LOCUS       NM_001319103            7021 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens opioid binding protein/cell adhesion molecule like
            (OPCML), transcript variant 3, mRNA.
ACCESSION   NM_001319103
VERSION     NM_001319103.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7021)
  AUTHORS   Khamko,R., Wasenang,W., Daduang,J., Settasatian,C. and
            Limpaiboon,T.
  TITLE     Combined OPCML and AXL Expression as a Prognostic Marker and OPCML
            Enhances AXL Inhibitor in Cholangiocarcinoma
  JOURNAL   In Vivo 36 (3), 1168-1177 (2022)
   PUBMED   35478117
  REMARK    GeneRIF: Combined OPCML and AXL Expression as a Prognostic Marker
            and OPCML Enhances AXL Inhibitor in Cholangiocarcinoma.
REFERENCE   2  (bases 1 to 7021)
  AUTHORS   Khamko,R., Daduang,J., Settasatian,C. and Limpaiboon,T.
  TITLE     OPCML Exerts Antitumor Effects in Cholangiocarcinoma via AXL/STAT3
            Inactivation and Rho GTPase Down-regulation
  JOURNAL   Cancer Genomics Proteomics 18 (6), 771-780 (2021)
   PUBMED   34697068
  REMARK    GeneRIF: OPCML Exerts Antitumor Effects in Cholangiocarcinoma via
            AXL/STAT3 Inactivation and Rho GTPase Down-regulation.
REFERENCE   3  (bases 1 to 7021)
  AUTHORS   Lian,B., Li,H., Liu,Y., Chai,D., Gao,Y., Zhang,Y., Zhou,J. and
            Li,J.
  TITLE     Expression and promoter methylation status of OPCML and its
            functions in the inhibition of cell proliferation, migration, and
            invasion in breast cancer
  JOURNAL   Breast Cancer 28 (2), 448-458 (2021)
   PUBMED   33108608
  REMARK    GeneRIF: Expression and promoter methylation status of OPCML and
            its functions in the inhibition of cell proliferation, migration,
            and invasion in breast cancer.
REFERENCE   4  (bases 1 to 7021)
  AUTHORS   Antony,J., Zanini,E., Birtley,J.R., Gabra,H. and Recchi,C.
  TITLE     Emerging roles for the GPI-anchored tumor suppressor OPCML in
            cancers
  JOURNAL   Cancer Gene Ther 28 (1-2), 18-26 (2021)
   PUBMED   32595215
  REMARK    GeneRIF: Emerging roles for the GPI-anchored tumor suppressor OPCML
            in cancers.
            Review article
REFERENCE   5  (bases 1 to 7021)
  AUTHORS   Fang,X., Dong,Y., Yang,R. and Wei,L.
  TITLE     LINC00619 restricts gastric cancer progression by preventing
            microRNA-224-5p-mediated inhibition of OPCML
  JOURNAL   Arch Biochem Biophys 689, 108390 (2020)
   PUBMED   32359894
  REMARK    GeneRIF: LINC00619 restricts gastric cancer progression by
            preventing microRNA-224-5p-mediated inhibition of OPCML.
REFERENCE   6  (bases 1 to 7021)
  AUTHORS   Li,C., Tang,L., Zhao,L., Li,L., Xiao,Q., Luo,X., Peng,W., Ren,G.,
            Tao,Q. and Xiang,T.
  TITLE     OPCML is frequently methylated in human colorectal cancer and its
            restored expression reverses EMT via downregulation of smad
            signaling
  JOURNAL   Am J Cancer Res 5 (5), 1635-1648 (2015)
   PUBMED   26175934
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7021)
  AUTHORS   Shark,K.B. and Lee,N.M.
  TITLE     Cloning, sequencing and localization to chromosome 11 of a cDNA
            encoding a human opioid-binding cell adhesion molecule (OBCAM)
  JOURNAL   Gene 155 (2), 213-217 (1995)
   PUBMED   7721093
REFERENCE   8  (bases 1 to 7021)
  AUTHORS   Struyk,A.F., Canoll,P.D., Wolfgang,M.J., Rosen,C.L., D'Eustachio,P.
            and Salzer,J.L.
  TITLE     Cloning of neurotrimin defines a new subfamily of differentially
            expressed neural cell adhesion molecules
  JOURNAL   J Neurosci 15 (3 Pt 2), 2141-2156 (1995)
   PUBMED   7891157
REFERENCE   9  (bases 1 to 7021)
  AUTHORS   Smith,M.W., Clark,S.P., Hutchinson,J.S., Wei,Y.H., Churukian,A.C.,
            Daniels,L.B., Diggle,K.L., Gen,M.W., Romo,A.J., Lin,Y. et al.
  TITLE     A sequence-tagged site map of human chromosome 11
  JOURNAL   Genomics 17 (3), 699-725 (1993)
   PUBMED   8244387
REFERENCE   10 (bases 1 to 7021)
  AUTHORS   Lane,C.M., Elde,R., Loh,H.H. and Lee,N.M.
  TITLE     Regulation of an opioid-binding protein in NG108-15 cells parallels
            regulation of delta-opioid receptors
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11234-11238 (1992)
   PUBMED   1333602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP005122.2, AK314077.1,
            BC143946.1, AP000843.5 and DA247864.1.
            
            On Nov 19, 2020 this sequence version replaced NM_001319103.1.
            
            Summary: This gene encodes a member of the IgLON subfamily in the
            immunoglobulin protein superfamily of proteins. The encoded
            preprotein is proteolytically processed to generate the mature
            protein. This protein is localized in the plasma membrane and may
            have an accessory role in opioid receptor function. This gene has
            an ortholog in rat and bovine. The opioid binding-cell adhesion
            molecule encoded by the rat gene binds opioid alkaloids in the
            presence of acidic lipids, exhibits selectivity for mu ligands and
            acts as a GPI-anchored protein. Since the encoded protein is highly
            conserved in species during evolution, it may have a fundamental
            role in mammalian systems. Alternative splicing results in multiple
            transcript variants, at least one of which encodes an isoform that
            is proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c). The encoded isoform
            (c) may undergo proteolytic processing similar to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143946.1, SRR1803615.21086.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AP005122.2         97319-97517         c
            200-721             AK314077.1         1-522
            722-3545            BC143946.1         1-2824
            3546-6751           AP000843.5         74983-78188         c
            6752-7021           DA247864.1         1-270
FEATURES             Location/Qualifiers
     source          1..7021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q25"
     gene            1..7021
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="opioid binding protein/cell adhesion molecule like"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
     exon            1..911
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             745..1809
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="isoform c precursor is encoded by transcript
                     variant 3; IgLON family member 1; opioid binding
                     protein/cell adhesion molecule-like preprotein"
                     /codon_start=1
                     /product="opioid-binding protein/cell adhesion molecule
                     isoform c precursor"
                     /protein_id="NP_001306032.1"
                     /db_xref="GeneID:4978"
                     /db_xref="HGNC:HGNC:8143"
                     /db_xref="MIM:600632"
                     /translation="MGVCGYLFLPWKCLVVVSLRLLFLVPTGVPVRSGDATFPKAMDN
                     VTVRQGESATLRCTIDDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYSIMI
                     QNVDVYDEGPYTCSVQTDNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCLAI
                     GRPEPTVTWRHLSVKEGQGFVSEDEYLEISDIKRDQSGEYECSALNDVAAPDVRKVKI
                     TVNYPPYISKAKNTGVSVGQKGILSCEASAVPMAEFQWFKEETRLATGLDGMRIENKG
                     RMSTLTFFNVSEKDYGNYTCVATNKLGNTNASITLYEISPSSAVAGPGAVIDGVNSAS
                     RALACLWLSGTLLAHFFIKF"
     exon            912..1144
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1270
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1408
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1529
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1681
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1708
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..7021
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6999..7004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="hexamer: AATAAA"
     polyA_site      7021
                     /gene="OPCML"
                     /gene_synonym="IGLON1; OBCAM; OPCM"
                     /note="major polyA site"
ORIGIN      
        1 gtctcgtgcc gcgtccccgg aggaggcggg ggccgccgtc cgcccagctc cccgtgcgcc
       61 cggagcctgc gccgggcggc gctcccccgg ctggccgcga gtcgccgacc gggctgcaga
      121 ggacggccac cgaccggacg accctggctg cgccggctgc gcgtccccgc cttggaactt
      181 tttgccgcct tggggttcca gatgcgagac ctggggctgg gggacacgta catctgtcca
      241 tgtgtgtgat ctaataaacc atttcctcct ctccttgaag ccgcagcttt ttatgacagc
      301 tcctgtatgt cagagacact tgccttcttc tttgggttat aaacttttga tgccagagct
      361 ctgcagaacg tgcccaactg aatcttaaag tagcgtctcg aagagagagg cagagaaagc
      421 gcaatctgtg accttcatcc ccgcaccttg cttcttcctc tcccctcctg gccgcctccc
      481 tcctccccag gggagcgtca agaaagctct ttttggatgc aggagggggc atctggttct
      541 gctaggctgg aaagctgagg caggatctga ggaagaattc tcagactccg gagagcccgg
      601 actcctctct tctccttccc cctgctcctg gcgaactctg ccccttccct cctccccgca
      661 ccgcttcccg agcccgctgg tgcgcggggc gggggaccag gactgtgcgg ctgccggagt
      721 cctgggaagt tgtggctgtc gagaatgggg gtctgtgggt acctgttcct gccctggaag
      781 tgcctcgtgg tcgtgtctct caggctgctg ttccttgtac ccacaggagt gcccgtgcgc
      841 agcggagatg ccaccttccc caaagctatg gacaacgtga cggtccggca gggggagagc
      901 gccaccctca ggtgtaccat agatgaccgg gtaacccggg tggcctggct aaaccgcagc
      961 accatcctct acgctgggaa tgacaagtgg tccatagacc ctcgtgtgat catcctggtc
     1021 aatacaccaa cccagtacag catcatgatc caaaatgtgg atgtgtatga cgaaggtccg
     1081 tacacctgct ctgtgcagac agacaatcat cccaaaacgt cccgggttca cctaatagtg
     1141 caagttcctc ctcagatcat gaatatctcc tcagacatca ctgtgaatga gggaagcagt
     1201 gtgaccctgc tgtgtcttgc tattggcaga ccagagccaa ctgtgacatg gagacacctg
     1261 tcagtcaagg aaggccaggg ctttgtaagt gaggatgagt acctggagat ctctgacatc
     1321 aagcgagacc agtccgggga gtacgaatgc agcgcgttga acgatgtcgc tgcgcccgat
     1381 gtgcggaaag taaaaatcac tgtaaactat cctccctata tctcaaaagc caagaacact
     1441 ggtgtttcag tcggtcagaa gggcatcctg agctgtgaag cctctgcagt ccccatggct
     1501 gaattccagt ggttcaagga agaaaccagg ttagccactg gtctggatgg aatgaggatt
     1561 gaaaacaaag gccgcatgtc cactctgact ttcttcaatg tttcagaaaa ggattatggg
     1621 aactatactt gtgtggccac gaacaagctt gggaacacca atgccagcat cacattgtat
     1681 gaaataagcc cctcatcagc agtggcaggg cctggagcag tcattgatgg tgtaaactcg
     1741 gcctccagag cactggcttg tctctggcta tcagggaccc tcttagccca cttcttcatc
     1801 aagttttgat aagaaatcct aggtcctctg agcaacgcct gcttctccat atcacagact
     1861 ttaatctaca ctgcggagag caaaccagct tgggcttctt tttgtttttt tctgttattc
     1921 tagatttgtt ttctttttgt ttttgtttat ttgtttgttt gcttttattt ccagcttgaa
     1981 tgagtggggt tgggggcggg gtgggcaggg ttctaccacg tgtaggataa tcattcattg
     2041 gtgtgtccaa aaatggggtc tgctcctgct accttgaccc ttccctttcc tctgcttctc
     2101 tcctcatcat cattcccaac aacatcctct gccacacaca acaaaacgta agtttcattt
     2161 gggcaaaaat tgagcctcac aataaacacc ctgaagacac aacttgactt ataacatagt
     2221 gcacagcaag agctacatcc aagtgtccta ttatctgtga ttattttctt aatgacaatg
     2281 tacatatgcc cccatccatg ttaattatta tctaattcca ttagggttca cgtcttttct
     2341 ttctgggaca ctatcctact atatccatat ctatagattt caatatagat gattgtgcca
     2401 tcttctgtag cccctccgct ctactcattc cttccaccat ctgcagagat ttgaagtttg
     2461 gggctatgca tgaaacccaa cactaaattt tgcaagtcaa gtaaccaaaa aagggggagg
     2521 cattttgaag atagaacctc tattttaaaa agagaagttc aactcataaa cgtgattgat
     2581 aggtggctga tttatttagg ttttgtcaag ctatctatca aagtaatggt acagttaccc
     2641 atctactcaa atatctgatt tatctcacca tccaattatc tacccacctg tcttcctctc
     2701 tagcaatcta tttactgttt atcaatctat caatgtaatt gtctaacact cctttctatt
     2761 ctctccctac tactcactat caattcatcc ccatatgaat ctctaaccat attgtatctc
     2821 tcccactgta ttcatttata caccatcagc agacattggc atcttcaaaa ttatctttca
     2881 acttctgtga aagccaacga tctcacaggt taacaaaata caaaagcaat accctgtgtt
     2941 gtggactctt taaaatctgg tatcctatcc acccaaggga gacactaaca gataggccaa
     3001 agtagcaagc taatgatcag tcactcacta ttcccagaag agcctgtgtt ttctaaaaca
     3061 ctttcttggg aagcagatca gcctagaaaa gttttgatta gcactgtggt tttccttttg
     3121 cacttgaagg acaaaggtgc cagcctttat gcttctctca acccttcaag aaagtacatg
     3181 tcaggaacct atggctggct ttccttagca gcaagaactt gagagaaaaa cacatctgtc
     3241 tctgcaatgc aaagtgaaga gtccacccgc ctgagtggga tgacttcagc tagagtctcc
     3301 tttctgctcc agttctggtt taatctgttt gaaaactatc cagtaaaaag ctgatggagg
     3361 ccaattacat ggcgggtgta ttgacaactc tggtatttgt ttcaggaagc tcttctaagc
     3421 tgagggcact tgagcaactg acttaatttt caagcacttg attaacacaa cactgcaaac
     3481 agaagggaga aagtgtcagt gacacagttt cctctgatgc agctgcttct ccaatggctt
     3541 tggggaagaa cttcaccagc tcttcaggtt caaagcagac ccagcataca aacaagagct
     3601 gagccacctt tgctgtcttg tctcctggga cgagaaggac tcatccagca aagttgcctg
     3661 ggattcaaaa taaaggcatt gcagaccgca caggtgtgct gcagggactg atccacagag
     3721 aggatgagaa tgcagcatca atcgcagacc tgccctgcct cagttggaaa accttttcag
     3781 gccctcagtc taaaaaataa aaaatatgag caccattgaa ttctgtgccc ttaatgctta
     3841 actggtcttc ttcctctggt atcagtgtcc tctttgtttt tgtccatcaa ggcacatgag
     3901 tgtgacctct gccatgggga aacacacaca gagatatcta tacatatata catacataca
     3961 aacataggct atcttggcac actaaatgct aagcactgtc ttaagaggta gagctggtgt
     4021 gagtgaaatt aatgttacat tttccagctg taaacagaca tctgcatttc ctagtgagct
     4081 gccaggagcc agattcggga accgtaactg atgtgccagg aatggtgcat tgattcccag
     4141 ttccagggat gatcatgagc aggcgcaaaa tcagaattaa aggtcgcaca tagacgtttc
     4201 agatctgtca ccaccttcag catctggagt tgagttggtg tcagatagtg tatgagaatt
     4261 aaatgtgtca tctgagcatg ctactgatga taaatttgtt actttggagt tgaataaatg
     4321 tgaaggctgt gaagagtgga cagtcttgga gaacacagtg cttgaaatgg acaagctgga
     4381 cctattcctc actccaagac ttgttctaca ggaaagggtc catgctcctt tggccaagat
     4441 catcagaacc tctcaaccca acaaggctgg cttcagggcc actatggaac cctgctgttc
     4501 ccccttccaa aggatactaa gatgcccctc tggtgggtac ctatcccagc cacgtttcag
     4561 agggagagaa atgctacagt tgatcctcat ctgtctgggg taaagacaac aaagtaaata
     4621 caacccaagg caactggggt actcactggg agtgaaaatg acttcttcac aacagacata
     4681 tttctgcttc tgtgtttttg tgtttctttg gtggggatgg cttcatggga gagtggctgt
     4741 cacccatcat tttgaagcat atagaacaac aaatgcttac acaagacaat atccacactt
     4801 ttccaacttc acacacggag agtacatgga gaatgcctac aggctagatt tgttcagggt
     4861 gccagtagtg ggcatggggt gggggcaagg caggacaaaa catacaagtc tgagcaagta
     4921 catctcttgc aggttttcca catgaaaagg aagccaaata agtcctgtta ggagattagg
     4981 tgagaggaat tagcaatgta gggactctga aacccttccc cttcccaaaa cagagttcat
     5041 atgcacttcc accaaagtaa tgccaatgaa agtgctcgtg ttaaggctgc agccaagctt
     5101 gtttttcagt agtttaatgt caagtgcctg atacagtcga ctgcaagtct aaacaagcat
     5161 gtttagtttt tctcattctt gctttaattc agggaggggg agatgtagag aagtggttgt
     5221 gaaaacatgt acaggcttta tgcagagcac tgcgcatggc tgttctgctg caactgtgct
     5281 ccacgaaaca gaagaaaagg taaggtgttg tgtcacaaag aggccccagt ctctttcttc
     5341 ttacatccat gcctcttact agatgataca tttacagatt gggcagtttg ttctcaaaac
     5401 ctgggtgaga agactattcc tggactctag caacttcaaa actgaggctg ggtttcagaa
     5461 tctttttctg catcaattca gtcaatttgc cttcaacaaa gagaagtcag caagttctat
     5521 ttatgctgaa agaactattc catgagaaaa gcagagaacc ccaaagtggg caggcaaccc
     5581 cgacgagagc ttatccctgt ggcggcatca ggagtggctg tacattgaat tttcaagtgc
     5641 tggttggctg tcgccagccc atggtaggag gggaggaatg gcttaagatg aggtaagatc
     5701 tggtggtggg gcatctttcc tcaattccat actgactttg atcttgagaa agaaaaactg
     5761 gctatgcatt acctaaaacc agtccaaaat gaaacagacc aacacacaca caaaagcaaa
     5821 ttgtcaatcc ctttggaatt aagggaagca gcataaggtt tttctttttg gaaaaaatgc
     5881 atttattttc tttttctcca acagcaagaa tcttttgttt tcattttgca cgtgacctta
     5941 tcttggaaac tcttataccc aattgcctcc cctcctatta ttcagagctt ccctgtcttt
     6001 ttacttgaag acaaataagt ttgagcactt gagtaaaact tcacaggtgt gtaagtagga
     6061 aggcaacatt ttcaaaaaga gaccatatga tgagaacgcc taatgatcac cacatgcaaa
     6121 caaacaaaac tgccagtctc atttcccaca tttcttactt aagagaagag aagtaaatga
     6181 aaggaagaag aaatagattt gtaattaaag atgtggcaaa aaagataggg ctgagccagt
     6241 tcaatttagc cttcaggtgc agaatactta gagtccaaag aaatgtggag tggacttaat
     6301 tagatgcagt tgtctttatc ctgaaagtag tgagctaagc ctaatttcca gcattttgaa
     6361 agagattcct ttttgtttct ttccatggtg ccctctttaa ggcacagagt tgctccacac
     6421 cactgggtgg agaaagaaag attgcgaacc ctcgaccatc cttttgaggc tacattctat
     6481 gttatttggc agatttataa agctatcagt aataacaatg ctatgtactg caagctgccc
     6541 ttgtgttagt taaagggagc atttttaatc gttcggaaat tttcgtgaca tgtcaagtgc
     6601 agttgtgagg actgtgtggg tgaacgaaaa tgtgtctgtc aagttcagag tcctttagat
     6661 ttaaaaaaaa attatgactt atcaatggtg ccgttatagc tgtgtcagac aatgggtgtg
     6721 cccattctca caattatcct tcaaaaaaaa tctatgttca aatgctttaa aaatttatca
     6781 cacgatacaa gagtatgact ttgtcagcct tctagagttc tttttttctt ttattttctt
     6841 tcgtattttt tccttcaaaa aatcaatgaa gacttgattt ctgtcaataa ttgtatcaag
     6901 ggtgaatata ctacctgaat tttgtgcatg ttacattgta gttgtaacct tttctaattc
     6961 aggatgaata cgagatggtt gtgattgtgc agtgtaccaa taaagttcga gaaatttgta
     7021 a
//
