emerging roles for the GPI-anchored tumor suppressor OPCML in
            cancers
  JOURNAL   Cancer Gene Ther 28 (1-2), 18-26 (2021)
   PUBMED   32595215
  REMARK    GeneRIF: Emerging roles for the GPI-anchored tumor suppressor OPCML
            in cancers.
            Review article
REFERENCE   5  (bases 1 to 6409)
  AUTHORS   Fang,X., Dong,Y., Yang,R. and Wei,L.
  TITLE     LINC00619 restricts gastric cancer progression by preventing
            microRNA-224-5p-mediated inhibition of OPCML
  JOURNAL   Arch Biochem Biophys 689, 108390 (2020)
   PUBMED   32359894
  REMARK    GeneRIF: LINC00619 restricts gastric cancer progression by
            preventing microRNA-224-5p-mediated inhibition of OPCML.
REFERENCE   6  (bases 1 to 6409)
  AUTHORS   Li,C., Tang,L., Zhao,L., Li,L., Xiao,Q., Luo,X., Peng,W., Ren,G.,
            Tao,Q. and Xiang,T.
  TITLE     OPCML is frequently methylated in human colorectal cancer and its
            restored expression reverses EMT via downregulation of smad
            signaling
  JOURNAL   Am J Cancer Res 5 (5), 1635-1648 (2015)
   PUBMED   26175934
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6409)
  AUTHORS   Shark,K.B. and Lee,N.M.
  TITLE     Cloning, sequencing and localization to chromosome 11 of a cDNA
            encoding a human opioid-binding cell adhesion molecule (OBCAM)
  JOURNAL   Gene 155 (2), 213-217 (1995)
   PUBMED   7721093
REFERENCE   8  (bases 1 to 6409)
  AUTHORS   Struyk,A.F., Canoll,P.D., Wolfgang,M.J., Rosen,C.L., D'Eustachio,P.
            and Salzer,J.L.
  TITLE     Cloning of neurotrimin defines a new subfamily of differentially
            expressed neural cell adhesion molecules
  JOURNAL   J Neurosci 15 (3 Pt 2), 2141-2156 (1995)
   PUBMED   7891157
REFERENCE   9  (bases 1 to 6409)
  AUTHORS   Smith,M.W., Clark,S.P., Hutchinson,J.S., Wei,Y.H., Churukian,A.C.,
            Daniels,L.B., Diggle,K.L., Gen,M.W., Romo,A.J., Lin,Y. et al.
  TITLE     A sequence-tagged site map of human chromosome 11
  JOURNAL   Genomics 17 (3), 699-725 (1993)
   PUBMED   8244387
REFERENCE   10 (bases 1 to 6409)
  AUTHORS   Lane,C.M., Elde,R., Loh,H.H. and Lee,N.M.
  TITLE     Regulation of an opioid-binding protein in NG108-15 cells parallels
            regulation of delta-opioid receptors
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11234-11238 (1992)
   PUBMED   1333602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP005122.2, AK316491.1,
            BC143946.1, AP000843.5 and DA247864.1.
            
            On Nov 19, 2020 this sequence version replaced NM_001319105.1.
            
            Summary: This gene encodes a member of the IgLON subfamily in the
            immunoglobulin protein superfamily of proteins. The encoded
            preprotein is proteolytically processed to generate the mature
            protein. This protein is localized in the plasma membrane and may
            have an accessory role in opioid receptor function. This gene has
            an ortholog in rat and bovine. The opioid binding-cell adhesion
            molecule encoded by the rat gene binds opioid alkaloids in the
            presence of acidic lipids, exhibits selectivity for mu ligands and
            acts as a GPI-anchored protein. Since the encoded protein is highly
            conserved in species during evolution, it may have a fundamental
            role in mammalian systems. Alternative splicing results in multiple
            transcript variants, at least one of which encodes an isoform that
            is proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (5) differs in the 5' UTR, lacks a
            portion of the 5' coding region, uses a downstream translation
            start site, and lacks an alternate in-frame exon in the 3' coding
            region compared to variant 3. The encoded isoform (e) is shorter
            and lacks a predicted signal peptide compared to isoform c.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.104073.1,
                                           SRR14372079.1207897.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AP005122.2         97450-97517         c
            69-1370             AK316491.1         1-1302
            1371-2933           BC143946.1         1262-2824
            2934-6139           AP000843.5         74983-78188         c
            6140-6409           DA247864.1         1-270
FEATURES             Location/Qualifiers
     source          1..6409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..6409
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="opioid binding protein/cell adhesion molecule like"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
     exon            1..241
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            242..326
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1197
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="isoform e is encoded by transcript variant 5; IgLON
                     family member 1; opioid binding protein/cell adhesion
                     molecule-like preprotein"
                     /codon_start=1
                     /product="opioid-binding protein/cell adhesion molecule
                     isoform e"
                     /protein_id="NP_001306034.1"
                     /db_xref="CCDS:CCDS81649.1"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
                     /translation="MDNVTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSID
                     PRVIILVNTPTQYSIMIQNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISS
                     DITVNEGSSVTLLCLAIGRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYE
                     CSALNDVAAPDVRKVKITVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKE
                     ETRLATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYGPGAV
                     IDGVNSASRALACLWLSGTLLAHFFIKF"
     exon            327..559
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            560..685
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            686..823
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            824..944
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1096
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..6409
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6387..6392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="hexamer: AATAAA"
     polyA_site      6409
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="major polyA site"
ORIGIN      
        1 gtctcgtgcc gcgtccccgg aggaggcggg ggccgccgtc cgcccagctc cccgtgcgcc
       61 cggagcctgc gccgggcggc gctcccccgg ctggccgcga gtcgccgacc gggctgcaga
      121 ggacggccac cgaccggacg accctggctg cgccggctgc gcgtccccgc cttggaactt
      181 tttgccgcct tggggttcca gatgcgagac ctggggctgg gggacacgta catctgtcca
      241 tgagtgcccg tgcgcagcgg agatgccacc ttccccaaag ctatggacaa cgtgacggtc
      301 cggcaggggg agagcgccac cctcaggtgt accatagatg accgggtaac ccgggtggcc
      361 tggctaaacc gcagcaccat cctctacgct gggaatgaca agtggtccat agaccctcgt
      421 gtgatcatcc tggtcaatac accaacccag tacagcatca tgatccaaaa tgtggatgtg
      481 tatgacgaag gtccgtacac ctgctctgtg cagacagaca atcatcccaa aacgtcccgg
      541 gttcacctaa tagtgcaagt tcctcctcag atcatgaata tctcctcaga catcactgtg
      601 aatgagggaa gcagtgtgac cctgctgtgt cttgctattg gcagaccaga gccaactgtg
      661 acatggagac acctgtcagt caaggaaggc cagggctttg taagtgagga tgagtacctg
      721 gagatctctg acatcaagcg agaccagtcc ggggagtacg aatgcagcgc gttgaacgat
      781 gtcgctgcgc ccgatgtgcg gaaagtaaaa atcactgtaa actatcctcc ctatatctca
      841 aaagccaaga acactggtgt ttcagtcggt cagaagggca tcctgagctg tgaagcctct
      901 gcagtcccca tggctgaatt ccagtggttc aaggaagaaa ccaggttagc cactggtctg
      961 gatggaatga ggattgaaaa caaaggccgc atgtccactc tgactttctt caatgtttca
     1021 gaaaaggatt atgggaacta tacttgtgtg gccacgaaca agcttgggaa caccaatgcc
     1081 agcatcacat tgtatgggcc tggagcagtc attgatggtg taaactcggc ctccagagca
     1141 ctggcttgtc tctggctatc agggaccctc ttagcccact tcttcatcaa gttttgataa
     1201 gaaatcctag gtcctctgag caacgcctgc ttctccatat cacagacttt aatctacact
     1261 gcggagagca aaccagcttg ggcttctttt tgtttttttc tgttattcta gatttgtttt
     1321 ctttttgttt ttgtttattt gtttgtttgc ttttatttcc agcttgaatg agtggggttg
     1381 ggggcggggt gggcagggtt ctaccacgtg taggataatc attcattggt gtgtccaaaa
     1441 atggggtctg ctcctgctac cttgaccctt ccctttcctc tgcttctctc ctcatcatca
     1501 ttcccaacaa catcctctgc cacacacaac aaaacgtaag tttcatttgg gcaaaaattg
     1561 agcctcacaa taaacaccct gaagacacaa cttgacttat aacatagtgc acagcaagag
     1621 ctacatccaa gtgtcctatt atctgtgatt attttcttaa tgacaatgta catatgcccc
     1681 catccatgtt aattattatc taattccatt agggttcacg tcttttcttt ctgggacact
     1741 atcctactat atccatatct atagatttca atatagatga ttgtgccatc ttctgtagcc
     1801 cctccgctct actcattcct tccaccatct gcagagattt gaagtttggg gctatgcatg
     1861 aaacccaaca ctaaattttg caagtcaagt aaccaaaaaa gggggaggca ttttgaagat
     1921 agaacctcta ttttaaaaag agaagttcaa ctcataaacg tgattgatag gtggctgatt
     1981 tatttaggtt ttgtcaagct atctatcaaa gtaatggtac agttacccat ctactcaaat
     2041 atctgattta tctcaccatc caattatcta cccacctgtc ttcctctcta gcaatctatt
     2101 tactgtttat caatctatca atgtaattgt ctaacactcc tttctattct ctccctacta
     2161 ctcactatca attcatcccc atatgaatct ctaaccatat tgtatctctc ccactgtatt
     2221 catttataca ccatcagcag acattggcat cttcaaaatt atctttcaac ttctgtgaaa
     2281 gccaacgatc tcacaggtta acaaaataca aaagcaatac cctgtgttgt ggactcttta
     2341 aaatctggta tcctatccac ccaagggaga cactaacaga taggccaaag tagcaagcta
     2401 atgatcagtc actcactatt cccagaagag cctgtgtttt ctaaaacact ttcttgggaa
     2461 gcagatcagc ctagaaaagt tttgattagc actgtggttt tccttttgca cttgaaggac
     2521 aaaggtgcca gcctttatgc ttctctcaac ccttcaagaa agtacatgtc aggaacctat
     2581 ggctggcttt ccttagcagc aagaacttga gagaaaaaca catctgtctc tgcaatgcaa
     2641 agtgaagagt ccacccgcct gagtgggatg acttcagcta gagtctcctt tctgctccag
     2701 ttctggttta atctgtttga aaactatcca gtaaaaagct gatggaggcc aattacatgg
     2761 cgggtgtatt gacaactctg gtatttgttt caggaagctc ttctaagctg agggcacttg
     2821 agcaactgac ttaattttca agcacttgat taacacaaca ctgcaaacag aagggagaaa
     2881 gtgtcagtga cacagtttcc tctgatgcag ctgcttctcc aatggctttg gggaagaact
     2941 tcaccagctc ttcaggttca aagcagaccc agcatacaaa caagagctga gccacctttg
     3001 ctgtcttgtc tcctgggacg agaaggactc atccagcaaa gttgcctggg attcaaaata
     3061 aaggcattgc agaccgcaca ggtgtgctgc agggactgat ccacagagag gatgagaatg
     3121 cagcatcaat cgcagacctg ccctgcctca gttggaaaac cttttcaggc cctcagtcta
     3181 aaaaataaaa aatatgagca ccattgaatt ctgtgccctt aatgcttaac tggtcttctt
     3241 cctctggtat cagtgtcctc tttgtttttg tccatcaagg cacatgagtg tgacctctgc
     3301 catggggaaa cacacacaga gatatctata catatataca tacatacaaa cataggctat
     3361 cttggcacac taaatgctaa gcactgtctt aagaggtaga gctggtgtga gtgaaattaa
     3421 tgttacattt tccagctgta aacagacatc tgcatttcct agtgagctgc caggagccag
     3481 attcgggaac cgtaactgat gtgccaggaa tggtgcattg attcccagtt ccagggatga
     3541 tcatgagcag gcgcaaaatc agaattaaag gtcgcacata gacgtttcag atctgtcacc
     3601 accttcagca tctggagttg agttggtgtc agatagtgta tgagaattaa atgtgtcatc
     3661 tgagcatgct actgatgata aatttgttac tttggagttg aataaatgtg aaggctgtga
     3721 agagtggaca gtcttggaga acacagtgct tgaaatggac aagctggacc tattcctcac
     3781 tccaagactt gttctacagg aaagggtcca tgctcctttg gccaagatca tcagaacctc
     3841 tcaacccaac aaggctggct tcagggccac tatggaaccc tgctgttccc ccttccaaag
     3901 gatactaaga tgcccctctg gtgggtacct atcccagcca cgtttcagag ggagagaaat
     3961 gctacagttg atcctcatct gtctggggta aagacaacaa agtaaataca acccaaggca
     4021 actggggtac tcactgggag tgaaaatgac ttcttcacaa cagacatatt tctgcttctg
     4081 tgtttttgtg tttctttggt ggggatggct tcatgggaga gtggctgtca cccatcattt
     4141 tgaagcatat agaacaacaa atgcttacac aagacaatat ccacactttt ccaacttcac
     4201 acacggagag tacatggaga atgcctacag gctagatttg ttcagggtgc cagtagtggg
     4261 catggggtgg gggcaaggca ggacaaaaca tacaagtctg agcaagtaca tctcttgcag
     4321 gttttccaca tgaaaaggaa gccaaataag tcctgttagg agattaggtg agaggaatta
     4381 gcaatgtagg gactctgaaa cccttcccct tcccaaaaca gagttcatat gcacttccac
     4441 caaagtaatg ccaatgaaag tgctcgtgtt aaggctgcag ccaagcttgt ttttcagtag
     4501 tttaatgtca agtgcctgat acagtcgact gcaagtctaa acaagcatgt ttagtttttc
     4561 tcattcttgc tttaattcag ggagggggag atgtagagaa gtggttgtga aaacatgtac
     4621 aggctttatg cagagcactg cgcatggctg ttctgctgca actgtgctcc acgaaacaga
     4681 agaaaaggta aggtgttgtg tcacaaagag gccccagtct ctttcttctt acatccatgc
     4741 ctcttactag atgatacatt tacagattgg gcagtttgtt ctcaaaacct gggtgagaag
     4801 actattcctg gactctagca acttcaaaac tgaggctggg tttcagaatc tttttctgca
     4861 tcaattcagt caatttgcct tcaacaaaga gaagtcagca agttctattt atgctgaaag
     4921 aactattcca tgagaaaagc agagaacccc aaagtgggca ggcaaccccg acgagagctt
     4981 atccctgtgg cggcatcagg agtggctgta cattgaattt tcaagtgctg gttggctgtc
     5041 gccagcccat ggtaggaggg gaggaatggc ttaagatgag gtaagatctg gtggtggggc
     5101 atctttcctc aattccatac tgactttgat cttgagaaag aaaaactggc tatgcattac
     5161 ctaaaaccag tccaaaatga aacagaccaa cacacacaca aaagcaaatt gtcaatccct
     5221 ttggaattaa gggaagcagc ataaggtttt tctttttgga aaaaatgcat ttattttctt
     5281 tttctccaac agcaagaatc ttttgttttc attttgcacg tgaccttatc ttggaaactc
     5341 ttatacccaa ttgcctcccc tcctattatt cagagcttcc ctgtcttttt acttgaagac
     5401 aaataagttt gagcacttga gtaaaacttc acaggtgtgt aagtaggaag gcaacatttt
     5461 caaaaagaga ccatatgatg agaacgccta atgatcacca catgcaaaca aacaaaactg
     5521 ccagtctcat ttcccacatt tcttacttaa gagaagagaa gtaaatgaaa ggaagaagaa
     5581 atagatttgt aattaaagat gtggcaaaaa agatagggct gagccagttc aatttagcct
     5641 tcaggtgcag aatacttaga gtccaaagaa atgtggagtg gacttaatta gatgcagttg
     5701 tctttatcct gaaagtagtg agctaagcct aatttccagc attttgaaag agattccttt
     5761 ttgtttcttt ccatggtgcc ctctttaagg cacagagttg ctccacacca ctgggtggag
     5821 aaagaaagat tgcgaaccct cgaccatcct tttgaggcta cattctatgt tatttggcag
     5881 atttataaag ctatcagtaa taacaatgct atgtactgca agctgccctt gtgttagtta
     5941 aagggagcat ttttaatcgt tcggaaattt tcgtgacatg tcaagtgcag ttgtgaggac
     6001 tgtgtgggtg aacgaaaatg tgtctgtcaa gttcagagtc ctttagattt aaaaaaaaat
     6061 tatgacttat caatggtgcc gttatagctg tgtcagacaa tgggtgtgcc cattctcaca
     6121 attatccttc aaaaaaaatc tatgttcaaa tgctttaaaa atttatcaca cgatacaaga
     6181 gtatgacttt gtcagccttc tagagttctt tttttctttt attttctttc gtattttttc
     6241 cttcaaaaaa tcaatgaaga cttgatttct gtcaataatt gtatcaaggg tgaatatact
     6301 acctgaattt tgtgcatgtt acattgtagt tgtaaccttt tctaattcag gatgaatacg
     6361 agatggttgt gattgtgcag tgtaccaata aagttcgaga aatttgtaa
//
